UniProtKB - Q9Z2N8 (ACL6A_MOUSE)
Actin-like protein 6A
Actl6a
Functioni
GO - Molecular functioni
- chromatin binding Source: MGI
GO - Biological processi
- ATP-dependent chromatin remodeling Source: GO_Central
- blastocyst formation Source: MGI
- chromatin remodeling Source: MGI
- DNA recombination Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
- histone H2A acetylation Source: UniProtKB
- histone H4 acetylation Source: UniProtKB
- nervous system development Source: UniProtKB
- neural retina development Source: Ensembl
- regulation of growth Source: UniProtKB-KW
- regulation of transcription by RNA polymerase II Source: GO_Central
- spinal cord development Source: Ensembl
Keywordsi
Molecular function | Activator, Chromatin regulator |
Biological process | DNA damage, DNA recombination, DNA repair, Growth regulation, Neurogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-3214858, RMTs methylate histone arginines R-MMU-5689603, UCH proteinases R-MMU-5696394, DNA Damage Recognition in GG-NER R-MMU-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
Names & Taxonomyi
Protein namesi | Recommended name: Actin-like protein 6AAlternative name(s): 53 kDa BRG1-associated factor A Actin-related protein Baf53a BRG1-associated factor 53A Short name: BAF53A |
Gene namesi | Name:Actl6a Synonyms:Actl6, Baf53a |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1861453, Actl6a |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- Ino80 complex Source: MGI
- npBAF complex Source: UniProtKB
- NuA4 histone acetyltransferase complex Source: UniProtKB
- nucleoplasm Source: MGI
- nucleus Source: MGI
- SWI/SNF complex Source: UniProtKB
Plasma Membrane
- plasma membrane Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000089134 | 2 – 429 | Actin-like protein 6AAdd BLAST | 428 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Cross-linki | 62 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 86 | PhosphoserineBy similarity | 1 | |
Modified residuei | 233 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9Z2N8 |
jPOSTi | Q9Z2N8 |
MaxQBi | Q9Z2N8 |
PaxDbi | Q9Z2N8 |
PRIDEi | Q9Z2N8 |
2D gel databases
REPRODUCTION-2DPAGEi | Q9Z2N8 |
PTM databases
iPTMneti | Q9Z2N8 |
PhosphoSitePlusi | Q9Z2N8 |
SwissPalmi | Q9Z2N8 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000027671, Expressed in urogenital fold and 330 other tissues |
Genevisiblei | Q9Z2N8, MM |
Interactioni
Subunit structurei
Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity.
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein.
Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41.
Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific.
Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3 (Probable).
Component of the BAF53 complex, at least composed of ACTL6A/BAF53A, RUVBL1/TIP49, SMARCA2/BRM/BAF190B and TRRAP/PAF400, and which may also include a HAT activity related to, but distinct from, that of KAT5.
Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin.
Component of SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). May be a component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (By similarity).
Interacts with SMARCA4/BRG1/BAF190A (By similarity).
Interacts with PHF10/BAF45A (PubMed:17640523).
Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80 (By similarity).
Interacts with DPF2 (By similarity).
2 PublicationsBy similarity2 PublicationsProtein-protein interaction databases
BioGRIDi | 207995, 25 interactors |
ComplexPortali | CPX-1232, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1233, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1234, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1235, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1240, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1241, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1242, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1243, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1248, Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant CPX-1251, Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex CPX-1252, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1253, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1254, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1255, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-4202, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant CPX-4204, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA2 variant CPX-4221, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant CPX-4222, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA4 variant CPX-878, INO80 chromatin remodeling complex CPX-976, SRCAP histone exchanging complex CPX-990, NuA4 histone acetyltransferase complex |
CORUMi | Q9Z2N8 |
IntActi | Q9Z2N8, 11 interactors |
MINTi | Q9Z2N8 |
STRINGi | 10090.ENSMUSP00000029214 |
Miscellaneous databases
RNActi | Q9Z2N8, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0679, Eukaryota |
GeneTreei | ENSGT00940000156305 |
HOGENOMi | CLU_027965_6_0_1 |
InParanoidi | Q9Z2N8 |
OMAi | DGIVEDW |
OrthoDBi | 649708at2759 |
PhylomeDBi | Q9Z2N8 |
