Atoh7

Functionⁱ

Transcription factor involved in the differentiation of most retinal ganglion cells, including those constituting the retino-hypothalamic tract.4 Publications

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
circadian rhythm
Source: MGI
Inferred from mutant phenotypeⁱ
- 12451142
entrainment of circadian clock
Source: MGI
Inferred from mutant phenotypeⁱ
- 12451142
neural retina development
Source: MGI
Inferred from mutant phenotypeⁱ
- 21441919
optic nerve development Source: MGI
regulation of transcription, DNA-templated Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Differentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein atonal homolog 7 Alternative name(s): Helix-loop-helix protein mATH-5 Short name: mATH5
Gene namesⁱ	Name:Atoh7 Synonyms:Ath5
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:1355553 Atoh7

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice are viable and fertile. However, due to a lack of most retinal ganglion cells, they are blind and unable to entrain normally to light/dark cycles.3 Publications

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000292407	1 – 149	Protein atonal homolog 7Add BLAST		149

Proteomic databases

PaxDbⁱ	Q9Z2E5
PRIDEⁱ	Q9Z2E5

PTM databases

PhosphoSitePlusⁱ	Q9Z2E5

PhosphoSitePlusⁱ

Q9Z2E5

Expressionⁱ

Developmental stageⁱ

Expression initiates at E11 in the central optic cup and is detected in retinal progenitor cells until birth. Not expressed in the adult retina. In addition to the eye, only expressed in the developing tenth cranial ganglion between E13.5 and E15.5.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000036816 Expressed in 65 organ(s), highest expression level in optic fissure
CleanExⁱ	MM_ATOH7
Genevisibleⁱ	Q9Z2E5 MM

Interactionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000039801

STRINGⁱ

10090.ENSMUSP00000039801

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Z2E5
SMRⁱ	Q9Z2E5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	41 – 93	bHLHPROSITE-ProRule annotationAdd BLAST		53

Phylogenomic databases

eggNOGⁱ	KOG4395 Eukaryota ENOG411269K LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00680000099860
HOGENOMⁱ	HOG000034180
HOVERGENⁱ	HBG094840
InParanoidⁱ	Q9Z2E5
KEGG Orthology (KO) More...KOⁱ	K09083
OMAⁱ	HYLPFAG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R1N
PhylomeDBⁱ	Q9Z2E5
TreeFamⁱ	TF315153

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR032663 Atoh7 IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
PANTHERⁱ	PTHR19290:SF99 PTHR19290:SF99, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9Z2E5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKSACKPHGP PAGARGAPPC AGAAERAVSC AGPGRLESAA RRRLAANARE 
        60         70         80         90        100
RRRMQGLNTA FDRLRRVVPQ WGQDKKLSKY ETLQMALSYI IALTRILAEA 
       110        120        130        140 
ERDWVGLRCE QRGRDHPYLP FPGARLQVDP EPYGQRLFGF QPEPFPMAS

Length:149

Mass (Da):16,569

Last modified:May 1, 1999 - v1

Checksum:ⁱDF78A25190B5FD3A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF071223 mRNA Translation: AAC68868.1 AF418923 Genomic DNA Translation: AAL11912.1 BC092234 mRNA Translation: AAH92234.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23896.1
NCBI Reference Sequences More...RefSeqⁱ	NP_058560.1, NM_016864.1
UniGeneⁱ	Mm.228661

Genome annotation databases

Ensemblⁱ	ENSMUST00000044059; ENSMUSP00000039801; ENSMUSG00000036816
GeneIDⁱ	53404
KEGGⁱ	mmu:53404
UCSC genome browser More...UCSCⁱ	uc007fjv.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Z2E5	Atonal bHLH transcription factor 7		RAT		149	UniRef90_Q9Z2E5
Uncharacterized protein		CRIGR		96
protein atonal homolog 7		MESAU		150
UPI000A311B69		MUSPA		149
UPI000A317868		MUSCR		149
+4

Protein	Similar proteins		Species	Score	Length	Source
Q9Z2E5	Protein atonal homolog 7		HUMAN		152	UniRef50_Q8N100
ATOH7 isoform 1		PANTR		152
Atonal bHLH transcription factor 7		GORGO		152
Uncharacterized protein		PIG		155
Uncharacterized protein		PAPAN		152
+96

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF071223 mRNA Translation: AAC68868.1 AF418923 Genomic DNA Translation: AAL11912.1 BC092234 mRNA Translation: AAH92234.1
CCDSⁱ	CCDS23896.1
RefSeqⁱ	NP_058560.1, NM_016864.1
UniGeneⁱ	Mm.228661

3D structure databases

ProteinModelPortalⁱ	Q9Z2E5
SMRⁱ	Q9Z2E5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000039801

STRINGⁱ

10090.ENSMUSP00000039801

PTM databases

PhosphoSitePlusⁱ	Q9Z2E5

PhosphoSitePlusⁱ

Q9Z2E5

Proteomic databases

PaxDbⁱ	Q9Z2E5
PRIDEⁱ	Q9Z2E5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000044059; ENSMUSP00000039801; ENSMUSG00000036816
GeneIDⁱ	53404
KEGGⁱ	mmu:53404
UCSCⁱ	uc007fjv.1 mouse

Organism-specific databases

CTDⁱ	220202
MGIⁱ	MGI:1355553 Atoh7

Phylogenomic databases

eggNOGⁱ	KOG4395 Eukaryota ENOG411269K LUCA
GeneTreeⁱ	ENSGT00680000099860
HOGENOMⁱ	HOG000034180
HOVERGENⁱ	HBG094840
InParanoidⁱ	Q9Z2E5
KOⁱ	K09083
OMAⁱ	HYLPFAG
OrthoDBⁱ	EOG091G0R1N
PhylomeDBⁱ	Q9Z2E5
TreeFamⁱ	TF315153

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9Z2E5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000036816 Expressed in 65 organ(s), highest expression level in optic fissure
CleanExⁱ	MM_ATOH7
Genevisibleⁱ	Q9Z2E5 MM

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR032663 Atoh7 IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
PANTHERⁱ	PTHR19290:SF99 PTHR19290:SF99, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ATOH7_MOUSE
Accessionⁱ	Q9Z2E5Primary (citable) accession number: Q9Z2E5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Z2E5 (ATOH7_MOUSE)

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Protein atonal homolog 7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