UniProtKB - Q9Z204 (HNRPC_MOUSE)
Heterogeneous nuclear ribonucleoproteins C1/C2
Hnrnpc
Functioni
GO - Molecular functioni
- deaminase binding Source: MGI
- enzyme inhibitor activity Source: MGI
- identical protein binding Source: MGI
- mRNA 3'-UTR binding Source: MGI
- mRNA binding Source: MGI
- N6-methyladenosine-containing RNA binding Source: UniProtKB
- poly(U) RNA binding Source: MGI
- protein domain specific binding Source: MGI
- ribonucleoprotein complex binding Source: MGI
- RNA binding Source: MGI
- telomerase RNA binding Source: MGI
GO - Biological processi
- 3'-UTR-mediated mRNA stabilization Source: MGI
- mRNA splicing, via spliceosome Source: UniProtKB
- negative regulation of mRNA modification Source: MGI
- negative regulation of telomere maintenance via telomerase Source: MGI
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
Reactomei | R-MMU-4570464, SUMOylation of RNA binding proteins R-MMU-72163, mRNA Splicing - Major Pathway R-MMU-72203, Processing of Capped Intron-Containing Pre-mRNA |
Names & Taxonomyi
Protein namesi | Recommended name: Heterogeneous nuclear ribonucleoproteins C1/C2Short name: hnRNP C1/C2 |
Gene namesi | Name:Hnrnpc Synonyms:Hnrpc |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107795, Hnrnpc |
Subcellular locationi
Nucleus
- Nucleus By similarity
Note: Component of ribonucleosomes.By similarity
Cytoskeleton
- actin cytoskeleton Source: UniProtKB
Cytosol
- cytosol Source: MGI
Nucleus
- catalytic step 2 spliceosome Source: MGI
- nucleoplasm Source: MGI
- nucleoplasmic periphery of the nuclear pore complex Source: MGI
- nucleus Source: MGI
- pronucleus Source: MGI
- spliceosomal complex Source: HGNC-UCL
- telomerase holoenzyme complex Source: MGI
Other locations
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Nucleus, SpliceosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000081845 | 2 – 313 | Heterogeneous nuclear ribonucleoproteins C1/C2Add BLAST | 312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Cross-linki | 8 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 50 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 89 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 94 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 113 | PhosphoserineBy similarity | 1 | |
Modified residuei | 115 | PhosphoserineBy similarity | 1 | |
Modified residuei | 121 | PhosphoserineCombined sources | 1 | |
Modified residuei | 162 | PhosphoserineBy similarity | 1 | |
Modified residuei | 166 | PhosphoserineBy similarity | 1 | |
Modified residuei | 176 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 176 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Cross-linki | 224 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 229 | PhosphoserineCombined sources | 1 | |
Modified residuei | 231 | PhosphoserineCombined sources | 1 | |
Modified residuei | 232 | PhosphoserineCombined sources | 1 | |
Cross-linki | 237 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 240 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 240 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 241 | PhosphoserineCombined sources | 1 | |
Modified residuei | 246 | PhosphoserineBy similarity | 1 | |
Modified residuei | 247 | PhosphoserineBy similarity | 1 | |
Modified residuei | 249 | PhosphoserineBy similarity | 1 | |
Cross-linki | 251 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 252 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 258 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity | ||
Cross-linki | 258 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 261 | PhosphoserineBy similarity | 1 | |
Modified residuei | 268 | PhosphoserineCombined sources | 1 | |
Modified residuei | 306 | PhosphoserineCombined sources | 1 | |
Modified residuei | 313 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9Z204 |
jPOSTi | Q9Z204 |
PaxDbi | Q9Z204 |
PeptideAtlasi | Q9Z204 |
PRIDEi | Q9Z204 |
TopDownProteomicsi | Q9Z204-1 [Q9Z204-1] Q9Z204-4 [Q9Z204-4] |
PTM databases
iPTMneti | Q9Z204 |
PhosphoSitePlusi | Q9Z204 |
SwissPalmi | Q9Z204 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000060373, Expressed in primitive streak and 303 other tissues |
ExpressionAtlasi | Q9Z204, baseline and differential |
Genevisiblei | Q9Z204, MM |
Interactioni
Subunit structurei
Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers.
Component of the 40S hnRNP particle. Identified in the spliceosome C complex.
Interacts with IGF2BP1.
Interacts with DHX9; this interaction is direct, enhanced probably by their concomitant binding to RNA and mediates the attachment to actin filaments (By similarity).
Interacts with PPIA/CYPA (By similarity).
By similarityGO - Molecular functioni
- deaminase binding Source: MGI
- identical protein binding Source: MGI
- protein domain specific binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 200356, 36 interactors |
DIPi | DIP-59747N |
IntActi | Q9Z204, 6 interactors |
MINTi | Q9Z204 |
STRINGi | 10090.ENSMUSP00000107237 |
Miscellaneous databases
RNActi | Q9Z204, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 87 | RRMPROSITE-ProRule annotationAdd BLAST | 72 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 191 – 226 | Sequence analysisAdd BLAST | 36 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 155 – 161 | Nuclear localization signalSequence analysis | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 181 – 303 | Asp/Glu-rich (acidic)Add BLAST | 123 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0118, Eukaryota |
GeneTreei | ENSGT00940000153402 |
HOGENOMi | CLU_079090_0_0_1 |
InParanoidi | Q9Z204 |
OMAi | RPAGDMY |
OrthoDBi | 1211602at2759 |
PhylomeDBi | Q9Z204 |
TreeFami | TF330974 |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR017347, hnRNP_C IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
PIRSFi | PIRSF037992, hnRNP-C_Raly, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASNVTNKTD PRSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIVGCSVHK
60 70 80 90 100
GFAFVQYVNE RNARAAVAGE DGRMIAGQVL DINLAAEPKV NRGKAGVKRS
110 120 130 140 150
AAEMYGSVPE HPSPSPLLSS SFDLDYDFQR DYYDRMYSYP ARVPPPPPIA
160 170 180 190 200
RAVVPSKRQR VSGNTSRRGK SGFNSKSGQR GSSSKSGKLK GDDLQAIKKE
210 220 230 240 250
LTQIKQKVDS LLESLEKIEK EQSKQADLSF SSPVEMKNEK SEEEQSSASV
260 270 280 290 300
KKDETNVKME SEAGADDSAE EGDLLDDDDN EDRGDDQLEL KDDEKEPEEG
310
EDDRDSANGE DDS
The sequence of this isoform differs from the canonical sequence as follows:
108-120: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2I3BQH3 | A0A2I3BQH3_MOUSE | Heterogeneous nuclear ribonucleopro... | Hnrnpc | 80 | Annotation score: | ||
A0A2I3BRM6 | A0A2I3BRM6_MOUSE | Heterogeneous nuclear ribonucleopro... | Hnrnpc | 117 | Annotation score: | ||
A0A2I3BQW7 | A0A2I3BQW7_MOUSE | Heterogeneous nuclear ribonucleopro... | Hnrnpc | 28 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 46 | C → R in AAH04706 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005832 | 108 – 120 | Missing in isoform C1, isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 13 | |
Alternative sequenceiVSP_019227 | 227 – 234 | Missing in isoform 4. 1 Publication | 8 | |
Alternative sequenceiVSP_005833 | 227 – 233 | Missing in isoform 3 and isoform 5. 1 Publication | 7 |
Sequence databases
Genome annotation databases
