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UniProtKB - Q9Z204 (HNRPC_MOUSE)

Entry version 175 (08 May 2019)
Sequence version 1 (01 May 1999)
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Protein

Heterogeneous nuclear ribonucleoproteins C1/C2

Gene

Hnrnpc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm6A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-4570464 SUMOylation of RNA binding proteins
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoproteins C1/C2
Short name:
hnRNP C1/C2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hnrnpc
Synonyms:Hnrpc
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:107795 Hnrnpc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000818452 – 313Heterogeneous nuclear ribonucleoproteins C1/C2Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki50Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki89Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei113PhosphoserineBy similarity1
Modified residuei115PhosphoserineBy similarity1
Modified residuei121PhosphoserineCombined sources1
Modified residuei162PhosphoserineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei176N6-acetyllysine; alternateCombined sources1
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki224Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei229PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Cross-linki237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki240Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki240Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei241PhosphoserineCombined sources1
Modified residuei246PhosphoserineBy similarity1
Modified residuei247PhosphoserineBy similarity1
Modified residuei249PhosphoserineBy similarity1
Cross-linki251Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki252Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei261PhosphoserineBy similarity1
Modified residuei268PhosphoserineCombined sources1
Modified residuei306PhosphoserineCombined sources1
Modified residuei313PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser-268 and Ser-306 in resting cells.By similarity
Sumoylated. Sumoylation reduces affinity for mRNA.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Z204

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Z204

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Z204

PeptideAtlas

More...PeptideAtlasi		Q9Z204

PRoteomics IDEntifications database

More...PRIDEi		Q9Z204

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q9Z204-1 [Q9Z204-1]
Q9Z204-4 [Q9Z204-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Z204

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Z204

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9Z204

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000060373 Expressed in 289 organ(s), highest expression level in primitive streak

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Z204 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Z204 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with DHX9; this interaction is direct, enhanced probably by their concomitant binding to RNA and mediates the attachment to actin filaments.By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		200356, 4 interactors

Database of interacting proteins

More...DIPi		DIP-59747N

Protein interaction database and analysis system

More...IntActi		Q9Z204, 5 interactors

Molecular INTeraction database

More...MINTi		Q9Z204

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000107237

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Z204

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 87RRMPROSITE-ProRule annotationAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili191 – 226Sequence analysisAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi155 – 161Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi181 – 303Asp/Glu-rich (acidic)Add BLAST123

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM HNRPC family. RALY subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0118 Eukaryota
COG0724 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153402

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Z204

KEGG Orthology (KO)

More...KOi		K12884

Identification of Orthologs from Complete Genome Data

More...OMAi		YLGACLR

Database of Orthologous Groups

More...OrthoDBi		1211602at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Z204

TreeFam database of animal gene trees

More...TreeFami		TF330974

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017347 hnRNP_C
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00076 RRM_1, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037992 hnRNP-C_Raly, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360 RRM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102 RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform C2 (identifier: Q9Z204-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASNVTNKTD PRSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIVGCSVHK 
        60         70         80         90        100
GFAFVQYVNE RNARAAVAGE DGRMIAGQVL DINLAAEPKV NRGKAGVKRS 
       110        120        130        140        150
AAEMYGSVPE HPSPSPLLSS SFDLDYDFQR DYYDRMYSYP ARVPPPPPIA 
       160        170        180        190        200
RAVVPSKRQR VSGNTSRRGK SGFNSKSGQR GSSSKSGKLK GDDLQAIKKE 
       210        220        230        240        250
LTQIKQKVDS LLESLEKIEK EQSKQADLSF SSPVEMKNEK SEEEQSSASV 
       260        270        280        290        300
KKDETNVKME SEAGADDSAE EGDLLDDDDN EDRGDDQLEL KDDEKEPEEG 
       310 
EDDRDSANGE DDS
Length:313
Mass (Da):34,385
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4AB834051E3E301B
GO
Isoform C1 (identifier: Q9Z204-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-120: Missing.

Show »
Length:300
Mass (Da):33,056
Checksum:i5D602FF5656B750B
GO
Isoform 3 (identifier: Q9Z204-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-120: Missing.
     227-233: Missing.

