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Protein

Vesicle-associated membrane protein-associated protein B

Gene

Vapb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUnfolded protein response

Enzyme and pathway databases

ReactomeiR-RNO-1660661 Sphingolipid de novo biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein-associated protein B
Short name:
VAMP-B
Short name:
VAMP-associated protein B
Short name:
VAP-B
Gene namesi
Name:Vapb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi68326 Vapb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 218CytoplasmicSequence analysisAdd BLAST217
Transmembranei219 – 239Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002134752 – 243Vesicle-associated membrane protein-associated protein BAdd BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei146PhosphoserineBy similarity1
Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei159PhosphoserineCombined sources1
Modified residuei206PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9Z269
PRIDEiQ9Z269

PTM databases

iPTMnetiQ9Z269
PhosphoSitePlusiQ9Z269
SwissPalmiQ9Z269

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSRNOG00000005331 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ9Z269 RN

Interactioni

Subunit structurei

Homodimer, and heterodimer with VAPA. Interacts with RMDN3, VAMP1 and VAMP2. Interacts (via MSP domain) with ZFYVE27. Interacts with KIF5A in a ZFYVE27-dependent manner. Interacts with STARD3 (via FFAT motif) (By similarity). Interacts with STARD3NL (via FFAT motif) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9Z269, 2 interactors
MINTiQ9Z269
STRINGi10116.ENSRNOP00000007554

Structurei

3D structure databases

ProteinModelPortaliQ9Z269
SMRiQ9Z269
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 124MSPPROSITE-ProRule annotationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili161 – 196Sequence analysisAdd BLAST36

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0439 Eukaryota
COG5066 LUCA
GeneTreeiENSGT00390000006947
HOGENOMiHOG000293182
HOVERGENiHBG028551
InParanoidiQ9Z269
KOiK10707
OMAiPDMTDME
OrthoDBiEOG091G0KJ2
PhylomeDBiQ9Z269
TreeFamiTF317024

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR000535 MSP_dom
IPR008962 PapD-like_sf
IPR016763 VAP
IPR030226 VapB
PANTHERiPTHR10809 PTHR10809, 1 hit
PTHR10809:SF12 PTHR10809:SF12, 1 hit
PfamiView protein in Pfam
PF00635 Motile_Sperm, 1 hit
PIRSFiPIRSF019693 VAMP-associated, 1 hit
SUPFAMiSSF49354 SSF49354, 1 hit
PROSITEiView protein in PROSITE
PS50202 MSP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z269-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR
60 70 80 90 100
RYCVRPNSGV IDAGASLNVS VMLQPFDYDP NEKSKHKFMV QSMFAPPDTS
110 120 130 140 150
DMEAVWKEAK PEDLMDSKLR CVFELPAENA KPHDVEINKI MPTSASKTEA
160 170 180 190 200
PVAAKPLTSP LDDAEVKKVM EECRRLQGEV QRLREESRQL KEEDGLRARK
210 220 230 240
ALPSNSPMAA LAASGKEEGL SARLLALVVL FFIVGVIIGK IAL
Length:243
Mass (Da):26,916
Last modified:January 23, 2007 - v3
Checksum:i870B177B0798B4EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086631 mRNA Translation: AAD13580.1
BC065576 mRNA Translation: AAH65576.1
RefSeqiNP_068619.1, NM_021847.3
UniGeneiRn.52500

Genome annotation databases

EnsembliENSRNOT00000007554; ENSRNOP00000007554; ENSRNOG00000005331
GeneIDi60431
KEGGirno:60431
UCSCiRGD:68326 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086631 mRNA Translation: AAD13580.1
BC065576 mRNA Translation: AAH65576.1
RefSeqiNP_068619.1, NM_021847.3
UniGeneiRn.52500

3D structure databases

ProteinModelPortaliQ9Z269
SMRiQ9Z269
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z269, 2 interactors
MINTiQ9Z269
STRINGi10116.ENSRNOP00000007554

PTM databases

iPTMnetiQ9Z269
PhosphoSitePlusiQ9Z269
SwissPalmiQ9Z269

Proteomic databases

PaxDbiQ9Z269
PRIDEiQ9Z269

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007554; ENSRNOP00000007554; ENSRNOG00000005331
GeneIDi60431
KEGGirno:60431
UCSCiRGD:68326 rat

Organism-specific databases

CTDi9217
RGDi68326 Vapb

Phylogenomic databases

eggNOGiKOG0439 Eukaryota
COG5066 LUCA
GeneTreeiENSGT00390000006947
HOGENOMiHOG000293182
HOVERGENiHBG028551
InParanoidiQ9Z269
KOiK10707
OMAiPDMTDME
OrthoDBiEOG091G0KJ2
PhylomeDBiQ9Z269
TreeFamiTF317024

Enzyme and pathway databases

ReactomeiR-RNO-1660661 Sphingolipid de novo biosynthesis

Miscellaneous databases

PROiPR:Q9Z269

Gene expression databases

BgeeiENSRNOG00000005331 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ9Z269 RN

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR000535 MSP_dom
IPR008962 PapD-like_sf
IPR016763 VAP
IPR030226 VapB
PANTHERiPTHR10809 PTHR10809, 1 hit
PTHR10809:SF12 PTHR10809:SF12, 1 hit
PfamiView protein in Pfam
PF00635 Motile_Sperm, 1 hit
PIRSFiPIRSF019693 VAMP-associated, 1 hit
SUPFAMiSSF49354 SSF49354, 1 hit
PROSITEiView protein in PROSITE
PS50202 MSP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVAPB_RAT
AccessioniPrimary (citable) accession number: Q9Z269
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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