Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peroxisomal membrane protein 11A

Gene

Pex11a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity). Promotes membrane protrusion and elongation on the peroxisomal surface.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPeroxisome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein 11A
Alternative name(s):
Peroxin-11A
Peroxisomal biogenesis factor 11A
Protein PEX11 homolog alpha
Short name:
PEX11-alpha
Gene namesi
Name:Pex11a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1338788 Pex11a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 93CytoplasmicSequence analysisAdd BLAST93
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 217LumenalSequence analysisAdd BLAST103
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 246CytoplasmicSequence analysis8

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Disruption phenotypei

Mice have no detectable defect in constitutive peroxisome division and display a normal peroxisome proliferation response when exposed to PPARalpha-activating drugs. However, they are defective in peroxisome proliferation induced by 4-phenylbutyrate (4-PBA).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001059651 – 246Peroxisomal membrane protein 11AAdd BLAST246

Proteomic databases

MaxQBiQ9Z211
PaxDbiQ9Z211
PRIDEiQ9Z211

PTM databases

iPTMnetiQ9Z211
PhosphoSitePlusiQ9Z211
SwissPalmiQ9Z211

Expressioni

Tissue specificityi

Strongly expressed in liver and at lower levels in heart, brain, kidney and testis.1 Publication

Inductioni

By ciprofibrate.1 Publication

Gene expression databases

BgeeiENSMUSG00000030545 Expressed in 273 organ(s), highest expression level in liver
CleanExiMM_PEX11A
GenevisibleiQ9Z211 MM

Interactioni

Subunit structurei

Homodimer. Heterodimer with PEX11G. Probably interacts with COPB2 and COPA. Interacts with PEX19. Interacts with FIS1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032761

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni218 – 238Required for homodimerization, interaction with PEX11G, and peroxisomal localizationBy similarityAdd BLAST21

Sequence similaritiesi

Belongs to the peroxin-11 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4186 Eukaryota
ENOG4111NS6 LUCA
GeneTreeiENSGT00390000014273
HOGENOMiHOG000251589
HOVERGENiHBG053771
InParanoidiQ9Z211
KOiK13351
OMAiTQYACAL
OrthoDBiEOG091G0H6Y
TreeFamiTF325704

Family and domain databases

InterProiView protein in InterPro
IPR008733 PEX11
PfamiView protein in Pfam
PF05648 PEX11, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z211-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAFIRVANQ SQGRDRLFRA TQHACMLLRY LLESKADKEA VVLKLKRLET
60 70 80 90 100
SVSTGRKWFR LGNVFHAIQA TEQSIQAADL APRLCLTLAN LNRVVYYICD
110 120 130 140 150
TVLWAKSVGL TSGVNREKWQ RWAARHYYYF LLLSLVRDLY EILLQMGQVA
160 170 180 190 200
RDRAKREKSS RDPPKYSVAN EETEWLQSFL LLLFQSLKRH PPLLLDTVKN
210 220 230 240
FCDILIPLNQ LGIYKSNLGV VGLGGLISSL AGLLTVVYPQ LKLKAR
Length:246
Mass (Da):28,153
Last modified:May 1, 1999 - v1
Checksum:iA11BAC5406D55D2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093669 mRNA Translation: AAC78659.1
BC023439 mRNA Translation: AAH23439.1
AK078954 mRNA Translation: BAC37477.1
CCDSiCCDS21386.1
RefSeqiNP_035198.1, NM_011068.1
UniGeneiMm.20615

Genome annotation databases

EnsembliENSMUST00000032761; ENSMUSP00000032761; ENSMUSG00000030545
GeneIDi18631
KEGGimmu:18631
UCSCiuc009hyy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093669 mRNA Translation: AAC78659.1
BC023439 mRNA Translation: AAH23439.1
AK078954 mRNA Translation: BAC37477.1
CCDSiCCDS21386.1
RefSeqiNP_035198.1, NM_011068.1
UniGeneiMm.20615

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032761

PTM databases

iPTMnetiQ9Z211
PhosphoSitePlusiQ9Z211
SwissPalmiQ9Z211

Proteomic databases

MaxQBiQ9Z211
PaxDbiQ9Z211
PRIDEiQ9Z211

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032761; ENSMUSP00000032761; ENSMUSG00000030545
GeneIDi18631
KEGGimmu:18631
UCSCiuc009hyy.1 mouse

Organism-specific databases

CTDi8800
MGIiMGI:1338788 Pex11a

Phylogenomic databases

eggNOGiKOG4186 Eukaryota
ENOG4111NS6 LUCA
GeneTreeiENSGT00390000014273
HOGENOMiHOG000251589
HOVERGENiHBG053771
InParanoidiQ9Z211
KOiK13351
OMAiTQYACAL
OrthoDBiEOG091G0H6Y
TreeFamiTF325704

Miscellaneous databases

PROiPR:Q9Z211
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030545 Expressed in 273 organ(s), highest expression level in liver
CleanExiMM_PEX11A
GenevisibleiQ9Z211 MM

Family and domain databases

InterProiView protein in InterPro
IPR008733 PEX11
PfamiView protein in Pfam
PF05648 PEX11, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPX11A_MOUSE
AccessioniPrimary (citable) accession number: Q9Z211
Secondary accession number(s): Q8C5B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again