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Entry version 137 (12 Aug 2020)
Sequence version 1 (01 May 1999)
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Protein

Adenylate cyclase type 10

Gene

Adcy10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the formation of the signaling molecule cAMP (PubMed:9874775). May function as sensor that mediates responses to changes in cellular bicarbonate and CO2 levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication, Mn2+1 PublicationNote: Binds 2 magnesium ions per subunit (By similarity). Is also active with manganese (in vitro) (PubMed:9874775).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by manganese or magnesium ions (PubMed:9874775). In the presence of magnesium ions, the enzyme is activated by bicarbonate (PubMed:12609998). Calcium mildly increases the enzyme activity, also in the presence of magnesium ions.By similarity2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1 mM for ATP-Mn2+1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi47Magnesium 1PROSITE-ProRule annotation1
    Metal bindingi47Magnesium 2PROSITE-ProRule annotation1
    Metal bindingi48Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei95BicarbonateBy similarity1
    Metal bindingi99Magnesium 1PROSITE-ProRule annotation1
    Metal bindingi99Magnesium 2PROSITE-ProRule annotation1
    Binding sitei99ATPBy similarity1
    Binding sitei144ATPBy similarity1
    Binding sitei167Bicarbonate; via amide nitrogen and carbonyl oxygenBy similarity1
    Binding sitei176BicarbonateBy similarity1
    Binding sitei337Bicarbonate; via amide nitrogenBy similarity1
    Binding sitei406ATP; via carbonyl oxygenBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi47 – 52ATPBy similarity6
    Nucleotide bindingi412 – 416ATPBy similarity5

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLyase
    Biological processcAMP biosynthesis
    LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    4.6.1.1, 5301

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-RNO-5610787, Hedgehog 'off' state

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Adenylate cyclase type 10 (EC:4.6.1.12 Publications)
    Alternative name(s):
    Germ cell soluble adenylyl cyclase1 Publication
    Short name:
    sAC
    Testicular soluble adenylyl cyclase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Adcy10
    Synonyms:Sac
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

    Organism-specific databases

    Rat genome database

    More...
    RGDi
    708450, Adcy10

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, Nucleus

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003171041 – 1608Adenylate cyclase type 10Add BLAST1608

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Cleavage may occur to generate the active 48 kDa form.1 Publication

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9Z286

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9Z286

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Detected in testis (at protein level). Preferentially expressed in testis.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSRNOG00000053410, Expressed in testis and 21 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9Z286, RN

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    GO - Molecular functioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    10116.ENSRNOP00000004326

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9Z286

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 179Guanylate cyclase 1PROSITE-ProRule annotationAdd BLAST138
    Domaini293 – 418Guanylate cyclase 2PROSITE-ProRule annotationAdd BLAST126

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The N-terminal guanylate cyclase domains are required for enzyme activity. Fragments containing the first 470 amino acid residues are fully active.1 Publication

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG502QPPT, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000001322

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_004055_1_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9Z286

    KEGG Orthology (KO)

    More...
    KOi
    K11265

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    TVDIRLN

    Database of Orthologous Groups

    More...
    OrthoDBi
    37924at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9Z286

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.70.1230, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001054, A/G_cyclase
    IPR016577, Adenylate_cyclase_typ10
    IPR029787, Nucleotide_cyclase
    IPR027417, P-loop_NTPase
    IPR011990, TPR-like_helical_dom_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00211, Guanylate_cyc, 2 hits

