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Protein

Dipeptidyl aminopeptidase-like protein 6

Gene

Dpp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes cell surface expression of the potassium channel KCND2 (PubMed:22311982). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:22311982). Has no dipeptidyl aminopeptidase activity (By similarity).By similarity1 Publication

GO - Molecular functioni

  • potassium channel regulator activity Source: UniProtKB
  • serine-type peptidase activity Source: InterPro

GO - Biological processi

Protein family/group databases

ESTHERimouse-DPP6 DPP4N_Peptidase_S9
MEROPSiS09.973

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl aminopeptidase-like protein 6
Alternative name(s):
DPPX
Dipeptidyl aminopeptidase-related protein
Dipeptidyl peptidase 6
Dipeptidyl peptidase IV-like protein
Dipeptidyl peptidase VI
Short name:
DPP VI
Gene namesi
Name:Dpp6
Synonyms:Dpp-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:94921 Dpp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34CytoplasmicSequence analysisAdd BLAST34
Transmembranei35 – 55Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini56 – 804ExtracellularSequence analysisAdd BLAST749

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Knockdown animals obtained using siRNA technology have smaller brains than their wild-type littermates. Performance on the standard Morris water maze indicated spatial memory defects and learning disabilities.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224101 – 804Dipeptidyl aminopeptidase-like protein 6Add BLAST804

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi350 ↔ 357By similarity
Glycosylationi410N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi466 ↔ 469By similarity
Glycosylationi474N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi475 ↔ 493By similarity
Glycosylationi505N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi674 ↔ 785By similarity
Glycosylationi752N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Z218
PaxDbiQ9Z218
PRIDEiQ9Z218

PTM databases

iPTMnetiQ9Z218
PhosphoSitePlusiQ9Z218
SwissPalmiQ9Z218

Expressioni

Tissue specificityi

Detected in brain cortex (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000061576 Expressed in 146 organ(s), highest expression level in cerebellum
CleanExiMM_DPP6
ExpressionAtlasiQ9Z218 baseline and differential
GenevisibleiQ9Z218 MM

Interactioni

Subunit structurei

Homodimer (in vitro). Interacts with KCND2. Identified in a complex with KCND2 and KCNIP2. Forms an octameric complex composed of four DPP6 subunits bound to the KCND2 tetramer.By similarity

Protein-protein interaction databases

BioGridi199301, 4 interactors
IntActiQ9Z218, 2 interactors
MINTiQ9Z218
STRINGi10090.ENSMUSP00000113441

Structurei

3D structure databases

ProteinModelPortaliQ9Z218
SMRiQ9Z218
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2100 Eukaryota
COG1506 LUCA
GeneTreeiENSGT00760000119233
HOGENOMiHOG000231875
HOVERGENiHBG105877
InParanoidiQ9Z218
PhylomeDBiQ9Z218

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9Z218-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNQTAGASNN VRCPPGKGHK ELVGSNPPQR NWKGIAIALL VILVICSLIV
60 70 80 90 100
TSVILLTPAE DTSLSQKKKV TVEDLFSEDF KIHDPEAKWI SNKEFIYRER
110 120 130 140 150
KGSVILRNVE TNNSTVLIEG KKIESLRAIR YEISPDKEYV LFSYNVEPVY
160 170 180 190 200
QHSHTGYYVL SKIPHGDPQS LDPPEVSNAK LQYAGWGPKG QQLIFIFENN
210 220 230 240 250
IYYCAHVGKQ AIRVVSTGKE GVIYNGLSDW LYEEEILKSH IAHWWSPDGT
260 270 280 290 300
RLAYATINDS RVPLMELPTY TGSVYPTVKP YHYPKAGSEN PSISLHVIGL
310 320 330 340 350
NGPTHDLEMM PPDDPRMREY YITMVKWATS TKVAVTWLNR AQNVSILTLC
360 370 380 390 400
DATTGVCTKK HEDESEAWLH RQNEEPVFSK DGRKFFFVRA IPQGGRGKFY
410 420 430 440 450
HITVSSSQPN SSNDNIQSIT SGDWDVTKIL SYDEKRNKIY FLSTEDLPRR
460 470 480 490 500
RHLYSANTVD DFNRQCLSCD LVENCTYVSA SFSHNMDFFL LKCEGPGVPT
510 520 530 540 550
VTVHNTTDKR RMFDLEANEE VQKAINDRQM PKIEYRKIEV EDYSLPMQIL
560 570 580 590 600
KPATFTDTAH YPLLLVVDGT PGSQSVTERF EVTWETVLVS SHGAVVVKCD
610 620 630 640 650
GRGSGFQGTK LLQEVRRRLG FLEEKDQMEA VRTMLKEQYI DKTRVAVFGK
660 670 680 690 700
DYGGYLSTYI LPAKGENQGQ TFTCGSALSP ITDFKLYASA FSERYLGLHG
710 720 730 740 750
LDNRAYEMTK LAHRVSALED QQFLIIHATA DEKIHFQHTA ELITQLIKGK
760 770 780 790 800
ANYSLQIYPD ESHYFHSVAL KQHLSRSIIG FFVECFRVQD KLPTATAKEE

