UniProtKB - Q9Z248 (AEBP2_MOUSE)
Zinc finger protein AEBP2
Aebp2
Functioni
Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene. Plays a role in nucleosome localization of the PRC2 complex.
1 Publication1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 254 – 279 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 293 – 315 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 321 – 345 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- transcription coregulator activity Source: MGI
GO - Biological processi
- chromatin organization Source: UniProtKB-KW
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Chromatin regulator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-212300, PRC2 methylates histones and DNA R-MMU-3214841, PKMTs methylate histone lysines |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein AEBP2Alternative name(s): Adipocyte enhancer-binding protein 2 Short name: AE-binding protein 2 |
Gene namesi | Name:Aebp2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1338038, Aebp2 |
VEuPathDBi | HostDB:ENSMUSG00000030232 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Note: Localizes to chromatin as part of the PRC2 complex.By similarity
Nucleus
- ESC/E(Z) complex Source: UniProtKB
- nucleoplasm Source: MGI
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 315 – 316 | HS → R: Abrogates transcriptional repression but does not affect DNA-binding. 1 Publication | 2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000341591 | 2 – 504 | Zinc finger protein AEBP2Add BLAST | 503 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 18 | PhosphoserineBy similarity | 1 | |
Modified residuei | 21 | PhosphoserineCombined sources | 1 | |
Modified residuei | 24 | PhosphoserineCombined sources | 1 | |
Modified residuei | 131 | PhosphoserineBy similarity | 1 | |
Modified residuei | 199 | PhosphoserineCombined sources | 1 | |
Modified residuei | 203 | PhosphoserineBy similarity | 1 | |
Modified residuei | 204 | PhosphoserineBy similarity | 1 | |
Modified residuei | 383 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q9Z248 |
MaxQBi | Q9Z248 |
PaxDbi | Q9Z248 |
PeptideAtlasi | Q9Z248 |
PRIDEi | Q9Z248 |
ProteomicsDBi | 285729 [Q9Z248-1] 285730 [Q9Z248-2] 285731 [Q9Z248-3] 285732 [Q9Z248-4] 285733 [Q9Z248-5] |
PTM databases
iPTMneti | Q9Z248 |
PhosphoSitePlusi | Q9Z248 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000030232, Expressed in metanephric cortical collecting duct and 306 other tissues |
ExpressionAtlasi | Q9Z248, baseline and differential |
Genevisiblei | Q9Z248, MM |
Interactioni
Subunit structurei
Self-associates (By similarity). Associates with the PRC2 complex, which consists of the core components EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP (PubMed:19026780, PubMed:20144788).
Found in a monomeric PRC2.2 (class 2) complex consisting of at least SUZ12, RBBP4, AEBP2 and JARID2 (By similarity). Within the PRC2 complex, interacts directly with SUZ12; competes with PHF19 for SUZ12 binding (By similarity).
Interacts with EED, EZH2, and RBBP4 (By similarity). May also interact with RBBP7 (By similarity).
