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Protein

Septin-5

Gene

Sept5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). Involved in cytokinesis (Potential). May play a role in platelet secretion.By similarityCurated1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei85GTPBy similarity1
Binding sitei111GTP; via amide nitrogenBy similarity1
Binding sitei248GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei263GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 58GTPBy similarity8
Nucleotide bindingi190 – 198GTPBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-5
Alternative name(s):
Cell division control-related protein 1
Short name:
CDCrel-1
Peanut-like protein 1
Gene namesi
Name:Sept5
Synonyms:Pnutl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1195461 Sept5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Mice have a normal life-span and show no apparent abnormalities, including synaptic properties and hippocampal neuron growth. In platelets, hyperresponsive degranulation phenotype.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735231 – 369Septin-5Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphothreonineCombined sources1
Modified residuei168Omega-N-methylarginineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei327PhosphoserineCombined sources1
Modified residuei336PhosphothreonineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9Z2Q6
MaxQBiQ9Z2Q6
PaxDbiQ9Z2Q6
PeptideAtlasiQ9Z2Q6
PRIDEiQ9Z2Q6

PTM databases

iPTMnetiQ9Z2Q6
PhosphoSitePlusiQ9Z2Q6
SwissPalmiQ9Z2Q6

Expressioni

Developmental stagei

Detected at 17 dpc in the brain. Expression increases during postnatal life and reaches a plateau at approximately P10 (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000072214 Expressed in 83 organ(s), highest expression level in brain
CleanExiMM_SEPT5
GenevisibleiQ9Z2Q6 MM

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with SEPT2 and SEPT5. Interaction with SEPT4 not detected. In platelets, associated with a complex containing STX4 (By similarity). Interacts with PRKN. This interaction leads to SEPT5 ubiquitination and degradation.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PRKNO602602EBI-772125,EBI-716346From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202285, 7 interactors
IntActiQ9Z2Q6, 7 interactors
MINTiQ9Z2Q6
STRINGi10090.ENSMUSP00000094750

Structurei

3D structure databases

ProteinModelPortaliQ9Z2Q6
SMRiQ9Z2Q6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 314Septin-type GPROSITE-ProRule annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 58G1 motifPROSITE-ProRule annotation8
Regioni108 – 111G3 motifPROSITE-ProRule annotation4
Regioni189 – 192G4 motifPROSITE-ProRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili338 – 369Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144020
HOVERGENiHBG065093
InParanoidiQ9Z2Q6
KOiK04557
OMAiSECWKPI
OrthoDBiEOG091G07TS
TreeFamiTF101079

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR030647 SEPT5
IPR016491 Septin
PANTHERiPTHR18884:SF68 PTHR18884:SF68, 1 hit
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9Z2Q6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTGLRYKSK LATPEDKQDI DKQYVGFATL PNQVHRKSVK KGFDFTLMVA
60 70 80 90 100
GESGLGKSTL VHSLFLTDLY KDRKLLSAEE RINQTVEILK HTVDIEEKGV
110 120 130 140 150
KLKLTIVDTP GFGDAVNNSE CWKPITDYVD QQFEQYFRDE SGLNRKNIQD
160 170 180 190 200
NRVHCCLYFI SPFGHGLRPV DVGFMKALHE KVNIVPLIAK ADCLVPSEIR
210 220 230 240 250
KLKDRIREEI DKFGIHVYQF PECDSDEDED FKQQDRELKE SAPFAVIGSN
260 270 280 290 300
TVVEAKGQRV RGRLYPWGIV EVENQAHCDF VKLRNMLIRT HMHDLKDVTC
310 320 330 340 350
DVHYENYRAH CIQQMTSKLT QDSRMESPIP ILPLPTPDAE TEKLIRMKDE
360
ELRRMQEMLQ KMKQQMQDQ
Length:369
Mass (Da):42,748
Last modified:December 6, 2005 - v2
Checksum:iD58468DBA9ADE626
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZNM7B7ZNM7_MOUSE
Sept5 protein
Sept5
381Annotation score:
A0A338P769A0A338P769_MOUSE
Septin-5
Sept5
378Annotation score:
A0A338P729A0A338P729_MOUSE
Septin-5
Sept5
248Annotation score:
A0A338P755A0A338P755_MOUSE
Septin-5
Sept5
126Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK134700 mRNA Translation: BAE22248.1
BC059848 mRNA Translation: AAH59848.1
BC141073 mRNA Translation: AAI41074.1
BC145331 mRNA Translation: AAI45332.1
AF033350 mRNA Translation: AAC83974.1
CCDSiCCDS57021.1
RefSeqiNP_998779.2, NM_213614.2
UniGeneiMm.20365
Mm.475622

Genome annotation databases

EnsembliENSMUST00000096987; ENSMUSP00000094750; ENSMUSG00000072214
GeneIDi18951
KEGGimmu:18951
UCSCiuc007yoj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK134700 mRNA Translation: BAE22248.1
BC059848 mRNA Translation: AAH59848.1
BC141073 mRNA Translation: AAI41074.1
BC145331 mRNA Translation: AAI45332.1
AF033350 mRNA Translation: AAC83974.1
CCDSiCCDS57021.1
RefSeqiNP_998779.2, NM_213614.2
UniGeneiMm.20365
Mm.475622

3D structure databases

ProteinModelPortaliQ9Z2Q6
SMRiQ9Z2Q6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202285, 7 interactors
IntActiQ9Z2Q6, 7 interactors
MINTiQ9Z2Q6
STRINGi10090.ENSMUSP00000094750

PTM databases

iPTMnetiQ9Z2Q6
PhosphoSitePlusiQ9Z2Q6
SwissPalmiQ9Z2Q6

Proteomic databases

EPDiQ9Z2Q6
MaxQBiQ9Z2Q6
PaxDbiQ9Z2Q6
PeptideAtlasiQ9Z2Q6
PRIDEiQ9Z2Q6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096987; ENSMUSP00000094750; ENSMUSG00000072214
GeneIDi18951
KEGGimmu:18951
UCSCiuc007yoj.1 mouse

Organism-specific databases

CTDi5413
MGIiMGI:1195461 Sept5

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144020
HOVERGENiHBG065093
InParanoidiQ9Z2Q6
KOiK04557
OMAiSECWKPI
OrthoDBiEOG091G07TS
TreeFamiTF101079

Miscellaneous databases

PROiPR:Q9Z2Q6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000072214 Expressed in 83 organ(s), highest expression level in brain
CleanExiMM_SEPT5
GenevisibleiQ9Z2Q6 MM

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR030647 SEPT5
IPR016491 Septin
PANTHERiPTHR18884:SF68 PTHR18884:SF68, 1 hit
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEPT5_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2Q6
Secondary accession number(s): B2RUC5, Q3UYG4, Q6PB74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 6, 2005
Last modified: September 12, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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