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Entry version 154 (11 Dec 2019)
Sequence version 2 (24 Jul 2007)
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Protein

Methyl-CpG-binding domain protein 1

Gene

Mbd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 can also repress transcription from unmethylated promoters.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi356ZincBy similarity1
Metal bindingi359ZincBy similarity1
Metal bindingi362ZincBy similarity1
Metal bindingi368ZincBy similarity1
Metal bindingi371ZincBy similarity1
Metal bindingi374ZincBy similarity1
Metal bindingi390ZincBy similarity1
Metal bindingi395ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri187 – 234CXXC-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri235 – 281CXXC-type 2PROSITE-ProRule annotationAdd BLAST47
Zinc fingeri348 – 396CXXC-type 3PROSITE-ProRule annotationAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3899300 SUMOylation of transcription cofactors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methyl-CpG-binding domain protein 1
Alternative name(s):
Methyl-CpG-binding protein MBD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mbd1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1333811 Mbd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000962591 – 636Methyl-CpG-binding domain protein 1Add BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki293Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei409PhosphoserineBy similarity1
Cross-linki443Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki461Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki520Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki520Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki559Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki559Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated with SUMO1 by PIAS1 and PIAS3 (By similarity). Sumoylation affects transcriptional silencing by preventing the interaction with SETDB1 (By similarity). In contrast, sumoylation may increase interaction with AFT7IP (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q9Z2E2

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z2E2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Z2E2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Z2E2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in kidney, liver and brain. Detected at lower levels in heart, lung, skeletal muscle, spleen and testis.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with OASL, AFT7IP, AFT7IP2 and BAHD1. Binds CHAF1A and the SUV39H1-CBX5 complex via the MBD domain. Binds MGP via the TRD domain. May be part of the MeCP1 complex. During DNA replication, it recruits SETDB1 to form a S phase-specific complex that facilitates methylation of H3 'Lys-9' during replication-coupled chromatin assembly and is at least composed of the CAF-1 subunit CHAF1A, MBD1 and SETDB1 (By similarity).

Isoform 2 interacts with the Ten-1 ICD form of TENM1.

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
201330, 1 interactor

Molecular INTeraction database

More...
MINTi
Q9Z2E2

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Z2E2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Z2E2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 69MBDPROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni550 – 612Transcriptional repression domain (TRD)By similarityAdd BLAST63

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi84 – 88Nuclear localization signalSequence analysis5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The methyl-CpG-binding domain (MBD) functions both in binding to methylated DNA and in protein interactions.By similarity
The third CXXC-type zinc finger mediates binding to DNA containing unmethylated CpG dinucleotides.By similarity
The transcriptional repression domain (TRD) is involved in transcription repression and in protein interactions.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri187 – 234CXXC-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri235 – 281CXXC-type 2PROSITE-ProRule annotationAdd BLAST47
Zinc fingeri348 – 396CXXC-type 3PROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Z2E2

KEGG Orthology (KO)

More...
KOi
K11589

Database of Orthologous Groups

More...
OrthoDBi
1431783at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Z2E2