By similarity2 PublicationsProtein-protein interaction databases
BioGRIDi | 198014, 6 interactors |
IntActi | Q9Z248, 5 interactors |
MINTi | Q9Z248 |
STRINGi | 10090.ENSMUSP00000084896 |
Miscellaneous databases
RNActi | Q9Z248, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 220 | DisorderedSequence analysisAdd BLAST | 220 | |
Regioni | 202 – 287 | Interaction with RBBP4By similarityAdd BLAST | 86 | |
Regioni | 345 – 387 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 400 – 471 | Interaction with SUZ12By similarityAdd BLAST | 72 | |
Regioni | 488 – 504 | Important for nucleosome binding activity of the PRC2 complexBy similarityAdd BLAST | 17 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 36 – 50 | Acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 84 – 103 | Acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 104 – 138 | Polar residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 163 – 178 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 345 – 362 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 254 – 279 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 293 – 315 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 321 – 345 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00510000048519 |
HOGENOMi | CLU_029789_0_0_1 |
InParanoidi | Q9Z248 |
OMAi | MDCEKSK |
OrthoDBi | 959457at2759 |
PhylomeDBi | Q9Z248 |
TreeFami | TF328864 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAALADMAD LEELSRLSPL SPGSPGPAAR GRAEPPEEEE EEDDEEAEAE
60 70 80 90 100
AVAALLLNGG AGGGAGGGEA ETMSEPSPES ASQAGGDEDE DEEDDEDEGS
110 120 130 140 150
SSGGAEEESS AESLVGSSSG GCSGDETRSL SPGAASSSSG DGDGKEGLEE
160 170 180 190 200
PKGPRGGPGG PGSSGGGSSS SSVVSSGGDE GYGTGGGGSS ATSGGRRGSL
210 220 230 240 250
EMSSDGEPLS RMDSEDSISS TLMDIDSTIS SGRSTPAMMN GQGSTTASSK
260 270 280 290 300
HIAYNCCWDQ CQACFNSSPD LADHIRSIHV DGQRGGVFVC LWKGCKVYNT
310 320 330 340 350
PSTSQSWLQR HMLTHSGDKP FKCVVGGCNA SFASQGGLAR HVPTHFSQQN
360 370 380 390 400
SSKVSSQPKA KEESPSKAGM NKRRKLKNKR RRSLPRPHDF FDAQTLDAIR
410 420 430 440 450
HRAICFNLSA HIESLGKGHS VVFHSTVIAK RKEESGKIKL LLHWMPEDIL
460 470 480 490 500
PDVWVNESER HQLKTKVVHL SKLPKDTALL LDPNIYRTMP QKRLKRFDIL
NFPR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF6V059 | F6V059_MOUSE | Zinc finger protein AEBP2 | Aebp2 | 180 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 95 | D → E in AAH31376 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 189 | S → T in AAD02854 (PubMed:10329662).Curated | 1 | |
Sequence conflicti | 273 | D → Y in BAC26241 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 355 | S → F in BAC26241 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034360 | 1 – 222 | Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 222 | |
Alternative sequenceiVSP_034361 | 116 – 197 | Missing in isoform 5. 1 PublicationAdd BLAST | 82 | |
Alternative sequenceiVSP_034362 | 497 – 504 | Missing in isoform 2, isoform 4 and isoform 5. 2 Publications | 8 | |
Alternative sequenceiVSP_034363 | 497 – 504 | FDILNFPR → TLIRKMFNLYLSKQ in isoform 3. 2 Publications | 8 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK029011 mRNA Translation: BAC26241.1 AK045838 mRNA Translation: BAC32508.1 Sequence problems. AK045987 mRNA Translation: BAC32562.1 Sequence problems. AK155272 mRNA Translation: BAE33156.1 BC031376 mRNA Translation: AAH31376.1 BC057681 mRNA Translation: AAH57681.1 AF090326 mRNA Translation: AAD02854.1 Frameshift. |
CCDSi | CCDS20673.1 [Q9Z248-2] CCDS20674.1 [Q9Z248-4] CCDS39689.2 [Q9Z248-1] CCDS80631.1 [Q9Z248-3] |
