Tsc22d3

Functionⁱ

Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 and isoform 4 inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.By similarity1 Publication

GO - Molecular functionⁱ

DNA-binding transcription factor activity Source: InterPro
MRF binding
Source: MGI
Inferred from physical interactionⁱ
- 20124407

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of activation-induced cell death of T cells
Source: MGI
Inferred from direct assayⁱ
- 9430225
negative regulation of skeletal muscle tissue development
Source: MGI
Inferred from direct assayⁱ
- 20124407
negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 20124407
response to osmotic stress
Source: MGI
Inferred from direct assayⁱ
- 17147695

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2672351 Stimuli-sensing channels

Reactomeⁱ

R-MMU-2672351 Stimuli-sensing channels

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: TSC22 domain family protein 3 Alternative name(s): Glucocorticoid-induced leucine zipper protein TSC22-related-inducible leucine zipper 3 Short name: Tilz3
Gene namesⁱ	Name:Tsc22d3 Synonyms:Dsip1, Dsipi, Gilz
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome X

Organism-specific databases

MGIⁱ	MGI:1196284 Tsc22d3

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000219371	1 – 137	TSC22 domain family protein 3Add BLAST		137

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	102	PhosphoserineBy similarity	1
Modified residueⁱ	125	PhosphothreonineCombined sources	1
Modified residueⁱ	128	PhosphothreonineCombined sources	1
Isoform 3 (identifier: Q9Z2S7-3)
Modified residueⁱ	40	PhosphoserineCombined sources	1
Isoform 4 (identifier: Q9Z2S7-4)
Modified residueⁱ	73	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9Z2S7
PeptideAtlas More...PeptideAtlasⁱ	Q9Z2S7
PRIDEⁱ	Q9Z2S7

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00265379

REPRODUCTION-2DPAGEⁱ

IPI00265379

PTM databases

iPTMnetⁱ	Q9Z2S7
PhosphoSitePlusⁱ	Q9Z2S7

Expressionⁱ

Tissue specificityⁱ

Constitutively expressed in lung, intestine, kidney and liver, most probably by resident cells from the macrophage lineage. Expression inversely correlates with T-cell activation, being higher in resting cells and lower in cells activated by TCR/CD3 triggering. Isoform 1 and isoform 4 are expressed in spleen and skeletal muscle (at protein level). Isoform 1 is expressed in thymus, lymph nodes, bone marrow, spleen, lung and skeletal muscle.3 Publications

Developmental stageⁱ

Isoform 1 and isoform 4 are expressed in differentiating myoblasts at a time of myotube formation.1 Publication

Inductionⁱ

By glucocorticoids in lymphoid cells and upon IL4, IL10, IL13 or glucocorticoid treatment in monocyte/macrophage cells. Transiently induced by IL2 deprivation in T-cells. Isoform 1 and isoform 4 expression is up-regulated by the synthetic glucocorticoid dexamethasone in differentiating myoblasts.4 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000031431 Expressed in 280 organ(s), highest expression level in skin of back
CleanExⁱ	MM_TSC22D3
ExpressionAtlasⁱ	Q9Z2S7 baseline and differential
Genevisibleⁱ	Q9Z2S7 MM

Interactionⁱ

Subunit structureⁱ

Can form homodimers, however it is likely to function as a monomer. Interacts with AP1 and NFKB1 (By similarity). Isoform 1 and isoform 4 interact with MYOD1. Isoform 1 interacts with HDAC1; this interaction affects HDAC1 activity on MYOG promoter and thus inhibits MYOD1 transcriptional activity.By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
Nedd4l	Q8CFI0	2	EBI-15771036,EBI-8046183
Raf1	Q99N57	2	EBI-15771036,EBI-397757
Sgk1	Q9WVC6	2	EBI-15771036,EBI-15591730

GO - Molecular functionⁱ

MRF binding
Source: MGI
Inferred from physical interactionⁱ
- 20124407

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	199919, 5 interactors
Database of interacting proteins More...DIPⁱ	DIP-48844N
IntActⁱ	Q9Z2S7, 5 interactors
STRINGⁱ	10090.ENSMUSP00000108620

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Z2S7
SMRⁱ	Q9Z2S7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 60	AP1-bindingAdd BLAST		60
Regionⁱ	76 – 97	Leucine-zipperAdd BLAST		22

Domainⁱ

The leucine-zipper is involved in homodimerization.