TreeFam database of animal gene trees

More...
TreeFami
TF350557

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016177 DNA-bd_dom_sf
IPR001739 Methyl_CpG_DNA-bd
IPR002857 Znf_CXXC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01429 MBD, 1 hit
PF02008 zf-CXXC, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00391 MBD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54171 SSF54171, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50982 MBD, 1 hit
PS51058 ZF_CXXC, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Z2E2-1) [UniParc]FASTAAdd to basket
Also known as: MBD1a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAESWQDCPA LGPGWKRRES FRKSGASFGR SDIYYQSPTG EKIRSKVELT
60 70 80 90 100
RYLGPACDLT LFDFRQGTLC HPIPKTHPLA VPSKKKKKPS KPAKTKKQQV
110 120 130 140 150
GLQRSEVRIE TPQGEYKAPT ATALASLSVS ASASSSASAS ASASSHAPVC
160 170 180 190 200
CENCGIHFSW DGVKRQRLKT LCKDCRAQRI AFNREQRMFK RVGCGDCAAC
210 220 230 240 250
LVKEDCGVCS TCRLQLPSDV ASGLYCKCER RRCLRIMEKS RGCGVCRGCQ
260 270 280 290 300
TQEDCGHCCI CLRSPRPGLK RQWRCLQRRC FWGKRDSSKR GSKVASQRHS
310 320 330 340 350
QAPPLPPHPA SQYTEPTELH ISDIAPTSPA EFIYYCVDED EDELQPYTNQ
360 370 380 390 400
RQNRKCGACA ACLRRMDCGR CDFCCDKPKF GGGNQKRQKC RWRQCLQFAM
410 420 430 440 450
KRLLPSAGSG SGEGAGLRPY QTHQTHQKRP ASARQLQLSS PLKAPWAVVT
460 470 480 490 500
APPGPVRDSR KQQAGRGSVL PQPDTDFVFL QEGTSSAMQM PGTAAASTEV
510 520 530 540 550
PVQAAQCSAP SWVVALPQVK QETADAPEEW TAVTTFLTSS TLQSGFPSKA
560 570 580 590 600
ADPDLSPVKQ EPPGPEEDGE EKKDDVSETT PAEEIGGVGT PVITEIFSLG
610 620 630
GTRLRDAEAW LPRLHKLLAV NEKEYFTELQ LKEEVL
Length:636
Mass (Da):70,023
Last modified:July 24, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02D8B94EBD522F65
GO
Isoform 2 (identifier: Q9Z2E2-2) [UniParc]FASTAAdd to basket
Also known as: MBD1b

The sequence of this isoform differs from the canonical sequence as follows:
     142-142: S → SSSASASAS
     345-400: Missing.

Show »
Length:588
Mass (Da):64,124
Checksum:i5C560DE1FDFA7D77
GO
Isoform 3 (identifier: Q9Z2E2-3) [UniParc]FASTAAdd to basket
Also known as: MBD1d

The sequence of this isoform differs from the canonical sequence as follows:
     142-142: S → SSSASASAS
     345-400: Missing.
     614-625: LHKLLAVNEKEY → SKDLKNPEAKMQ
     626-636: Missing.

Show »
Length:577
Mass (Da):62,725
Checksum:i5D4C5CDDC6FD98BF
GO
Isoform 4 (identifier: Q9Z2E2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     345-400: Missing.

Show »
Length:580
Mass (Da):63,475
Checksum:i90686B0BDD2E34B2
GO
Isoform 5 (identifier: Q9Z2E2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     345-400: Missing.
     614-625: LHKLLAVNEKEY → SKDLKNPEAKMQ
     626-636: Missing.

Show »
Length:569
Mass (Da):62,076
Checksum:iB450A440E447410B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J159A0A0R4J159_MOUSE
Methyl-CpG-binding domain protein 1
Mbd1
588Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YDI1A0A286YDI1_MOUSE
Methyl-CpG-binding domain protein 1
Mbd1
644Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YCP6A0A286YCP6_MOUSE
Methyl-CpG-binding domain protein 1
Mbd1
467Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8MPN9A0A5F8MPN9_MOUSE
Methyl-CpG-binding domain protein 1
Mbd1
613Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti109I → R in BAB23419 (PubMed:16141072).Curated1
Sequence conflicti109I → R in AAH69837 (PubMed:15489334).Curated1
Sequence conflicti146H → R in AAH69837 (PubMed:15489334).Curated1
Sequence conflicti457R → Q in AAC68869 (PubMed:9774669).Curated1
Sequence conflicti457R → Q in AAD48908 (PubMed:10441743).Curated1
Sequence conflicti457R → Q in BAE33700 (PubMed:16141072).Curated1
Sequence conflicti484T → A in AAC68869 (PubMed:9774669).Curated1
Sequence conflicti484T → A in AAD48908 (PubMed:10441743).Curated1
Sequence conflicti484T → A in BAE33700 (PubMed:16141072).Curated1
Sequence conflicti497S → C in AAC68869 (PubMed:9774669).Curated1
Sequence conflicti497S → C in AAD48908 (PubMed:10441743).Curated1
Sequence conflicti497S → C in BAE33700 (PubMed:16141072).Curated1
Sequence conflicti556S → P in AAC68869 (PubMed:9774669).Curated1
Sequence conflicti556S → P in AAD48908 (PubMed:10441743).Curated1
Sequence conflicti556S → P in BAE33700 (PubMed:16141072).Curated1
Sequence conflicti604L → F in AAH69837 (PubMed:15489334).Curated1
Isoform 2 (identifier: Q9Z2E2-2)
Sequence conflicti144S → F in AAH69837 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011072142S → SSSASASAS in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_011073345 – 400Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST56
Alternative sequenceiVSP_011074614 – 625LHKLL…NEKEY → SKDLKNPEAKMQ in isoform 3 and isoform 5. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_011075626 – 636Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST11

