UniProtKB - Q9Z1Y0 (RHOV_RAT)
Protein
Rho-related GTP-binding protein RhoV
Gene
Rhov
Organism
Rattus norvegicus (Rat)
Status
Functioni
Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.1 Publication
Cofactori
Mg2+By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 38 – 45 | GTP1 Publication | 8 | |
Nucleotide bindingi | 85 – 89 | GTPBy similarity | 5 | |
Nucleotide bindingi | 143 – 146 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- Cdc42 protein signal transduction Source: GO_Central
- cell migration Source: GO_Central
- cell projection assembly Source: GO_Central
- endocytosis Source: GO_Central
- signal transduction Source: RGD
Keywordsi
Ligand | GTP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-RNO-194840, Rho GTPase cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Rho-related GTP-binding protein RhoVAlternative name(s): Rho family GTPase Chp |
Gene namesi | Name:RhovImported |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 628824, Rhov |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Lipid-anchor 2 Publications; Cytoplasmic side 2 Publications
Endosome
- Endosome membrane 2 Publications; Lipid-anchor 2 Publications; Cytoplasmic side 2 Publications
Note: Treatment with TNF activates endosomal but not plasma membrane RHOV.2 Publications
Endosome
- endosome membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Endosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 40 | G → V: Constitutively GTP-bound and constitutively active. 1 Publication | 1 | |
Mutagenesisi | 56 | Y → L: Increase in GDP/GTP cycling. 1 Publication | 1 | |
Mutagenesisi | 226 – 228 | RCR → QCQ: Loss of subcellular location to plasma membrane, decreased association with endomembranes. 1 Publication | 3 | |
Mutagenesisi | 226 | R → Q: Loss of subcellular location to plasma membrane. 1 Publication | 1 | |
Mutagenesisi | 227 | C → S: No effect on subcellular location. 1 Publication | 1 | |
Mutagenesisi | 228 | R → Q: Loss of subcellular location to plasma membrane. 1 Publication | 1 | |
Mutagenesisi | 229 | W → Y: Loss of subcellular location to plasma and endosomal membrane. 1 Publication | 1 | |
Mutagenesisi | 230 – 231 | KK → QQ: Loss of subcellular location to plasma membrane, decreased association with endomembranes. 1 Publication | 2 | |
Mutagenesisi | 230 | K → Q: Loss of subcellular location to plasma membrane, decreased association with endomembranes. 1 Publication | 1 | |
Mutagenesisi | 231 | K → Q: Loss of subcellular location to plasma membrane, decreased association with endomembranes. 1 Publication | 1 | |
Mutagenesisi | 234 | C → S: Loss of subcellular location to plasma and endosomal membranes. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000326440 | 1 – 236 | Rho-related GTP-binding protein RhoVAdd BLAST | 236 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 25 | PhosphoserineBy similarity | 1 | |
Lipidationi | 234 | S-palmitoyl cysteine1 Publication | 1 |
Keywords - PTMi
Lipoprotein, Palmitate, PhosphoproteinProteomic databases
PaxDbi | Q9Z1Y0 |
PRIDEi | Q9Z1Y0 |
PTM databases
PhosphoSitePlusi | Q9Z1Y0 |
SwissPalmi | Q9Z1Y0 |
Expressioni
Tissue specificityi
Highly expressed in brain and testis and at lower levels in spleen and lung.1 Publication
Gene expression databases
Genevisiblei | Q9Z1Y0, RN |
Interactioni
Subunit structurei
Interacts with PAK2.
1 PublicationBinary interactionsi
Q9Z1Y0
With | #Exp. | IntAct |
---|---|---|
Stk17b [Q91XS8] | 2 | EBI-77480,EBI-77460 |
Protein-protein interaction databases
IntActi | Q9Z1Y0, 2 interactors |
STRINGi | 10116.ENSRNOP00000018277 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0393, Eukaryota |
InParanoidi | Q9Z1Y0 |
OrthoDBi | 1091615at2759 |
PhylomeDBi | Q9Z1Y0 |
TreeFami | TF321839 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR003578, Small_GTPase_Rho |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51420, RHO, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9Z1Y0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPPRELSEAE PPPLPASTPP PRRRSAPPEL GIKCVLVGDG AVGKSSLIVS
60 70 80 90 100
YTCNGYPSRY RPTALDTFSV QVLVDGAPVR IELWDTAGQE DFDRLRSLCY
110 120 130 140 150
PDTDVFLACF SVVQPSSFQN ITEKWLPEIR THNPQAPVLL VGTQADLRDD
160 170 180 190 200
VNVLIQLDQG GREGPVPEPQ AQGLAEKIRA CCYLECSALT QKNLKEVFDS
210 220 230
AILSAIEHKA RLEKKLNAKG VRTLSRCRWK KFFCFV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0H2UHK9 | A0A0H2UHK9_RAT | Rho-related GTP-binding protein Rho... | Rhov | 276 | Annotation score: | ||
A0A0G2K2C8 | A0A0G2K2C8_RAT | Rho-related GTP-binding protein Rho... | Rhov | 213 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF097887 mRNA Translation: AAC69198.1 BC086990 mRNA Translation: AAH86990.1 |
RefSeqi | NP_612551.2, NM_138542.2 |
Genome annotation databases
GeneIDi | 171581 |
KEGGi | rno:171581 |
UCSCi | RGD:628824, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF097887 mRNA Translation: AAC69198.1 BC086990 mRNA Translation: AAH86990.1 |
RefSeqi | NP_612551.2, NM_138542.2 |
3D structure databases
SMRi | Q9Z1Y0 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9Z1Y0, 2 interactors |
STRINGi | 10116.ENSRNOP00000018277 |
PTM databases
PhosphoSitePlusi | Q9Z1Y0 |
SwissPalmi | Q9Z1Y0 |
Proteomic databases
PaxDbi | Q9Z1Y0 |
PRIDEi | Q9Z1Y0 |
Genome annotation databases
GeneIDi | 171581 |
KEGGi | rno:171581 |
UCSCi | RGD:628824, rat |
Organism-specific databases
CTDi | 171177 |
RGDi | 628824, Rhov |
Phylogenomic databases
eggNOGi | KOG0393, Eukaryota |
InParanoidi | Q9Z1Y0 |
OrthoDBi | 1091615at2759 |
PhylomeDBi | Q9Z1Y0 |
TreeFami | TF321839 |
Enzyme and pathway databases
Reactomei | R-RNO-194840, Rho GTPase cycle |
Miscellaneous databases
PROi | PR:Q9Z1Y0 |
Gene expression databases
Genevisiblei | Q9Z1Y0, RN |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR003578, Small_GTPase_Rho |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51420, RHO, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RHOV_RAT | |
Accessioni | Q9Z1Y0Primary (citable) accession number: Q9Z1Y0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families