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF011131, Soluble_adenylyl_cyclase, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00044, CYCc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48452, SSF48452, 1 hit
    SSF52540, SSF52540, 1 hit
    SSF55073, SSF55073, 2 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50125, GUANYLATE_CYCLASE_2, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 1 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
    Note: A number of isoforms are produced.
    Isoform 1 (identifier: Q9Z286-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MSARRQELQD RAIVKIAAHL PDLIVYGDFS PERPSVKCFD GVLMFVDISG
    60 70 80 90 100
    FTAMTEKFST AMYMDRGAEQ LVEILNYYIS AIVEKVLIFG GDILKFAGDA
    110 120 130 140 150
    LLALWKVERK QLKNIITVVI KCSLEIHGLF EAKEVEEGLD IRVKIGLAAG
    160 170 180 190 200
    HITMLVFGDE TRNYFLVIGQ AVDDVRLAQN MAQMNDVILS PNCWQLCDRS
    210 220 230 240 250
    MIEIERIPDQ RAVKVSFLKP PPTFNFDEFF AKCMAFMDYY PSGDHKNFLR
    260 270 280 290 300
    LACMLESDPE LELSLQKYVM EIILKQIDDK QLRGYLSELR PVTIVFVNLM
    310 320 330 340 350
    FKEQDKAEVI GSAIQAACVH ITSVLKVFRG QINKVFMFDK GCSFLCVFGF
    360 370 380 390 400
    PGEKAPDEIT HALESAVDIF DFCSQVHKIR TVSIGVASGI VFCGIVGHTV
    410 420 430 440 450
    RHEYTVIGQK VNIAARMMMY YPGIVTCDSV TYDGSNLPAY FFKELPKKVM
    460 470 480 490 500
    KGVADPGPVY QCLGLNEKVM FGMAYLICNR YEGYPLLGRV REIDYFMSTM
    510 520 530 540 550
    KDFLMTNCSR VLMYEGLPGY GKSQVLMEIE YLASQHENHR AVAIALTKIS
    560 570 580 590 600
    FHQNFYTIQI LMANVLGLDT CKHYKERQTN LQNRVKTLLD DKYHCLLNDI
    610 620 630 640 650
    FHVQFPVSRE MSRMSKIRKQ KQLEALFMKI LEQTVREERI IFIIDEAQFV
    660 670 680 690 700
    DVASWAFIEK LIRSMPIFIV MSLCPFPETP CAAANAIMKN RNTTYITLGT
    710 720 730 740 750
    MQPQEIRDKV CVDLSVSSIP RELDSYLVEG SCGIPYYCEE LLKNLDHHRI
    760 770 780 790 800
    LIFQQAEAEE KTNVTWNNLF KYSVKPTEDM YLYTSIAAGQ KEACYLTSGV
    810 820 830 840 850
    RLKNLSPPAS LKEISLVQLD SMSLSHQMLV RCAAIIGLTF TTELLFEILP
    860 870 880 890 900
    CWNMKMMIKA LATLVESNVF DCFRSSKDLQ LALKQNVTTF EVHYRSLSLK
    910 920 930 940 950
    SKEGLAYSEE EQLREMEGEV IECRILRFCR PIMQKTAYEL WLKDQKKVLH
    960 970 980 990 1000
    LKCARFLEES AHRCNHCRNR DFIPYHHFIA DIRLNTLDMD TVKKMVKSHG
    1010 1020 1030 1040 1050
    FKTEDEVIFS KSEIPRKFKF PENISITETR EKILHFFDNV IIKMRTSQDD
    1060 1070 1080 1090 1100
    VIPLESCHCE ELLQIVILPL AQHFVALEEN NKALYYFLEL ASAYLILGDN
    1110 1120 1130 1140 1150
    YNAYMYLGEG ERLLKSLTNE DSWSQTFEYA TFYSLKGEIC FNMGQMVLAK
    1160 1170 1180 1190 1200
    KMLRKALKLL NRMFPCNLLS LTFQMHIEKN RLSHFMNQHT QEGSLPGKKL
    1210 1220 1230 1240 1250
    AQLFLQSSCF SLLWKIYSLN FFFHYKYYGR LAAIMQMNTS LETQNNFQII
    1260 1270 1280 1290 1300
    KAFLDFSLYR HLAGYEGVWF KYEILVMEQL LNLPLKGEAF EIMAYAADAL
    1310 1320 1330 1340 1350
    GHIKFLTGHL DLAIELGSRA HKMWSLLRNP NKYHMVLCRL SKPLFLKSRY
    1360 1370 1380 1390 1400
    KHLVQVLGWL WDLSVTEEHI FSKAFFYFVC LDIMLYSGFI YRTFEECLEF
    1410 1420 1430 1440 1450
    IHHNEDNRIL KFQSGLLLGL YSCIAVWYAR LQEWDNFYKF SNRAKTLVTR
    1460 1470 1480 1490 1500
    RTPTVLYYEG ISRYMEGQVL HLQKQIEEQA ENAQDSGVEL LKALETLVAQ
    1510 1520 1530 1540 1550
    NTTGPVFYPR LYHLMAYVCI LMGDGHSCDF FLNTALELSE TQGNLLEKCW
    1560 1570 1580 1590 1600
    LSMSKEWWYS APELTGDQWL QTVLSLPSWD KIVSGNVTLQ DVQKNKFLMR

