Ptgdr2

Functionⁱ

Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca²⁺ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity).By similarity2 Publications

GO - Molecular functionⁱ

G-protein coupled receptor activity
Source: MGI
Inferred from direct assayⁱ
- 12878180
neuropeptide binding Source: GO_Central
prostaglandin D receptor activity
Source: MGI
Inferred from direct assayⁱ
- 12878180
- 25142465
prostaglandin F receptor activity
Source: MGI
Inferred from direct assayⁱ
- 12878180
prostaglandin J receptor activity
Source: MGI
Inferred from direct assayⁱ
- 12878180

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 12878180
calcium-mediated signaling
Source: MGI
Inferred from direct assayⁱ
- 12878180
chemical synaptic transmission Source: GO_Central
chemotaxis
Source: MGI
Inferred from direct assayⁱ
- 12878180
G-protein coupled receptor signaling pathway
Source: MGI
Inferred from sequence or structural similarityⁱ
- 9931443
negative regulation of male germ cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 25142465
neuropeptide signaling pathway Source: GO_Central
positive regulation of G-protein coupled receptor protein signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 12878180

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-MMU-391908 Prostanoid ligand receptors R-MMU-418594 G alpha (i) signalling events

Reactomeⁱ

R-MMU-391908 Prostanoid ligand receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Prostaglandin D2 receptor 2 Alternative name(s): Chemoattractant receptor-homologous molecule expressed on Th2 cells G-protein coupled receptor 44 CD_antigen: CD294, Gpr44
Gene namesⁱ	Name:Ptgdr2 Synonyms:Crth2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:1330275 Ptgdr2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 32	ExtracellularSequence analysisAdd BLAST	32
Transmembraneⁱ	33 – 55	Helical; Name=1Sequence analysisAdd BLAST	23
Topological domainⁱ	56 – 66	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	67 – 88	Helical; Name=2Sequence analysisAdd BLAST	22
Topological domainⁱ	89 – 105	ExtracellularSequence analysisAdd BLAST	17
Transmembraneⁱ	106 – 126	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	127 – 145	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	146 – 167	Helical; Name=4Sequence analysisAdd BLAST	22
Topological domainⁱ	168 – 209	ExtracellularSequence analysisAdd BLAST	42
Transmembraneⁱ	210 – 230	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	231 – 246	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	247 – 268	Helical; Name=6Sequence analysisAdd BLAST	22
Topological domainⁱ	269 – 287	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	288 – 307	Helical; Name=7Sequence analysisAdd BLAST	20
Topological domainⁱ	308 – 357	CytoplasmicSequence analysisAdd BLAST	50

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Deficient mice are fertile and grew normally. Ear-swelling responses induced by hapten-specific IgE are less pronounced in deficient mice, giving 35-55% of the responses of normal mice. The reduction in cutaneous responses is associated with decreased infiltration of lymphocytes, eosinophils, and basophils and decreased production of macrophage-derived chemokine and RANTES at inflammatory sites. In models of chronic contact hypersensitivity induced by repeated hapten application, CRTH2-deficient mice result in a reduction by approximately half of skin responses and low levels (63% of control) of serum IgE production.1 Publication

Chemistry databases

ChEMBLⁱ	CHEMBL2291
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	339

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069573	1 – 382	Prostaglandin D2 receptor 2Add BLAST		382

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	3	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	21	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	24	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	103 ↔ 181	PROSITE-ProRule annotation
Modified residueⁱ	330	PhosphoserineBy similarity	1
Modified residueⁱ	344	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9Z2J6
PRIDEⁱ	Q9Z2J6

PTM databases

iPTMnetⁱ	Q9Z2J6
PhosphoSitePlusⁱ	Q9Z2J6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000034117 Expressed in 16 organ(s), highest expression level in cerebral cortex
CleanExⁱ	MM_GPR44
Genevisibleⁱ	Q9Z2J6 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000036159

