UniProtKB - Q9Z2E5 (ATOH7_MOUSE)
Transcription factor Atoh7
Atoh7
Functioni
Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (PubMed:33712461).
Dimerization with TCF3 isoform E47 may be required in certain situations (By similarity).
Binds to gene promoters and enhancer elements, and thereby regulates a transcriptional program of retinal ganglion cell (RGC) determinant genes (PubMed:33712461).
Although the exact mechanism is not certain, retinal transcription regulation by ATOH7 has a role in RGC determination and survival, photoreceptor population development, targeting of RGC axons to the optic nerve and development of the retino-hypothalamic tract (PubMed:11493566, PubMed:11156601, PubMed:12451142, PubMed:33712461).
Binds to its own promoter and enhancer sequences, suggesting autoregulation of ATOH7 transcription (PubMed:33712461).
Required for retinal circadian rhythm photoentrainment (PubMed:12451142, PubMed:26392540).
Plays a role in brainstem auditory signaling and binaural processing (PubMed:17977745).
By similarity6 PublicationsGO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
- transcription cis-regulatory region binding Source: UniProtKB
GO - Biological processi
- circadian rhythm Source: MGI
- entrainment of circadian clock Source: MGI
- entrainment of circadian clock by photoperiod Source: UniProtKB
- neural retina development Source: MGI
- neuron differentiation Source: GO_Central
- optic nerve development Source: MGI
- positive regulation of retinal ganglion cell axon guidance Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of transcription by RNA polymerase II Source: UniProtKB
- response to auditory stimulus Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor Atoh7CuratedAlternative name(s): Atonal bHLH transcription factor 7Imported Helix-loop-helix protein mATH-51 Publication Short name: mATH51 Publication Protein atonal homolog 7Imported |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1355553, Atoh7 |
VEuPathDBi | HostDB:ENSMUSG00000036816 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- Perikaryon 1 Publication
- axon 1 Publication
Nucleus
- nucleus Source: UniProtKB
Other locations
- axon Source: UniProtKB
- perikaryon Source: UniProtKB
Keywords - Cellular componenti
Cell projection, NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000292407 | 1 – 149 | Transcription factor Atoh7Add BLAST | 149 |
Proteomic databases
PaxDbi | Q9Z2E5 |
PRIDEi | Q9Z2E5 |
PTM databases
PhosphoSitePlusi | Q9Z2E5 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000036816, Expressed in optic fissure and 90 other tissues |
Genevisiblei | Q9Z2E5, MM |
Interactioni
Subunit structurei
Forms a heterodimer with TCF3 isoform E47; interaction may be required for DNA-binding in certain situations.
By similarityGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000039801 |
Miscellaneous databases
RNActi | Q9Z2E5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 93 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Phylogenomic databases
eggNOGi | KOG4395, Eukaryota |
GeneTreei | ENSGT00940000161556 |
HOGENOMi | CLU_145503_0_0_1 |
InParanoidi | Q9Z2E5 |
OMAi | WVSLHCE |
OrthoDBi | 1453771at2759 |
PhylomeDBi | Q9Z2E5 |
TreeFami | TF315153 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR032663, Atoh7 IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR19290:SF99, PTHR19290:SF99, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MKSACKPHGP PAGARGAPPC AGAAERAVSC AGPGRLESAA RRRLAANARE
60 70 80 90 100
RRRMQGLNTA FDRLRRVVPQ WGQDKKLSKY ETLQMALSYI IALTRILAEA
110 120 130 140
ERDWVGLRCE QRGRDHPYLP FPGARLQVDP EPYGQRLFGF QPEPFPMAS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF071223 mRNA Translation: AAC68868.1 AF418923 Genomic DNA Translation: AAL11912.1 BC092234 mRNA Translation: AAH92234.1 |
CCDSi | CCDS23896.1 |
RefSeqi | NP_058560.1, NM_016864.1 |
Genome annotation databases
Ensembli | ENSMUST00000044059; ENSMUSP00000039801; ENSMUSG00000036816 |
GeneIDi | 53404 |
KEGGi | mmu:53404 |
UCSCi | uc007fjv.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF071223 mRNA Translation: AAC68868.1 AF418923 Genomic DNA Translation: AAL11912.1 BC092234 mRNA Translation: AAH92234.1 |
CCDSi | CCDS23896.1 |
RefSeqi | NP_058560.1, NM_016864.1 |
3D structure databases
AlphaFoldDBi | Q9Z2E5 |
SMRi | Q9Z2E5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000039801 |
PTM databases
PhosphoSitePlusi | Q9Z2E5 |
Proteomic databases
PaxDbi | Q9Z2E5 |
PRIDEi | Q9Z2E5 |
Protocols and materials databases
Antibodypediai | 28437, 223 antibodies from 26 providers |
DNASUi | 53404 |
Genome annotation databases
Ensembli | ENSMUST00000044059; ENSMUSP00000039801; ENSMUSG00000036816 |
GeneIDi | 53404 |
KEGGi | mmu:53404 |
UCSCi | uc007fjv.1, mouse |
Organism-specific databases
CTDi | 220202 |
MGIi | MGI:1355553, Atoh7 |
VEuPathDBi | HostDB:ENSMUSG00000036816 |
Phylogenomic databases
eggNOGi | KOG4395, Eukaryota |
GeneTreei | ENSGT00940000161556 |
HOGENOMi | CLU_145503_0_0_1 |
InParanoidi | Q9Z2E5 |
OMAi | WVSLHCE |
OrthoDBi | 1453771at2759 |
PhylomeDBi | Q9Z2E5 |
TreeFami | TF315153 |
Miscellaneous databases
BioGRID-ORCSi | 53404, 1 hit in 75 CRISPR screens |
ChiTaRSi | Atoh7, mouse |
PROi | PR:Q9Z2E5 |
RNActi | Q9Z2E5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000036816, Expressed in optic fissure and 90 other tissues |
Genevisiblei | Q9Z2E5, MM |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR032663, Atoh7 IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR19290:SF99, PTHR19290:SF99, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ATOH7_MOUSE | |
Accessioni | Q9Z2E5Primary (citable) accession number: Q9Z2E5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | May 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot