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Protein

Zinc finger protein AEBP2

Gene

Aebp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3 (By similarity). DNA-binding transcriptional repressor.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri293 – 315C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 345C2H2-type 3PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212300 PRC2 methylates histones and DNA
R-MMU-3214841 PKMTs methylate histone lysines

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein AEBP2
Alternative name(s):
Adipocyte enhancer-binding protein 2
Short name:
AE-binding protein 2
Gene namesi
Name:Aebp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1338038 Aebp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi315 – 316HS → R: Abrogates transcriptional repression but does not affect DNA-binding. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003415912 – 504Zinc finger protein AEBP2Add BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei18PhosphoserineBy similarity1
Modified residuei21PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei131PhosphoserineBy similarity1
Modified residuei199PhosphoserineCombined sources1
Modified residuei203PhosphoserineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei383PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9Z248
PeptideAtlasiQ9Z248
PRIDEiQ9Z248

PTM databases

iPTMnetiQ9Z248
PhosphoSitePlusiQ9Z248

Expressioni

Tissue specificityi

Expressed in brain, brown adipose tissue, white adipose tissue, heart, kidney, lung, skeletal muscle, small intestine and spleen. Expressed at low levels in liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000030232 Expressed in 283 organ(s), highest expression level in metanephric cortical collecting duct
ExpressionAtlasiQ9Z248 baseline and differential
GenevisibleiQ9Z248 MM

Interactioni

Subunit structurei

Self-associates (By similarity). Interacts with EED, EZH2, RBBP4 and SUZ12 (By similarity). Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. May also interact with RBBP7 (By similarity).By similarity

Protein-protein interaction databases

BioGridi198014, 5 interactors
IntActiQ9Z248, 5 interactors
MINTiQ9Z248
STRINGi10090.ENSMUSP00000084896

Structurei

3D structure databases

ProteinModelPortaliQ9Z248
SMRiQ9Z248
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni202 – 287Interaction with RBBP4By similarityAdd BLAST86
Regioni346 – 504Interaction with SUZ12By similarityAdd BLAST159

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 112Glu-richAdd BLAST79
Compositional biasi59 – 198Gly-richAdd BLAST140
Compositional biasi100 – 234Ser-richAdd BLAST135

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri293 – 315C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 345C2H2-type 3PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00510000048519
HOGENOMiHOG000033826
HOVERGENiHBG061621
InParanoidiQ9Z248
KOiK17452
OMAiRSTPVMM
OrthoDBiEOG091G0594
PhylomeDBiQ9Z248
TreeFamiTF328864

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Z248-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAALADMAD LEELSRLSPL SPGSPGPAAR GRAEPPEEEE EEDDEEAEAE
60 70 80 90 100
AVAALLLNGG AGGGAGGGEA ETMSEPSPES ASQAGGDEDE DEEDDEDEGS
110 120 130 140 150
SSGGAEEESS AESLVGSSSG GCSGDETRSL SPGAASSSSG DGDGKEGLEE
160 170 180 190 200
PKGPRGGPGG PGSSGGGSSS SSVVSSGGDE GYGTGGGGSS ATSGGRRGSL
210 220 230 240 250
EMSSDGEPLS RMDSEDSISS TLMDIDSTIS SGRSTPAMMN GQGSTTASSK
260 270 280 290 300
HIAYNCCWDQ CQACFNSSPD LADHIRSIHV DGQRGGVFVC LWKGCKVYNT
310 320 330 340 350
PSTSQSWLQR HMLTHSGDKP FKCVVGGCNA SFASQGGLAR HVPTHFSQQN
360 370 380 390 400
SSKVSSQPKA KEESPSKAGM NKRRKLKNKR RRSLPRPHDF FDAQTLDAIR
410 420 430 440 450
HRAICFNLSA HIESLGKGHS VVFHSTVIAK RKEESGKIKL LLHWMPEDIL
460 470 480 490 500
PDVWVNESER HQLKTKVVHL SKLPKDTALL LDPNIYRTMP QKRLKRFDIL

NFPR
Length:504
Mass (Da):52,963
Last modified:June 10, 2008 - v2
Checksum:iB08BF191E9C4A289
GO
Isoform 2 (identifier: Q9Z248-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     497-504: Missing.

Show »
Length:496
Mass (Da):51,960
Checksum:iE5A37F94432336E3
GO
Isoform 3 (identifier: Q9Z248-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.
     497-504: FDILNFPR → TLIRKMFNLYLSKQ

Show »
Length:288
Mass (Da):32,501
Checksum:iE484297639CBAE11
GO
Isoform 4 (identifier: Q9Z248-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.
     497-504: Missing.

Show »
Length:274
Mass (Da):30,764
Checksum:i588029CAA56B6C64
GO
Isoform 5 (identifier: Q9Z248-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-197: Missing.
     497-504: Missing.

