UniProtKB - Q9Z2V9 (CCNI_MOUSE)

BLAST

>sp|Q9Z2V9|CCNI_MOUSE Cyclin-I OS=Mus musculus OX=10090 GN=Ccni PE=2 SV=4
MKFPGPLENQRLSSLLERAISREAQMWKVNVPKIPTNQNVSPSQRDEVIQWLAKLKYQFN
LYPETFALASSLLDRFLATVKAHPKYLNCIAISCFFLAAKTVEEDEKIPVLKVLARDSFC
GCSSSEILRMERIILDKLNWDLHTATPLDFLHIFHAIAVSARPQLLFSLPKLSPSQHLAV
LTKQLLHCMACNQLLQFKGSMLALAMVSLEMEKLIPDWLPLTIELLQKAQMDSSQLIHCR
ELVAYHLSALQSALPLNSVYVYRPLKHTLVTCDKGAFKLHPSSVSGPDFSKDNSKPEVPV
RGPAAFHLHLPAASGCKQTSAKRKVEEMEVDDFYDGIKRLYNEDNGPENVGSVCGTDLSR
QEGHASPCPPLQPVSVM

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History
Entry version 116 (07 Nov 2018)
Sequence version 4 (03 Oct 2012)
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Protein

Cyclin-I

Gene

Ccni

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mitotic cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell proliferation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein phosphorylation Source: GOC
regulation of cell cycle
Source: MGI
Traceable author statementⁱ
- 11054536
regulation of cyclin-dependent protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of mitotic nuclear division
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cyclin

Molecular function

Cyclin

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-I
Gene namesⁱ	Name:Ccni
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:1341077 Ccni

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080477	1 – 377	Cyclin-IAdd BLAST		377

Proteomic databases

PaxDbⁱ	Q9Z2V9
PRIDEⁱ	Q9Z2V9

PTM databases

iPTMnetⁱ	Q9Z2V9
PhosphoSitePlusⁱ	Q9Z2V9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000063015 Expressed in 41 organ(s), highest expression level in cerebellum
CleanExⁱ	MM_CCNI
ExpressionAtlasⁱ	Q9Z2V9 baseline and differential
Genevisibleⁱ	Q9Z2V9 MM

Interactionⁱ

GO - Molecular functionⁱ

protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000050189

STRINGⁱ

10090.ENSMUSP00000050189

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Z2V9
SMRⁱ	Q9Z2V9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0653 Eukaryota COG5024 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062971
HOGENOMⁱ	HOG000142252
HOVERGENⁱ	HBG050841
InParanoidⁱ	Q9Z2V9
OMAⁱ	RPKYLNC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HQN
TreeFamⁱ	TF101007

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00043 CYCLIN, 1 hit
InterProⁱ	View protein in InterPro IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR028856 Cyclin_I IPR006671 Cyclin_N
PANTHERⁱ	PTHR10177 PTHR10177, 1 hit PTHR10177:SF187 PTHR10177:SF187, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00134 Cyclin_N, 1 hit
PIRSFⁱ	PIRSF001771 Cyclin_A_B_D_E, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q9Z2V9-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MKFPGPLENQ RLSSLLERAI SREAQMWKVN VPKIPTNQNV SPSQRDEVIQ 
        60         70         80         90        100
WLAKLKYQFN LYPETFALAS SLLDRFLATV KAHPKYLNCI AISCFFLAAK 
       110        120        130        140        150
TVEEDEKIPV LKVLARDSFC GCSSSEILRM ERIILDKLNW DLHTATPLDF 
       160        170        180        190        200
LHIFHAIAVS ARPQLLFSLP KLSPSQHLAV LTKQLLHCMA CNQLLQFKGS 
       210        220        230        240        250
MLALAMVSLE MEKLIPDWLP LTIELLQKAQ MDSSQLIHCR ELVAYHLSAL 
       260        270        280        290        300
QSALPLNSVY VYRPLKHTLV TCDKGAFKLH PSSVSGPDFS KDNSKPEVPV 
       310        320        330        340        350
RGPAAFHLHL PAASGCKQTS AKRKVEEMEV DDFYDGIKRL YNEDNGPENV 
       360        370 
GSVCGTDLSR QEGHASPCPP LQPVSVM

