UniProtKB - Q9Z2S7 (T22D3_MOUSE)
TSC22 domain family protein 3
Tsc22d3
Functioni
Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity).
Isoform 1 and isoform 4 inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.
By similarity1 PublicationGO - Biological processi
- negative regulation of activation-induced cell death of T cells Source: MGI
- regulation of transcription by RNA polymerase II Source: InterPro
- response to osmotic stress Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-2672351, Stimuli-sensing channels |
Names & Taxonomyi
Protein namesi | Recommended name: TSC22 domain family protein 3Alternative name(s): Glucocorticoid-induced leucine zipper protein TSC22-related-inducible leucine zipper 3 Short name: Tilz3 |
Gene namesi | Name:Tsc22d3 Synonyms:Dsip1, Dsipi, Gilz |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1196284, Tsc22d3 |
VEuPathDBi | HostDB:ENSMUSG00000031431 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219371 | 1 – 137 | TSC22 domain family protein 3Add BLAST | 137 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 102 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 125 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 128 | PhosphothreonineCombined sources | 1 | ||
Isoform 3 (identifier: Q9Z2S7-3) | |||||
Modified residuei | 40 | PhosphoserineCombined sources | 1 | ||
Isoform 4 (identifier: Q9Z2S7-4) | |||||
Modified residuei | 73 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9Z2S7 |
jPOSTi | Q9Z2S7 |
MaxQBi | Q9Z2S7 |
PaxDbi | Q9Z2S7 |
PeptideAtlasi | Q9Z2S7 |
PRIDEi | Q9Z2S7 |
ProteomicsDBi | 263227 [Q9Z2S7-1] 263228 [Q9Z2S7-2] 263229 [Q9Z2S7-3] 263230 [Q9Z2S7-4] |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00265379 |
PTM databases
iPTMneti | Q9Z2S7 |
PhosphoSitePlusi | Q9Z2S7 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000031431, Expressed in skin of back and 302 other tissues |
ExpressionAtlasi | Q9Z2S7, baseline and differential |
Genevisiblei | Q9Z2S7, MM |
Interactioni
Subunit structurei
Can form homodimers, however it is likely to function as a monomer.
Interacts with AP1 and NFKB1 (By similarity). Isoform 1 and isoform 4 interact with MYOD1.
Isoform 1 interacts with HDAC1; this interaction affects HDAC1 activity on MYOG promoter and thus inhibits MYOD1 transcriptional activity.
By similarity2 PublicationsBinary interactionsi
Isoform 3 [Q9Z2S7-3]
With | #Exp. | IntAct |
---|---|---|
Nedd4l [Q8CFI0] | 2 | EBI-15771036,EBI-8046183 |
Raf1 [Q99N57] | 2 | EBI-15771036,EBI-397757 |
Sgk1 [Q9WVC6] | 2 | EBI-15771036,EBI-15591730 |
Protein-protein interaction databases
BioGRIDi | 199919, 5 interactors |
DIPi | DIP-48844N |
IntActi | Q9Z2S7, 8 interactors |
STRINGi | 10090.ENSMUSP00000108620 |
Miscellaneous databases
RNActi | Q9Z2S7, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 60 | AP1-bindingAdd BLAST | 60 | |
Regioni | 76 – 97 | Leucine-zipperAdd BLAST | 22 | |
Regioni | 101 – 137 | DisorderedSequence analysisAdd BLAST | 37 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4797, Eukaryota |
GeneTreei | ENSGT00940000156656 |
HOGENOMi | CLU_148757_0_0_1 |
InParanoidi | Q9Z2S7 |
OMAi | YQSPMEV |
OrthoDBi | 1602203at2759 |
PhylomeDBi | Q9Z2S7 |
TreeFami | TF329224 |
Family and domain databases
InterProi | View protein in InterPro IPR000580, TSC-22_Dip_Bun |
Pfami | View protein in Pfam PF01166, TSC22, 1 hit |
PROSITEi | View protein in PROSITE PS01289, TSC22, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNTEMYQTPM EVAVYQLHNF SISFFSSLLG GDVVSVKLDN SASGASVVAL
60 70 80 90 100
DNKIEQAMDL VKNHLMYAVR EEVEVLKEQI RELLEKNSQL ERENTLLKTL
110 120 130
ASPEQLEKFQ SRLSPEEPAP EAPETPETPE APGGSAV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB1AVF2 | B1AVF2_MOUSE | TSC22 domain family protein 3 | Tsc22d3 | 113 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 22 | I → T in AAD01789 (PubMed:9430225).Curated | 1 | |
Sequence conflicti | 33 | V → L in AAG41221 (Ref. 3) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012690 | 1 – 57 | Missing in isoform 2. 2 PublicationsAdd BLAST | 57 | |
Alternative sequenceiVSP_012691 | 1 – 40 | MNTEM…VKLDN → MAQPKTECRSPVGLDCCNCC LDLANRCELQKEKSGESPGS PFVSNFRQLQEKLVFENLNT DKLNNIMRQDSMEPVVRDPC YLINEGICNRNIDQTMLSIL LFFH in isoform 3. 1 PublicationAdd BLAST | 40 | |