Show »
Length:293
Mass (Da):32,323
Checksum:i7AC110DB06014FEC
GO
Isoform 4 (identifier: Q9Z204-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-120: Missing.
     227-234: Missing.

Show »
Length:292
Mass (Da):32,223
Checksum:i84A26D34AABD5806
GO
Isoform 5 (identifier: Q9Z204-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-233: Missing.

Show »
Length:306
Mass (Da):33,651
Checksum:i7AD8B459F9A7FF9B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BQH3A0A2I3BQH3_MOUSE
Heterogeneous nuclear ribonucleopro...
Hnrnpc
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BRM6A0A2I3BRM6_MOUSE
Heterogeneous nuclear ribonucleopro...
Hnrnpc
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQW7A0A2I3BQW7_MOUSE
Heterogeneous nuclear ribonucleopro...
Hnrnpc
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46C → R in AAH04706 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005832108 – 120Missing in isoform C1, isoform 3 and isoform 4. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_019227227 – 234Missing in isoform 4. 1 Publication8
Alternative sequenceiVSP_005833227 – 233Missing in isoform 3 and isoform 5. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF095257 mRNA Translation: AAD03717.1
AF095258 Genomic DNA Translation: AAD19892.1
AK011336 mRNA Translation: BAB27553.1
AK012633 mRNA Translation: BAB28370.1
AK019958 mRNA Translation: BAB31934.1
AK088245 mRNA Translation: BAC40233.1
AK088678 mRNA Translation: BAC40499.1
AK089061 mRNA Translation: BAC40728.1
AK166590 mRNA Translation: BAE38877.1
AK168802 mRNA Translation: BAE40632.1
BC004706 mRNA Translation: AAH04706.1
BC095922 mRNA Translation: AAH95922.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS36917.1 [Q9Z204-1]

NCBI Reference Sequences

More...RefSeqi		NP_001164452.1, NM_001170981.1 [Q9Z204-2]
NP_001164453.1, NM_001170982.1 [Q9Z204-2]
NP_001164454.1, NM_001170983.1 [Q9Z204-3]
NP_001164455.1, NM_001170984.1 [Q9Z204-4]
NP_058580.1, NM_016884.3 [Q9Z204-1]
XP_006518634.1, XM_006518571.3 [Q9Z204-1]
XP_006518635.1, XM_006518572.3
XP_006518637.1, XM_006518574.2
XP_006518641.1, XM_006518578.2
XP_006518644.1, XM_006518581.2
XP_017171338.1, XM_017315849.1
XP_017171339.1, XM_017315850.1 [Q9Z204-5]
XP_017171340.1, XM_017315851.1
XP_017171344.1, XM_017315855.1 [Q9Z204-2]
XP_017171345.1, XM_017315856.1
XP_017171346.1, XM_017315857.1
XP_017171347.1, XM_017315858.1
XP_017171348.1, XM_017315859.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000111610; ENSMUSP00000107237; ENSMUSG00000060373 [Q9Z204-1]
ENSMUST00000164655; ENSMUSP00000133052; ENSMUSG00000060373 [Q9Z204-1]
ENSMUST00000227242; ENSMUSP00000154757; ENSMUSG00000060373 [Q9Z204-2]
ENSMUST00000227458; ENSMUSP00000154238; ENSMUSG00000060373 [Q9Z204-4]
ENSMUST00000227536; ENSMUSP00000154737; ENSMUSG00000060373 [Q9Z204-2]
ENSMUST00000228198; ENSMUSP00000154212; ENSMUSG00000060373 [Q9Z204-5]
ENSMUST00000228232; ENSMUSP00000154619; ENSMUSG00000060373 [Q9Z204-3]
ENSMUST00000228748; ENSMUSP00000154166; ENSMUSG00000060373 [Q9Z204-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		15381

