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Entry version 149 (12 Aug 2020)
Sequence version 1 (01 May 1999)
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Protein

Protein diaphanous homolog 3

Gene

Diaph3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (PubMed:10678165, PubMed:23558171). Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor (PubMed:10678165, PubMed:23558171). Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization (PubMed:10678165). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (PubMed:10678165). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (PubMed:23558171).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5663220, RHO GTPases Activate Formins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein diaphanous homolog 3
Alternative name(s):
Diaphanous-related formin-3
Short name:
DRF3
p134mDIA2
Short name:
mDIA21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Diaph3
Synonyms:Diap3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1927222, Diaph3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi18 – 19RK → AA: Decreased accumulation in the nucleus. 1 Publication2
Mutagenesisi35 – 36KR → AA: Abolished accumulation in the nucleus. 1 Publication2
Mutagenesisi118K → R: No loss of ubiquitination; when associated with R-119, R-493 and R-494. 1 Publication1
Mutagenesisi119K → R: No loss of ubiquitination; when associated with R-118, R-493 and R-494. 1 Publication1
Mutagenesisi268 – 269VK → AA: Does not affect subcellular location. 1 Publication2
Mutagenesisi274 – 277VCIV → ACIA: Does not affect subcellular location. 1 Publication4
Mutagenesisi493K → R: No loss of ubiquitination; when associated with R-118, R-119 and R-494. 1 Publication1
Mutagenesisi494K → R: No loss of ubiquitination; when associated with R-118, R-119 and R-493. 1 Publication1
Mutagenesisi1041M → A: Impaired ability to release autoinhibition, leading to defects in actin nucleation and elongation factor activity in the nucleus. 1 Publication1
Mutagenesisi1168L → G: Accumulation in the nucleus due to defects in nuclear export. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001948981 – 1171Protein diaphanous homolog 3Add BLAST1171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei47PhosphothreonineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei154PhosphoserineBy similarity1
Modified residuei604PhosphoserineBy similarity1
Modified residuei1072PhosphoserineBy similarity1
Modified residuei1157PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Z207

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Z207

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Z207

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z207

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Z207

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Z207

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Increased expression in S phase and mitotic cells; levels decrease as cells enter in G0/G1 phase due to proteasomal degradation (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022021, Expressed in blood and 198 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Z207, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Z207, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
207965, 16 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Z207

Database of interacting proteins

More...
DIPi
DIP-29533N

Protein interaction database and analysis system

More...
IntActi
Q9Z207, 5 interactors

Molecular INTeraction database

More...
MINTi
Q9Z207

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000022599

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Z207, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Z207

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini93 – 455GBD/FH3PROSITE-ProRule annotationAdd BLAST363
Domaini540 – 610FH1Add BLAST71
Domaini615 – 1013FH2PROSITE-ProRule annotationAdd BLAST399
Domaini1036 – 1066DADPROSITE-ProRule annotationAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili373 – 403Sequence analysisAdd BLAST31
Coiled coili478 – 533Sequence analysisAdd BLAST56
Coiled coili887 – 918Sequence analysisAdd BLAST32
Coiled coili988 – 1038Sequence analysisAdd BLAST51

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi16 – 39Nuclear localization signal1 PublicationAdd BLAST24
Motifi1162 – 1171Nuclear export signal1 Publication10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1055 – 1058Arg/Lys-rich (basic)4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain (PubMed:23558171). This autoinhibition is released upon competitive binding of an activated GTPase (PubMed:23558171). The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (PubMed:23558171).1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1924, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157767

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Z207

KEGG Orthology (KO)

More...
KOi
K05745

Identification of Orthologs from Complete Genome Data

More...
OMAi
VTKMSIF

Database of Orthologous Groups

More...
OrthoDBi
1204639at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Z207

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.2220, 1 hit
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR014767, DAD_dom
IPR010465, Drf_DAD
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf
IPR010472, FH3_dom
IPR027654, Formin_DIAPH3
IPR014768, GBD/FH3_dom
IPR010473, GTPase-bd

