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Entry version 157 (10 Feb 2021)
Sequence version 1 (01 May 1999)
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Protein

G1/S-specific cyclin-E2

Gene

Ccne2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the control of the cell cycle at the late G1 and early S phase.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1538133, G0 and Early G1
R-MMU-187577, SCF(Skp2)-mediated degradation of p27/p21
R-MMU-2559586, DNA Damage/Telomere Stress Induced Senescence
R-MMU-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69200, Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-MMU-69202, Cyclin E associated events during G1/S transition
R-MMU-69231, Cyclin D associated events in G1
R-MMU-69563, p53-Dependent G1 DNA Damage Response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G1/S-specific cyclin-E2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ccne2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1329034, Ccne2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000804621 – 404G1/S-specific cyclin-E2Add BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei392PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Z238

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Z238

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Z238

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z238

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Z238

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Z238

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels in adult testis, thymus and brain. Lower levels in placenta, spleen and colon.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028212, Expressed in liver and 293 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Z238, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Z238, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2082, Cyclin E2-CDK2 complex

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000029866

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Z238, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Z238

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi297 – 300Poly-Ala4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin E subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0655, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156934

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020695_8_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Z238

Identification of Orthologs from Complete Genome Data

More...
OMAi
SWGCSKD

Database of Orthologous Groups

More...
OrthoDBi
993640at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Z238

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00043, CYCLIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR028858, Cyclin_E
IPR006671, Cyclin_N

The PANTHER Classification System

More...
PANTHERi
PTHR10177, PTHR10177, 1 hit
PTHR10177:SF70, PTHR10177:SF70, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00385, CYCLIN, 1 hit
SM01332, Cyclin_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47954, SSF47954, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00292, CYCLINS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Z238-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRSSRLQA KQHAQPNQPD SPQETQIIQA KKRKTAQDVK KRKEEITKKH
60 70 80 90 100
QYEIRNCWPP VLSGGISPCI IIETPHKEIG TSDFSRFTNY RFKNLFINPS
110 120 130 140 150
PLPDLSWACS QEVWQNMLQK ENRYVHDKHF QVLHSDLEPQ MRSILLDWLL
160 170 180 190 200
EVCEVYTLHR ETFYLAQDFF DRFMLTQKDV NKNMLQLIGI TSLFIASKLE
210 220 230 240 250
EIYAPKLQEF AYVTDGACSE VDILKMELNI LKALKWELCP VTVISWLNLF
260 270 280 290 300
LQVDAVKDVP KVLLPQYSQE TFIQIAQLLD LCILAIDSLE FQYRILAAAA
310 320 330 340 350
LCHFTSIEVV KKASGLEWDD ISECVDWMVP FVSVVKSVSP VKLKTFKKIP
360 370 380 390 400
MEDRHNIQTH TNYLALLNEV NYVNIYRKGG QLSPVCNGGI MTPPKSTEKP

PGKH
Length:404
Mass (Da):46,669
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0612C4ACBEE47DAA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2API1A2API1_MOUSE
G1/S-specific cyclin-E2
Ccne2
403Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6Missing in AAD08817 (PubMed:9858585).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF091432 mRNA Translation: AAC80527.1
AF106691 mRNA Translation: AAD08817.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17965.1

NCBI Reference Sequences

More...
RefSeqi
NP_001032211.1, NM_001037134.2
NP_001269872.1, NM_001282943.1
NP_033960.1, NM_009830.3
XP_006537636.1, XM_006537573.3
XP_006537637.1, XM_006537574.3
XP_006537638.1, XM_006537575.3
XP_011248215.1, XM_011249913.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000108324; ENSMUSP00000103960; ENSMUSG00000028212
ENSMUST00000170901; ENSMUSP00000130693; ENSMUSG00000028212

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12448

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12448

UCSC genome browser

More...
UCSCi
uc008rzd.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091432 mRNA Translation: AAC80527.1
AF106691 mRNA Translation: AAD08817.1
CCDSiCCDS17965.1
RefSeqiNP_001032211.1, NM_001037134.2
NP_001269872.1, NM_001282943.1
NP_033960.1, NM_009830.3
XP_006537636.1, XM_006537573.3
XP_006537637.1, XM_006537574.3
XP_006537638.1, XM_006537575.3
XP_011248215.1, XM_011249913.2

3D structure databases

SMRiQ9Z238
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-2082, Cyclin E2-CDK2 complex
STRINGi10090.ENSMUSP00000029866

PTM databases

iPTMnetiQ9Z238
PhosphoSitePlusiQ9Z238

Proteomic databases

EPDiQ9Z238
MaxQBiQ9Z238
PaxDbiQ9Z238
PRIDEiQ9Z238

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3593, 347 antibodies

Genome annotation databases

EnsembliENSMUST00000108324; ENSMUSP00000103960; ENSMUSG00000028212
ENSMUST00000170901; ENSMUSP00000130693; ENSMUSG00000028212
GeneIDi12448
KEGGimmu:12448
UCSCiuc008rzd.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9134
MGIiMGI:1329034, Ccne2

Phylogenomic databases

eggNOGiKOG0655, Eukaryota
GeneTreeiENSGT00940000156934
HOGENOMiCLU_020695_8_0_1
InParanoidiQ9Z238
OMAiSWGCSKD
OrthoDBi993640at2759
PhylomeDBiQ9Z238

Enzyme and pathway databases

ReactomeiR-MMU-1538133, G0 and Early G1
R-MMU-187577, SCF(Skp2)-mediated degradation of p27/p21
R-MMU-2559586, DNA Damage/Telomere Stress Induced Senescence
R-MMU-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69200, Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-MMU-69202, Cyclin E associated events during G1/S transition
R-MMU-69231, Cyclin D associated events in G1
R-MMU-69563, p53-Dependent G1 DNA Damage Response

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
12448, 0 hits in 17 CRISPR screens

Protein Ontology

More...
PROi
PR:Q9Z238
RNActiQ9Z238, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028212, Expressed in liver and 293 other tissues
ExpressionAtlasiQ9Z238, baseline and differential
GenevisibleiQ9Z238, MM

Family and domain databases

CDDicd00043, CYCLIN, 1 hit
InterProiView protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR028858, Cyclin_E
IPR006671, Cyclin_N
PANTHERiPTHR10177, PTHR10177, 1 hit
PTHR10177:SF70, PTHR10177:SF70, 1 hit
PfamiView protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385, CYCLIN, 1 hit
SM01332, Cyclin_C, 1 hit
SUPFAMiSSF47954, SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292, CYCLINS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCNE2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z238
Secondary accession number(s): Q9QWU5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: February 10, 2021
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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