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Protein

Molybdopterin synthase catalytic subunit

Gene

Mocs2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.UniRule annotation

Miscellaneous

This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.

Catalytic activityi

Cyclic pyranopterin phosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein].UniRule annotation

Pathwayi: molybdopterin biosynthesis

This protein is involved in the pathway molybdopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway molybdopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei159SubstrateUniRule annotation1

GO - Molecular functioni

  • identical protein binding Source: MGI
  • molybdopterin synthase activity Source: UniProtKB

GO - Biological processi

  • molybdopterin cofactor biosynthetic process Source: GO_Central
  • Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis

Enzyme and pathway databases

UniPathwayi
UPA00344

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdopterin synthase catalytic subunitUniRule annotation (EC:2.8.1.12UniRule annotation)
Alternative name(s):
Molybdenum cofactor synthesis protein 2 large subunitUniRule annotation
Molybdenum cofactor synthesis protein 2BUniRule annotation
Short name:
MOCS2BUniRule annotation
Gene namesi
Name:Mocs2UniRule annotation
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1336894 Mocs2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001631121 – 189Molybdopterin synthase catalytic subunitAdd BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Z223
MaxQBiQ9Z223
PaxDbiQ9Z223
PeptideAtlasiQ9Z223
PRIDEiQ9Z223

PTM databases

iPTMnetiQ9Z223
PhosphoSitePlusiQ9Z223

Expressioni

Gene expression databases

CleanExiMM_MOCS2

Interactioni

Subunit structurei

Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

MINTiQ9Z223
STRINGi10090.ENSMUSP00000015680

Structurei

3D structure databases

ProteinModelPortaliQ9Z223
SMRiQ9Z223
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni143 – 144Substrate bindingUniRule annotation2
Regioni166 – 168Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the MoaE family. MOCS2B subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG3307 Eukaryota
COG0314 LUCA
HOGENOMiHOG000280877
InParanoidiQ9Z223
KOiK03635
TreeFamiTF314334

Family and domain databases

CDDicd00756 MoaE, 1 hit
Gene3Di3.90.1170.40, 1 hit
HAMAPiMF_03052 MOC2B, 1 hit
InterProiView protein in InterPro
IPR036563 MoaE_sf
IPR028888 MOCS2B_euk
IPR003448 Mopterin_biosynth_MoaE
PfamiView protein in Pfam
PF02391 MoaE, 1 hit
SUPFAMiSSF54690 SSF54690, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Z223-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSLEISNSC FSPETRSPSS RQSVEDNASE PSGKDVDDVQ EKPKDIIQFT
60 70 80 90 100
AEKLSVGEVS QLVVSPLCGA VSLFVGTTRN NFEGKKVISL EYEAYVPMAE
110 120 130 140 150
NEIRKICNDI RQKWPVRHIA VFHRLGLVPV SEASTVIAVS SAHRAASLEA
160 170 180
VSYAIDSLKA KVPIWKKEIY EESTSSWKRN KECFWAAGD
Length:189
Mass (Da):20,924
Last modified:April 14, 2009 - v3
Checksum:iE16ACB553F92E3BF
GO
Isoform 2 (identifier: Q9Z223-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-170: EIY → GLT
     171-189: Missing.

Show »
Length:170
Mass (Da):18,576
Checksum:iA16C33A6F885018F
GO
Isoform 3 (identifier: Q9Z223-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-189: Missing.

