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Protein

Protein fem-1 homolog B

Gene

Fem1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 (By similarity).By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • branching involved in prostate gland morphogenesis Source: MGI
  • epithelial cell maturation Source: MGI
  • epithelial cell maturation involved in prostate gland development Source: MGI
  • protein ubiquitination Source: MGI
  • regulation of DNA damage checkpoint Source: UniProtKB
  • regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  • regulation of ubiquitin-protein transferase activity Source: MGI

Keywordsi

Biological processApoptosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fem-1 homolog B
Short name:
FEM1b
Alternative name(s):
FEM1-beta
Fem-1-like death receptor-binding protein alpha
Fem-1-like in apoptotic pathway protein alpha
Short name:
F1A-alpha
mt-Fem
Gene namesi
Name:Fem1b
Synonyms:F1aa, Kiaa0396
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1335087 Fem1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Abnormal glucose tolerance predominantly due to defective glucose-stimulated insulin secretion.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245311 – 627Protein fem-1 homolog BAdd BLAST627

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei342 – 343Cleavage; by a caspase-3-like proteaseBy similarity2

Proteomic databases

MaxQBiQ9Z2G0
PaxDbiQ9Z2G0
PeptideAtlasiQ9Z2G0
PRIDEiQ9Z2G0

PTM databases

iPTMnetiQ9Z2G0
PhosphoSitePlusiQ9Z2G0

Expressioni

Tissue specificityi

Expressed in pancreatic islets, within both beta cells and non-beta cells (at protein level). Highly expressed in adult testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000032244
CleanExiMM_FEM1B
GenevisibleiQ9Z2G0 MM

Interactioni

Subunit structurei

Homooligomer. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, ELOB, ELOC and FEM1B. Interacts with PPM1F and PHTF1. Interacts with the death domain of FAS/TNFRSF6 and TNFRSF1A (By similarity). Interacts with CHEK1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199631, 3 interactors
IntActiQ9Z2G0, 1 interactor
STRINGi10090.ENSMUSP00000034775

Structurei

3D structure databases

ProteinModelPortaliQ9Z2G0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 74ANK 1Add BLAST30
Repeati87 – 116ANK 2Add BLAST30
Repeati120 – 149ANK 3Add BLAST30
Repeati153 – 182ANK 4Add BLAST30
Repeati186 – 215ANK 5Add BLAST30
Repeati218 – 248ANK 6Add BLAST31
Repeati344 – 377TPRAdd BLAST34
Repeati483 – 527ANK 7Add BLAST45
Repeati531 – 568ANK 8Add BLAST38

Sequence similaritiesi

Belongs to the fem-1 family.Curated

Keywords - Domaini

ANK repeat, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0508 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00920000149051
HOVERGENiHBG057774
InParanoidiQ9Z2G0
KOiK10349
OMAiYRTRKRW
OrthoDBiEOG091G03I9
PhylomeDBiQ9Z2G0
TreeFamiTF351376

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 4 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 2 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 8 hits
SUPFAMiSSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 2 hits
PS50088 ANK_REPEAT, 6 hits

Sequencei

Sequence statusi: Complete.

Q9Z2G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGLAGYVYK AASEGKVLTL AALLLNRSES DIRYLLGYVS QQGGQRSTPL
60 70 80 90 100
IIAARNGHAK VVRLLLEHYR VQTQQTGTVR FDGYVIDGAT ALWCAAGAGH
110 120 130 140 150
FEVVKLLVSH GANVNHTTVT NSTPLRAACF DGRLDIVKYL VENNANISIA
160 170 180 190 200
NKYDNTCLMI AAYKGHTDVV RYLLEQRADP NAKAHCGATA LHFAAEAGHI
210 220 230 240 250
DIVKELIKWR AAIVVNGHGM TPLKVAAESC KADVVELLLS HADCDRRSRI
260 270 280 290 300
EALELLGASF ANDRENYDIM KTYHYLYLAM LERFQDGDNI LEKEVLPPIH
310 320 330 340 350
AYGNRTECRN PQELEAIRQD RDALHMEGLI VRERILGADN IDVSHPIIYR
360 370 380 390 400
GAVYADNMEF EQCIKLWLHA LHLRQKGNRN THKDLLRFAQ VFSQMIHLNE
410 420 430 440 450
AVKAPDIECV LRCSVLEIEQ SMNRVKNISD ADVHSAMDNY ECNLYTFLYL
460 470 480 490 500
VCISTKTQCS EEDQCRINKQ IYNLIHLDPR TREGFSLLHL AVNSNTPVDD
510 520 530 540 550
FHTNDVCSFP NALVTKLLLD CGAEVNAVDN EGNSALHIIV QYNRPISDFL
560 570 580 590 600
TLHSIIISLV EAGAHTDMTN KQNKTPLDKS TTGVSEILLK TQMKMSLKCL
610 620
AARAVRANDI NYQDQIPRTL EEFVGFH
Length:627
Mass (Da):70,223
Last modified:May 1, 1999 - v1
Checksum:i72D4ABA2D4576F1B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184A → V in BAE21305 (PubMed:16141072).Curated1
Sequence conflicti201D → G in AAF05315 (PubMed:10542291).Curated1
Sequence conflicti513L → R in BAB33298 (Ref. 3) Curated1
Sequence conflicti540V → A in AAF05315 (PubMed:10542291).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064448 mRNA Translation: AAC82373.1
AF178633 mRNA Translation: AAF05315.1
AB022863 mRNA Translation: BAB33298.1
AK032338 mRNA Translation: BAC27822.1
AK132692 mRNA Translation: BAE21305.1
AK145371 mRNA Translation: BAE26395.1
AK149329 mRNA Translation: BAE28816.1
AK154060 mRNA Translation: BAE32347.1
AK160393 mRNA Translation: BAE35763.1
BC068236 mRNA Translation: AAH68236.1
AK122272 mRNA Translation: BAC65554.1
CCDSiCCDS23266.1
RefSeqiNP_034323.1, NM_010193.4
UniGeneiMm.24069

Genome annotation databases

EnsembliENSMUST00000034775; ENSMUSP00000034775; ENSMUSG00000032244
GeneIDi14155
KEGGimmu:14155
UCSCiuc009qam.3 mouse

Similar proteinsi

Entry informationi

Entry nameiFEM1B_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2G0
Secondary accession number(s): Q3TV57
, Q3ULQ3, Q3V148, Q80U13, Q99NC9, Q9QZL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 1999
Last modified: June 20, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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