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Protein

Uroplakin-1b

Gene

Upk1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).By similarity

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • epithelial cell differentiation Source: MGI
  • response to bacterium Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Uroplakin-1b
Short name:
UP1b
Alternative name(s):
Uroplakin Ib
Short name:
UPIb
Gene namesi
Name:Upk1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:98912 Upk1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 59ExtracellularSequence analysisAdd BLAST23
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 86CytoplasmicSequence analysis6
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 229ExtracellularSequence analysisAdd BLAST122
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 260CytoplasmicSequence analysis10

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192901 – 260Uroplakin-1bAdd BLAST260

Post-translational modificationi

N-glycosylated with high-mannose oligosaccharides.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9Z2C6
PaxDbiQ9Z2C6
PRIDEiQ9Z2C6

PTM databases

PhosphoSitePlusiQ9Z2C6

Expressioni

Tissue specificityi

Bladder epithelium.

Gene expression databases

BgeeiENSMUSG00000049436 Expressed in 126 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_UPK1B
GenevisibleiQ9Z2C6 MM

Interactioni

Subunit structurei

Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).By similarity

Protein-protein interaction databases

IntActiQ9Z2C6, 2 interactors
STRINGi10090.ENSMUSP00000052469

Structurei

3D structure databases

ProteinModelPortaliQ9Z2C6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00390000000126
HOGENOMiHOG000230653
HOVERGENiHBG054305
InParanoidiQ9Z2C6
KOiK17347
OMAiIGMCGIA
OrthoDBiEOG091G0G8N
PhylomeDBiQ9Z2C6
TreeFamiTF335659

Family and domain databases

InterProiView protein in InterPro
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
IPR034766 Uroplakin-1b
PANTHERiPTHR19282:SF24 PTHR19282:SF24, 1 hit
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
SUPFAMiSSF48652 SSF48652, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z2C6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKDDSTVRC FQGLLIFGHV IVGMCGIALT AECIFFVSDQ HSLYPLLEAT
60 70 80 90 100
NNDDIFGAAW IGMFVGICLF CLSVLAIVGI MKSNRKILLA YFIMMFIVYG
110 120 130 140 150
FEVASCITAA TQRDFFTTNL FLKQMLMRYQ NNSPPTNDDE WKNNGVTKTW
160 170 180 190 200
DRLMLQDHCC GVNGPSDWQK YTSAFRVENN DADYPWPRQC CVMDKLKEPL
210 220 230 240 250
NLDACKLGVP GYYHSQGCYE LISGPMDRHA WGVAWFGFAI LCWTFWVLLG
260
TMFYWSRIEY
Length:260
Mass (Da):29,762
Last modified:January 23, 2007 - v3
Checksum:i91EB5816D59070A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136T → N in AAD02834 (PubMed:10343097).Curated1
Sequence conflicti140E → Q in AAD02834 (PubMed:10343097).Curated1
Sequence conflicti253F → L in BAC38760 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274865 mRNA Translation: AAM97593.1
AK053004 mRNA Translation: BAC35237.1
AK083101 mRNA Translation: BAC38760.1
AK086926 mRNA Translation: BAC39763.1
BC046604 mRNA Translation: AAH46604.1
AF073956 Genomic DNA Translation: AAD02834.1
CCDSiCCDS28174.1
RefSeqiNP_849255.2, NM_178924.4
XP_017172432.1, XM_017316943.1
UniGeneiMm.130793

Genome annotation databases

EnsembliENSMUST00000057767; ENSMUSP00000052469; ENSMUSG00000049436
GeneIDi22268
KEGGimmu:22268
UCSCiuc007zfm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274865 mRNA Translation: AAM97593.1
AK053004 mRNA Translation: BAC35237.1
AK083101 mRNA Translation: BAC38760.1
AK086926 mRNA Translation: BAC39763.1
BC046604 mRNA Translation: AAH46604.1
AF073956 Genomic DNA Translation: AAD02834.1
CCDSiCCDS28174.1
RefSeqiNP_849255.2, NM_178924.4
XP_017172432.1, XM_017316943.1
UniGeneiMm.130793

3D structure databases

ProteinModelPortaliQ9Z2C6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z2C6, 2 interactors
STRINGi10090.ENSMUSP00000052469

PTM databases

PhosphoSitePlusiQ9Z2C6

Proteomic databases

MaxQBiQ9Z2C6
PaxDbiQ9Z2C6
PRIDEiQ9Z2C6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057767; ENSMUSP00000052469; ENSMUSG00000049436
GeneIDi22268
KEGGimmu:22268
UCSCiuc007zfm.2 mouse

Organism-specific databases

CTDi7348
MGIiMGI:98912 Upk1b

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00390000000126
HOGENOMiHOG000230653
HOVERGENiHBG054305
InParanoidiQ9Z2C6
KOiK17347
OMAiIGMCGIA
OrthoDBiEOG091G0G8N
PhylomeDBiQ9Z2C6
TreeFamiTF335659

Miscellaneous databases

PROiPR:Q9Z2C6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049436 Expressed in 126 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_UPK1B
GenevisibleiQ9Z2C6 MM

Family and domain databases

InterProiView protein in InterPro
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
IPR034766 Uroplakin-1b
PANTHERiPTHR19282:SF24 PTHR19282:SF24, 1 hit
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
SUPFAMiSSF48652 SSF48652, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUPK1B_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2C6
Secondary accession number(s): Q8C448, Q8K4M0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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