UniProtKB - Q9Z2J6 (PD2R2_MOUSE)
Protein
Prostaglandin D2 receptor 2
Gene
Ptgdr2
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity).By similarity2 Publications
GO - Molecular functioni
- G protein-coupled receptor activity Source: MGI
- neuropeptide binding Source: GO_Central
- peptide binding Source: GO_Central
- prostaglandin D receptor activity Source: MGI
- prostaglandin F receptor activity Source: MGI
- prostaglandin J receptor activity Source: MGI
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: MGI
- calcium-mediated signaling Source: MGI
- chemotaxis Source: MGI
- G protein-coupled receptor signaling pathway Source: MGI
- negative regulation of male germ cell proliferation Source: MGI
- neuropeptide signaling pathway Source: GO_Central
- positive regulation of G protein-coupled receptor signaling pathway Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-391908 Prostanoid ligand receptors R-MMU-418594 G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Prostaglandin D2 receptor 2Alternative name(s): Chemoattractant receptor-homologous molecule expressed on Th2 cells G-protein coupled receptor 44 CD_antigen: CD294, Gpr44 |
Gene namesi | Name:Ptgdr2 Synonyms:Crth2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1330275 Ptgdr2 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Internalized receptors colocalized with RAB11A.By similarity
Plasma Membrane
- integral component of plasma membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 32 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 33 – 55 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 56 – 66 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 67 – 88 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 89 – 105 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 106 – 126 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 127 – 145 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 146 – 167 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 168 – 209 | ExtracellularSequence analysisAdd BLAST | 42 | |
Transmembranei | 210 – 230 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 231 – 246 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 247 – 268 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 269 – 287 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 288 – 307 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 308 – 357 | CytoplasmicSequence analysisAdd BLAST | 50 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Deficient mice are fertile and grew normally. Ear-swelling responses induced by hapten-specific IgE are less pronounced in deficient mice, giving 35-55% of the responses of normal mice. The reduction in cutaneous responses is associated with decreased infiltration of lymphocytes, eosinophils, and basophils and decreased production of macrophage-derived chemokine and RANTES at inflammatory sites. In models of chronic contact hypersensitivity induced by repeated hapten application, CRTH2-deficient mice result in a reduction by approximately half of skin responses and low levels (63% of control) of serum IgE production.1 Publication
Chemistry databases
ChEMBLi | CHEMBL2291 |
GuidetoPHARMACOLOGYi | 339 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069573 | 1 – 382 | Prostaglandin D2 receptor 2Add BLAST | 382 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 3 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 21 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 24 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 103 ↔ 181 | PROSITE-ProRule annotation | ||
Modified residuei | 330 | PhosphoserineBy similarity | 1 | |
Modified residuei | 344 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q9Z2J6 |
PRIDEi | Q9Z2J6 |
PTM databases
iPTMneti | Q9Z2J6 |
PhosphoSitePlusi | Q9Z2J6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000034117 Expressed in 16 organ(s), highest expression level in cerebral cortex |
Genevisiblei | Q9Z2J6 MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000036159 |
