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UniProtKB - Q9Z248 (AEBP2_MOUSE)

Entry version 159 (23 Feb 2022)
Sequence version 2 (10 Jun 2008)
Previous versions | rss
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Protein

Zinc finger protein AEBP2

Gene

Aebp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene. Plays a role in nucleosome localization of the PRC2 complex.

1 Publication1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri254 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri293 – 315C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 345C2H2-type 3PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription coregulator activity Source: MGI
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-212300, PRC2 methylates histones and DNA
R-MMU-3214841, PKMTs methylate histone lysines

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein AEBP2
Alternative name(s):
Adipocyte enhancer-binding protein 2
Short name:
AE-binding protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aebp2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1338038, Aebp2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000030232

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi315 – 316HS → R: Abrogates transcriptional repression but does not affect DNA-binding. 1 Publication2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003415912 – 504Zinc finger protein AEBP2Add BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei18PhosphoserineBy similarity1
Modified residuei21PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei131PhosphoserineBy similarity1
Modified residuei199PhosphoserineCombined sources1
Modified residuei203PhosphoserineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei383PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Z248

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Z248

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Z248

PeptideAtlas

More...PeptideAtlasi		Q9Z248

PRoteomics IDEntifications database

More...PRIDEi		Q9Z248

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		285729 [Q9Z248-1]
285730 [Q9Z248-2]
285731 [Q9Z248-3]
285732 [Q9Z248-4]
285733 [Q9Z248-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Z248

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Z248

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, brown adipose tissue, white adipose tissue, heart, kidney, lung, skeletal muscle, small intestine and spleen. Expressed at low levels in liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000030232, Expressed in metanephric cortical collecting duct and 306 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Z248, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Z248, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates (By similarity). Associates with the PRC2 complex, which consists of the core components EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP (PubMed:19026780, PubMed:20144788).

Found in a monomeric PRC2.2 (class 2) complex consisting of at least SUZ12, RBBP4, AEBP2 and JARID2 (By similarity). Within the PRC2 complex, interacts directly with SUZ12; competes with PHF19 for SUZ12 binding (By similarity).

Interacts with EED, EZH2, and RBBP4 (By similarity). May also interact with RBBP7 (By similarity).

By similarity2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		198014, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q9Z248, 5 interactors

Molecular INTeraction database

More...MINTi		Q9Z248

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000084896

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Z248, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Z248

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 220DisorderedSequence analysisAdd BLAST220
Regioni202 – 287Interaction with RBBP4By similarityAdd BLAST86
Regioni345 – 387DisorderedSequence analysisAdd BLAST43
Regioni400 – 471Interaction with SUZ12By similarityAdd BLAST72
Regioni488 – 504Important for nucleosome binding activity of the PRC2 complexBy similarityAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 50Acidic residuesSequence analysisAdd BLAST15
Compositional biasi84 – 103Acidic residuesSequence analysisAdd BLAST20
Compositional biasi104 – 138Polar residuesSequence analysisAdd BLAST35
Compositional biasi163 – 178Polar residuesSequence analysisAdd BLAST16
Compositional biasi345 – 362Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AEBP2/jing C2H2-type zinc-finger family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri293 – 315C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 345C2H2-type 3PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00510000048519

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_029789_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Z248

Identification of Orthologs from Complete Genome Data

More...OMAi		MDCEKSK

Database of Orthologous Groups

More...OrthoDBi		959457at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Z248