Sequence similaritiesⁱ

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IRR1 Eukaryota ENOG410YAFT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063062
HOGENOMⁱ	HOG000015349
HOVERGENⁱ	HBG075918
InParanoidⁱ	Q9Z2S7
OMAⁱ	STEMFAK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06PM
PhylomeDBⁱ	Q9Z2S7
TreeFamⁱ	TF329224

Family and domain databases

InterProⁱ	View protein in InterPro IPR000580 TSC-22_Dip_Bun
PANTHERⁱ	PTHR12348 PTHR12348, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01166 TSC22, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD007152 TSC-22_Dip_Bun, 1 hit
PROSITEⁱ	View protein in PROSITE PS01289 TSC22, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Z2S7-1) [UniParc]FASTA Add to basket

Also known as: Tilz3b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNTEMYQTPM EVAVYQLHNF SISFFSSLLG GDVVSVKLDN SASGASVVAL 
        60         70         80         90        100
DNKIEQAMDL VKNHLMYAVR EEVEVLKEQI RELLEKNSQL ERENTLLKTL 
       110        120        130 
ASPEQLEKFQ SRLSPEEPAP EAPETPETPE APGGSAV

Length:137

Mass (Da):15,177

Last modified:February 1, 2005 - v2

Checksum:ⁱA11D7B69037F111E

GO

Isoform 2 (identifier: Q9Z2S7-2) [UniParc]FASTA Add to basket

Also known as: Tilz3a

The sequence of this isoform differs from the canonical sequence as follows:
1-57: Missing.

« Hide

        10         20         30         40         50
MDLVKNHLMY AVREEVEVLK EQIRELLEKN SQLERENTLL KTLASPEQLE 
        60         70         80
KFQSRLSPEE PAPEAPETPE TPEAPGGSAV

Show »

Length:80

Mass (Da):9,040

Checksum:ⁱ2174BA0EC92DDCFC

GO

Isoform 3 (identifier: Q9Z2S7-3) [UniParc]FASTA Add to basket

Also known as: Tilz3c

The sequence of this isoform differs from the canonical sequence as follows:
1-40: MNTEMYQTPM...GDVVSVKLDN → MAQPKTECRS...TMLSILLFFH

« Hide

        10         20         30         40         50
MAQPKTECRS PVGLDCCNCC LDLANRCELQ KEKSGESPGS PFVSNFRQLQ 
        60         70         80         90        100
EKLVFENLNT DKLNNIMRQD SMEPVVRDPC YLINEGICNR NIDQTMLSIL 
       110        120        130        140        150
LFFHSASGAS VVALDNKIEQ AMDLVKNHLM YAVREEVEVL KEQIRELLEK 
       160        170        180        190        200
NSQLERENTL LKTLASPEQL EKFQSRLSPE EPAPEAPETP ETPEAPGGSA 

V

Show »

Length:201

Mass (Da):22,565

Checksum:ⁱB12F0480154A20DE

GO

Isoform 4 (identifier: Q9Z2S7-4) [UniParc]FASTA Add to basket

Also known as: Long Gilz, L-Gilz

The sequence of this isoform differs from the canonical sequence as follows:
1-40: MNTEMYQTPM...GDVVSVKLDN → MESQKASSAG...TMLSILLFFH

« Hide

        10         20         30         40         50
MESQKASSAG AHLPAAPDLP EQAAAAAASK PEKMAQPKTE CRSPVGLDCC 
        60         70         80         90        100
NCCLDLANRC ELQKEKSGES PGSPFVSNFR QLQEKLVFEN LNTDKLNNIM 
       110        120        130        140        150
RQDSMEPVVR DPCYLINEGI CNRNIDQTML SILLFFHSAS GASVVALDNK 
       160        170        180        190        200
IEQAMDLVKN HLMYAVREEV EVLKEQIREL LEKNSQLERE NTLLKTLASP 
       210        220        230 
EQLEKFQSRL SPEEPAPEAP ETPETPEAPG GSAV

Show »