Note: No experimental confirmation available.
Show »
Length:126
Mass (Da):14,029
Checksum:iAA1B1B004C49AECE
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9Z224MOC2A_MOUSE
Molybdopterin synthase sulfur carri...
Mocs2
88Annotation score:
A0A0R4J206A0A0R4J206_MOUSE
Molybdopterin synthase catalytic su...
Mocs2 MOCS2
189Annotation score:
F6ZGI7F6ZGI7_MOUSE
Molybdopterin synthase sulfur carri...
Mocs2 MOCS2
88Annotation score:
E9PVP5E9PVP5_MOUSE
Molybdopterin synthase catalytic su...
Mocs2
157Annotation score:
E9PUX1E9PUX1_MOUSE
Molybdopterin synthase catalytic su...
Mocs2
82Annotation score:
V9GX15V9GX15_MOUSE
Molybdopterin synthase catalytic su...
Mocs2
37Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15T → M in AAD14601 (PubMed:10053003).Curated1
Sequence conflicti15T → M in BAB22306 (PubMed:16141072).Curated1
Sequence conflicti15T → M in BAB26707 (PubMed:16141072).Curated1
Sequence conflicti15T → M in BAC37393 (PubMed:16141072).Curated1
Sequence conflicti17S → L in AAD14601 (PubMed:10053003).Curated1
Sequence conflicti17S → L in BAB22306 (PubMed:16141072).Curated1
Sequence conflicti17S → L in BAB26707 (PubMed:16141072).Curated1
Sequence conflicti17S → L in BAC37393 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036808127 – 189Missing in isoform 3. CuratedAdd BLAST63
Alternative sequenceiVSP_010081168 – 170EIY → GLT in isoform 2. 1 Publication3
Alternative sequenceiVSP_010082171 – 189Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091872 mRNA Translation: AAD14601.1
AK002719 mRNA Translation: BAB22306.1
AK010112 mRNA Translation: BAB26707.2
AK078782 mRNA Translation: BAC37393.1
CH466568 Genomic DNA Translation: EDL18371.1
CH466568 Genomic DNA Translation: EDL18372.1
BC024371 mRNA Translation: AAH24371.1
CCDSiCCDS49371.1 [Q9Z223-2]
RefSeqiNP_001106845.1, NM_001113374.1
NP_038854.2, NM_013826.3
UniGeneiMm.19027

Genome annotation databases

GeneIDi17434
KEGGimmu:17434
UCSCiuc007rxv.2 mouse [Q9Z223-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091872 mRNA Translation: AAD14601.1
AK002719 mRNA Translation: BAB22306.1
AK010112 mRNA Translation: BAB26707.2
AK078782 mRNA Translation: BAC37393.1
CH466568 Genomic DNA Translation: EDL18371.1
CH466568 Genomic DNA Translation: EDL18372.1
BC024371 mRNA Translation: AAH24371.1
CCDSiCCDS49371.1 [Q9Z223-2]
RefSeqiNP_001106845.1, NM_001113374.1
NP_038854.2, NM_013826.3
UniGeneiMm.19027

3D structure databases

ProteinModelPortaliQ9Z223
SMRiQ9Z223
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiQ9Z223
STRINGi10090.ENSMUSP00000015680

PTM databases

iPTMnetiQ9Z223
PhosphoSitePlusiQ9Z223

Proteomic databases

EPDiQ9Z223
MaxQBiQ9Z223
PaxDbiQ9Z223
PeptideAtlasiQ9Z223
PRIDEiQ9Z223

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17434
KEGGimmu:17434
UCSCiuc007rxv.2 mouse [Q9Z223-2]

Organism-specific databases

CTDi4338
MGIiMGI:1336894 Mocs2

Phylogenomic databases

eggNOGiKOG3307 Eukaryota
COG0314 LUCA
HOGENOMiHOG000280877
InParanoidiQ9Z223
KOiK03635
TreeFamiTF314334

Enzyme and pathway databases

UniPathwayi
UPA00344

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

CleanExiMM_MOCS2

Family and domain databases

CDDicd00756 MoaE, 1 hit
Gene3Di3.90.1170.40, 1 hit
HAMAPiMF_03052 MOC2B, 1 hit
InterProiView protein in InterPro
IPR036563 MoaE_sf
IPR028888 MOCS2B_euk
IPR003448 Mopterin_biosynth_MoaE
PfamiView protein in Pfam
PF02391 MoaE, 1 hit
SUPFAMiSSF54690 SSF54690, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOC2B_MOUSE
AccessioniPrimary (citable) accession number: Q9Z223
Secondary accession number(s): Q8C5E5, Q8R1M7, Q9DCK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: April 14, 2009
Last modified: February 28, 2018
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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