    VNILDNPF
    Length:1,608
    Mass (Da):185,854
    Last modified:May 1, 1999 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBEF6D3F60A5D2556
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF081941 mRNA Translation: AAD04035.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T17201

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_067716.1, NM_021684.1 [Q9Z286-1]
    XP_008767899.1, XM_008769677.2 [Q9Z286-1]
    XP_008767900.1, XM_008769678.2 [Q9Z286-1]
    XP_008767901.1, XM_008769679.2 [Q9Z286-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSRNOT00000082677; ENSRNOP00000072356; ENSRNOG00000053410 [Q9Z286-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    59320

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    rno:59320

    UCSC genome browser

    More...
    UCSCi
    RGD:708450, rat [Q9Z286-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF081941 mRNA Translation: AAD04035.1
    PIRiT17201
    RefSeqiNP_067716.1, NM_021684.1 [Q9Z286-1]
    XP_008767899.1, XM_008769677.2 [Q9Z286-1]
    XP_008767900.1, XM_008769678.2 [Q9Z286-1]
    XP_008767901.1, XM_008769679.2 [Q9Z286-1]

    3D structure databases

    SMRiQ9Z286
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000004326

    Proteomic databases

    PaxDbiQ9Z286
    PRIDEiQ9Z286

    Genome annotation databases

    EnsembliENSRNOT00000082677; ENSRNOP00000072356; ENSRNOG00000053410 [Q9Z286-1]
    GeneIDi59320
    KEGGirno:59320
    UCSCiRGD:708450, rat [Q9Z286-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

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    CTDi
    55811
    RGDi708450, Adcy10

    Phylogenomic databases

    eggNOGiENOG502QPPT, Eukaryota
    GeneTreeiENSGT00390000001322
    HOGENOMiCLU_004055_1_0_1
    InParanoidiQ9Z286
    KOiK11265
    OMAiTVDIRLN
    OrthoDBi37924at2759
    PhylomeDBiQ9Z286

    Enzyme and pathway databases

    BRENDAi4.6.1.1, 5301
    ReactomeiR-RNO-5610787, Hedgehog 'off' state

    Miscellaneous databases

    Protein Ontology

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    PROi
    PR:Q9Z286

    Gene expression databases

    BgeeiENSRNOG00000053410, Expressed in testis and 21 other tissues
    GenevisibleiQ9Z286, RN

    Family and domain databases

    Gene3Di3.30.70.1230, 2 hits
    InterProiView protein in InterPro
    IPR001054, A/G_cyclase
    IPR016577, Adenylate_cyclase_typ10
    IPR029787, Nucleotide_cyclase
    IPR027417, P-loop_NTPase
    IPR011990, TPR-like_helical_dom_sf
    PfamiView protein in Pfam
    PF00211, Guanylate_cyc, 2 hits
    PIRSFiPIRSF011131, Soluble_adenylyl_cyclase, 1 hit
    SMARTiView protein in SMART
    SM00044, CYCc, 1 hit
    SUPFAMiSSF48452, SSF48452, 1 hit
    SSF52540, SSF52540, 1 hit
    SSF55073, SSF55073, 2 hits
    PROSITEiView protein in PROSITE
    PS50125, GUANYLATE_CYCLASE_2, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADCYA_RAT
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z286
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 1, 1999
    Last modified: August 12, 2020
    This is version 137 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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