TreeFam database of animal gene trees

More...TreeFami		TF328864

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Z248-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAALADMAD LEELSRLSPL SPGSPGPAAR GRAEPPEEEE EEDDEEAEAE 
        60         70         80         90        100
AVAALLLNGG AGGGAGGGEA ETMSEPSPES ASQAGGDEDE DEEDDEDEGS 
       110        120        130        140        150
SSGGAEEESS AESLVGSSSG GCSGDETRSL SPGAASSSSG DGDGKEGLEE 
       160        170        180        190        200
PKGPRGGPGG PGSSGGGSSS SSVVSSGGDE GYGTGGGGSS ATSGGRRGSL 
       210        220        230        240        250
EMSSDGEPLS RMDSEDSISS TLMDIDSTIS SGRSTPAMMN GQGSTTASSK 
       260        270        280        290        300
HIAYNCCWDQ CQACFNSSPD LADHIRSIHV DGQRGGVFVC LWKGCKVYNT 
       310        320        330        340        350
PSTSQSWLQR HMLTHSGDKP FKCVVGGCNA SFASQGGLAR HVPTHFSQQN 
       360        370        380        390        400
SSKVSSQPKA KEESPSKAGM NKRRKLKNKR RRSLPRPHDF FDAQTLDAIR 
       410        420        430        440        450
HRAICFNLSA HIESLGKGHS VVFHSTVIAK RKEESGKIKL LLHWMPEDIL 
       460        470        480        490        500
PDVWVNESER HQLKTKVVHL SKLPKDTALL LDPNIYRTMP QKRLKRFDIL 

NFPR
Length:504
Mass (Da):52,963
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB08BF191E9C4A289
GO
Isoform 2 (identifier: Q9Z248-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     497-504: Missing.

Show »
Length:496
Mass (Da):51,960
Checksum:iE5A37F94432336E3
GO
Isoform 3 (identifier: Q9Z248-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.
     497-504: FDILNFPR → TLIRKMFNLYLSKQ

Show »
Length:288
Mass (Da):32,501
Checksum:iE484297639CBAE11
GO
Isoform 4 (identifier: Q9Z248-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.
     497-504: Missing.

Show »
Length:274
Mass (Da):30,764
Checksum:i588029CAA56B6C64
GO
Isoform 5 (identifier: Q9Z248-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-197: Missing.
     497-504: Missing.

Show »
Length:414
Mass (Da):44,767
Checksum:i55A81750356EB17B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6V059F6V059_MOUSE
Zinc finger protein AEBP2
Aebp2
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD02854 differs from that shown. Reason: Frameshift.Curated
The sequence BAC32508 differs from that shown. Reason: Frameshift.Curated
The sequence BAC32562 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti95D → E in AAH31376 (PubMed:15489334).Curated1
Sequence conflicti189S → T in AAD02854 (PubMed:10329662).Curated1
Sequence conflicti273D → Y in BAC26241 (PubMed:16141072).Curated1
Sequence conflicti355S → F in BAC26241 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0343601 – 222Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST222
Alternative sequenceiVSP_034361116 – 197Missing in isoform 5. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_034362497 – 504Missing in isoform 2, isoform 4 and isoform 5. 2 Publications8
Alternative sequenceiVSP_034363497 – 504FDILNFPR → TLIRKMFNLYLSKQ in isoform 3. 2 Publications8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK029011 mRNA Translation: BAC26241.1
AK045838 mRNA Translation: BAC32508.1 Sequence problems.
AK045987 mRNA Translation: BAC32562.1 Sequence problems.
AK155272 mRNA Translation: BAE33156.1
BC031376 mRNA Translation: AAH31376.1
BC057681 mRNA Translation: AAH57681.1
AF090326 mRNA Translation: AAD02854.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS20673.1 [Q9Z248-2]
CCDS20674.1 [Q9Z248-4]
CCDS39689.2 [Q9Z248-1]
CCDS80631.1 [Q9Z248-3]

NCBI Reference Sequences

More...RefSeqi		NP_001005605.1, NM_001005605.2 [Q9Z248-2]
NP_001296365.1, NM_001309436.1 [Q9Z248-3]
NP_001296366.1, NM_001309437.1 [Q9Z248-3]
NP_033767.2, NM_009637.4 [Q9Z248-1]
NP_848918.1, NM_178803.2 [Q9Z248-4]
XP_006506969.1, XM_006506906.1 [Q9Z248-2]
XP_006506972.1, XM_006506909.3 [Q9Z248-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000032359; ENSMUSP00000032359; ENSMUSG00000030232 [Q9Z248-4]
ENSMUST00000087614; ENSMUSP00000084896; ENSMUSG00000030232 [Q9Z248-2]
ENSMUST00000095350; ENSMUSP00000092993; ENSMUSG00000030232 [Q9Z248-1]
ENSMUST00000160836; ENSMUSP00000124148; ENSMUSG00000030232 [Q9Z248-3]
ENSMUST00000161335; ENSMUSP00000125479; ENSMUSG00000030232 [Q9Z248-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11569

