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UniProtKB - Q9Z2S7 (T22D3_MOUSE)

Entry version 156 (22 Apr 2020)
Sequence version 2 (01 Feb 2005)
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Protein

TSC22 domain family protein 3

Gene

Tsc22d3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 and isoform 4 inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-2672351 Stimuli-sensing channels

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TSC22 domain family protein 3
Alternative name(s):
Glucocorticoid-induced leucine zipper protein
TSC22-related-inducible leucine zipper 3
Short name:
Tilz3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tsc22d3
Synonyms:Dsip1, Dsipi, Gilz
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1196284 Tsc22d3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002193711 – 137TSC22 domain family protein 3Add BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei102PhosphoserineBy similarity1
Modified residuei125PhosphothreonineCombined sources1
Modified residuei128PhosphothreonineCombined sources1
Isoform 3 (identifier: Q9Z2S7-3)
Modified residuei40PhosphoserineCombined sources1
Isoform 4 (identifier: Q9Z2S7-4)
Modified residuei73PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Z2S7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Z2S7

PeptideAtlas

More...PeptideAtlasi		Q9Z2S7

PRoteomics IDEntifications database

More...PRIDEi		Q9Z2S7

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00265379

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Z2S7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Z2S7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Constitutively expressed in lung, intestine, kidney and liver, most probably by resident cells from the macrophage lineage. Expression inversely correlates with T-cell activation, being higher in resting cells and lower in cells activated by TCR/CD3 triggering. Isoform 1 and isoform 4 are expressed in spleen and skeletal muscle (at protein level). Isoform 1 is expressed in thymus, lymph nodes, bone marrow, spleen, lung and skeletal muscle.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 1 and isoform 4 are expressed in differentiating myoblasts at a time of myotube formation.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By glucocorticoids in lymphoid cells and upon IL4, IL10, IL13 or glucocorticoid treatment in monocyte/macrophage cells. Transiently induced by IL2 deprivation in T-cells. Isoform 1 and isoform 4 expression is up-regulated by the synthetic glucocorticoid dexamethasone in differentiating myoblasts.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000031431 Expressed in skin of back and 279 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Z2S7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Z2S7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can form homodimers, however it is likely to function as a monomer.

Interacts with AP1 and NFKB1 (By similarity). Isoform 1 and isoform 4 interact with MYOD1.

Isoform 1 interacts with HDAC1; this interaction affects HDAC1 activity on MYOG promoter and thus inhibits MYOD1 transcriptional activity.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		199919, 5 interactors

Database of interacting proteins

More...DIPi		DIP-48844N

Protein interaction database and analysis system

More...IntActi		Q9Z2S7, 5 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000108620

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Z2S7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Z2S7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 60AP1-bindingAdd BLAST60
Regioni76 – 97Leucine-zipperAdd BLAST22

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The leucine-zipper is involved in homodimerization.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IRR1 Eukaryota
ENOG410YAFT LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156656

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_148757_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Z2S7

Identification of Orthologs from Complete Genome Data

More...OMAi		YQLHNFN

Database of Orthologous Groups

More...OrthoDBi		1602203at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Z2S7

TreeFam database of animal gene trees

More...TreeFami		TF329224

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000580 TSC-22_Dip_Bun

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01166 TSC22, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01289 TSC22, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Z2S7-1) [UniParc]FASTAAdd to basket
Also known as: Tilz3b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNTEMYQTPM EVAVYQLHNF SISFFSSLLG GDVVSVKLDN SASGASVVAL 
        60         70         80         90        100
DNKIEQAMDL VKNHLMYAVR EEVEVLKEQI RELLEKNSQL ERENTLLKTL 
       110        120        130 
ASPEQLEKFQ SRLSPEEPAP EAPETPETPE APGGSAV
Length:137
Mass (Da):15,177
Last modified:February 1, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA11D7B69037F111E
GO
Isoform 2 (identifier: Q9Z2S7-2) [UniParc]FASTAAdd to basket
Also known as: Tilz3a

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.

Show »
Length:80
Mass (Da):9,040
Checksum:i2174BA0EC92DDCFC
GO
Isoform 3 (identifier: Q9Z2S7-3) [UniParc]FASTAAdd to basket
Also known as: Tilz3c

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: MNTEMYQTPM...GDVVSVKLDN → MAQPKTECRS...TMLSILLFFH

Show »
Length:201
Mass (Da):22,565
Checksum:iB12F0480154A20DE
GO
Isoform 4 (identifier: Q9Z2S7-4) [UniParc]FASTAAdd to basket
Also known as: Long Gilz, L-Gilz