The PANTHER Classification System

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PANTHERi
PTHR45691:SF9, PTHR45691:SF9, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06345, Drf_DAD, 1 hit
PF06367, Drf_FH3, 1 hit
PF06371, Drf_GBD, 1 hit
PF02181, FH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01139, Drf_FH3, 1 hit
SM01140, Drf_GBD, 1 hit
SM00498, FH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51231, DAD, 1 hit
PS51444, FH2, 1 hit
PS51232, GBD_FH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9Z207-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERHRARALG RDSKSSRRKG LQSAPPAGPY EPGEKRPKLH LNIRTLTDDM
60 70 80 90 100
LDKFASIRIP GSKKERPPLP HLKTVSGISD SSSLSSETME NNPKALPESE
110 120 130 140 150
VLKLFEKMME DMNLNEDKKA PLREKDFGIK KEMVMQYINT ASKTGSLRSS
160 170 180 190 200
RQISPQEFLH ELKMGYTDER LFTYLESLRV SLTSHPVSWV QSFGHEGLGL
210 220 230 240 250
LLDILEKLIN GQIQEKVVKK TQHKVIQCLR ALMNTQYGLE RIMSDKRSLS
260 270 280 290 300
LLAKAMDPRQ PAMMADVVKL LSAVCIVGEE SILEEVLEAL TSAGEERKID
310 320 330 340 350
RFFSIVEGLR HNSVNLQVAC MQLINALVTS PDDLDFRLHL RNEFMRCGLK
360 370 380 390 400
EILPNLKGIK NDGLDIQLKV FDEHKEEDLS EFFHRLEDIR AELDEASDVY
410 420 430 440 450
SMLWDTVKET RAEGHFLSIL QHLLLIRNDR FIREQYFKLI DECVSQIVLH
460 470 480 490 500
RDGTDPDFTY RKRLDLDLSQ FVDVCIDQAK LDEWEEKASE HCKKFEKECT
510 520 530 540 550
DHQETQAQLQ KREAKINELQ AELQAFKSQF GALPPGTKIP LQPSVEGEAG
560 570 580 590 600
PSALPPAPPA LSGGVPPPPP PPPPPPPPLP GMPMPFGGPV PPPPPLGFLG
610 620 630 640 650
GQSSIPLNLP FGLKPKKEFK PEISMRRLNW LKIGPNEMSE NCFWIKVNEN
660 670 680 690 700
KYENRDLLCK LENTFCCQEK EKRNTNDFDE KKVIKKRMKE LKFLDPKIAQ
710 720 730 740 750
NLSIFLSSFR VPYEKIRTMI LEVDETQLSE SMIQNLIKHL PDEEQLKSLS
760 770 780 790 800
QFRSDYNSLC EPEQFAVVMS NVKRLRPRLS AILFKLQFEE QVNNIKPDIM
810 820 830 840 850
AVSTACEEIK KSKGFSKLLE LVLLMGNYMN AGSRNAQTFG FDLSSLCKLK
860 870 880 890 900
DTKSADQKTT LLHFLVDVCE EKHADILHFV DDLAHLDKAS RVSVEMLEKN
910 920 930 940 950
VKQMGRQLQQ LEKNLETFPP PEDLHDKFVI KMSSFVISAN EQYEKLSTLL
960 970 980 990 1000
GSMTQLYQSI MGYYAVDMKK VSVEEFFNDL NNFRTSFMLA LKENIKKREA
1010 1020 1030 1040 1050
AEKEKRARIA KERAEKERLE RQQEKKRLLE MKTEGDETGV MDSLLEALQS
1060 1070 1080 1090 1100
GAAFRDRRKR TPKLKDIRQS LSPMSQRPVL KVCNHENQKM QLTEGSRPHH
1110 1120 1130 1140 1150
SINCNSTRTP VAKELNYNLD THASTGRIKA VEKEACNAES NKKKEMELLG
1160 1170
SVAKSESVPE VEALLARLRA L
Length:1,171
Mass (Da):133,686
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95347A854CABC7CF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WIG5F8WIG5_MOUSE
Protein diaphanous homolog 3
Diaph3
1,171Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3UVP0Q3UVP0_MOUSE
Protein diaphanous homolog 3
Diaph3 Diap3
656Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQ45A0A2I3BQ45_MOUSE
Protein diaphanous homolog 3
Diaph3
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF094519 mRNA Translation: AAC71771.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36990.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T17454

NCBI Reference Sequences

More...
RefSeqi
NP_062644.1, NM_019670.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000168889; ENSMUSP00000129420; ENSMUSG00000022021

Database of genes from NCBI RefSeq genomes

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GeneIDi
56419

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:56419

UCSC genome browser

More...
UCSCi
uc007uub.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF094519 mRNA Translation: AAC71771.1
CCDSiCCDS36990.1
PIRiT17454
RefSeqiNP_062644.1, NM_019670.1

3D structure databases

SMRiQ9Z207
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi207965, 16 interactors
CORUMiQ9Z207
DIPiDIP-29533N
IntActiQ9Z207, 5 interactors
MINTiQ9Z207
STRINGi10090.ENSMUSP00000022599

PTM databases

iPTMnetiQ9Z207
PhosphoSitePlusiQ9Z207

Proteomic databases

EPDiQ9Z207
MaxQBiQ9Z207
PaxDbiQ9Z207
PRIDEiQ9Z207

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
24286, 251 antibodies

Genome annotation databases

EnsembliENSMUST00000168889; ENSMUSP00000129420; ENSMUSG00000022021
GeneIDi56419
KEGGimmu:56419
UCSCiuc007uub.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
81624
MGIiMGI:1927222, Diaph3

Phylogenomic databases

eggNOGiKOG1924, Eukaryota
GeneTreeiENSGT00940000157767
InParanoidiQ9Z207
KOiK05745
OMAiVTKMSIF
OrthoDBi1204639at2759
PhylomeDBiQ9Z207

Enzyme and pathway databases

ReactomeiR-MMU-5663220, RHO GTPases Activate Formins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
56419, 2 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Diaph3, mouse

Protein Ontology

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PROi
PR:Q9Z207
RNActiQ9Z207, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000022021, Expressed in blood and 198 other tissues
ExpressionAtlasiQ9Z207, baseline and differential
GenevisibleiQ9Z207, MM

Family and domain databases

Gene3Di1.20.58.2220, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR014767, DAD_dom
IPR010465, Drf_DAD
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf
IPR010472, FH3_dom
IPR027654, Formin_DIAPH3
IPR014768, GBD/FH3_dom
IPR010473, GTPase-bd
PANTHERiPTHR45691:SF9, PTHR45691:SF9, 1 hit
PfamiView protein in Pfam
PF06345, Drf_DAD, 1 hit
PF06367, Drf_FH3, 1 hit
PF06371, Drf_GBD, 1 hit
PF02181, FH2, 1 hit
SMARTiView protein in SMART
SM01139, Drf_FH3, 1 hit
SM01140, Drf_GBD, 1 hit
SM00498, FH2, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51231, DAD, 1 hit
PS51444, FH2, 1 hit
PS51232, GBD_FH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDIAP3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z207
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: August 12, 2020
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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