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Protein

Prostaglandin D2 receptor 2

Gene

Ptgdr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-391908 Prostanoid ligand receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor 2
Alternative name(s):
Chemoattractant receptor-homologous molecule expressed on Th2 cells
G-protein coupled receptor 44
CD_antigen: CD294, Gpr44
Gene namesi
Name:Ptgdr2
Synonyms:Crth2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1330275 Ptgdr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 55Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini56 – 66CytoplasmicSequence analysisAdd BLAST11
Transmembranei67 – 88Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini89 – 105ExtracellularSequence analysisAdd BLAST17
Transmembranei106 – 126Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini127 – 145CytoplasmicSequence analysisAdd BLAST19
Transmembranei146 – 167Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini168 – 209ExtracellularSequence analysisAdd BLAST42
Transmembranei210 – 230Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini231 – 246CytoplasmicSequence analysisAdd BLAST16
Transmembranei247 – 268Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini269 – 287ExtracellularSequence analysisAdd BLAST19
Transmembranei288 – 307Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini308 – 357CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Deficient mice are fertile and grew normally. Ear-swelling responses induced by hapten-specific IgE are less pronounced in deficient mice, giving 35-55% of the responses of normal mice. The reduction in cutaneous responses is associated with decreased infiltration of lymphocytes, eosinophils, and basophils and decreased production of macrophage-derived chemokine and RANTES at inflammatory sites. In models of chronic contact hypersensitivity induced by repeated hapten application, CRTH2-deficient mice result in a reduction by approximately half of skin responses and low levels (63% of control) of serum IgE production.1 Publication

Chemistry databases

ChEMBLiCHEMBL2291
GuidetoPHARMACOLOGYi339

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695731 – 382Prostaglandin D2 receptor 2Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 181PROSITE-ProRule annotation
Modified residuei330PhosphoserineBy similarity1
Modified residuei344PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9Z2J6
PRIDEiQ9Z2J6

PTM databases

iPTMnetiQ9Z2J6
PhosphoSitePlusiQ9Z2J6

Expressioni

Gene expression databases

BgeeiENSMUSG00000034117 Expressed in 16 organ(s), highest expression level in cerebral cortex
CleanExiMM_GPR44
GenevisibleiQ9Z2J6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036159

Chemistry databases

BindingDBiQ9Z2J6

Structurei

3D structure databases

ProteinModelPortaliQ9Z2J6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi329 – 332Involved in the recycling of CRTH2By similarity4

Domaini

The 329-DSEL-332 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for GRK2 and GPRK5/GRK5 to promote agonist-induced internalization (By similarity). Thr-346 is a major site for PKC-induced internalization of the receptor (By similarity).By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IV6V Eukaryota
ENOG410YAX7 LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000234122
HOVERGENiHBG099857
InParanoidiQ9Z2J6
KOiK06715
OMAiQTVVTTW
OrthoDBiEOG091G0FTA
PhylomeDBiQ9Z2J6
TreeFamiTF330976

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z2J6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANVTLKPLC PLLEEMVQLP NHSNSSLRYI DHVSVLLHGL ASLLGLVENG
60 70 80 90 100
LILFVVGCRM RQTVVTTWVL HLALSDLLAA ASLPFFTYFL AVGHSWELGT
110 120 130 140 150
TFCKLHSSVF FLNMFASGFL LSAISLDRCL QVVRPVWAQN HRTVAVAHRV
160 170 180 190 200
CLMLWALAVL NTIPYFVFRD TIPRLDGRIM CYYNLLLWNP GPDRDTTCDY
210 220 230 240 250
RQKALAVSKF LLAFMVPLAI IASSHVAVSL RLHHRGRQRT GRFVRLVAAI
260 270 280 290 300
VVAFVLCWGP YHIFSLLEAR AHSVTTLRQL ASRGLPFVTS LAFFNSVVNP
310 320 330 340 350
LLYVFTCPDM LYKLRRSLRA VLESVLVEDS DQSGGLRNRR RRASSTATPA
360 370 380
STLLLADRIP QLRPTRLIGW MRRGSAEVPQ RV
Length:382
Mass (Da):42,950
Last modified:May 1, 1999 - v1
Checksum:i8CCB898B93795B04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054507 Genomic DNA Translation: AAD13525.1
AB109091 Genomic DNA Translation: BAC81436.1
AB109092 mRNA Translation: BAC81437.1
CH466534 Genomic DNA Translation: EDL41395.1
BC111906 mRNA Translation: AAI11907.1
CCDSiCCDS29592.1
RefSeqiNP_034092.1, NM_009962.3
XP_006526758.1, XM_006526695.3
XP_006526759.1, XM_006526696.3
XP_011245450.1, XM_011247148.2
UniGeneiMm.470721

Genome annotation databases

EnsembliENSMUST00000037261; ENSMUSP00000036159; ENSMUSG00000034117
GeneIDi14764
KEGGimmu:14764
UCSCiuc008gri.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPD2R2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2J6
Secondary accession number(s): Q54A00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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