TreeFami | TF312863 |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR004001, Actin_CS IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00432, ACTINS_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSGGVYGGDE VGALVFDIGS YTVRAGYAGE DCPKVDFPTA IGVVLERDDG
60 70 80 90 100
STMMEIDGDK GKQGGPTYYI DTNALRVPRE NMEAISPLKN GMVEDWDSFQ
110 120 130 140 150
AILDHTYKMH VKSEASLHPV LMSEAPWNTR AKREKLTELM FEHYSIPAFF
160 170 180 190 200
LCKTAVLTAF ANGRSTGLIL DSGATHTTAI PVHDGYVLQQ GIVKSPLAGD
210 220 230 240 250
FITMQCRELF QEMNIELIPP YMIASKEAVR EGSPANWKRK EKLPQVTRSW
260 270 280 290 300
HNYMCNCVIQ DFQASVLQVS DSTYDEQVAA QMPTVHYEFP NGYNCDFGAE
310 320 330 340 350
RLKIPEGLFD PSNVKGLSGN TMLGVSHVVT TSVGMCDIDI RPGLYGSVIV
360 370 380 390 400
AGGNTLIQSF TDRLNRELSQ KTPPSMRLKL IANNTTVERR FSSWIGGSIL
410 420
ASLGTFQQMW ISKQEYEEGG KQCVERKCP
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A6YWR1 | A0A0A6YWR1_MOUSE | Actin-like protein 6A | Actl6a | 54 | Annotation score: | ||
D3YVN1 | D3YVN1_MOUSE | Actin-like protein 6A | Actl6a | 204 | Annotation score: | ||
A0A0A6YWG8 | A0A0A6YWG8_MOUSE | Actin-like protein 6A | Actl6a | 245 | Annotation score: | ||
A0A0A6YW15 | A0A0A6YW15_MOUSE | Actin-like protein 6A | Actl6a | 77 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 38 | P → H in BAC41116 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 153 | K → Q in BAC41116 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 322 | M → I in AAC94992 (PubMed:9845365).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF041476 mRNA Translation: AAC94992.1 AK090154 mRNA Translation: BAC41116.1 BC001994 mRNA Translation: AAH01994.1 |
CCDSi | CCDS17298.1 |
RefSeqi | NP_062647.2, NM_019673.2 |
Genome annotation databases
Ensembli | ENSMUST00000029214; ENSMUSP00000029214; ENSMUSG00000027671 |
GeneIDi | 56456 |
KEGGi | mmu:56456 |
UCSCi | uc012coo.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF041476 mRNA Translation: AAC94992.1 AK090154 mRNA Translation: BAC41116.1 BC001994 mRNA Translation: AAH01994.1 |
CCDSi | CCDS17298.1 |
RefSeqi | NP_062647.2, NM_019673.2 |
3D structure databases
SMRi | Q9Z2N8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 207995, 25 interactors |
ComplexPortali | CPX-1232, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1233, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1234, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1235, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1240, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1241, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1242, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1243, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1248, Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant CPX-1251, Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex CPX-1252, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1253, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1254, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1255, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-4202, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant CPX-4204, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA2 variant CPX-4221, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant CPX-4222, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA4 variant CPX-878, INO80 chromatin remodeling complex CPX-976, SRCAP histone exchanging complex CPX-990, NuA4 histone acetyltransferase complex |
CORUMi | Q9Z2N8 |
IntActi | Q9Z2N8, 11 interactors |
MINTi | Q9Z2N8 |
STRINGi | 10090.ENSMUSP00000029214 |
PTM databases
iPTMneti | Q9Z2N8 |
PhosphoSitePlusi | Q9Z2N8 |
SwissPalmi | Q9Z2N8 |
2D gel databases
REPRODUCTION-2DPAGEi | Q9Z2N8 |
Proteomic databases
EPDi | Q9Z2N8 |
jPOSTi | Q9Z2N8 |
MaxQBi | Q9Z2N8 |
PaxDbi | Q9Z2N8 |
PRIDEi | Q9Z2N8 |
Protocols and materials databases
Antibodypediai | 33747, 365 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000029214; ENSMUSP00000029214; ENSMUSG00000027671 |
GeneIDi | 56456 |
KEGGi | mmu:56456 |
UCSCi | uc012coo.1, mouse |
Organism-specific databases
CTDi | 86 |
MGIi | MGI:1861453, Actl6a |
Phylogenomic databases
eggNOGi | KOG0679, Eukaryota |
GeneTreei | ENSGT00940000156305 |
HOGENOMi | CLU_027965_6_0_1 |
InParanoidi | Q9Z2N8 |
OMAi | DGIVEDW |
OrthoDBi | 649708at2759 |
PhylomeDBi | Q9Z2N8 |
TreeFami | TF312863 |
Enzyme and pathway databases
Reactomei | R-MMU-3214858, RMTs methylate histone arginines R-MMU-5689603, UCH proteinases R-MMU-5696394, DNA Damage Recognition in GG-NER R-MMU-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
Miscellaneous databases
BioGRID-ORCSi | 56456, 9 hits in 17 CRISPR screens |
ChiTaRSi | Actl6a, mouse |
PROi | PR:Q9Z2N8 |
RNActi | Q9Z2N8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027671, Expressed in urogenital fold and 330 other tissues |
Genevisiblei | Q9Z2N8, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR004001, Actin_CS IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00432, ACTINS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACL6A_MOUSE | |
Accessioni | Q9Z2N8Primary (citable) accession number: Q9Z2N8 Secondary accession number(s): Q8C1W3, Q99M56 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | September 19, 2002 | |
Last modified: | December 2, 2020 | |
This is version 179 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families