UniProtKB - Q9Z262 (CLD6_MOUSE)
Protein
Claudin-6
Gene
Cldn6
Organism
Mus musculus (Mouse)
Status
Functioni
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- structural molecule activity Source: InterPro
- virus receptor activity Source: MGI
GO - Biological processi
- bicellular tight junction assembly Source: GO_Central
- calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
- cell adhesion Source: GO_Central
- cell-cell junction organization Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Claudin-6Alternative name(s): Skullin |
Gene namesi | Name:Cldn6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1859284, Cldn6 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Other locations
- tight junction 1 Publication
Plasma Membrane
- apicolateral plasma membrane Source: UniProtKB
- plasma membrane Source: MGI
Other locations
- bicellular tight junction Source: UniProtKB
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 7 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 8 – 28 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 29 – 81 | ExtracellularSequence analysisAdd BLAST | 53 | |
Transmembranei | 82 – 102 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 103 – 116 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 117 – 137 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 138 – 163 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 164 – 184 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 185 – 219 | CytoplasmicSequence analysisAdd BLAST | 35 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Tight junctionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144749 | 1 – 219 | Claudin-6Add BLAST | 219 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 201 | PhosphoserineBy similarity | 1 | |
Modified residuei | 203 | PhosphoserineBy similarity | 1 | |
Modified residuei | 207 | PhosphoserineBy similarity | 1 | |
Modified residuei | 211 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9Z262 |
PRIDEi | Q9Z262 |
PTM databases
iPTMneti | Q9Z262 |
PhosphoSitePlusi | Q9Z262 |
Expressioni
Tissue specificityi
Expressed mostly in embryonic tissues.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000023906, Expressed in dorsal pancreas and 150 other tissues |
ExpressionAtlasi | Q9Z262, baseline and differential |
Genevisiblei | Q9Z262, MM |
Interactioni
Subunit structurei
Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (PubMed:10601346).
Interacts with CLDN1, CD81 and OCLN (By similarity).
By similarity1 PublicationGO - Molecular functioni
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
MINTi | Q9Z262 |
STRINGi | 10090.ENSMUSP00000024699 |
Miscellaneous databases
RNActi | Q9Z262, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 218 – 219 | Interactions with TJP1, TJP2 and TJP3By similarity | 2 |
Sequence similaritiesi
Belongs to the claudin family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSCN, Eukaryota |
GeneTreei | ENSGT00940000163060 |
HOGENOMi | CLU_076370_1_2_1 |
InParanoidi | Q9Z262 |
OMAi | SCTLPMW |
OrthoDBi | 1231389at2759 |
PhylomeDBi | Q9Z262 |
TreeFami | TF331936 |
Family and domain databases
InterProi | View protein in InterPro IPR006187, Claudin IPR003925, Claudin6 IPR017974, Claudin_CS IPR004031, PMP22/EMP/MP20/Claudin |
PANTHERi | PTHR12002, PTHR12002, 1 hit PTHR12002:SF41, PTHR12002:SF41, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01445, CLAUDIN6 |
PROSITEi | View protein in PROSITE PS01346, CLAUDIN, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Z262-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASTGLQILG IVLTLLGWVN ALVSCALPMW KVTAFIGNSI VVAQMVWEGL
60 70 80 90 100
WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVVTLLI VLLGLLVYLA
110 120 130 140 150
GAKCTTCVED RNSKSRLVLI SGIIFVISGV LTLIPVCWTA HSIIQDFYNP
160 170 180 190 200
LVADAQKREL GASLYLGWAA SGLLLLGGGL LCCACSSGGT QGPRHYMACY
210
STSVPHSRGP SEYPTKNYV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 34 | A → T in AAK02012 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087824 mRNA Translation: AAD09759.1 AF125305 mRNA Translation: AAK02012.1 AK010560 mRNA Translation: BAB27028.1 AK010682 mRNA Translation: BAB27114.1 BC005718 mRNA Translation: AAH05718.1 |
CCDSi | CCDS28457.1 |
RefSeqi | NP_061247.1, NM_018777.4 XP_006524704.1, XM_006524641.1 |
Genome annotation databases
Ensembli | ENSMUST00000024699; ENSMUSP00000024699; ENSMUSG00000023906 ENSMUST00000232719; ENSMUSP00000156498; ENSMUSG00000023906 ENSMUST00000233364; ENSMUSP00000156806; ENSMUSG00000023906 |
GeneIDi | 54419 |
KEGGi | mmu:54419 |
UCSCi | uc008asw.3, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087824 mRNA Translation: AAD09759.1 AF125305 mRNA Translation: AAK02012.1 AK010560 mRNA Translation: BAB27028.1 AK010682 mRNA Translation: BAB27114.1 BC005718 mRNA Translation: AAH05718.1 |
CCDSi | CCDS28457.1 |
RefSeqi | NP_061247.1, NM_018777.4 XP_006524704.1, XM_006524641.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
MINTi | Q9Z262 |
STRINGi | 10090.ENSMUSP00000024699 |
PTM databases
iPTMneti | Q9Z262 |
PhosphoSitePlusi | Q9Z262 |
Proteomic databases
PaxDbi | Q9Z262 |
PRIDEi | Q9Z262 |
Protocols and materials databases
Antibodypediai | 23973, 544 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000024699; ENSMUSP00000024699; ENSMUSG00000023906 ENSMUST00000232719; ENSMUSP00000156498; ENSMUSG00000023906 ENSMUST00000233364; ENSMUSP00000156806; ENSMUSG00000023906 |
GeneIDi | 54419 |
KEGGi | mmu:54419 |
UCSCi | uc008asw.3, mouse |
Organism-specific databases
CTDi | 9074 |
MGIi | MGI:1859284, Cldn6 |
Phylogenomic databases
eggNOGi | ENOG502QSCN, Eukaryota |
GeneTreei | ENSGT00940000163060 |
HOGENOMi | CLU_076370_1_2_1 |
InParanoidi | Q9Z262 |
OMAi | SCTLPMW |
OrthoDBi | 1231389at2759 |
PhylomeDBi | Q9Z262 |
TreeFami | TF331936 |
Miscellaneous databases
BioGRID-ORCSi | 54419, 0 hits in 17 CRISPR screens |
ChiTaRSi | Cldn6, mouse |
PROi | PR:Q9Z262 |
RNActi | Q9Z262, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000023906, Expressed in dorsal pancreas and 150 other tissues |
ExpressionAtlasi | Q9Z262, baseline and differential |
Genevisiblei | Q9Z262, MM |
Family and domain databases
InterProi | View protein in InterPro IPR006187, Claudin IPR003925, Claudin6 IPR017974, Claudin_CS IPR004031, PMP22/EMP/MP20/Claudin |
PANTHERi | PTHR12002, PTHR12002, 1 hit PTHR12002:SF41, PTHR12002:SF41, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01445, CLAUDIN6 |
PROSITEi | View protein in PROSITE PS01346, CLAUDIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLD6_MOUSE | |
Accessioni | Q9Z262Primary (citable) accession number: Q9Z262 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families