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Protein

Myotubularin-related protein 2

Gene

Mtmr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate.1 Publication

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.1 Publication
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.1 Publication

Activity regulationi

Interaction with SBF1 increases phosphatase activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei417Phosphocysteine intermediate1
Binding sitei463SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism

Enzyme and pathway databases

BRENDAi3.1.3.95 3474
ReactomeiR-MMU-1483248 Synthesis of PIPs at the ER membrane
R-MMU-1660516 Synthesis of PIPs at the early endosome membrane
R-MMU-1660517 Synthesis of PIPs at the late endosome membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 2
Alternative name(s):
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.951 Publication)
Phosphatidylinositol-3-phosphate phosphatase (EC:3.1.3.641 Publication)
Gene namesi
Name:Mtmr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1924366 Mtmr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi103G → E: Severely impaired interaction with membranes and strongly reduced catalytic activity. 2 Publications1
Mutagenesisi417C → A: Loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000949351 – 643Myotubularin-related protein 2Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei9PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Ser-58 decreases MTMR2 localization to endocytic vesicular structures.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Z2D1
MaxQBiQ9Z2D1
PaxDbiQ9Z2D1
PeptideAtlasiQ9Z2D1
PRIDEiQ9Z2D1

PTM databases

iPTMnetiQ9Z2D1
PhosphoSitePlusiQ9Z2D1

Expressioni

Tissue specificityi

Detected in fetal forebrain, dorsal root ganglia, trigeminal ganglia, kidney, adrenal gland and lung. Detected in adult dorsal root ganglia, neurons of the central nervous system, motor neurons, cell soma and neurites of sensory neurons, olfactory bulb, cerebellum and hippocampus.1 Publication

Gene expression databases

BgeeiENSMUSG00000031918 Expressed in 217 organ(s), highest expression level in testis
CleanExiMM_MTMR2
ExpressionAtlasiQ9Z2D1 baseline and differential
GenevisibleiQ9Z2D1 MM

Interactioni

Subunit structurei

Homooligomer and heterooligomer. Interacts with SBF1 and SBF2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218525, 7 interactors
IntActiQ9Z2D1, 5 interactors
STRINGi10090.ENSMUSP00000034396

Structurei

3D structure databases

ProteinModelPortaliQ9Z2D1
SMRiQ9Z2D1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 139GRAMAdd BLAST72
Domaini205 – 580Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST376

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni330 – 333Substrate bindingBy similarity4
Regioni355 – 356Substrate bindingBy similarity2
Regioni417 – 423Substrate bindingBy similarity7

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili593 – 627By similarityAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 53Ser-richAdd BLAST50

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1089 Eukaryota
ENOG410XPTU LUCA
GeneTreeiENSGT00760000118832
HOGENOMiHOG000210598
HOVERGENiHBG000220
InParanoidiQ9Z2D1
KOiK18081
OrthoDBiEOG091G04DS
TreeFamiTF315197

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR004182 GRAM
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PANTHERiPTHR10807 PTHR10807, 1 hit
PfamiView protein in Pfam
PF02893 GRAM, 1 hit
PF06602 Myotub-related, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9Z2D1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKSSSCESL GAQLPAARLP SEDSLSSAST SHSENSVHTK SASAISSDSI
60 70 80 90 100
STSADNFSPD LRVLREANKL AEMEEPALLP GENIKDMAKD VTYICPFTGA
110 120 130 140 150
VRGTLTVTSY RLYFKSMERD PPFVLDASLG VISRVEKIGG ASSRGENSYG
160 170 180 190 200
LETVCKDIRN LRFAHKPEGR TRRSIFENLM KYAFPVSNGL PLFAFEYKEV
210 220 230 240 250
FPENGWKLYD PLLEYRRQGI PNESWRITKI NERYELCDTY PALLVVPANI
260 270 280 290 300
PDEELKRVAS FRSRGRIPVL SWIHPESQAT VTRCSQPMVG VSGKRSKEDE
310 320 330 340 350
KYLQAIMDSN AQSHKIFIFD ARPSVNAVAN KAKGGGYESE DAYQNAELVF
360 370 380 390 400
LDIHNIHVMR ESLRKLKEIV YPTIEETHWL SNLESTHWLE HIKLILAGAL
410 420 430 440 450
RIADKVESGK TSVVVHCSDG WDRTAQLTSL AMLMLDGYYR TIRGFEVLVE
460 470 480 490 500
KEWLSFGHRF QLRVGHGDKN HADADRSPVF LQFIDCVWQM TRQFPTAFEF
510 520 530 540 550
NEYFLITILD HLYSCLFGTF LCNSEQQRGK ENLPKKTVSL WSYINSQLED
560 570 580 590 600
FTNPLYGSYS NHVLYPVASM RHLELWVGYY IRWNPRMKPQ EPIHSRYKEL
610 620 630 640
LAKRAELQRK VEELQREISN RSTSSSERAS SPAQCVTPVQ TVV
Length:643
Mass (Da):73,232
Last modified:July 27, 2011 - v3
Checksum:iFD4E43867CBB9864
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P572Q6P572_MOUSE
Mtmr2 protein
Mtmr2
571Annotation score:
B8JJF3B8JJF3_MOUSE
Myotubularin-related protein 2
Mtmr2
105Annotation score:
F6T2Q0F6T2Q0_MOUSE
Myotubularin-related protein 2
Mtmr2
67Annotation score:
B8JJF6B8JJF6_MOUSE
MCG16810, isoform CRA_b
Mtmr2 mCG_16810
82Annotation score:

Sequence cautioni

The sequence AAC80002 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY055832 mRNA Translation: AAL14198.1
CT010488 Genomic DNA Translation: CAX15666.1
CH466522 Genomic DNA Translation: EDL24975.1
AF073880 mRNA Translation: AAC80002.1 Different initiation.
CCDSiCCDS22818.3
RefSeqiNP_076347.3, NM_023858.3
UniGeneiMm.210405

Genome annotation databases

EnsembliENSMUST00000034396; ENSMUSP00000034396; ENSMUSG00000031918
GeneIDi77116
KEGGimmu:77116
UCSCiuc009odz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY055832 mRNA Translation: AAL14198.1
CT010488 Genomic DNA Translation: CAX15666.1
CH466522 Genomic DNA Translation: EDL24975.1
AF073880 mRNA Translation: AAC80002.1 Different initiation.
CCDSiCCDS22818.3
RefSeqiNP_076347.3, NM_023858.3
UniGeneiMm.210405

3D structure databases

ProteinModelPortaliQ9Z2D1
SMRiQ9Z2D1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218525, 7 interactors
IntActiQ9Z2D1, 5 interactors
STRINGi10090.ENSMUSP00000034396

PTM databases

iPTMnetiQ9Z2D1
PhosphoSitePlusiQ9Z2D1

Proteomic databases

EPDiQ9Z2D1
MaxQBiQ9Z2D1
PaxDbiQ9Z2D1
PeptideAtlasiQ9Z2D1
PRIDEiQ9Z2D1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034396; ENSMUSP00000034396; ENSMUSG00000031918
GeneIDi77116
KEGGimmu:77116
UCSCiuc009odz.2 mouse

Organism-specific databases

CTDi8898
MGIiMGI:1924366 Mtmr2

Phylogenomic databases

eggNOGiKOG1089 Eukaryota
ENOG410XPTU LUCA
GeneTreeiENSGT00760000118832
HOGENOMiHOG000210598
HOVERGENiHBG000220
InParanoidiQ9Z2D1
KOiK18081
OrthoDBiEOG091G04DS
TreeFamiTF315197

Enzyme and pathway databases

BRENDAi3.1.3.95 3474
ReactomeiR-MMU-1483248 Synthesis of PIPs at the ER membrane
R-MMU-1660516 Synthesis of PIPs at the early endosome membrane
R-MMU-1660517 Synthesis of PIPs at the late endosome membrane

Miscellaneous databases

PROiPR:Q9Z2D1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031918 Expressed in 217 organ(s), highest expression level in testis
CleanExiMM_MTMR2
ExpressionAtlasiQ9Z2D1 baseline and differential
GenevisibleiQ9Z2D1 MM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR004182 GRAM
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PANTHERiPTHR10807 PTHR10807, 1 hit
PfamiView protein in Pfam
PF02893 GRAM, 1 hit
PF06602 Myotub-related, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTMR2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2D1
Secondary accession number(s): B8JJF4, Q8VHA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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