Alternative sequenceiVSP_055016 | 1 – 40 | MNTEM…VKLDN → MESQKASSAGAHLPAAPDLP EQAAAAAASKPEKMAQPKTE CRSPVGLDCCNCCLDLANRC ELQKEKSGESPGSPFVSNFR QLQEKLVFENLNTDKLNNIM RQDSMEPVVRDPCYLINEGI CNRNIDQTMLSILLFFH in isoform 4. 1 PublicationAdd BLAST | 40 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF024519 mRNA Translation: AAD01789.1 EU818782 mRNA Translation: ACJ09091.1 AF201287 mRNA Translation: AAG41220.1 AF201288 mRNA Translation: AAG41221.1 AF201289 mRNA Translation: AAG41222.1 AK083389 mRNA Translation: BAC38897.1 AK144196 mRNA Translation: BAE25761.1 AL683809 Genomic DNA No translation available. BC028813 mRNA Translation: AAH28813.1 |
CCDSi | CCDS30440.1 [Q9Z2S7-1] CCDS41150.1 [Q9Z2S7-3] |
RefSeqi | NP_001070832.1, NM_001077364.1 [Q9Z2S7-3] NP_034416.3, NM_010286.4 [Q9Z2S7-1] XP_006528562.1, XM_006528499.3 [Q9Z2S7-3] XP_006528563.1, XM_006528500.3 [Q9Z2S7-3] XP_006528564.1, XM_006528501.3 XP_006528566.1, XM_006528503.3 [Q9Z2S7-2] XP_006528567.1, XM_006528504.3 [Q9Z2S7-3] XP_006528568.1, XM_006528505.3 [Q9Z2S7-3] |
Genome annotation databases
Ensembli | ENSMUST00000055738; ENSMUSP00000062589; ENSMUSG00000031431 [Q9Z2S7-1] ENSMUST00000112996; ENSMUSP00000108620; ENSMUSG00000031431 [Q9Z2S7-3] |
GeneIDi | 14605 |
KEGGi | mmu:14605 |
UCSCi | uc009ukz.2, mouse [Q9Z2S7-1] uc009ulb.1, mouse [Q9Z2S7-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF024519 mRNA Translation: AAD01789.1 EU818782 mRNA Translation: ACJ09091.1 AF201287 mRNA Translation: AAG41220.1 AF201288 mRNA Translation: AAG41221.1 AF201289 mRNA Translation: AAG41222.1 AK083389 mRNA Translation: BAC38897.1 AK144196 mRNA Translation: BAE25761.1 AL683809 Genomic DNA No translation available. BC028813 mRNA Translation: AAH28813.1 |
CCDSi | CCDS30440.1 [Q9Z2S7-1] CCDS41150.1 [Q9Z2S7-3] |
RefSeqi | NP_001070832.1, NM_001077364.1 [Q9Z2S7-3] NP_034416.3, NM_010286.4 [Q9Z2S7-1] XP_006528562.1, XM_006528499.3 [Q9Z2S7-3] XP_006528563.1, XM_006528500.3 [Q9Z2S7-3] XP_006528564.1, XM_006528501.3 XP_006528566.1, XM_006528503.3 [Q9Z2S7-2] XP_006528567.1, XM_006528504.3 [Q9Z2S7-3] XP_006528568.1, XM_006528505.3 [Q9Z2S7-3] |
3D structure databases
AlphaFoldDBi | Q9Z2S7 |
SMRi | Q9Z2S7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199919, 5 interactors |
DIPi | DIP-48844N |
IntActi | Q9Z2S7, 8 interactors |
STRINGi | 10090.ENSMUSP00000108620 |
PTM databases
iPTMneti | Q9Z2S7 |
PhosphoSitePlusi | Q9Z2S7 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00265379 |
Proteomic databases
EPDi | Q9Z2S7 |
jPOSTi | Q9Z2S7 |
MaxQBi | Q9Z2S7 |
PaxDbi | Q9Z2S7 |
PeptideAtlasi | Q9Z2S7 |
PRIDEi | Q9Z2S7 |
ProteomicsDBi | 263227 [Q9Z2S7-1] 263228 [Q9Z2S7-2] 263229 [Q9Z2S7-3] 263230 [Q9Z2S7-4] |
Protocols and materials databases
Antibodypediai | 29322, 439 antibodies from 32 providers |
DNASUi | 14605 |
Genome annotation databases
Ensembli | ENSMUST00000055738; ENSMUSP00000062589; ENSMUSG00000031431 [Q9Z2S7-1] ENSMUST00000112996; ENSMUSP00000108620; ENSMUSG00000031431 [Q9Z2S7-3] |
GeneIDi | 14605 |
KEGGi | mmu:14605 |
UCSCi | uc009ukz.2, mouse [Q9Z2S7-1] uc009ulb.1, mouse [Q9Z2S7-3] |
Organism-specific databases
CTDi | 1831 |
MGIi | MGI:1196284, Tsc22d3 |
VEuPathDBi | HostDB:ENSMUSG00000031431 |
Phylogenomic databases
eggNOGi | KOG4797, Eukaryota |
GeneTreei | ENSGT00940000156656 |
HOGENOMi | CLU_148757_0_0_1 |
InParanoidi | Q9Z2S7 |
OMAi | YQSPMEV |
OrthoDBi | 1602203at2759 |
PhylomeDBi | Q9Z2S7 |
TreeFami | TF329224 |
Enzyme and pathway databases
Reactomei | R-MMU-2672351, Stimuli-sensing channels |
Miscellaneous databases
BioGRID-ORCSi | 14605, 2 hits in 70 CRISPR screens |
ChiTaRSi | Tsc22d3, mouse |
PROi | PR:Q9Z2S7 |
RNActi | Q9Z2S7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031431, Expressed in skin of back and 302 other tissues |
ExpressionAtlasi | Q9Z2S7, baseline and differential |
Genevisiblei | Q9Z2S7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000580, TSC-22_Dip_Bun |
Pfami | View protein in Pfam PF01166, TSC22, 1 hit |
PROSITEi | View protein in PROSITE PS01289, TSC22, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | T22D3_MOUSE | |
Accessioni | Q9Z2S7Primary (citable) accession number: Q9Z2S7 Secondary accession number(s): B1AVF3 Q9EQN2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 2001 |
Last sequence update: | February 1, 2005 | |
Last modified: | May 25, 2022 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families