UniProtKB - Q9Z2V9 (CCNI_MOUSE)
Protein
Cyclin-I
Gene
Ccni
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
GO - Biological processi
- mitotic cell cycle phase transition Source: GO_Central
- regulation of cell cycle Source: MGI
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Keywordsi
Molecular function | Cyclin |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-I |
Gene namesi | Name:Ccni |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1341077, Ccni |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Other locations
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- cytoplasm Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080477 | 1 – 377 | Cyclin-IAdd BLAST | 377 |
Proteomic databases
PaxDbi | Q9Z2V9 |
PRIDEi | Q9Z2V9 |
PTM databases
iPTMneti | Q9Z2V9 |
PhosphoSitePlusi | Q9Z2V9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000063015, Expressed in cortical plate and 74 other tissues |
Genevisiblei | Q9Z2V9, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000050189 |
Miscellaneous databases
RNActi | Q9Z2V9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the cyclin family.Curated
Phylogenomic databases
eggNOGi | KOG0653, Eukaryota |
GeneTreei | ENSGT00940000154827 |
HOGENOMi | CLU_062642_1_0_1 |
InParanoidi | Q9Z2V9 |
OMAi | NWDLHMA |
OrthoDBi | 1015714at2759 |
TreeFami | TF101007 |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR028856, Cyclin_I IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF187, PTHR10177:SF187, 1 hit |
Pfami | View protein in Pfam PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit |
SUPFAMi | SSF47954, SSF47954, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9Z2V9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKFPGPLENQ RLSSLLERAI SREAQMWKVN VPKIPTNQNV SPSQRDEVIQ
60 70 80 90 100
WLAKLKYQFN LYPETFALAS SLLDRFLATV KAHPKYLNCI AISCFFLAAK
110 120 130 140 150
TVEEDEKIPV LKVLARDSFC GCSSSEILRM ERIILDKLNW DLHTATPLDF
160 170 180 190 200
LHIFHAIAVS ARPQLLFSLP KLSPSQHLAV LTKQLLHCMA CNQLLQFKGS
210 220 230 240 250
MLALAMVSLE MEKLIPDWLP LTIELLQKAQ MDSSQLIHCR ELVAYHLSAL
260 270 280 290 300
QSALPLNSVY VYRPLKHTLV TCDKGAFKLH PSSVSGPDFS KDNSKPEVPV
310 320 330 340 350
RGPAAFHLHL PAASGCKQTS AKRKVEEMEV DDFYDGIKRL YNEDNGPENV
360 370
GSVCGTDLSR QEGHASPCPP LQPVSVM
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z680 | D3Z680_MOUSE | Cyclin-I | Ccni | 172 | Annotation score: | ||
A0A0J9YU25 | A0A0J9YU25_MOUSE | Cyclin-I | Ccni | 148 | Annotation score: | ||
D3Z602 | D3Z602_MOUSE | Cyclin-I | Ccni | 81 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 161 | A → T in AAD01253 (PubMed:11054536).Curated | 1 | |
Sequence conflicti | 161 | A → T in AAF43391 (PubMed:11054536).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC134827 Genomic DNA No translation available. CH466617 Genomic DNA Translation: EDL05230.1 CH466617 Genomic DNA Translation: EDL05231.1 AF005886 mRNA Translation: AAD01253.2 AF228740, AF228739 Genomic DNA Translation: AAF43391.1 |
CCDSi | CCDS19436.1 |
RefSeqi | NP_059063.2, NM_017367.3 XP_006534799.1, XM_006534736.3 |
Genome annotation databases
Ensembli | ENSMUST00000058550; ENSMUSP00000050189; ENSMUSG00000063015 |
GeneIDi | 12453 |
KEGGi | mmu:12453 |
UCSCi | uc008yed.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC134827 Genomic DNA No translation available. CH466617 Genomic DNA Translation: EDL05230.1 CH466617 Genomic DNA Translation: EDL05231.1 AF005886 mRNA Translation: AAD01253.2 AF228740, AF228739 Genomic DNA Translation: AAF43391.1 |
CCDSi | CCDS19436.1 |
RefSeqi | NP_059063.2, NM_017367.3 XP_006534799.1, XM_006534736.3 |
3D structure databases
SMRi | Q9Z2V9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000050189 |
PTM databases
iPTMneti | Q9Z2V9 |
PhosphoSitePlusi | Q9Z2V9 |
Proteomic databases
PaxDbi | Q9Z2V9 |
PRIDEi | Q9Z2V9 |
Protocols and materials databases
Antibodypediai | 4127, 163 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000058550; ENSMUSP00000050189; ENSMUSG00000063015 |
GeneIDi | 12453 |
KEGGi | mmu:12453 |
UCSCi | uc008yed.2, mouse |
Organism-specific databases
CTDi | 10983 |
MGIi | MGI:1341077, Ccni |
Phylogenomic databases
eggNOGi | KOG0653, Eukaryota |
GeneTreei | ENSGT00940000154827 |
HOGENOMi | CLU_062642_1_0_1 |
InParanoidi | Q9Z2V9 |
OMAi | NWDLHMA |
OrthoDBi | 1015714at2759 |
TreeFami | TF101007 |
Miscellaneous databases
BioGRID-ORCSi | 12453, 1 hit in 17 CRISPR screens |
ChiTaRSi | Ccni, mouse |
PROi | PR:Q9Z2V9 |
RNActi | Q9Z2V9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000063015, Expressed in cortical plate and 74 other tissues |
Genevisiblei | Q9Z2V9, MM |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR028856, Cyclin_I IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF187, PTHR10177:SF187, 1 hit |
Pfami | View protein in Pfam PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit |
SUPFAMi | SSF47954, SSF47954, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCNI_MOUSE | |
Accessioni | Q9Z2V9Primary (citable) accession number: Q9Z2V9 Secondary accession number(s): G3X985 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | October 3, 2012 | |
Last modified: | December 2, 2020 | |
This is version 130 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families