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Protein

Claudin-6

Gene

Cldn6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-6
Alternative name(s):
Skullin
Gene namesi
Name:Cldn6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1859284 Cldn6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 116CytoplasmicSequence analysisAdd BLAST14
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 163ExtracellularSequence analysisAdd BLAST26
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 219CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447491 – 219Claudin-6Add BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei201PhosphoserineBy similarity1
Modified residuei203PhosphoserineBy similarity1
Modified residuei207PhosphoserineBy similarity1
Modified residuei211PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z262
PRIDEiQ9Z262

PTM databases

iPTMnetiQ9Z262
PhosphoSitePlusiQ9Z262

Expressioni

Tissue specificityi

Expressed mostly in embryonic tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000023906 Expressed in 131 organ(s), highest expression level in dorsal pancreas
CleanExiMM_CLDN6
ExpressionAtlasiQ9Z262 baseline and differential
GenevisibleiQ9Z262 MM

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (PubMed:10601346). Interacts with CLDN1, CD81 and OCLN (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

MINTiQ9Z262
STRINGi10090.ENSMUSP00000024699

Structurei

3D structure databases

ProteinModelPortaliQ9Z262
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni218 – 219Interactions with TJP1, TJP2 and TJP3By similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIJR Eukaryota
ENOG410YA61 LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiQ9Z262
KOiK06087
OMAiFGWVNAL
OrthoDBiEOG091G0MMR
PhylomeDBiQ9Z262
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003925 Claudin6
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF41 PTHR12002:SF41, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01445 CLAUDIN6
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z262-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTGLQILG IVLTLLGWVN ALVSCALPMW KVTAFIGNSI VVAQMVWEGL
60 70 80 90 100
WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVVTLLI VLLGLLVYLA
110 120 130 140 150
GAKCTTCVED RNSKSRLVLI SGIIFVISGV LTLIPVCWTA HSIIQDFYNP
160 170 180 190 200
LVADAQKREL GASLYLGWAA SGLLLLGGGL LCCACSSGGT QGPRHYMACY
210
STSVPHSRGP SEYPTKNYV
Length:219
Mass (Da):23,388
Last modified:May 1, 1999 - v1
Checksum:i00CF687FAB687E1F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34A → T in AAK02012 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087824 mRNA Translation: AAD09759.1
AF125305 mRNA Translation: AAK02012.1
AK010560 mRNA Translation: BAB27028.1
AK010682 mRNA Translation: BAB27114.1
BC005718 mRNA Translation: AAH05718.1
CCDSiCCDS28457.1
RefSeqiNP_061247.1, NM_018777.4
XP_006524704.1, XM_006524641.1
UniGeneiMm.86421

Genome annotation databases

EnsembliENSMUST00000024699; ENSMUSP00000024699; ENSMUSG00000023906
GeneIDi54419
KEGGimmu:54419
UCSCiuc008asw.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087824 mRNA Translation: AAD09759.1
AF125305 mRNA Translation: AAK02012.1
AK010560 mRNA Translation: BAB27028.1
AK010682 mRNA Translation: BAB27114.1
BC005718 mRNA Translation: AAH05718.1
CCDSiCCDS28457.1
RefSeqiNP_061247.1, NM_018777.4
XP_006524704.1, XM_006524641.1
UniGeneiMm.86421

3D structure databases

ProteinModelPortaliQ9Z262
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiQ9Z262
STRINGi10090.ENSMUSP00000024699

PTM databases

iPTMnetiQ9Z262
PhosphoSitePlusiQ9Z262

Proteomic databases

PaxDbiQ9Z262
PRIDEiQ9Z262

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024699; ENSMUSP00000024699; ENSMUSG00000023906
GeneIDi54419
KEGGimmu:54419
UCSCiuc008asw.3 mouse

Organism-specific databases

CTDi9074
MGIiMGI:1859284 Cldn6

Phylogenomic databases

eggNOGiENOG410IIJR Eukaryota
ENOG410YA61 LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiQ9Z262
KOiK06087
OMAiFGWVNAL
OrthoDBiEOG091G0MMR
PhylomeDBiQ9Z262
TreeFamiTF331936

Miscellaneous databases

PROiPR:Q9Z262
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023906 Expressed in 131 organ(s), highest expression level in dorsal pancreas
CleanExiMM_CLDN6
ExpressionAtlasiQ9Z262 baseline and differential
GenevisibleiQ9Z262 MM

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003925 Claudin6
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF41 PTHR12002:SF41, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01445 CLAUDIN6
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD6_MOUSE
AccessioniPrimary (citable) accession number: Q9Z262
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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