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Protein

Thyroid receptor-interacting protein 6

Gene

Trip6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid receptor-interacting protein 6
Short name:
TR-interacting protein 6
Short name:
TRIP-6
Alternative name(s):
Zyxin-related protein 1
Short name:
ZRP-1
Gene namesi
Name:Trip6
Synonyms:Zrp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1343458 Trip6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi479 – 480Missing : Interacts with PDLIM4. Loss of interaction with PTPN13. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002746891 – 480Thyroid receptor-interacting protein 6Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei25Omega-N-methylarginine; alternateBy similarity1
Modified residuei55Phosphotyrosine; by SRCBy similarity1
Modified residuei92PhosphoserineCombined sources1
Modified residuei111Omega-N-methylarginineBy similarity1
Modified residuei183Omega-N-methylarginineBy similarity1
Modified residuei190Omega-N-methylarginineCombined sources1
Modified residuei193PhosphoserineBy similarity1
Modified residuei209Omega-N-methylarginineCombined sources1
Modified residuei242Omega-N-methylarginineCombined sources1

Post-translational modificationi

Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13 (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9Z1Y4
PaxDbiQ9Z1Y4
PRIDEiQ9Z1Y4

PTM databases

iPTMnetiQ9Z1Y4
PhosphoSitePlusiQ9Z1Y4

Expressioni

Tissue specificityi

Highly expressed in kidney, stomach, lung, heart and testis. Low expression levels in brain, colon, thymus, pancreas and skin. Not expressed in skeletal muscle.1 Publication

Developmental stagei

Expressed throughout development in all embryonic stages analyzed, 10.5 days post coitum (dpc) to 18.5 dpc. In 16.5 dpc embryos highly expressed in skin, lung, thymus, duodenum and the ependymal cell layer surrounding the ventricles in brain. Highly expressed also in the salivary glands, tongue, vibrissae, choroid plexus, blood vessel walls, esophagus and midgut. Low expression levels in spinal cord, heart and liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000023348
CleanExiMM_TRIP6
ExpressionAtlasiQ9Z1Y4 baseline and differential
GenevisibleiQ9Z1Y4 MM

Interactioni

Subunit structurei

Specifically interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone (By similarity). Interacts (via the third LIM domain and C-terminus) with PTPN13 (via the second PDZ domain). Interacts (via the second LIM domain or via the third LIM domain plus C-terminus) with PDLIM4 (via PDZ domain). Found in a complex with PTPN13 and PDLIM4 (PubMed:10826496). Interacts with SVIL isoform 2. Interacts with LPAR2 but not other LPA receptors. Interacts with PRKAA2. Interacts with MAGI1. Interacts with SCRIB (By similarity). In case of infection, interacts with S.typhimurium protein sseI (PubMed:17095609).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Pdlim4P702712EBI-643879,EBI-7288319

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204317, 1 interactor
IntActiQ9Z1Y4, 7 interactors
MINTiQ9Z1Y4
STRINGi10090.ENSMUSP00000024119

Structurei

3D structure databases

ProteinModelPortaliQ9Z1Y4
SMRiQ9Z1Y4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini281 – 339LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST59
Domaini341 – 401LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini404 – 471LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni473 – 480Interaction with MAGI1 and PTPN13By similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 256Pro-richAdd BLAST253

Domaini

The LIM zinc-binding domains mediate interaction with LPAR2.By similarity

Sequence similaritiesi

Belongs to the zyxin/ajuba family.Curated

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1701 Eukaryota
ENOG410Y3GP LUCA
GeneTreeiENSGT00760000119039
HOGENOMiHOG000220910
HOVERGENiHBG093602
InParanoidiQ9Z1Y4
KOiK12792
OMAiAGYRSHR
OrthoDBiEOG091G085F
PhylomeDBiQ9Z1Y4
TreeFamiTF320310

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 3 hits
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q9Z1Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGPTWLPPK QPEPSRLPQG RSLPRGALGP PTAHGATLQP HPRVNFCPLP
60 70 80 90 100
PEHCYQPPGV PEDRGPTWVG SHGTPQRLQG LPPDRGIIRP GSLDAEIDSL
110 120 130 140 150
TSMLADLDGG RSHAPRRPDR QAFEAPPPHA YRGGSLKPSG GAVPTPMLPA
160 170 180 190 200
SHYGGPTPAS YATASTPAGP AFPVQVKVAQ PVRGCGLPRR GASQASGPLP
210 220 230 240 250
GPHFPLTGRG EVWGAGYRSH REPGPGVPEG PSGVHIPAGG GRGGGHEPQG
260 270 280 290 300
PLGQPPEEEL ERLTKKLVHD MSHPPSGEYF GRCGGCGEDV VGDGAGVVAL
310 320 330 340 350
DRVFHIGCFV CSTCRAQLRG QHFYAVERRA YCESCYVATL EKCSTCSEPI
360 370 380 390 400
LDRILRAMGK AYHPGCFTCV VCHRGLDGIP FTVDATSQIH CIEDFHRKFA
410 420 430 440 450
PRCSVCGGAI MPEPGQEETV RIVALDRSFH IGCYKCEECG LLLSSEGECQ
460 470 480
GCYPLDGHIL CKACSAWRIQ ELSATVTTDC
Length:480
Mass (Da):50,934
Last modified:May 1, 1999 - v1
Checksum:iFA6C5A79D4834CF1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141G → D in BAE35042 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116823 mRNA Translation: AAD45984.1
AF097511 mRNA Translation: AAC72380.1
AF312033 Genomic DNA Translation: AAK28821.1
AK010435 mRNA Translation: BAB26937.1
AK159387 mRNA Translation: BAE35042.1
CCDSiCCDS19765.1
RefSeqiNP_035769.1, NM_011639.3
UniGeneiMm.27063

Genome annotation databases

EnsembliENSMUST00000024119; ENSMUSP00000024119; ENSMUSG00000023348
GeneIDi22051
KEGGimmu:22051
UCSCiuc009acd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTRIP6_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1Y4
Secondary accession number(s): Q3TX74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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