Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein atonal homolog 7

Gene

Atoh7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor involved in the differentiation of most retinal ganglion cells, including those constituting the retino-hypothalamic tract.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein atonal homolog 7
Alternative name(s):
Helix-loop-helix protein mATH-5
Short name:
mATH5
Gene namesi
Name:Atoh7
Synonyms:Ath5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1355553 Atoh7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile. However, due to a lack of most retinal ganglion cells, they are blind and unable to entrain normally to light/dark cycles.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002924071 – 149Protein atonal homolog 7Add BLAST149

Proteomic databases

PaxDbiQ9Z2E5
PRIDEiQ9Z2E5

PTM databases

PhosphoSitePlusiQ9Z2E5

Expressioni

Developmental stagei

Expression initiates at E11 in the central optic cup and is detected in retinal progenitor cells until birth. Not expressed in the adult retina. In addition to the eye, only expressed in the developing tenth cranial ganglion between E13.5 and E15.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000036816 Expressed in 65 organ(s), highest expression level in optic fissure
CleanExiMM_ATOH7
GenevisibleiQ9Z2E5 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039801

Structurei

3D structure databases

ProteinModelPortaliQ9Z2E5
SMRiQ9Z2E5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 93bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4395 Eukaryota
ENOG411269K LUCA
GeneTreeiENSGT00680000099860
HOGENOMiHOG000034180
HOVERGENiHBG094840
InParanoidiQ9Z2E5
KOiK09083
OMAiHYLPFAG
OrthoDBiEOG091G0R1N
PhylomeDBiQ9Z2E5
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR032663 Atoh7
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR19290:SF99 PTHR19290:SF99, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z2E5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSACKPHGP PAGARGAPPC AGAAERAVSC AGPGRLESAA RRRLAANARE
60 70 80 90 100
RRRMQGLNTA FDRLRRVVPQ WGQDKKLSKY ETLQMALSYI IALTRILAEA
110 120 130 140
ERDWVGLRCE QRGRDHPYLP FPGARLQVDP EPYGQRLFGF QPEPFPMAS
Length:149
Mass (Da):16,569
Last modified:May 1, 1999 - v1
Checksum:iDF78A25190B5FD3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071223 mRNA Translation: AAC68868.1
AF418923 Genomic DNA Translation: AAL11912.1
BC092234 mRNA Translation: AAH92234.1
CCDSiCCDS23896.1
RefSeqiNP_058560.1, NM_016864.1
UniGeneiMm.228661

Genome annotation databases

EnsembliENSMUST00000044059; ENSMUSP00000039801; ENSMUSG00000036816
GeneIDi53404
KEGGimmu:53404
UCSCiuc007fjv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071223 mRNA Translation: AAC68868.1
AF418923 Genomic DNA Translation: AAL11912.1
BC092234 mRNA Translation: AAH92234.1
CCDSiCCDS23896.1
RefSeqiNP_058560.1, NM_016864.1
UniGeneiMm.228661

3D structure databases

ProteinModelPortaliQ9Z2E5
SMRiQ9Z2E5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039801

PTM databases

PhosphoSitePlusiQ9Z2E5

Proteomic databases

PaxDbiQ9Z2E5
PRIDEiQ9Z2E5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044059; ENSMUSP00000039801; ENSMUSG00000036816
GeneIDi53404
KEGGimmu:53404
UCSCiuc007fjv.1 mouse

Organism-specific databases

CTDi220202
MGIiMGI:1355553 Atoh7

Phylogenomic databases

eggNOGiKOG4395 Eukaryota
ENOG411269K LUCA
GeneTreeiENSGT00680000099860
HOGENOMiHOG000034180
HOVERGENiHBG094840
InParanoidiQ9Z2E5
KOiK09083
OMAiHYLPFAG
OrthoDBiEOG091G0R1N
PhylomeDBiQ9Z2E5
TreeFamiTF315153

Miscellaneous databases

PROiPR:Q9Z2E5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036816 Expressed in 65 organ(s), highest expression level in optic fissure
CleanExiMM_ATOH7
GenevisibleiQ9Z2E5 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR032663 Atoh7
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR19290:SF99 PTHR19290:SF99, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATOH7_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again