STRINGⁱ

10090.ENSMUSP00000036159

Chemistry databases

BindingDBⁱ	Q9Z2J6

BindingDBⁱ

Q9Z2J6

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Z2J6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	329 – 332	Involved in the recycling of CRTH2By similarity		4

Domainⁱ

The 329-DSEL-332 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for GRK2 and GPRK5/GRK5 to promote agonist-induced internalization (By similarity). Thr-346 is a major site for PKC-induced internalization of the receptor (By similarity).By similarity

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IV6V Eukaryota ENOG410YAX7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118990
HOGENOMⁱ	HOG000234122
HOVERGENⁱ	HBG099857
InParanoidⁱ	Q9Z2J6
KEGG Orthology (KO) More...KOⁱ	K06715
OMAⁱ	QTVVTTW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FTA
PhylomeDBⁱ	Q9Z2J6
TreeFamⁱ	TF330976

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9Z2J6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MANVTLKPLC PLLEEMVQLP NHSNSSLRYI DHVSVLLHGL ASLLGLVENG 
        60         70         80         90        100
LILFVVGCRM RQTVVTTWVL HLALSDLLAA ASLPFFTYFL AVGHSWELGT 
       110        120        130        140        150
TFCKLHSSVF FLNMFASGFL LSAISLDRCL QVVRPVWAQN HRTVAVAHRV 
       160        170        180        190        200
CLMLWALAVL NTIPYFVFRD TIPRLDGRIM CYYNLLLWNP GPDRDTTCDY 
       210        220        230        240        250
RQKALAVSKF LLAFMVPLAI IASSHVAVSL RLHHRGRQRT GRFVRLVAAI 
       260        270        280        290        300
VVAFVLCWGP YHIFSLLEAR AHSVTTLRQL ASRGLPFVTS LAFFNSVVNP 
       310        320        330        340        350
LLYVFTCPDM LYKLRRSLRA VLESVLVEDS DQSGGLRNRR RRASSTATPA 
       360        370        380 
STLLLADRIP QLRPTRLIGW MRRGSAEVPQ RV

Length:382

Mass (Da):42,950

Last modified:May 1, 1999 - v1

Checksum:ⁱ8CCB898B93795B04

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF054507 Genomic DNA Translation: AAD13525.1 AB109091 Genomic DNA Translation: BAC81436.1 AB109092 mRNA Translation: BAC81437.1 CH466534 Genomic DNA Translation: EDL41395.1 BC111906 mRNA Translation: AAI11907.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29592.1
NCBI Reference Sequences More...RefSeqⁱ	NP_034092.1, NM_009962.3 XP_006526758.1, XM_006526695.3 XP_006526759.1, XM_006526696.3 XP_011245450.1, XM_011247148.2
UniGeneⁱ	Mm.470721

Genome annotation databases

Ensemblⁱ	ENSMUST00000037261; ENSMUSP00000036159; ENSMUSG00000034117
GeneIDⁱ	14764
KEGGⁱ	mmu:14764
UCSC genome browser More...UCSCⁱ	uc008gri.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Z2J6	Prostaglandin D2 receptor 2		RAT		403	UniRef90_Q9Z2J6
UPI000A3179B7		MUSCR		382
UPI000A3128BA		MUSPA		381

Protein	Similar proteins		Species	Score	Length	Source
Q9Z2J6	Prostaglandin D2 receptor 2		RAT		403	UniRef50_Q9Z2J6
Prostaglandin D2 receptor 2		SARHA		357
Putative G-protein coupled receptor 44		TUPCH		377
prostaglandin D2 receptor 2		DIPOR		429
Prostaglandin D2 receptor 2		HORSE		311
+65

Entry informationⁱ

Entry nameⁱ	PD2R2_MOUSE
Accessionⁱ	Q9Z2J6Primary (citable) accession number: Q9Z2J6 Secondary accession number(s): Q54A00
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	May 1, 1999
	Last modified:	September 12, 2018
	This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Z2J6 (PD2R2_MOUSE)

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Prostaglandin D2 receptor 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