Cldn6

Functionⁱ

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functionⁱ

identical protein binding Source: UniProtKB
structural molecule activity Source: InterPro
virus receptor activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
cell-cell junction organization
Source: MGI
Inferred from direct assayⁱ
- 17130295

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Claudin-6 Alternative name(s): Skullin
Gene namesⁱ	Name:Cldn6
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 17

Organism-specific databases

MGIⁱ	MGI:1859284 Cldn6

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 7	CytoplasmicSequence analysis	7
Transmembraneⁱ	8 – 28	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	29 – 81	ExtracellularSequence analysisAdd BLAST	53
Transmembraneⁱ	82 – 102	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	103 – 116	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	117 – 137	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	138 – 163	ExtracellularSequence analysisAdd BLAST	26
Transmembraneⁱ	164 – 184	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	185 – 219	CytoplasmicSequence analysisAdd BLAST	35

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144749	1 – 219	Claudin-6Add BLAST		219

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	201	PhosphoserineBy similarity	1
Modified residueⁱ	203	PhosphoserineBy similarity	1
Modified residueⁱ	207	PhosphoserineBy similarity	1
Modified residueⁱ	211	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9Z262
PRIDEⁱ	Q9Z262

PTM databases

iPTMnetⁱ	Q9Z262
PhosphoSitePlusⁱ	Q9Z262

Expressionⁱ

Tissue specificityⁱ

Expressed mostly in embryonic tissues.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000023906 Expressed in 131 organ(s), highest expression level in dorsal pancreas
CleanExⁱ	MM_CLDN6
ExpressionAtlasⁱ	Q9Z262 baseline and differential
Genevisibleⁱ	Q9Z262 MM

Interactionⁱ

Subunit structureⁱ

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (PubMed:10601346). Interacts with CLDN1, CD81 and OCLN (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

identical protein binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Molecular INTeraction database More...MINTⁱ	Q9Z262
STRINGⁱ	10090.ENSMUSP00000024699

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Z262
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	218 – 219	Interactions with TJP1, TJP2 and TJP3By similarity		2

Sequence similaritiesⁱ

Belongs to the claudin family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IIJR Eukaryota ENOG410YA61 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118928
HOGENOMⁱ	HOG000220937
HOVERGENⁱ	HBG000643
InParanoidⁱ	Q9Z262
KEGG Orthology (KO) More...KOⁱ	K06087
OMAⁱ	FGWVNAL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MMR
PhylomeDBⁱ	Q9Z262
TreeFamⁱ	TF331936

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187 Claudin IPR003925 Claudin6 IPR017974 Claudin_CS IPR004031 PMP22/EMP/MP20/Claudin
PANTHERⁱ	PTHR12002 PTHR12002, 1 hit PTHR12002:SF41 PTHR12002:SF41, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01445 CLAUDIN6
PROSITEⁱ	View protein in PROSITE PS01346 CLAUDIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9Z262-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASTGLQILG IVLTLLGWVN ALVSCALPMW KVTAFIGNSI VVAQMVWEGL 
        60         70         80         90        100
WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVVTLLI VLLGLLVYLA 
       110        120        130        140        150
GAKCTTCVED RNSKSRLVLI SGIIFVISGV LTLIPVCWTA HSIIQDFYNP 
       160        170        180        190        200
LVADAQKREL GASLYLGWAA SGLLLLGGGL LCCACSSGGT QGPRHYMACY 
       210 
STSVPHSRGP SEYPTKNYV

Length:219

Mass (Da):23,388

Last modified:May 1, 1999 - v1

Checksum:ⁱ00CF687FAB687E1F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	34	A → T in AAK02012 (Ref. 2) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF087824 mRNA Translation: AAD09759.1 AF125305 mRNA Translation: AAK02012.1 AK010560 mRNA Translation: BAB27028.1 AK010682 mRNA Translation: BAB27114.1 BC005718 mRNA Translation: AAH05718.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS28457.1
NCBI Reference Sequences More...RefSeqⁱ	NP_061247.1, NM_018777.4 XP_006524704.1, XM_006524641.1
UniGeneⁱ	Mm.86421

Genome annotation databases

Ensemblⁱ	ENSMUST00000024699; ENSMUSP00000024699; ENSMUSG00000023906
GeneIDⁱ	54419
KEGGⁱ	mmu:54419
UCSC genome browser More...UCSCⁱ	uc008asw.3 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Z262	Claudin		MOUSE		219	UniRef100_Q9Z262

Protein	Similar proteins		Species	Score	Length	Source
Q9Z262	Claudin-6		HUMAN		220	UniRef90_P56747
Claudin (Fragment)		ESCRO		267
Claudin		DELLE		221
Claudin		Yangtze finless porpoise		221
Claudin		MUSPF		221
+68

Protein	Similar proteins		Species	Score	Length	Source
Q9Z262	Claudin-6		HUMAN		220	UniRef50_P56747
Claudin (Fragment)		ESCRO		267
Claudin		MUSPF		221
Claudin		PHYCD		221
Claudin		DELLE		221
+69

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF087824 mRNA Translation: AAD09759.1 AF125305 mRNA Translation: AAK02012.1 AK010560 mRNA Translation: BAB27028.1 AK010682 mRNA Translation: BAB27114.1 BC005718 mRNA Translation: AAH05718.1
CCDSⁱ	CCDS28457.1
RefSeqⁱ	NP_061247.1, NM_018777.4 XP_006524704.1, XM_006524641.1
UniGeneⁱ	Mm.86421

3D structure databases

ProteinModelPortalⁱ	Q9Z262
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

MINTⁱ	Q9Z262
STRINGⁱ	10090.ENSMUSP00000024699

PTM databases

iPTMnetⁱ	Q9Z262
PhosphoSitePlusⁱ	Q9Z262

Proteomic databases

PaxDbⁱ	Q9Z262
PRIDEⁱ	Q9Z262

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000024699; ENSMUSP00000024699; ENSMUSG00000023906
GeneIDⁱ	54419
KEGGⁱ	mmu:54419
UCSCⁱ	uc008asw.3 mouse

Organism-specific databases

CTDⁱ	9074
MGIⁱ	MGI:1859284 Cldn6

Phylogenomic databases

eggNOGⁱ	ENOG410IIJR Eukaryota ENOG410YA61 LUCA
GeneTreeⁱ	ENSGT00760000118928
HOGENOMⁱ	HOG000220937
HOVERGENⁱ	HBG000643
InParanoidⁱ	Q9Z262
KOⁱ	K06087
OMAⁱ	FGWVNAL
OrthoDBⁱ	EOG091G0MMR
PhylomeDBⁱ	Q9Z262
TreeFamⁱ	TF331936

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9Z262
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000023906 Expressed in 131 organ(s), highest expression level in dorsal pancreas
CleanExⁱ	MM_CLDN6
ExpressionAtlasⁱ	Q9Z262 baseline and differential
Genevisibleⁱ	Q9Z262 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187 Claudin IPR003925 Claudin6 IPR017974 Claudin_CS IPR004031 PMP22/EMP/MP20/Claudin
PANTHERⁱ	PTHR12002 PTHR12002, 1 hit PTHR12002:SF41 PTHR12002:SF41, 1 hit
Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01445 CLAUDIN6
PROSITEⁱ	View protein in PROSITE PS01346 CLAUDIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLD6_MOUSE
Accessionⁱ	Q9Z262Primary (citable) accession number: Q9Z262
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Z262 (CLD6_MOUSE)

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Claudin-6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