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Protein

Molybdopterin synthase sulfur carrier subunit

Gene

Mocs2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.UniRule annotation

Miscellaneous

This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B) from an overlapping reading frame.

Pathwayi: molybdopterin biosynthesis

This protein is involved in the pathway molybdopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway molybdopterin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

  • identical protein binding Source: MGI
  • molybdopterin synthase activity Source: MGI
  • nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  • molybdopterin cofactor biosynthetic process Source: GO_Central
  • Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB

Keywordsi

Biological processMolybdenum cofactor biosynthesis
LigandNucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00344

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdopterin synthase sulfur carrier subunitUniRule annotation
Alternative name(s):
Molybdenum cofactor synthesis protein 2 small subunitUniRule annotation
Molybdenum cofactor synthesis protein 2AUniRule annotation
Short name:
MOCS2AUniRule annotation
Sulfur carrier protein MOCS2AUniRule annotation
Gene namesi
Name:Mocs2UniRule annotation
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1336894 Mocs2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002091351 – 88Molybdopterin synthase sulfur carrier subunitAdd BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei881-thioglycine; alternateUniRule annotation1
Modified residuei88Glycyl adenylate; alternateUniRule annotation1

Post-translational modificationi

C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.UniRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Z224
MaxQBiQ9Z224
PRIDEiQ9Z224

Expressioni

Gene expression databases

CleanExiMM_MOCS2

Interactioni

Subunit structurei

Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9Z224
SMRiQ9Z224
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MoaD family. MOCS2A subfamily.UniRule annotation

Family and domain databases

Gene3Di3.10.20.30, 1 hit
HAMAPiMF_03051 MOCS2A, 1 hit
InterProiView protein in InterPro
IPR012675 Beta-grasp_dom_sf
IPR028887 MOCS2A
IPR016155 Mopterin_synth/thiamin_S_b
IPR003749 ThiS/MoaD-like
PfamiView protein in Pfam
PF02597 ThiS, 1 hit
SUPFAMiSSF54285 SSF54285, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q9Z224-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPRCQIDVL YFAKSAEIAG VRSETISVPQ EIKASELWKE LEMLHPGLAD
60 70 80
VRNQVIFAVR QEYVELGDQQ LLLQPGDEVA IIPPISGG
Length:88
Mass (Da):9,745
Last modified:May 1, 1999 - v1
Checksum:i5F422EE81E7EA81E
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9Z223MOC2B_MOUSE
Molybdopterin synthase catalytic su...
Mocs2
189Annotation score:
A0A0R4J206A0A0R4J206_MOUSE
Molybdopterin synthase catalytic su...
Mocs2 MOCS2
189Annotation score:
F6ZGI7F6ZGI7_MOUSE
Molybdopterin synthase sulfur carri...
Mocs2 MOCS2
88Annotation score:
E9PVP5E9PVP5_MOUSE
Molybdopterin synthase catalytic su...
Mocs2
157Annotation score:
E9PUX1E9PUX1_MOUSE
Molybdopterin synthase catalytic su...
Mocs2
82Annotation score:
V9GX15V9GX15_MOUSE
Molybdopterin synthase catalytic su...
Mocs2
37Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091872 mRNA Translation: AAD14600.1
CCDSiCCDS49369.1
UniGeneiMm.19027

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091872 mRNA Translation: AAD14600.1
CCDSiCCDS49369.1
UniGeneiMm.19027

3D structure databases

ProteinModelPortaliQ9Z224
SMRiQ9Z224
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiQ9Z224
MaxQBiQ9Z224
PRIDEiQ9Z224

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1336894 Mocs2

Enzyme and pathway databases

UniPathwayi
UPA00344

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

CleanExiMM_MOCS2

Family and domain databases

Gene3Di3.10.20.30, 1 hit
HAMAPiMF_03051 MOCS2A, 1 hit
InterProiView protein in InterPro
IPR012675 Beta-grasp_dom_sf
IPR028887 MOCS2A
IPR016155 Mopterin_synth/thiamin_S_b
IPR003749 ThiS/MoaD-like
PfamiView protein in Pfam
PF02597 ThiS, 1 hit
SUPFAMiSSF54285 SSF54285, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOC2A_MOUSE
AccessioniPrimary (citable) accession number: Q9Z224
Secondary accession number(s): Q9D6Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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