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:15381

UCSC genome browser

More...UCSCi		uc007tob.2 mouse [Q9Z204-1]
uc007toc.2 mouse [Q9Z204-4]
uc007tod.2 mouse [Q9Z204-2]
uc007toe.2 mouse [Q9Z204-3]
uc007tof.2 mouse [Q9Z204-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095257 mRNA Translation: AAD03717.1
AF095258 Genomic DNA Translation: AAD19892.1
AK011336 mRNA Translation: BAB27553.1
AK012633 mRNA Translation: BAB28370.1
AK019958 mRNA Translation: BAB31934.1
AK088245 mRNA Translation: BAC40233.1
AK088678 mRNA Translation: BAC40499.1
AK089061 mRNA Translation: BAC40728.1
AK166590 mRNA Translation: BAE38877.1
AK168802 mRNA Translation: BAE40632.1
BC004706 mRNA Translation: AAH04706.1
BC095922 mRNA Translation: AAH95922.1
CCDSiCCDS36917.1 [Q9Z204-1]
RefSeqiNP_001164452.1, NM_001170981.1 [Q9Z204-2]
NP_001164453.1, NM_001170982.1 [Q9Z204-2]
NP_001164454.1, NM_001170983.1 [Q9Z204-3]
NP_001164455.1, NM_001170984.1 [Q9Z204-4]
NP_058580.1, NM_016884.3 [Q9Z204-1]
XP_006518634.1, XM_006518571.3 [Q9Z204-1]
XP_006518635.1, XM_006518572.3
XP_006518637.1, XM_006518574.2
XP_006518641.1, XM_006518578.2
XP_006518644.1, XM_006518581.2
XP_017171338.1, XM_017315849.1
XP_017171339.1, XM_017315850.1 [Q9Z204-5]
XP_017171340.1, XM_017315851.1
XP_017171344.1, XM_017315855.1 [Q9Z204-2]
XP_017171345.1, XM_017315856.1
XP_017171346.1, XM_017315857.1
XP_017171347.1, XM_017315858.1
XP_017171348.1, XM_017315859.1

3D structure databases

SMRiQ9Z204
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200356, 4 interactors
DIPiDIP-59747N
IntActiQ9Z204, 5 interactors
MINTiQ9Z204
STRINGi10090.ENSMUSP00000107237

PTM databases

iPTMnetiQ9Z204
PhosphoSitePlusiQ9Z204
SwissPalmiQ9Z204

Proteomic databases

EPDiQ9Z204
jPOSTiQ9Z204
PaxDbiQ9Z204
PeptideAtlasiQ9Z204
PRIDEiQ9Z204
TopDownProteomicsiQ9Z204-1 [Q9Z204-1]
Q9Z204-4 [Q9Z204-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111610; ENSMUSP00000107237; ENSMUSG00000060373 [Q9Z204-1]
ENSMUST00000164655; ENSMUSP00000133052; ENSMUSG00000060373 [Q9Z204-1]
ENSMUST00000227242; ENSMUSP00000154757; ENSMUSG00000060373 [Q9Z204-2]
ENSMUST00000227458; ENSMUSP00000154238; ENSMUSG00000060373 [Q9Z204-4]
ENSMUST00000227536; ENSMUSP00000154737; ENSMUSG00000060373 [Q9Z204-2]
ENSMUST00000228198; ENSMUSP00000154212; ENSMUSG00000060373 [Q9Z204-5]
ENSMUST00000228232; ENSMUSP00000154619; ENSMUSG00000060373 [Q9Z204-3]
ENSMUST00000228748; ENSMUSP00000154166; ENSMUSG00000060373 [Q9Z204-3]
GeneIDi15381
KEGGimmu:15381
UCSCiuc007tob.2 mouse [Q9Z204-1]
uc007toc.2 mouse [Q9Z204-4]
uc007tod.2 mouse [Q9Z204-2]
uc007toe.2 mouse [Q9Z204-3]
uc007tof.2 mouse [Q9Z204-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3183
MGIiMGI:107795 Hnrnpc

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00940000153402
InParanoidiQ9Z204
KOiK12884
OMAiYLGACLR
OrthoDBi1211602at2759
PhylomeDBiQ9Z204
TreeFamiTF330974

Enzyme and pathway databases

ReactomeiR-MMU-4570464 SUMOylation of RNA binding proteins
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Hnrnpc mouse

Protein Ontology

More...PROi		PR:Q9Z204

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000060373 Expressed in 289 organ(s), highest expression level in primitive streak
ExpressionAtlasiQ9Z204 baseline and differential
GenevisibleiQ9Z204 MM

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR017347 hnRNP_C
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PIRSFiPIRSF037992 hnRNP-C_Raly, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHNRPC_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z204
Secondary accession number(s): Q3TLB5
, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 1999
Last modified: May 8, 2019
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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