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Protein

Tubby-related protein 1

Gene

Tulp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells. Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro) (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.By similarity4 Publications

GO - Molecular functioni

GO - Biological processi

  • dendrite development Source: UniProtKB
  • detection of light stimulus involved in visual perception Source: MGI
  • eye photoreceptor cell development Source: UniProtKB
  • phagocytosis, recognition Source: MGI
  • photoreceptor cell maintenance Source: UniProtKB
  • positive regulation of phagocytosis Source: UniProtKB
  • protein localization to photoreceptor outer segment Source: MGI
  • receptor localization to non-motile cilium Source: GO_Central
  • retina development in camera-type eye Source: MGI
  • retina homeostasis Source: MGI
  • vesicle-mediated transport Source: MGI

Keywordsi

Biological processPhagocytosis, Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Tubby-related protein 1
Alternative name(s):
Tubby-like protein 1
Gene namesi
Name:Tulp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:109571 Tulp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Secreted, Synapse

Pathology & Biotechi

Disruption phenotypei

Malformation of photoreceptor synapses, followed by photoreceptor degeneration.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001864671 – 543Tubby-related protein 1Add BLAST543

Proteomic databases

MaxQBiQ9Z273
PaxDbiQ9Z273
PRIDEiQ9Z273

PTM databases

PhosphoSitePlusiQ9Z273

Expressioni

Tissue specificityi

Retina specific. Detected in the outer plexiform layer in photoreceptor cells (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000037446
CleanExiMM_TULP1
ExpressionAtlasiQ9Z273 baseline and differential
GenevisibleiQ9Z273 MM

Interactioni

Subunit structurei

Homodimer (Probable). May interact with ABCF1, PSIP1, ZEB1 and HMGB2 (Potential). Interacts with F-actin (By similarity). Interacts with DNM1. Interacts with TUB. Interacts with TYRO3.By similarityCurated4 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049070

Structurei

3D structure databases

ProteinModelPortaliQ9Z273
SMRiQ9Z273
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi118 – 127Poly-Asp10
Compositional biasi128 – 132Poly-Glu5
Compositional biasi246 – 254Poly-Glu9

Sequence similaritiesi

Belongs to the TUB family.Curated

Phylogenomic databases

eggNOGiKOG2502 Eukaryota
ENOG410XQFT LUCA
GeneTreeiENSGT00610000085970
HOGENOMiHOG000016044
HOVERGENiHBG018010
InParanoidiQ9Z273
KOiK19600
OrthoDBiEOG091G04TF
PhylomeDBiQ9Z273
TreeFamiTF314076

Family and domain databases

Gene3Di3.20.90.10, 1 hit
InterProiView protein in InterPro
IPR025659 Tubby-like_C
IPR000007 Tubby_C
IPR018066 Tubby_C_CS
PfamiView protein in Pfam
PF01167 Tub, 1 hit
PRINTSiPR01573 SUPERTUBBY
SUPFAMiSSF54518 SSF54518, 1 hit
PROSITEiView protein in PROSITE
PS01200 TUB_1, 1 hit
PS01201 TUB_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLQEETLRE VWASDSGHEE DCLSPEPPLR PKQRPAQGQK LRKKKPETPD
60 70 80 90 100
SLESKPRKAG AGRRKHEEPP ADSAEPRAAQ TVYAKFLRDP EAKKRDPREN
110 120 130 140 150
FLVARAPDLG GEENSEEDSD DDDNDDDEEE EEKKEGKKEK SSLPPKKAPK
160 170 180 190 200
EREKKAKALG PRGDVGSPDA PRKPLRTKKK EVGEGTKLRK AKKKGPGETD
210 220 230 240 250
KDPAGSPAAL RKEFPAAMFL VGEGGAAEKG VKKKGPPKGS EEEKKEEEEE
260 270 280 290 300
VEEEVASAVM KNSNQKGRAK GKGKKKVKEE RASSPPVEVG EPREFVLQPA
310 320 330 340 350
PQGRAVRCRL TRDKKGMDRG MYPSYFLHLD TEKKVFLLAG RKRKRSKTAN
360 370 380 390 400
YLISSDPTNL SRGGENFIGK LRSNLLGNRF TVFDNGQNPQ RGGGGDVGSL
410 420 430 440 450
RQELAAVVYE TNVLGFRGPR RMTVIIPGMN SDNERVPIRP RNASDGLLVR
460 470 480 490 500
WQNKTLESLI ELHNKPPIWN EDSGSYTLNF QGRVTQASVK NFQIVHADDP
510 520 530 540
DYIVLQFGRV AEDAFTLDYR YPLCALQAFA IALSSFDGKL ACE
Length:543
Mass (Da):60,336
Last modified:May 1, 1999 - v1
Checksum:i0F0D9E4D2A2731E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085681 mRNA Translation: AAD13757.1
AF105711 mRNA Translation: AAD38451.1
CCDSiCCDS28578.1
RefSeqiNP_067453.1, NM_021478.2
UniGeneiMm.42102

Genome annotation databases

EnsembliENSMUST00000041819; ENSMUSP00000049070; ENSMUSG00000037446
GeneIDi22157
KEGGimmu:22157
UCSCiuc008bqv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTULP1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z273
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 1999
Last modified: November 22, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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