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Protein

Protein phosphatase 1 regulatory subunit 17

Gene

Ppp1r17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 17
Alternative name(s):
G substrate
Gene namesi
Name:Ppp1r17
Synonyms:Gsbs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1333876 Ppp1r17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi72T → A: Does not potentiate the phosphorylation of the CREB transcription factor; when associated with A-123. 1 Publication1
Mutagenesisi123T → A: Does not potentiate the phosphorylation of the CREB transcription factor; when associated with A-72. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004145761 – 159Protein phosphatase 1 regulatory subunit 17Add BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72Phosphothreonine; by PKG/PRKG11 Publication1
Modified residuei123Phosphothreonine; by PKG/PRKG11 Publication1

Post-translational modificationi

Substrate for cGMP-dependent protein kinase (By similarity). Phosphorylation of Thr-72 and Thr-123 is required for its phosphatase activity. Phosphorylated by PRKG1 isoform alpha.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z2E4
PaxDbiQ9Z2E4
PeptideAtlasiQ9Z2E4
PRIDEiQ9Z2E4

PTM databases

iPTMnetiQ9Z2E4
PhosphoSitePlusiQ9Z2E4

Expressioni

Tissue specificityi

Expressed in Purkinje cells of the cerebellum, hippocampus, pons, medulla and eye.1 Publication

Gene expression databases

BgeeiENSMUSG00000002930 Expressed in 102 organ(s), highest expression level in dorsal root ganglion
GenevisibleiQ9Z2E4 MM

Interactioni

Protein-protein interaction databases

IntActiQ9Z2E4, 1 interactor
MINTiQ9Z2E4
STRINGi10090.ENSMUSP00000059708

Structurei

3D structure databases

ProteinModelPortaliQ9Z2E4
SMRiQ9Z2E4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IMZI Eukaryota
ENOG410Y65X LUCA
GeneTreeiENSGT00390000005586
HOGENOMiHOG000069880
HOVERGENiHBG005927
InParanoidiQ9Z2E4
KOiK08067
OMAiPGVISEH
OrthoDBiEOG091G0OSZ
PhylomeDBiQ9Z2E4
TreeFamiTF335928

Family and domain databases

InterProiView protein in InterPro
IPR033242 PPP1R17
PANTHERiPTHR15387 PTHR15387, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z2E4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTEMMTTEP VPPLELSDDI LGKLDPQCSP SDDLSDQFIK DCDLKKKPRK
60 70 80 90 100
GKNVQATLNV ESDQKKPRRK DTPAVHIPPF IPGVISEHLI KRYDVQERIP
110 120 130 140 150
KAKSGPALHN SDMEQKRPRR KDTPALHMPP FVAGLTLLRD ESAGVILEDE

EMDGDKLAI
Length:159
Mass (Da):17,815
Last modified:May 1, 1999 - v1
Checksum:i18B5ECA9E925856C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071562 mRNA Translation: AAD12589.1
AF500906 mRNA Translation: AAM21706.1
AK078335 mRNA Translation: BAC37224.1
AC079365 Genomic DNA No translation available.
CH466597 Genomic DNA Translation: EDK98736.1
BC026822 mRNA Translation: AAH26822.1
CCDSiCCDS20169.1
RefSeqiNP_035283.1, NM_011153.3
UniGeneiMm.42096

Genome annotation databases

EnsembliENSMUST00000052827; ENSMUSP00000059708; ENSMUSG00000002930
GeneIDi19051
KEGGimmu:19051
UCSCiuc009cay.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071562 mRNA Translation: AAD12589.1
AF500906 mRNA Translation: AAM21706.1
AK078335 mRNA Translation: BAC37224.1
AC079365 Genomic DNA No translation available.
CH466597 Genomic DNA Translation: EDK98736.1
BC026822 mRNA Translation: AAH26822.1
CCDSiCCDS20169.1
RefSeqiNP_035283.1, NM_011153.3
UniGeneiMm.42096

3D structure databases

ProteinModelPortaliQ9Z2E4
SMRiQ9Z2E4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z2E4, 1 interactor
MINTiQ9Z2E4
STRINGi10090.ENSMUSP00000059708

PTM databases

iPTMnetiQ9Z2E4
PhosphoSitePlusiQ9Z2E4

Proteomic databases

MaxQBiQ9Z2E4
PaxDbiQ9Z2E4
PeptideAtlasiQ9Z2E4
PRIDEiQ9Z2E4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052827; ENSMUSP00000059708; ENSMUSG00000002930
GeneIDi19051
KEGGimmu:19051
UCSCiuc009cay.1 mouse

Organism-specific databases

CTDi10842
MGIiMGI:1333876 Ppp1r17

Phylogenomic databases

eggNOGiENOG410IMZI Eukaryota
ENOG410Y65X LUCA
GeneTreeiENSGT00390000005586
HOGENOMiHOG000069880
HOVERGENiHBG005927
InParanoidiQ9Z2E4
KOiK08067
OMAiPGVISEH
OrthoDBiEOG091G0OSZ
PhylomeDBiQ9Z2E4
TreeFamiTF335928

Miscellaneous databases

ChiTaRSiPpp1r17 mouse
PROiPR:Q9Z2E4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002930 Expressed in 102 organ(s), highest expression level in dorsal root ganglion
GenevisibleiQ9Z2E4 MM

Family and domain databases

InterProiView protein in InterPro
IPR033242 PPP1R17
PANTHERiPTHR15387 PTHR15387, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPR17_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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