Length:234

Mass (Da):25,778

Checksum:ⁱC7CEDB07D24D4185

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	B1AVF2	B1AVF2_MOUSE		TSC22 domain family protein 3 TSC22 domain family protein 3	Tsc22d3	113	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	22	I → T in AAD01789 (PubMed:9430225).Curated		1
Sequence conflictⁱ	33	V → L in AAG41221 (Ref. 3) Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_012690	1 – 57	Missing in isoform 2. 2 PublicationsAdd BLAST	57
Alternative sequenceⁱVSP_012691	1 – 40	MNTEM…VKLDN → MAQPKTECRSPVGLDCCNCC LDLANRCELQKEKSGESPGS PFVSNFRQLQEKLVFENLNT DKLNNIMRQDSMEPVVRDPC YLINEGICNRNIDQTMLSIL LFFH in isoform 3. 1 PublicationAdd BLAST	40
Alternative sequenceⁱVSP_055016	1 – 40	MNTEM…VKLDN → MESQKASSAGAHLPAAPDLP EQAAAAAASKPEKMAQPKTE CRSPVGLDCCNCCLDLANRC ELQKEKSGESPGSPFVSNFR QLQEKLVFENLNTDKLNNIM RQDSMEPVVRDPCYLINEGI CNRNIDQTMLSILLFFH in isoform 4. 1 PublicationAdd BLAST	40

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF024519 mRNA Translation: AAD01789.1 EU818782 mRNA Translation: ACJ09091.1 AF201287 mRNA Translation: AAG41220.1 AF201288 mRNA Translation: AAG41221.1 AF201289 mRNA Translation: AAG41222.1 AK083389 mRNA Translation: BAC38897.1 AK144196 mRNA Translation: BAE25761.1 AL683809 Genomic DNA No translation available. BC028813 mRNA Translation: AAH28813.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30440.1 [Q9Z2S7-1] CCDS41150.1 [Q9Z2S7-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001070832.1, NM_001077364.1 [Q9Z2S7-3] NP_034416.3, NM_010286.4 [Q9Z2S7-1] XP_006528562.1, XM_006528499.3 [Q9Z2S7-3] XP_006528563.1, XM_006528500.3 [Q9Z2S7-3] XP_006528564.1, XM_006528501.3 XP_006528566.1, XM_006528503.3 [Q9Z2S7-2] XP_006528567.1, XM_006528504.3 [Q9Z2S7-3] XP_006528568.1, XM_006528505.3 [Q9Z2S7-3]
UniGeneⁱ	Mm.22216

Genome annotation databases

Ensemblⁱ	ENSMUST00000055738; ENSMUSP00000062589; ENSMUSG00000031431 [Q9Z2S7-1] ENSMUST00000112996; ENSMUSP00000108620; ENSMUSG00000031431 [Q9Z2S7-3]
GeneIDⁱ	14605
KEGGⁱ	mmu:14605
UCSC genome browser More...UCSCⁱ	uc009ukz.2 mouse [Q9Z2S7-1] uc009ulb.1 mouse [Q9Z2S7-3]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Z2S7	TSC22 domain family protein 3		HUMAN		134	UniRef90_Q9Z2S7
TSC22 domain family protein 3		PONAB		134
TSC22 domain family protein 3		RAT		134
Uncharacterized protein		MYOLU		137
TSC22 domain family protein 3 isoform 2		MACMU		134
+76
Q9Z2S7-2	Isoform 4 of TSC22 domain family protein 3		MOUSE		234	UniRef90_Q9Z2S7-4
UPI000A318365		MUSCR		201
Isoform 3 of TSC22 domain family protein 3		MOUSE		201
Q9Z2S7-3	Isoform 4 of TSC22 domain family protein 3		MOUSE		234	UniRef90_Q9Z2S7-4
UPI000A318365		MUSCR		201
Isoform 2 of TSC22 domain family protein 3		MOUSE		80
Q9Z2S7-4	Isoform 3 of TSC22 domain family protein 3		MOUSE		201	UniRef90_Q9Z2S7-4
UPI000A318365		MUSCR		201
Isoform 2 of TSC22 domain family protein 3		MOUSE		80

Protein	Similar proteins		Species	Score	Length	Source
Q9Z2S7	TSC22 domain family protein 3		RAT		134	UniRef50_Q9Z2S7
TSC22 domain family protein 3		HUMAN		134
TSC22 domain family protein 3		PONAB		134
Uncharacterized protein		MYOLU		137
TSC22 domain family member 3		SAIBB		134
+141
Q9Z2S7-2	Isoform 4 of TSC22 domain family protein 3		MOUSE		234	UniRef50_Q9Z2S7-4
TSC22 domain family protein 3	)	PIG		77
Si:ch211-220e11.3		DANRE		207
Uncharacterized protein		NOMLE		200
TSC22 domain family member 3		PANTR		200
+217
Q9Z2S7-3	Isoform 4 of TSC22 domain family protein 3		MOUSE		234	UniRef50_Q9Z2S7-4
TSC22 domain family protein 3	)	PIG		77
Si:ch211-220e11.3		DANRE		207
Uncharacterized protein		NOMLE		200
TSC22 domain family member 3		PANTR		200
+217
Q9Z2S7-4	TSC22 domain family protein 3	)	PIG		77	UniRef50_Q9Z2S7-4
Isoform 3 of TSC22 domain family protein 3		MOUSE		201
Si:ch211-220e11.3		DANRE		207
Uncharacterized protein		NOMLE		200
TSC22 domain family member 3		PANTR		200
+217