Ensembli | ENSMUST00000111610; ENSMUSP00000107237; ENSMUSG00000060373 [Q9Z204-1] ENSMUST00000164655; ENSMUSP00000133052; ENSMUSG00000060373 [Q9Z204-1] ENSMUST00000227242; ENSMUSP00000154757; ENSMUSG00000060373 [Q9Z204-2] ENSMUST00000227458; ENSMUSP00000154238; ENSMUSG00000060373 [Q9Z204-4] ENSMUST00000227536; ENSMUSP00000154737; ENSMUSG00000060373 [Q9Z204-2] ENSMUST00000228198; ENSMUSP00000154212; ENSMUSG00000060373 [Q9Z204-5] ENSMUST00000228232; ENSMUSP00000154619; ENSMUSG00000060373 [Q9Z204-3] ENSMUST00000228748; ENSMUSP00000154166; ENSMUSG00000060373 [Q9Z204-3] |
GeneIDi | 15381 |
KEGGi | mmu:15381 |
UCSCi | uc007tob.2, mouse [Q9Z204-1] uc007toc.2, mouse [Q9Z204-4] uc007tod.2, mouse [Q9Z204-2] uc007toe.2, mouse [Q9Z204-3] uc007tof.2, mouse [Q9Z204-5] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
BMRBi | Q9Z204 |
SMRi | Q9Z204 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200356, 36 interactors |
DIPi | DIP-59747N |
IntActi | Q9Z204, 6 interactors |
MINTi | Q9Z204 |
STRINGi | 10090.ENSMUSP00000107237 |
PTM databases
iPTMneti | Q9Z204 |
PhosphoSitePlusi | Q9Z204 |
SwissPalmi | Q9Z204 |
Proteomic databases
EPDi | Q9Z204 |
jPOSTi | Q9Z204 |
PaxDbi | Q9Z204 |
PeptideAtlasi | Q9Z204 |
PRIDEi | Q9Z204 |
TopDownProteomicsi | Q9Z204-1 [Q9Z204-1] Q9Z204-4 [Q9Z204-4] |
Genome annotation databases
Ensembli | ENSMUST00000111610; ENSMUSP00000107237; ENSMUSG00000060373 [Q9Z204-1] ENSMUST00000164655; ENSMUSP00000133052; ENSMUSG00000060373 [Q9Z204-1] ENSMUST00000227242; ENSMUSP00000154757; ENSMUSG00000060373 [Q9Z204-2] ENSMUST00000227458; ENSMUSP00000154238; ENSMUSG00000060373 [Q9Z204-4] ENSMUST00000227536; ENSMUSP00000154737; ENSMUSG00000060373 [Q9Z204-2] ENSMUST00000228198; ENSMUSP00000154212; ENSMUSG00000060373 [Q9Z204-5] ENSMUST00000228232; ENSMUSP00000154619; ENSMUSG00000060373 [Q9Z204-3] ENSMUST00000228748; ENSMUSP00000154166; ENSMUSG00000060373 [Q9Z204-3] |
GeneIDi | 15381 |
KEGGi | mmu:15381 |
UCSCi | uc007tob.2, mouse [Q9Z204-1] uc007toc.2, mouse [Q9Z204-4] uc007tod.2, mouse [Q9Z204-2] uc007toe.2, mouse [Q9Z204-3] uc007tof.2, mouse [Q9Z204-5] |
Organism-specific databases
CTDi | 3183 |
MGIi | MGI:107795, Hnrnpc |
Phylogenomic databases
eggNOGi | KOG0118, Eukaryota |
GeneTreei | ENSGT00940000153402 |
HOGENOMi | CLU_079090_0_0_1 |
InParanoidi | Q9Z204 |
OMAi | RPAGDMY |
OrthoDBi | 1211602at2759 |
PhylomeDBi | Q9Z204 |
TreeFami | TF330974 |
Enzyme and pathway databases
Reactomei | R-MMU-4570464, SUMOylation of RNA binding proteins R-MMU-72163, mRNA Splicing - Major Pathway R-MMU-72203, Processing of Capped Intron-Containing Pre-mRNA |
Miscellaneous databases
BioGRID-ORCSi | 15381, 6 hits in 16 CRISPR screens |
ChiTaRSi | Hnrnpc, mouse |
PROi | PR:Q9Z204 |
RNActi | Q9Z204, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000060373, Expressed in primitive streak and 303 other tissues |
ExpressionAtlasi | Q9Z204, baseline and differential |
Genevisiblei | Q9Z204, MM |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR017347, hnRNP_C IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
PIRSFi | PIRSF037992, hnRNP-C_Raly, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HNRPC_MOUSE | |
Accessioni | Q9Z204Primary (citable) accession number: Q9Z204 Secondary accession number(s): Q3TLB5 Q9CY83 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 185 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families