EEED
Length:804
Mass (Da):91,260
Last modified:May 1, 1999 - v1
Checksum:i09CFCE7AAD8A7168
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PWX1E9PWX1_MOUSE
Dipeptidyl aminopeptidase-like prot...
Dpp6
859Annotation score:
Q5U4C2Q5U4C2_MOUSE
Dipeptidyl aminopeptidase-like prot...
Dpp6
801Annotation score:
Q80VM5Q80VM5_MOUSE
Dipeptidyl aminopeptidase-like prot...
Dpp6
803Annotation score:
D6RFR3D6RFR3_MOUSE
Dipeptidyl aminopeptidase-like prot...
Dpp6
40Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti440 – 455Missing in AAC98381 (PubMed:9811881).CuratedAdd BLAST16
Sequence conflicti638Q → P in AAC97365 (PubMed:9811881).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092507 mRNA Translation: AAC97366.1
AF092506 mRNA Translation: AAC97365.1
AF092505 Genomic DNA Translation: AAC98381.1
CCDSiCCDS19139.1
RefSeqiNP_034205.1, NM_010075.2
NP_997165.2, NM_207282.3
UniGeneiMm.42078

Genome annotation databases

EnsembliENSMUST00000071500; ENSMUSP00000071435; ENSMUSG00000061576
GeneIDi13483
KEGGimmu:13483
UCSCiuc008wtk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092507 mRNA Translation: AAC97366.1
AF092506 mRNA Translation: AAC97365.1
AF092505 Genomic DNA Translation: AAC98381.1
CCDSiCCDS19139.1
RefSeqiNP_034205.1, NM_010075.2
NP_997165.2, NM_207282.3
UniGeneiMm.42078

3D structure databases

ProteinModelPortaliQ9Z218
SMRiQ9Z218
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199301, 4 interactors
IntActiQ9Z218, 2 interactors
MINTiQ9Z218
STRINGi10090.ENSMUSP00000113441

Protein family/group databases

ESTHERimouse-DPP6 DPP4N_Peptidase_S9
MEROPSiS09.973

PTM databases

iPTMnetiQ9Z218
PhosphoSitePlusiQ9Z218
SwissPalmiQ9Z218

Proteomic databases

MaxQBiQ9Z218
PaxDbiQ9Z218
PRIDEiQ9Z218

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071500; ENSMUSP00000071435; ENSMUSG00000061576
GeneIDi13483
KEGGimmu:13483
UCSCiuc008wtk.2 mouse

Organism-specific databases

CTDi1804
MGIiMGI:94921 Dpp6

Phylogenomic databases

eggNOGiKOG2100 Eukaryota
COG1506 LUCA
GeneTreeiENSGT00760000119233
HOGENOMiHOG000231875
HOVERGENiHBG105877
InParanoidiQ9Z218
PhylomeDBiQ9Z218

Miscellaneous databases

ChiTaRSiDpp6 mouse
PROiPR:Q9Z218
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061576 Expressed in 146 organ(s), highest expression level in cerebellum
CleanExiMM_DPP6
ExpressionAtlasiQ9Z218 baseline and differential
GenevisibleiQ9Z218 MM

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDPP6_MOUSE
AccessioniPrimary (citable) accession number: Q9Z218
Secondary accession number(s): Q9QWW2, Q9Z219
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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