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Protein

39S ribosomal protein L40, mitochondrial

Gene

Mrpl40

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L40, mitochondrial
Short name:
L40mt
Short name:
MRP-L40
Alternative name(s):
Nuclear localization signal-containing protein deleted in velocardiofacial syndrome homolog
Gene namesi
Name:Mrpl40
Synonyms:Nlvcf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1332635 Mrpl40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46MitochondrionBy similarityAdd BLAST46
ChainiPRO_000003055947 – 20639S ribosomal protein L40, mitochondrialAdd BLAST160

Proteomic databases

EPDiQ9Z2Q5
MaxQBiQ9Z2Q5
PaxDbiQ9Z2Q5
PRIDEiQ9Z2Q5

PTM databases

iPTMnetiQ9Z2Q5
PhosphoSitePlusiQ9Z2Q5

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000022706 Expressed in 287 organ(s), highest expression level in embryo
CleanExiMM_MRPL40
ExpressionAtlasiQ9Z2Q5 baseline and differential
GenevisibleiQ9Z2Q5 MM

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.By similarity

Protein-protein interaction databases

BioGridi201786, 1 interactor
STRINGi10090.ENSMUSP00000023391

Structurei

3D structure databases

ProteinModelPortaliQ9Z2Q5
SMRiQ9Z2Q5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4778 Eukaryota
ENOG4111PQW LUCA
GeneTreeiENSGT00390000010239
HOGENOMiHOG000015976
HOVERGENiHBG044505
InParanoidiQ9Z2Q5
KOiK17421
OrthoDBiEOG091G0RI9
PhylomeDBiQ9Z2Q5
TreeFamiTF105982

Family and domain databases

InterProiView protein in InterPro
IPR039145 MRPL40
IPR019192 Ribosomal_L28/L40_mit
PANTHERiPTHR13359 PTHR13359, 1 hit
PfamiView protein in Pfam
PF09812 MRP-L28, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Z2Q5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATGVMLCAA RALRPRSWIP GTCQAHVRHT HQRASLLAFW DLIPMRAEPL
60 70 80 90 100
RKKKKVDPRK DQAAKDRLKK RIRKLEKASQ ELIPIEDFIT PVRFLDKSRQ
110 120 130 140 150
RPQEEHSPEE SERRALLLKR WALFKQQEHE MERDAIRSML EAQQEALEEL
160 170 180 190 200
KLESAELYAE AIKRDTSLFP FEKEGPHYTP PISNYQAPEG RYNDITKVYT

QVEFKR
Length:206
Mass (Da):24,301
Last modified:May 27, 2002 - v2
Checksum:i9AF9D8095D7B28D2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z7C0D3Z7C0_MOUSE
39S ribosomal protein L40, mitochon...
Mrpl40
162Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti200T → K1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034092 mRNA Translation: AAC70905.1
BC028436 mRNA Translation: AAH28436.1
AK018757 mRNA Translation: BAB31389.1
CCDSiCCDS28030.1
RefSeqiNP_035052.2, NM_010922.2
UniGeneiMm.20918

Genome annotation databases

EnsembliENSMUST00000023391; ENSMUSP00000023391; ENSMUSG00000022706
GeneIDi18100
KEGGimmu:18100
UCSCiuc007yop.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034092 mRNA Translation: AAC70905.1
BC028436 mRNA Translation: AAH28436.1
AK018757 mRNA Translation: BAB31389.1
CCDSiCCDS28030.1
RefSeqiNP_035052.2, NM_010922.2
UniGeneiMm.20918

3D structure databases

ProteinModelPortaliQ9Z2Q5
SMRiQ9Z2Q5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201786, 1 interactor
STRINGi10090.ENSMUSP00000023391

PTM databases

iPTMnetiQ9Z2Q5
PhosphoSitePlusiQ9Z2Q5

Proteomic databases

EPDiQ9Z2Q5
MaxQBiQ9Z2Q5
PaxDbiQ9Z2Q5
PRIDEiQ9Z2Q5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023391; ENSMUSP00000023391; ENSMUSG00000022706
GeneIDi18100
KEGGimmu:18100
UCSCiuc007yop.2 mouse

Organism-specific databases

CTDi64976
MGIiMGI:1332635 Mrpl40

Phylogenomic databases

eggNOGiKOG4778 Eukaryota
ENOG4111PQW LUCA
GeneTreeiENSGT00390000010239
HOGENOMiHOG000015976
HOVERGENiHBG044505
InParanoidiQ9Z2Q5
KOiK17421
OrthoDBiEOG091G0RI9
PhylomeDBiQ9Z2Q5
TreeFamiTF105982

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Miscellaneous databases

PROiPR:Q9Z2Q5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022706 Expressed in 287 organ(s), highest expression level in embryo
CleanExiMM_MRPL40
ExpressionAtlasiQ9Z2Q5 baseline and differential
GenevisibleiQ9Z2Q5 MM

Family and domain databases

InterProiView protein in InterPro
IPR039145 MRPL40
IPR019192 Ribosomal_L28/L40_mit
PANTHERiPTHR13359 PTHR13359, 1 hit
PfamiView protein in Pfam
PF09812 MRP-L28, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM40_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2Q5
Secondary accession number(s): Q9CS52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: November 7, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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