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:11569

UCSC genome browser

More...UCSCi		uc009eoi.1, mouse [Q9Z248-1]
uc009eol.1, mouse [Q9Z248-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029011 mRNA Translation: BAC26241.1
AK045838 mRNA Translation: BAC32508.1 Sequence problems.
AK045987 mRNA Translation: BAC32562.1 Sequence problems.
AK155272 mRNA Translation: BAE33156.1
BC031376 mRNA Translation: AAH31376.1
BC057681 mRNA Translation: AAH57681.1
AF090326 mRNA Translation: AAD02854.1 Frameshift.
CCDSiCCDS20673.1 [Q9Z248-2]
CCDS20674.1 [Q9Z248-4]
CCDS39689.2 [Q9Z248-1]
CCDS80631.1 [Q9Z248-3]
RefSeqiNP_001005605.1, NM_001005605.2 [Q9Z248-2]
NP_001296365.1, NM_001309436.1 [Q9Z248-3]
NP_001296366.1, NM_001309437.1 [Q9Z248-3]
NP_033767.2, NM_009637.4 [Q9Z248-1]
NP_848918.1, NM_178803.2 [Q9Z248-4]
XP_006506969.1, XM_006506906.1 [Q9Z248-2]
XP_006506972.1, XM_006506909.3 [Q9Z248-3]

3D structure databases

SMRiQ9Z248
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi198014, 6 interactors
IntActiQ9Z248, 5 interactors
MINTiQ9Z248
STRINGi10090.ENSMUSP00000084896

PTM databases

iPTMnetiQ9Z248
PhosphoSitePlusiQ9Z248

Proteomic databases

jPOSTiQ9Z248
MaxQBiQ9Z248
PaxDbiQ9Z248
PeptideAtlasiQ9Z248
PRIDEiQ9Z248
ProteomicsDBi285729 [Q9Z248-1]
285730 [Q9Z248-2]
285731 [Q9Z248-3]
285732 [Q9Z248-4]
285733 [Q9Z248-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23931, 220 antibodies from 26 providers

The DNASU plasmid repository

More...DNASUi		11569

Genome annotation databases

EnsembliENSMUST00000032359; ENSMUSP00000032359; ENSMUSG00000030232 [Q9Z248-4]
ENSMUST00000087614; ENSMUSP00000084896; ENSMUSG00000030232 [Q9Z248-2]
ENSMUST00000095350; ENSMUSP00000092993; ENSMUSG00000030232 [Q9Z248-1]
ENSMUST00000160836; ENSMUSP00000124148; ENSMUSG00000030232 [Q9Z248-3]
ENSMUST00000161335; ENSMUSP00000125479; ENSMUSG00000030232 [Q9Z248-3]
GeneIDi11569
KEGGimmu:11569
UCSCiuc009eoi.1, mouse [Q9Z248-1]
uc009eol.1, mouse [Q9Z248-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		121536
MGIiMGI:1338038, Aebp2
VEuPathDBiHostDB:ENSMUSG00000030232

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00510000048519
HOGENOMiCLU_029789_0_0_1
InParanoidiQ9Z248
OMAiMDCEKSK
OrthoDBi959457at2759
PhylomeDBiQ9Z248
TreeFamiTF328864

Enzyme and pathway databases

ReactomeiR-MMU-212300, PRC2 methylates histones and DNA
R-MMU-3214841, PKMTs methylate histone lysines

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11569, 1 hit in 65 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Aebp2, mouse

Protein Ontology

More...PROi		PR:Q9Z248
RNActiQ9Z248, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000030232, Expressed in metanephric cortical collecting duct and 306 other tissues
ExpressionAtlasiQ9Z248, baseline and differential
GenevisibleiQ9Z248, MM

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 3 hits
SUPFAMiSSF57667, SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAEBP2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z248
Secondary accession number(s): Q6PF91
, Q78HB0, Q8BGV1, Q8CE51
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: February 23, 2022
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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