RefSeqi | NP_001005605.1, NM_001005605.2 [Q9Z248-2] NP_001296365.1, NM_001309436.1 [Q9Z248-3] NP_001296366.1, NM_001309437.1 [Q9Z248-3] NP_033767.2, NM_009637.4 [Q9Z248-1] NP_848918.1, NM_178803.2 [Q9Z248-4] XP_006506969.1, XM_006506906.1 [Q9Z248-2] XP_006506972.1, XM_006506909.3 [Q9Z248-3] |
Genome annotation databases
Ensembli | ENSMUST00000032359; ENSMUSP00000032359; ENSMUSG00000030232 [Q9Z248-4] ENSMUST00000087614; ENSMUSP00000084896; ENSMUSG00000030232 [Q9Z248-2] ENSMUST00000095350; ENSMUSP00000092993; ENSMUSG00000030232 [Q9Z248-1] ENSMUST00000160836; ENSMUSP00000124148; ENSMUSG00000030232 [Q9Z248-3] ENSMUST00000161335; ENSMUSP00000125479; ENSMUSG00000030232 [Q9Z248-3] |
GeneIDi | 11569 |
KEGGi | mmu:11569 |
UCSCi | uc009eoi.1, mouse [Q9Z248-1] uc009eol.1, mouse [Q9Z248-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK029011 mRNA Translation: BAC26241.1 AK045838 mRNA Translation: BAC32508.1 Sequence problems. AK045987 mRNA Translation: BAC32562.1 Sequence problems. AK155272 mRNA Translation: BAE33156.1 BC031376 mRNA Translation: AAH31376.1 BC057681 mRNA Translation: AAH57681.1 AF090326 mRNA Translation: AAD02854.1 Frameshift. |
CCDSi | CCDS20673.1 [Q9Z248-2] CCDS20674.1 [Q9Z248-4] CCDS39689.2 [Q9Z248-1] CCDS80631.1 [Q9Z248-3] |
RefSeqi | NP_001005605.1, NM_001005605.2 [Q9Z248-2] NP_001296365.1, NM_001309436.1 [Q9Z248-3] NP_001296366.1, NM_001309437.1 [Q9Z248-3] NP_033767.2, NM_009637.4 [Q9Z248-1] NP_848918.1, NM_178803.2 [Q9Z248-4] XP_006506969.1, XM_006506906.1 [Q9Z248-2] XP_006506972.1, XM_006506909.3 [Q9Z248-3] |
3D structure databases
SMRi | Q9Z248 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198014, 6 interactors |
IntActi | Q9Z248, 5 interactors |
MINTi | Q9Z248 |
STRINGi | 10090.ENSMUSP00000084896 |
PTM databases
iPTMneti | Q9Z248 |
PhosphoSitePlusi | Q9Z248 |
Proteomic databases
jPOSTi | Q9Z248 |
MaxQBi | Q9Z248 |
PaxDbi | Q9Z248 |
PeptideAtlasi | Q9Z248 |
PRIDEi | Q9Z248 |
ProteomicsDBi | 285729 [Q9Z248-1] 285730 [Q9Z248-2] 285731 [Q9Z248-3] 285732 [Q9Z248-4] 285733 [Q9Z248-5] |
Protocols and materials databases
Antibodypediai | 23931, 220 antibodies from 26 providers |
DNASUi | 11569 |
Genome annotation databases
Ensembli | ENSMUST00000032359; ENSMUSP00000032359; ENSMUSG00000030232 [Q9Z248-4] ENSMUST00000087614; ENSMUSP00000084896; ENSMUSG00000030232 [Q9Z248-2] ENSMUST00000095350; ENSMUSP00000092993; ENSMUSG00000030232 [Q9Z248-1] ENSMUST00000160836; ENSMUSP00000124148; ENSMUSG00000030232 [Q9Z248-3] ENSMUST00000161335; ENSMUSP00000125479; ENSMUSG00000030232 [Q9Z248-3] |
GeneIDi | 11569 |
KEGGi | mmu:11569 |
UCSCi | uc009eoi.1, mouse [Q9Z248-1] uc009eol.1, mouse [Q9Z248-3] |
Organism-specific databases
CTDi | 121536 |
MGIi | MGI:1338038, Aebp2 |
VEuPathDBi | HostDB:ENSMUSG00000030232 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00510000048519 |
HOGENOMi | CLU_029789_0_0_1 |
InParanoidi | Q9Z248 |
OMAi | MDCEKSK |
OrthoDBi | 959457at2759 |
PhylomeDBi | Q9Z248 |
TreeFami | TF328864 |
Enzyme and pathway databases
Reactomei | R-MMU-212300, PRC2 methylates histones and DNA R-MMU-3214841, PKMTs methylate histone lysines |
Miscellaneous databases
BioGRID-ORCSi | 11569, 1 hit in 65 CRISPR screens |
ChiTaRSi | Aebp2, mouse |
PROi | PR:Q9Z248 |
RNActi | Q9Z248, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030232, Expressed in metanephric cortical collecting duct and 306 other tissues |
ExpressionAtlasi | Q9Z248, baseline and differential |
Genevisiblei | Q9Z248, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | AEBP2_MOUSE | |
Accessioni | Q9Z248Primary (citable) accession number: Q9Z248 Secondary accession number(s): Q6PF91 Q8CE51 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | June 10, 2008 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families