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Protein

PDZ domain-containing protein GIPC1

Gene

Gipc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in G protein-linked signaling.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ domain-containing protein GIPC1
Alternative name(s):
GAIP C-terminus-interacting protein
GLUT1 C-terminal-binding protein
Short name:
GLUT1CBP
RGS-GAIP-interacting protein
RGS19-interacting protein 1
Synectin
Gene namesi
Name:Gipc1
Synonyms:Gipc, Rgs19ip1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi68338 Gipc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000874941 – 333PDZ domain-containing protein GIPC1Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68PhosphoserineBy similarity1
Modified residuei222PhosphoserineBy similarity1
Modified residuei225PhosphoserineBy similarity1
Modified residuei232PhosphoserineBy similarity1
Modified residuei242PhosphothreonineBy similarity1
Modified residuei247PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z254
PRIDEiQ9Z254

PTM databases

iPTMnetiQ9Z254
PhosphoSitePlusiQ9Z254

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSRNOG00000003864 Expressed in 10 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ9Z254 RN

Interactioni

Subunit structurei

Interacts with SDC4/syndecan-4 and SEMA4C/semaphorin-4C (By similarity). Interacts with RGS19 (C-terminus), GLUT1 (C-terminus), ACTN1, KIF1B, MYO6 and PLEKHG5.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Plekhg5Q6RFZ73EBI-991162,EBI-9079908

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249850, 4 interactors
IntActiQ9Z254, 4 interactors
MINTiQ9Z254
STRINGi10116.ENSRNOP00000005374

Structurei

3D structure databases

ProteinModelPortaliQ9Z254
SMRiQ9Z254
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 213PDZPROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the GIPC family.Curated

Phylogenomic databases

eggNOGiKOG3938 Eukaryota
ENOG410XQ87 LUCA
GeneTreeiENSGT00390000003420
HOGENOMiHOG000293347
HOVERGENiHBG000898
InParanoidiQ9Z254
KOiK20056
OMAiMIESING
OrthoDBiEOG091G0D3X
PhylomeDBiQ9Z254
TreeFamiTF313878

Family and domain databases

InterProiView protein in InterPro
IPR017379 GIPC1/2/3
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR12259 PTHR12259, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PIRSFiPIRSF038083 UCP038083_GIPC, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z254-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLGLGRRKK APPLVENEEA EPSRSGLGVG EPGPLGGSGA GESQMGLPPP
60 70 80 90 100
PASLRPRLVF HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPAAEVMFC
110 120 130 140 150
TLNTHKVDMD KLLGGQIGLE DFIFAHVKGQ RKEVEVFKSE DALGLTITDN
160 170 180 190 200
GAGYAFIKRI KEGSVIDHIQ LISVGDMIEA INGQSLLGCR HYEVARLLKE
210 220 230 240 250
LPRGRTFTLK LTEPRKAFDM ISQRSSGGHP GSGPQLGTGR GTLRLRSRGP
260 270 280 290 300
ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL
310 320 330
AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY
Length:333
Mass (Da):36,133
Last modified:May 1, 2007 - v2
Checksum:i2DE14E6839A218D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti253V → I in AAC67549 (PubMed:9770488).Curated1
Sequence conflicti270D → E in AAC67549 (PubMed:9770488).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089817 mRNA Translation: AAC67549.1
AF032120 mRNA Translation: AAC69268.1
BC070505 mRNA Translation: AAH70505.1
RefSeqiNP_445793.1, NM_053341.1
XP_017456861.1, XM_017601372.1
UniGeneiRn.30044

Genome annotation databases

EnsembliENSRNOT00000005374; ENSRNOP00000005374; ENSRNOG00000003864
GeneIDi83823
KEGGirno:83823

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089817 mRNA Translation: AAC67549.1
AF032120 mRNA Translation: AAC69268.1
BC070505 mRNA Translation: AAH70505.1
RefSeqiNP_445793.1, NM_053341.1
XP_017456861.1, XM_017601372.1
UniGeneiRn.30044

3D structure databases

ProteinModelPortaliQ9Z254
SMRiQ9Z254
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249850, 4 interactors
IntActiQ9Z254, 4 interactors
MINTiQ9Z254
STRINGi10116.ENSRNOP00000005374

PTM databases

iPTMnetiQ9Z254
PhosphoSitePlusiQ9Z254

Proteomic databases

PaxDbiQ9Z254
PRIDEiQ9Z254

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005374; ENSRNOP00000005374; ENSRNOG00000003864
GeneIDi83823
KEGGirno:83823

Organism-specific databases

CTDi10755
RGDi68338 Gipc1

Phylogenomic databases

eggNOGiKOG3938 Eukaryota
ENOG410XQ87 LUCA
GeneTreeiENSGT00390000003420
HOGENOMiHOG000293347
HOVERGENiHBG000898
InParanoidiQ9Z254
KOiK20056
OMAiMIESING
OrthoDBiEOG091G0D3X
PhylomeDBiQ9Z254
TreeFamiTF313878

Miscellaneous databases

PROiPR:Q9Z254

Gene expression databases

BgeeiENSRNOG00000003864 Expressed in 10 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ9Z254 RN

Family and domain databases

InterProiView protein in InterPro
IPR017379 GIPC1/2/3
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR12259 PTHR12259, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PIRSFiPIRSF038083 UCP038083_GIPC, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGIPC1_RAT
AccessioniPrimary (citable) accession number: Q9Z254
Secondary accession number(s): Q6GR70, Q9QUQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2007
Last modified: October 10, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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