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: MNTEMYQTPM...GDVVSVKLDN → MESQKASSAG...TMLSILLFFH

Show »
Length:234
Mass (Da):25,778
Checksum:iC7CEDB07D24D4185
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AVF2B1AVF2_MOUSE
TSC22 domain family protein 3
Tsc22d3
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22I → T in AAD01789 (PubMed:9430225).Curated1
Sequence conflicti33V → L in AAG41221 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0126901 – 57Missing in isoform 2. 2 PublicationsAdd BLAST57
Alternative sequenceiVSP_0126911 – 40MNTEM…VKLDN → MAQPKTECRSPVGLDCCNCC LDLANRCELQKEKSGESPGS PFVSNFRQLQEKLVFENLNT DKLNNIMRQDSMEPVVRDPC YLINEGICNRNIDQTMLSIL LFFH in isoform 3. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_0550161 – 40MNTEM…VKLDN → MESQKASSAGAHLPAAPDLP EQAAAAAASKPEKMAQPKTE CRSPVGLDCCNCCLDLANRC ELQKEKSGESPGSPFVSNFR QLQEKLVFENLNTDKLNNIM RQDSMEPVVRDPCYLINEGI CNRNIDQTMLSILLFFH in isoform 4. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF024519 mRNA Translation: AAD01789.1
EU818782 mRNA Translation: ACJ09091.1
AF201287 mRNA Translation: AAG41220.1
AF201288 mRNA Translation: AAG41221.1
AF201289 mRNA Translation: AAG41222.1
AK083389 mRNA Translation: BAC38897.1
AK144196 mRNA Translation: BAE25761.1
AL683809 Genomic DNA No translation available.
BC028813 mRNA Translation: AAH28813.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30440.1 [Q9Z2S7-1]
CCDS41150.1 [Q9Z2S7-3]

NCBI Reference Sequences

More...RefSeqi		NP_001070832.1, NM_001077364.1 [Q9Z2S7-3]
NP_034416.3, NM_010286.4 [Q9Z2S7-1]
XP_006528562.1, XM_006528499.3 [Q9Z2S7-3]
XP_006528563.1, XM_006528500.3 [Q9Z2S7-3]
XP_006528564.1, XM_006528501.3
XP_006528566.1, XM_006528503.3 [Q9Z2S7-2]
XP_006528567.1, XM_006528504.3 [Q9Z2S7-3]
XP_006528568.1, XM_006528505.3 [Q9Z2S7-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000055738; ENSMUSP00000062589; ENSMUSG00000031431 [Q9Z2S7-1]
ENSMUST00000112996; ENSMUSP00000108620; ENSMUSG00000031431 [Q9Z2S7-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		14605

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:14605

UCSC genome browser

More...UCSCi		uc009ukz.2 mouse [Q9Z2S7-1]
uc009ulb.1 mouse [Q9Z2S7-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024519 mRNA Translation: AAD01789.1
EU818782 mRNA Translation: ACJ09091.1
AF201287 mRNA Translation: AAG41220.1
AF201288 mRNA Translation: AAG41221.1
AF201289 mRNA Translation: AAG41222.1
AK083389 mRNA Translation: BAC38897.1
AK144196 mRNA Translation: BAE25761.1
AL683809 Genomic DNA No translation available.
BC028813 mRNA Translation: AAH28813.1
CCDSiCCDS30440.1 [Q9Z2S7-1]
CCDS41150.1 [Q9Z2S7-3]
RefSeqiNP_001070832.1, NM_001077364.1 [Q9Z2S7-3]
NP_034416.3, NM_010286.4 [Q9Z2S7-1]
XP_006528562.1, XM_006528499.3 [Q9Z2S7-3]
XP_006528563.1, XM_006528500.3 [Q9Z2S7-3]
XP_006528564.1, XM_006528501.3
XP_006528566.1, XM_006528503.3 [Q9Z2S7-2]
XP_006528567.1, XM_006528504.3 [Q9Z2S7-3]
XP_006528568.1, XM_006528505.3 [Q9Z2S7-3]

3D structure databases

SMRiQ9Z2S7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi199919, 5 interactors
DIPiDIP-48844N
IntActiQ9Z2S7, 5 interactors
STRINGi10090.ENSMUSP00000108620

PTM databases

iPTMnetiQ9Z2S7
PhosphoSitePlusiQ9Z2S7

2D gel databases

REPRODUCTION-2DPAGEiIPI00265379

Proteomic databases

EPDiQ9Z2S7
PaxDbiQ9Z2S7
PeptideAtlasiQ9Z2S7
PRIDEiQ9Z2S7

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29322 407 antibodies

Genome annotation databases

EnsembliENSMUST00000055738; ENSMUSP00000062589; ENSMUSG00000031431 [Q9Z2S7-1]
ENSMUST00000112996; ENSMUSP00000108620; ENSMUSG00000031431 [Q9Z2S7-3]
GeneIDi14605
KEGGimmu:14605
UCSCiuc009ukz.2 mouse [Q9Z2S7-1]
uc009ulb.1 mouse [Q9Z2S7-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1831
MGIiMGI:1196284 Tsc22d3

Phylogenomic databases

eggNOGiENOG410IRR1 Eukaryota
ENOG410YAFT LUCA
GeneTreeiENSGT00940000156656
HOGENOMiCLU_148757_0_0_1
InParanoidiQ9Z2S7
OMAiYQLHNFN
OrthoDBi1602203at2759
PhylomeDBiQ9Z2S7
TreeFamiTF329224

Enzyme and pathway databases

ReactomeiR-MMU-2672351 Stimuli-sensing channels

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Tsc22d3 mouse

Protein Ontology

More...PROi		PR:Q9Z2S7
RNActiQ9Z2S7 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000031431 Expressed in skin of back and 279 other tissues
ExpressionAtlasiQ9Z2S7 baseline and differential
GenevisibleiQ9Z2S7 MM

Family and domain databases

InterProiView protein in InterPro
IPR000580 TSC-22_Dip_Bun
PfamiView protein in Pfam
PF01166 TSC22, 1 hit
PROSITEiView protein in PROSITE
PS01289 TSC22, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT22D3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z2S7
Secondary accession number(s): B1AVF3
, C6EX03, Q3UNI6, Q8K160, Q9EQN0, Q9EQN1, Q9EQN2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: February 1, 2005
Last modified: April 22, 2020
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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