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Protein

Nexilin

Gene

Nexn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity.By similarity

GO - Molecular functioni

  • actin filament binding Source: RGD
  • structural constituent of muscle Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nexilin
Gene namesi
Name:NexnImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi708354 Nexn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003020871 – 656NexilinAdd BLAST656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80PhosphoserineCombined sources1
Modified residuei221PhosphoserineBy similarity1
Modified residuei330PhosphoserineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei345PhosphoserineCombined sources1
Modified residuei350PhosphothreonineBy similarity1
Modified residuei544PhosphoserineCombined sources1
Modified residuei549PhosphoserineCombined sources1
Modified residuei551PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z2J4
PRIDEiQ9Z2J4

PTM databases

iPTMnetiQ9Z2J4
PhosphoSitePlusiQ9Z2J4

Expressioni

Tissue specificityi

Expressed in brain, testis, spleen and fibroblasts (at protein level). Not detected in liver, kidney or epithelial cells (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000012512
ExpressionAtlasiQ9Z2J4 baseline and differential
GenevisibleiQ9Z2J4 RN

Interactioni

Subunit structurei

Interacts with F-actin.1 Publication

GO - Molecular functioni

  • actin filament binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016968

Structurei

3D structure databases

ProteinModelPortaliQ9Z2J4
SMRiQ9Z2J4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini562 – 650Ig-likeSequence analysisAdd BLAST89

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 555Glu-richSequence analysisAdd BLAST513

Keywords - Domaini

Immunoglobulin domain

Phylogenomic databases

eggNOGiENOG410IF6R Eukaryota
ENOG4110P6X LUCA
GeneTreeiENSGT00730000111176
HOGENOMiHOG000285935
HOVERGENiHBG066529
InParanoidiQ9Z2J4
PhylomeDBiQ9Z2J4

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
PfamiView protein in Pfam
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9Z2J4-1) [UniParc]FASTAAdd to basket
Also known as: b-Nexilin1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNDVSQKAEI LLSSSKPVPK SYVPKLGKGD VKDKFEAMQR AREERNQRRS
60 70 80 90 100
RDEKQRRKEQ YIREREWNRR KQEIKDMLAS DEEEEPSKVE KAYVPKLTGT
110 120 130 140 150
VKGKFDEMEK HRQEEQRKRT EEERKRRIEQ DLLEKRKMQR ELAKRAEQEG
160 170 180 190 200
DDSLLITVVP AKSYRAAANR KDPEDLDREH RNGRVSQEEE KTRHEEECRA
210 220 230 240 250
LKEAKCLSLV MDDETEAKKE SRFPGKLKST FEELERQRQE NRKKQAEEEA
260 270 280 290 300
RRRLEEERRA FEEARRNMVN EEDESQDTET VFKEYRPGKL RLSFEEIERQ
310 320 330 340 350
RREEEKRKAE EEARRRMEEE KKAFAEARRS MVLDDDSPEI YKAVSQESLT
360 370 380 390 400
PGKLEINFEQ LLRQKMEEER RRTEEERRQK LEMEKQEFEQ LRQEMGKEEE
410 420 430 440 450
ENESFGLSRE YEELIKLKRS GSIQAKNLKS KFEKIGQLSE KEVQKKIEEE
460 470 480 490 500
RAKRRAIDLE IKEREAENFH EDDDVDVKPA KKSESPFTHK VNMKARFEQM
510 520 530 540 550
AKARQEEEQR RIEEQKLLRM QFEQKEIDAA LQKKREDDEE EEGSIVNGST
560 570 580 590 600
TEDEEQTRSG APWFKKPLRN TSVVDSEPVR FTVKVTGEPK PEVTWWFEGE
610 620 630 640 650
LLQDGEDYQY IERGETYCLY LPETFPEDGG EYMCKAVNSK GSAASTCILT

IEMDDY
Length:656
Mass (Da):78,393
Last modified:May 1, 1999 - v1
Checksum:i98A4F2AF0396A7F2
GO
Isoform 21 Publication (identifier: Q9Z2J4-2) [UniParc]FASTAAdd to basket
Also known as: s-Nexilin1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     11-74: Missing.
     148-148: Q → QIEDINNTGTESASE

Show »
Length:606
Mass (Da):71,943
Checksum:iD08CC05CE6902F3E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05252811 – 74Missing in isoform 2. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_052529148Q → QIEDINNTGTESASE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056034 mRNA Translation: AAC95128.1
AF056035 mRNA Translation: AAC95129.1
RefSeqiNP_631976.1, NM_139230.1 [Q9Z2J4-1]
NP_631977.1, NM_139231.1 [Q9Z2J4-2]
XP_006233545.1, XM_006233483.3 [Q9Z2J4-1]
XP_006233546.1, XM_006233484.2 [Q9Z2J4-2]
UniGeneiRn.107975

Genome annotation databases

EnsembliENSRNOT00000016967; ENSRNOP00000016968; ENSRNOG00000012512 [Q9Z2J4-1]
ENSRNOT00000066780; ENSRNOP00000058811; ENSRNOG00000012512 [Q9Z2J4-2]
GeneIDi246172
KEGGirno:246172

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNEXN_RAT
AccessioniPrimary (citable) accession number: Q9Z2J4
Secondary accession number(s): Q9Z2J3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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