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Protein

Cyclin-I

Gene

Ccni

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: MGI
  • protein kinase binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCyclin

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-I
Gene namesi
Name:Ccni
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1341077 Ccni

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804771 – 377Cyclin-IAdd BLAST377

Proteomic databases

PaxDbiQ9Z2V9
PRIDEiQ9Z2V9

PTM databases

iPTMnetiQ9Z2V9
PhosphoSitePlusiQ9Z2V9

Expressioni

Gene expression databases

BgeeiENSMUSG00000063015 Expressed in 41 organ(s), highest expression level in cerebellum
CleanExiMM_CCNI
ExpressionAtlasiQ9Z2V9 baseline and differential
GenevisibleiQ9Z2V9 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050189

Structurei

3D structure databases

ProteinModelPortaliQ9Z2V9
SMRiQ9Z2V9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00530000062971
HOGENOMiHOG000142252
HOVERGENiHBG050841
InParanoidiQ9Z2V9
OMAiRPKYLNC
OrthoDBiEOG091G0HQN
TreeFamiTF101007

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR028856 Cyclin_I
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PTHR10177:SF187 PTHR10177:SF187, 1 hit
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
PIRSFiPIRSF001771 Cyclin_A_B_D_E, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9Z2V9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFPGPLENQ RLSSLLERAI SREAQMWKVN VPKIPTNQNV SPSQRDEVIQ
60 70 80 90 100
WLAKLKYQFN LYPETFALAS SLLDRFLATV KAHPKYLNCI AISCFFLAAK
110 120 130 140 150
TVEEDEKIPV LKVLARDSFC GCSSSEILRM ERIILDKLNW DLHTATPLDF
160 170 180 190 200
LHIFHAIAVS ARPQLLFSLP KLSPSQHLAV LTKQLLHCMA CNQLLQFKGS
210 220 230 240 250
MLALAMVSLE MEKLIPDWLP LTIELLQKAQ MDSSQLIHCR ELVAYHLSAL
260 270 280 290 300
QSALPLNSVY VYRPLKHTLV TCDKGAFKLH PSSVSGPDFS KDNSKPEVPV
310 320 330 340 350
RGPAAFHLHL PAASGCKQTS AKRKVEEMEV DDFYDGIKRL YNEDNGPENV
360 370
GSVCGTDLSR QEGHASPCPP LQPVSVM
Length:377
Mass (Da):42,197
Last modified:October 3, 2012 - v4
Checksum:i828A6E59846ED5BE
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z680D3Z680_MOUSE
Cyclin-I
Ccni
172Annotation score:
A0A0J9YU25A0A0J9YU25_MOUSE
Cyclin-I
Ccni
148Annotation score:
D3Z602D3Z602_MOUSE
Cyclin-I
Ccni
81Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161A → T in AAD01253 (PubMed:11054536).Curated1
Sequence conflicti161A → T in AAF43391 (PubMed:11054536).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134827 Genomic DNA No translation available.
CH466617 Genomic DNA Translation: EDL05230.1
CH466617 Genomic DNA Translation: EDL05231.1
AF005886 mRNA Translation: AAD01253.2
AF228740, AF228739 Genomic DNA Translation: AAF43391.1
CCDSiCCDS19436.1
RefSeqiNP_059063.2, NM_017367.3
XP_006534799.1, XM_006534736.3
UniGeneiMm.250419

Genome annotation databases

EnsembliENSMUST00000058550; ENSMUSP00000050189; ENSMUSG00000063015
GeneIDi12453
KEGGimmu:12453
UCSCiuc008yed.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134827 Genomic DNA No translation available.
CH466617 Genomic DNA Translation: EDL05230.1
CH466617 Genomic DNA Translation: EDL05231.1
AF005886 mRNA Translation: AAD01253.2
AF228740, AF228739 Genomic DNA Translation: AAF43391.1
CCDSiCCDS19436.1
RefSeqiNP_059063.2, NM_017367.3
XP_006534799.1, XM_006534736.3
UniGeneiMm.250419

3D structure databases

ProteinModelPortaliQ9Z2V9
SMRiQ9Z2V9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050189

PTM databases

iPTMnetiQ9Z2V9
PhosphoSitePlusiQ9Z2V9

Proteomic databases

PaxDbiQ9Z2V9
PRIDEiQ9Z2V9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058550; ENSMUSP00000050189; ENSMUSG00000063015
GeneIDi12453
KEGGimmu:12453
UCSCiuc008yed.2 mouse

Organism-specific databases

CTDi10983
MGIiMGI:1341077 Ccni

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00530000062971
HOGENOMiHOG000142252
HOVERGENiHBG050841
InParanoidiQ9Z2V9
OMAiRPKYLNC
OrthoDBiEOG091G0HQN
TreeFamiTF101007

Miscellaneous databases

PROiPR:Q9Z2V9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063015 Expressed in 41 organ(s), highest expression level in cerebellum
CleanExiMM_CCNI
ExpressionAtlasiQ9Z2V9 baseline and differential
GenevisibleiQ9Z2V9 MM

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR028856 Cyclin_I
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PTHR10177:SF187 PTHR10177:SF187, 1 hit
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
PIRSFiPIRSF001771 Cyclin_A_B_D_E, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCNI_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2V9
Secondary accession number(s): G3X985
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 116 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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