Chemistry databases
BindingDBi | Q9Z2J6 |
Structurei
3D structure databases
ProteinModelPortali | Q9Z2J6 |
SMRi | Q9Z2J6 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 329 – 332 | Involved in the recycling of CRTH2By similarity | 4 |
Domaini
The 329-DSEL-332 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for GRK2 and GPRK5/GRK5 to promote agonist-induced internalization (By similarity). Thr-346 is a major site for PKC-induced internalization of the receptor (By similarity).By similarity
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IV6V Eukaryota ENOG410YAX7 LUCA |
GeneTreei | ENSGT00940000162009 |
HOGENOMi | HOG000234122 |
HOVERGENi | HBG099857 |
InParanoidi | Q9Z2J6 |
KOi | K06715 |
OMAi | VTTWVLH |
OrthoDBi | 1102944at2759 |
PhylomeDBi | Q9Z2J6 |
TreeFami | TF330976 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Z2J6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANVTLKPLC PLLEEMVQLP NHSNSSLRYI DHVSVLLHGL ASLLGLVENG
60 70 80 90 100
LILFVVGCRM RQTVVTTWVL HLALSDLLAA ASLPFFTYFL AVGHSWELGT
110 120 130 140 150
TFCKLHSSVF FLNMFASGFL LSAISLDRCL QVVRPVWAQN HRTVAVAHRV
160 170 180 190 200
CLMLWALAVL NTIPYFVFRD TIPRLDGRIM CYYNLLLWNP GPDRDTTCDY
210 220 230 240 250
RQKALAVSKF LLAFMVPLAI IASSHVAVSL RLHHRGRQRT GRFVRLVAAI
260 270 280 290 300
VVAFVLCWGP YHIFSLLEAR AHSVTTLRQL ASRGLPFVTS LAFFNSVVNP
310 320 330 340 350
LLYVFTCPDM LYKLRRSLRA VLESVLVEDS DQSGGLRNRR RRASSTATPA
360 370 380
STLLLADRIP QLRPTRLIGW MRRGSAEVPQ RV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF054507 Genomic DNA Translation: AAD13525.1 AB109091 Genomic DNA Translation: BAC81436.1 AB109092 mRNA Translation: BAC81437.1 CH466534 Genomic DNA Translation: EDL41395.1 BC111906 mRNA Translation: AAI11907.1 |
CCDSi | CCDS29592.1 |
RefSeqi | NP_034092.1, NM_009962.3 XP_006526758.1, XM_006526695.3 XP_006526759.1, XM_006526696.3 XP_011245450.1, XM_011247148.2 |
UniGenei | Mm.470721 |
Genome annotation databases
Ensembli | ENSMUST00000037261; ENSMUSP00000036159; ENSMUSG00000034117 |
GeneIDi | 14764 |
KEGGi | mmu:14764 |
UCSCi | uc008gri.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF054507 Genomic DNA Translation: AAD13525.1 AB109091 Genomic DNA Translation: BAC81436.1 AB109092 mRNA Translation: BAC81437.1 CH466534 Genomic DNA Translation: EDL41395.1 BC111906 mRNA Translation: AAI11907.1 |
CCDSi | CCDS29592.1 |
RefSeqi | NP_034092.1, NM_009962.3 XP_006526758.1, XM_006526695.3 XP_006526759.1, XM_006526696.3 XP_011245450.1, XM_011247148.2 |
UniGenei | Mm.470721 |
3D structure databases
ProteinModelPortali | Q9Z2J6 |
SMRi | Q9Z2J6 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000036159 |
Chemistry databases
BindingDBi | Q9Z2J6 |
ChEMBLi | CHEMBL2291 |
GuidetoPHARMACOLOGYi | 339 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q9Z2J6 |
PhosphoSitePlusi | Q9Z2J6 |
Proteomic databases
PaxDbi | Q9Z2J6 |
PRIDEi | Q9Z2J6 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000037261; ENSMUSP00000036159; ENSMUSG00000034117 |
GeneIDi | 14764 |
KEGGi | mmu:14764 |
UCSCi | uc008gri.1 mouse |
Organism-specific databases
CTDi | 11251 |
MGIi | MGI:1330275 Ptgdr2 |
Phylogenomic databases
eggNOGi | ENOG410IV6V Eukaryota ENOG410YAX7 LUCA |
GeneTreei | ENSGT00940000162009 |
HOGENOMi | HOG000234122 |
HOVERGENi | HBG099857 |
InParanoidi | Q9Z2J6 |
KOi | K06715 |
OMAi | VTTWVLH |
OrthoDBi | 1102944at2759 |
PhylomeDBi | Q9Z2J6 |
TreeFami | TF330976 |
Enzyme and pathway databases
Reactomei | R-MMU-391908 Prostanoid ligand receptors R-MMU-418594 G alpha (i) signalling events |
Miscellaneous databases
PROi | PR:Q9Z2J6 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034117 Expressed in 16 organ(s), highest expression level in cerebral cortex |
Genevisiblei | Q9Z2J6 MM |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | PD2R2_MOUSE | |
Accessioni | Q9Z2J6Primary (citable) accession number: Q9Z2J6 Secondary accession number(s): Q54A00 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 13, 2019 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries