Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peroxisomal membrane protein 11B

Gene

Pex11b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPeroxisome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein 11B
Alternative name(s):
Peroxin-11B
Peroxisomal biogenesis factor 11B
Protein PEX11 homolog beta
Short name:
PEX11-beta
Gene namesi
Name:Pex11b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1338882 Pex11b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Disruption phenotypei

Mice have a marked decrease in peroxisome abundance. They share several phenotypes with Zellweger syndrome mouse models, including neuronal migration defects, hypotonia, a developmental delay, and neonatal lethality but no detectable defect in peroxisomal protein import and only mild defects in peroxisomal metabolic function.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001059681 – 259Peroxisomal membrane protein 11BAdd BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Z210
MaxQBiQ9Z210
PaxDbiQ9Z210
PeptideAtlasiQ9Z210
PRIDEiQ9Z210

PTM databases

iPTMnetiQ9Z210
PhosphoSitePlusiQ9Z210
SwissPalmiQ9Z210

Expressioni

Gene expression databases

BgeeiENSMUSG00000028102 Expressed in 249 organ(s), highest expression level in testis
CleanExiMM_PEX11B
ExpressionAtlasiQ9Z210 baseline and differential
GenevisibleiQ9Z210 MM

Interactioni

Subunit structurei

Homodimer. Heterodimer with PEX11G. Interacts with PEX19. Interacts with FIS1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202116, 1 interactor
STRINGi10090.ENSMUSP00000037962

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni211 – 259Interaction with PEX19, PEX11G and FIS1 and peroxisome targetingBy similarityAdd BLAST49

Sequence similaritiesi

Belongs to the peroxin-11 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4186 Eukaryota
ENOG4111NS6 LUCA
GeneTreeiENSGT00390000014273
HOGENOMiHOG000251589
HOVERGENiHBG053771
InParanoidiQ9Z210
KOiK13352
OMAiCDFFIPL
OrthoDBiEOG091G0H6Y
TreeFamiTF325704

Family and domain databases

InterProiView protein in InterPro
IPR008733 PEX11
PfamiView protein in Pfam
PF05648 PEX11, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9Z210-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAWVRFSAQ SQARERLCRA AQYACSLLGH ALQRHGASPE LQKQIRQLEG
60 70 80 90 100
HLSLGRKLLR LGNSTDALES AKRAVHLSDV VLRFCITVSH LNRALYFACD
110 120 130 140 150
NVLWAGKSGL APRVDQEKWA QRSFRYYLFS LIMNLSRDAY EIRLLMEQET
160 170 180 190 200
SAYSRRMKVS GVGVSGGVET VGPGGPGTPG GSLPQLALKF RLRILLLARV
210 220 230 240 250
LRGHPPLLLD VLRNACDLFI PLDKLGLWRC GPGIVGLCGL ISSILSILTL

ICPWLRLKP
Length:259
Mass (Da):28,710
Last modified:May 1, 1999 - v1
Checksum:iC0E1BF979E325EB2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PXK7E9PXK7_MOUSE
Peroxisomal membrane protein 11B
Pex11b
245Annotation score:
D6RFR1D6RFR1_MOUSE
Peroxisomal membrane protein 11B
Pex11b
50Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119W → R in BAC38453 (PubMed:16141072).Curated1
Sequence conflicti217D → N in BAB27791 (PubMed:16141072).Curated1
Sequence conflicti227L → F in BAB27791 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093671 mRNA Translation: AAC78661.1
AK011709 mRNA Translation: BAB27791.1
AK082279 mRNA Translation: BAC38453.1
BC013812 mRNA Translation: AAH13812.1
BC054414 mRNA Translation: AAH54414.1
CCDSiCCDS17643.1
RefSeqiNP_001155859.1, NM_001162387.1
NP_035199.3, NM_011069.3
UniGeneiMm.20901

Genome annotation databases

EnsembliENSMUST00000048766; ENSMUSP00000037962; ENSMUSG00000028102
ENSMUST00000118557; ENSMUSP00000113365; ENSMUSG00000028102
GeneIDi18632
KEGGimmu:18632
UCSCiuc008qnn.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093671 mRNA Translation: AAC78661.1
AK011709 mRNA Translation: BAB27791.1
AK082279 mRNA Translation: BAC38453.1
BC013812 mRNA Translation: AAH13812.1
BC054414 mRNA Translation: AAH54414.1
CCDSiCCDS17643.1
RefSeqiNP_001155859.1, NM_001162387.1
NP_035199.3, NM_011069.3
UniGeneiMm.20901

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202116, 1 interactor
STRINGi10090.ENSMUSP00000037962

PTM databases

iPTMnetiQ9Z210
PhosphoSitePlusiQ9Z210
SwissPalmiQ9Z210

Proteomic databases

EPDiQ9Z210
MaxQBiQ9Z210
PaxDbiQ9Z210
PeptideAtlasiQ9Z210
PRIDEiQ9Z210

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048766; ENSMUSP00000037962; ENSMUSG00000028102
ENSMUST00000118557; ENSMUSP00000113365; ENSMUSG00000028102
GeneIDi18632
KEGGimmu:18632
UCSCiuc008qnn.2 mouse

Organism-specific databases

CTDi8799
MGIiMGI:1338882 Pex11b

Phylogenomic databases

eggNOGiKOG4186 Eukaryota
ENOG4111NS6 LUCA
GeneTreeiENSGT00390000014273
HOGENOMiHOG000251589
HOVERGENiHBG053771
InParanoidiQ9Z210
KOiK13352
OMAiCDFFIPL
OrthoDBiEOG091G0H6Y
TreeFamiTF325704

Miscellaneous databases

PROiPR:Q9Z210
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028102 Expressed in 249 organ(s), highest expression level in testis
CleanExiMM_PEX11B
ExpressionAtlasiQ9Z210 baseline and differential
GenevisibleiQ9Z210 MM

Family and domain databases

InterProiView protein in InterPro
IPR008733 PEX11
PfamiView protein in Pfam
PF05648 PEX11, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPX11B_MOUSE
AccessioniPrimary (citable) accession number: Q9Z210
Secondary accession number(s): Q8C4G1, Q9D090
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again