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Protein

PDZ domain-containing protein GIPC2

Gene

Gipc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ domain-containing protein GIPC2
Alternative name(s):
SemaF cytoplasmic domain-associated protein 2
Short name:
SEMCAP-2
Gene namesi
Name:Gipc2
Synonyms:Semcap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1889209 Gipc2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471891 – 314PDZ domain-containing protein GIPC2Add BLAST314

Proteomic databases

EPDiQ9Z2H7
MaxQBiQ9Z2H7
PaxDbiQ9Z2H7
PeptideAtlasiQ9Z2H7
PRIDEiQ9Z2H7

PTM databases

iPTMnetiQ9Z2H7
PhosphoSitePlusiQ9Z2H7

Expressioni

Tissue specificityi

Expressed in kidney and lung (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000039131 Expressed in 209 organ(s), highest expression level in colon
CleanExiMM_GIPC2
GenevisibleiQ9Z2H7 MM

Interactioni

Subunit structurei

Probably interacts with SEMA5A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Sema4cQ641513EBI-987119,EBI-987075

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9Z2H7, 4 interactors
MINTiQ9Z2H7
STRINGi10090.ENSMUSP00000037328

Structurei

3D structure databases

ProteinModelPortaliQ9Z2H7
SMRiQ9Z2H7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 197PDZPROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the GIPC family.Curated

Phylogenomic databases

eggNOGiKOG3938 Eukaryota
ENOG410XQ87 LUCA
GeneTreeiENSGT00390000003420
HOGENOMiHOG000293347
HOVERGENiHBG000898
InParanoidiQ9Z2H7
KOiK20056
OMAiWRHYDVA
OrthoDBiEOG091G0D3X
PhylomeDBiQ9Z2H7
TreeFamiTF313878

Family and domain databases

InterProiView protein in InterPro
IPR017379 GIPC1/2/3
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR12259 PTHR12259, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PIRSFiPIRSF038083 UCP038083_GIPC, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z2H7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLGLRGKKK AAKSKEAARL VEGERSSGSQ GVPGPPAPAR KLVFHAQLAH
60 70 80 90 100
GSATGRVEDF SSISELYAKI AGVFEIAPSE ILFCTLNTPK IDMGKLLGGQ
110 120 130 140 150
LGLEDFIFAH VKGTKKEVNV YKSEDSLGLT ITDNGVGYAF IKRIKDGSTI
160 170 180 190 200
DSVKTICVGD HIECINGENI VGWRHFEVAK KLKELKKEEL FTLQLIEPKK
210 220 230 240 250
AFEIGPRSKA GKTSTEKIGT SRGTLRLRSK GPATVEELPS EAKAKAIGKV
260 270 280 290 300
DDLLELYMGI RDIDLATTMF EAGKDKSNPD EFAVALDETL GDFAFPDEFL
310
FDVWGAISDM KQGR
Length:314
Mass (Da):34,118
Last modified:May 1, 1999 - v1
Checksum:iC73E40AD8DFCF8FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89P → H in BAB25591 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061262 mRNA Translation: AAC72310.1
AK008307 mRNA Translation: BAB25591.1
AK008626 mRNA Translation: BAB25788.1
AK168560 mRNA Translation: BAE40433.1
BC013440 mRNA Translation: AAH13440.1
CCDSiCCDS17914.1
RefSeqiNP_058563.1, NM_016867.1
UniGeneiMm.97

Genome annotation databases

EnsembliENSMUST00000046614; ENSMUSP00000037328; ENSMUSG00000039131
GeneIDi54120
KEGGimmu:54120
UCSCiuc008rsp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061262 mRNA Translation: AAC72310.1
AK008307 mRNA Translation: BAB25591.1
AK008626 mRNA Translation: BAB25788.1
AK168560 mRNA Translation: BAE40433.1
BC013440 mRNA Translation: AAH13440.1
CCDSiCCDS17914.1
RefSeqiNP_058563.1, NM_016867.1
UniGeneiMm.97

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5V6HX-ray3.60A/C/E/G/I240-314[»]
ProteinModelPortaliQ9Z2H7
SMRiQ9Z2H7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z2H7, 4 interactors
MINTiQ9Z2H7
STRINGi10090.ENSMUSP00000037328

PTM databases

iPTMnetiQ9Z2H7
PhosphoSitePlusiQ9Z2H7

Proteomic databases

EPDiQ9Z2H7
MaxQBiQ9Z2H7
PaxDbiQ9Z2H7
PeptideAtlasiQ9Z2H7
PRIDEiQ9Z2H7

Protocols and materials databases

DNASUi54120
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046614; ENSMUSP00000037328; ENSMUSG00000039131
GeneIDi54120
KEGGimmu:54120
UCSCiuc008rsp.1 mouse

Organism-specific databases

CTDi54810
MGIiMGI:1889209 Gipc2

Phylogenomic databases

eggNOGiKOG3938 Eukaryota
ENOG410XQ87 LUCA
GeneTreeiENSGT00390000003420
HOGENOMiHOG000293347
HOVERGENiHBG000898
InParanoidiQ9Z2H7
KOiK20056
OMAiWRHYDVA
OrthoDBiEOG091G0D3X
PhylomeDBiQ9Z2H7
TreeFamiTF313878

Miscellaneous databases

PROiPR:Q9Z2H7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039131 Expressed in 209 organ(s), highest expression level in colon
CleanExiMM_GIPC2
GenevisibleiQ9Z2H7 MM

Family and domain databases

InterProiView protein in InterPro
IPR017379 GIPC1/2/3
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR12259 PTHR12259, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PIRSFiPIRSF038083 UCP038083_GIPC, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGIPC2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2H7
Secondary accession number(s): Q9CVG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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