Note: No experimental confirmation available.
Show »
Length:414
Mass (Da):44,767
Checksum:i55A81750356EB17B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6V059F6V059_MOUSE
Zinc finger protein AEBP2
Aebp2
180Annotation score:

Sequence cautioni

The sequence AAD02854 differs from that shown. Reason: Frameshift at position 192.Curated
The sequence BAC32508 differs from that shown. Reason: Frameshift at position 472.Curated
The sequence BAC32562 differs from that shown. Reason: Frameshift at position 472.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95D → E in AAH31376 (PubMed:15489334).Curated1
Sequence conflicti189S → T in AAD02854 (PubMed:10329662).Curated1
Sequence conflicti273D → Y in BAC26241 (PubMed:16141072).Curated1
Sequence conflicti355S → F in BAC26241 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0343601 – 222Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST222
Alternative sequenceiVSP_034361116 – 197Missing in isoform 5. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_034362497 – 504Missing in isoform 2, isoform 4 and isoform 5. 2 Publications8
Alternative sequenceiVSP_034363497 – 504FDILNFPR → TLIRKMFNLYLSKQ in isoform 3. 2 Publications8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029011 mRNA Translation: BAC26241.1
AK045838 mRNA Translation: BAC32508.1 Sequence problems.
AK045987 mRNA Translation: BAC32562.1 Sequence problems.
AK155272 mRNA Translation: BAE33156.1
BC031376 mRNA Translation: AAH31376.1
BC057681 mRNA Translation: AAH57681.1
AF090326 mRNA Translation: AAD02854.1 Frameshift.
CCDSiCCDS20673.1 [Q9Z248-2]
CCDS20674.1 [Q9Z248-4]
CCDS39689.2 [Q9Z248-1]
CCDS80631.1 [Q9Z248-3]
RefSeqiNP_001005605.1, NM_001005605.2 [Q9Z248-2]
NP_001296365.1, NM_001309436.1 [Q9Z248-3]
NP_001296366.1, NM_001309437.1 [Q9Z248-3]
NP_033767.2, NM_009637.4 [Q9Z248-1]
NP_848918.1, NM_178803.2 [Q9Z248-4]
XP_006506969.1, XM_006506906.1 [Q9Z248-2]
XP_006506972.1, XM_006506909.3 [Q9Z248-3]
UniGeneiMm.479349
Mm.86453

Genome annotation databases

EnsembliENSMUST00000032359; ENSMUSP00000032359; ENSMUSG00000030232 [Q9Z248-4]
ENSMUST00000087614; ENSMUSP00000084896; ENSMUSG00000030232 [Q9Z248-2]
ENSMUST00000095350; ENSMUSP00000092993; ENSMUSG00000030232 [Q9Z248-1]
ENSMUST00000160836; ENSMUSP00000124148; ENSMUSG00000030232 [Q9Z248-3]
ENSMUST00000161335; ENSMUSP00000125479; ENSMUSG00000030232 [Q9Z248-3]
GeneIDi11569
KEGGimmu:11569
UCSCiuc009eoi.1 mouse [Q9Z248-1]
uc009eol.1 mouse [Q9Z248-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029011 mRNA Translation: BAC26241.1
AK045838 mRNA Translation: BAC32508.1 Sequence problems.
AK045987 mRNA Translation: BAC32562.1 Sequence problems.
AK155272 mRNA Translation: BAE33156.1
BC031376 mRNA Translation: AAH31376.1
BC057681 mRNA Translation: AAH57681.1
AF090326 mRNA Translation: AAD02854.1 Frameshift.
CCDSiCCDS20673.1 [Q9Z248-2]
CCDS20674.1 [Q9Z248-4]
CCDS39689.2 [Q9Z248-1]
CCDS80631.1 [Q9Z248-3]
RefSeqiNP_001005605.1, NM_001005605.2 [Q9Z248-2]
NP_001296365.1, NM_001309436.1 [Q9Z248-3]
NP_001296366.1, NM_001309437.1 [Q9Z248-3]
NP_033767.2, NM_009637.4 [Q9Z248-1]
NP_848918.1, NM_178803.2 [Q9Z248-4]
XP_006506969.1, XM_006506906.1 [Q9Z248-2]
XP_006506972.1, XM_006506909.3 [Q9Z248-3]
UniGeneiMm.479349
Mm.86453

3D structure databases

ProteinModelPortaliQ9Z248
SMRiQ9Z248
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198014, 5 interactors
IntActiQ9Z248, 5 interactors
MINTiQ9Z248
STRINGi10090.ENSMUSP00000084896

PTM databases

iPTMnetiQ9Z248
PhosphoSitePlusiQ9Z248

Proteomic databases

PaxDbiQ9Z248
PeptideAtlasiQ9Z248
PRIDEiQ9Z248

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032359; ENSMUSP00000032359; ENSMUSG00000030232 [Q9Z248-4]
ENSMUST00000087614; ENSMUSP00000084896; ENSMUSG00000030232 [Q9Z248-2]
ENSMUST00000095350; ENSMUSP00000092993; ENSMUSG00000030232 [Q9Z248-1]
ENSMUST00000160836; ENSMUSP00000124148; ENSMUSG00000030232 [Q9Z248-3]
ENSMUST00000161335; ENSMUSP00000125479; ENSMUSG00000030232 [Q9Z248-3]
GeneIDi11569
KEGGimmu:11569
UCSCiuc009eoi.1 mouse [Q9Z248-1]
uc009eol.1 mouse [Q9Z248-3]

Organism-specific databases

CTDi121536
MGIiMGI:1338038 Aebp2

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00510000048519
HOGENOMiHOG000033826
HOVERGENiHBG061621
InParanoidiQ9Z248
KOiK17452
OMAiRSTPVMM
OrthoDBiEOG091G0594
PhylomeDBiQ9Z248
TreeFamiTF328864

Enzyme and pathway databases

ReactomeiR-MMU-212300 PRC2 methylates histones and DNA
R-MMU-3214841 PKMTs methylate histone lysines

Miscellaneous databases

ChiTaRSiAebp2 mouse
PROiPR:Q9Z248
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030232 Expressed in 283 organ(s), highest expression level in metanephric cortical collecting duct
ExpressionAtlasiQ9Z248 baseline and differential
GenevisibleiQ9Z248 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiAEBP2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z248
Secondary accession number(s): Q6PF91
, Q78HB0, Q8BGV1, Q8CE51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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