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF072240 mRNA Translation: AAC68869.1
AF120978 Genomic DNA Translation: AAD48908.1
AK004624 mRNA Translation: BAB23419.1
AK032535 mRNA Translation: BAC27914.1
AK156401 mRNA Translation: BAE33700.1
AK166042 mRNA Translation: BAE38538.1
BC069837 mRNA Translation: AAH69837.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS50321.1 [Q9Z2E2-2]

NCBI Reference Sequences

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RefSeqi
NP_038622.2, NM_013594.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
17190

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:17190

UCSC genome browser

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UCSCi
uc008fpj.2 mouse [Q9Z2E2-2]
uc008fpk.1 mouse [Q9Z2E2-5]
uc012bex.1 mouse [Q9Z2E2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072240 mRNA Translation: AAC68869.1
AF120978 Genomic DNA Translation: AAD48908.1
AK004624 mRNA Translation: BAB23419.1
AK032535 mRNA Translation: BAC27914.1
AK156401 mRNA Translation: BAE33700.1
AK166042 mRNA Translation: BAE38538.1
BC069837 mRNA Translation: AAH69837.1
CCDSiCCDS50321.1 [Q9Z2E2-2]
RefSeqiNP_038622.2, NM_013594.2

3D structure databases

SMRiQ9Z2E2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi201330, 1 interactor
MINTiQ9Z2E2

PTM databases

iPTMnetiQ9Z2E2
PhosphoSitePlusiQ9Z2E2

Proteomic databases

PeptideAtlasiQ9Z2E2
PRIDEiQ9Z2E2

Genome annotation databases

GeneIDi17190
KEGGimmu:17190
UCSCiuc008fpj.2 mouse [Q9Z2E2-2]
uc008fpk.1 mouse [Q9Z2E2-5]
uc012bex.1 mouse [Q9Z2E2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4152
MGIiMGI:1333811 Mbd1

Phylogenomic databases

InParanoidiQ9Z2E2
KOiK11589
OrthoDBi1431783at2759
PhylomeDBiQ9Z2E2
TreeFamiTF350557

Enzyme and pathway databases

ReactomeiR-MMU-3899300 SUMOylation of transcription cofactors

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Mbd1 mouse

Protein Ontology

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PROi
PR:Q9Z2E2
RNActiQ9Z2E2 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR016177 DNA-bd_dom_sf
IPR001739 Methyl_CpG_DNA-bd
IPR002857 Znf_CXXC
PfamiView protein in Pfam
PF01429 MBD, 1 hit
PF02008 zf-CXXC, 3 hits
SMARTiView protein in SMART
SM00391 MBD, 1 hit
SUPFAMiSSF54171 SSF54171, 1 hit
PROSITEiView protein in PROSITE
PS50982 MBD, 1 hit
PS51058 ZF_CXXC, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMBD1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z2E2
Secondary accession number(s): Q3TMA4
, Q3U101, Q6NSW0, Q792D6, Q8CCL9, Q9DC19
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 24, 2007
Last modified: December 11, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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