Length:377

Mass (Da):42,197

Last modified:October 3, 2012 - v4

Checksum:ⁱ828A6E59846ED5BE

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3Z680	D3Z680_MOUSE	Cyclin-I Cyclin-I	Ccni	172	Annotation score:
A0A0J9YU25	A0A0J9YU25_MOUSE	Cyclin-I Cyclin-I	Ccni	148	Annotation score:
D3Z602	D3Z602_MOUSE	Cyclin-I Cyclin-I	Ccni	81	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	161	A → T in AAD01253 (PubMed:11054536).Curated		1
Sequence conflictⁱ	161	A → T in AAF43391 (PubMed:11054536).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC134827 Genomic DNA No translation available. CH466617 Genomic DNA Translation: EDL05230.1 CH466617 Genomic DNA Translation: EDL05231.1 AF005886 mRNA Translation: AAD01253.2 AF228740, AF228739 Genomic DNA Translation: AAF43391.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19436.1
NCBI Reference Sequences More...RefSeqⁱ	NP_059063.2, NM_017367.3 XP_006534799.1, XM_006534736.3
UniGeneⁱ	Mm.250419

Genome annotation databases

Ensemblⁱ	ENSMUST00000058550; ENSMUSP00000050189; ENSMUSG00000063015
GeneIDⁱ	12453
KEGGⁱ	mmu:12453
UCSC genome browser More...UCSCⁱ	uc008yed.2 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q9Z2V9	Cyclin-I (Fragment)		MOUSE		81	UniRef100_Q9Z2V9
Cyclin-I (Fragment)		MOUSE		172

Protein	Similar proteins		Species	Score	Length	Source
Q9Z2V9	Cyclin-I		HUMAN		377	UniRef90_Q14094
Cyclin I		GORGO		377
Uncharacterized protein		AILME		386
Cyclin I		HORSE		384
Putative cyclin b (Fragment)		DESRO		384
+102

Protein	Similar proteins		Species	Score	Length	Source
Q9Z2V9	Cyclin-I		HUMAN		377	UniRef50_Q14094
Cyclin I		GORGO		377
Uncharacterized protein		AILME		386
Cyclin I		HORSE		384
Uncharacterized protein		MYOLU		384
+355

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC134827 Genomic DNA No translation available. CH466617 Genomic DNA Translation: EDL05230.1 CH466617 Genomic DNA Translation: EDL05231.1 AF005886 mRNA Translation: AAD01253.2 AF228740, AF228739 Genomic DNA Translation: AAF43391.1
CCDSⁱ	CCDS19436.1
RefSeqⁱ	NP_059063.2, NM_017367.3 XP_006534799.1, XM_006534736.3
UniGeneⁱ	Mm.250419

3D structure databases

ProteinModelPortalⁱ	Q9Z2V9
SMRⁱ	Q9Z2V9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000050189

STRINGⁱ

10090.ENSMUSP00000050189

PTM databases

iPTMnetⁱ	Q9Z2V9
PhosphoSitePlusⁱ	Q9Z2V9

Proteomic databases

PaxDbⁱ	Q9Z2V9
PRIDEⁱ	Q9Z2V9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000058550; ENSMUSP00000050189; ENSMUSG00000063015
GeneIDⁱ	12453
KEGGⁱ	mmu:12453
UCSCⁱ	uc008yed.2 mouse

Organism-specific databases

CTDⁱ	10983
MGIⁱ	MGI:1341077 Ccni

Phylogenomic databases

eggNOGⁱ	KOG0653 Eukaryota COG5024 LUCA
GeneTreeⁱ	ENSGT00530000062971
HOGENOMⁱ	HOG000142252
HOVERGENⁱ	HBG050841
InParanoidⁱ	Q9Z2V9
OMAⁱ	RPKYLNC
OrthoDBⁱ	EOG091G0HQN
TreeFamⁱ	TF101007

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9Z2V9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000063015 Expressed in 41 organ(s), highest expression level in cerebellum
CleanExⁱ	MM_CCNI
ExpressionAtlasⁱ	Q9Z2V9 baseline and differential
Genevisibleⁱ	Q9Z2V9 MM

Family and domain databases

CDDⁱ	cd00043 CYCLIN, 1 hit
InterProⁱ	View protein in InterPro IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR028856 Cyclin_I IPR006671 Cyclin_N
PANTHERⁱ	PTHR10177 PTHR10177, 1 hit PTHR10177:SF187 PTHR10177:SF187, 1 hit
Pfamⁱ	View protein in Pfam PF00134 Cyclin_N, 1 hit
PIRSFⁱ	PIRSF001771 Cyclin_A_B_D_E, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCNI_MOUSE
Accessionⁱ	Q9Z2V9Primary (citable) accession number: Q9Z2V9 Secondary accession number(s): G3X985
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	October 3, 2012
	Last modified:	November 7, 2018
	This is version 116 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Z2V9 (CCNI_MOUSE)

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Cyclin-I

Ccni

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