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF024519 mRNA Translation: AAD01789.1 EU818782 mRNA Translation: ACJ09091.1 AF201287 mRNA Translation: AAG41220.1 AF201288 mRNA Translation: AAG41221.1 AF201289 mRNA Translation: AAG41222.1 AK083389 mRNA Translation: BAC38897.1 AK144196 mRNA Translation: BAE25761.1 AL683809 Genomic DNA No translation available. BC028813 mRNA Translation: AAH28813.1
CCDSⁱ	CCDS30440.1 [Q9Z2S7-1] CCDS41150.1 [Q9Z2S7-3]
RefSeqⁱ	NP_001070832.1, NM_001077364.1 [Q9Z2S7-3] NP_034416.3, NM_010286.4 [Q9Z2S7-1] XP_006528562.1, XM_006528499.3 [Q9Z2S7-3] XP_006528563.1, XM_006528500.3 [Q9Z2S7-3] XP_006528564.1, XM_006528501.3 XP_006528566.1, XM_006528503.3 [Q9Z2S7-2] XP_006528567.1, XM_006528504.3 [Q9Z2S7-3] XP_006528568.1, XM_006528505.3 [Q9Z2S7-3]
UniGeneⁱ	Mm.22216

3D structure databases

ProteinModelPortalⁱ	Q9Z2S7
SMRⁱ	Q9Z2S7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199919, 5 interactors
DIPⁱ	DIP-48844N
IntActⁱ	Q9Z2S7, 5 interactors
STRINGⁱ	10090.ENSMUSP00000108620

PTM databases

iPTMnetⁱ	Q9Z2S7
PhosphoSitePlusⁱ	Q9Z2S7

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00265379

REPRODUCTION-2DPAGEⁱ

IPI00265379

Proteomic databases

PaxDbⁱ	Q9Z2S7
PeptideAtlasⁱ	Q9Z2S7
PRIDEⁱ	Q9Z2S7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000055738; ENSMUSP00000062589; ENSMUSG00000031431 [Q9Z2S7-1] ENSMUST00000112996; ENSMUSP00000108620; ENSMUSG00000031431 [Q9Z2S7-3]
GeneIDⁱ	14605
KEGGⁱ	mmu:14605
UCSCⁱ	uc009ukz.2 mouse [Q9Z2S7-1] uc009ulb.1 mouse [Q9Z2S7-3]

Organism-specific databases

CTDⁱ	1831
MGIⁱ	MGI:1196284 Tsc22d3

Phylogenomic databases

eggNOGⁱ	ENOG410IRR1 Eukaryota ENOG410YAFT LUCA
GeneTreeⁱ	ENSGT00530000063062
HOGENOMⁱ	HOG000015349
HOVERGENⁱ	HBG075918
InParanoidⁱ	Q9Z2S7
OMAⁱ	STEMFAK
OrthoDBⁱ	EOG091G06PM
PhylomeDBⁱ	Q9Z2S7
TreeFamⁱ	TF329224

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2672351 Stimuli-sensing channels

Reactomeⁱ

R-MMU-2672351 Stimuli-sensing channels

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9Z2S7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000031431 Expressed in 280 organ(s), highest expression level in skin of back
CleanExⁱ	MM_TSC22D3
ExpressionAtlasⁱ	Q9Z2S7 baseline and differential
Genevisibleⁱ	Q9Z2S7 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000580 TSC-22_Dip_Bun
PANTHERⁱ	PTHR12348 PTHR12348, 1 hit
Pfamⁱ	View protein in Pfam PF01166 TSC22, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD007152 TSC-22_Dip_Bun, 1 hit
PROSITEⁱ	View protein in PROSITE PS01289 TSC22, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	T22D3_MOUSE
Accessionⁱ	Q9Z2S7Primary (citable) accession number: Q9Z2S7 Secondary accession number(s): B1AVF3 Q9EQN2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
	Last sequence update:	February 1, 2005
	Last modified:	September 12, 2018
	This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q9Z2S7 (T22D3_MOUSE)

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TSC22 domain family protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