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UniProtKB - Q9Z1X4 (ILF3_MOUSE)

Entry version 176 (10 Feb 2021)
Sequence version 2 (12 Apr 2005)
Previous versions | rss
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Protein

Interleukin enhancer-binding factor 3

Gene

Ilf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response. Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processAntiviral defense, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin enhancer-binding factor 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ilf3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1339973, Ilf3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001260711 – 898Interleukin enhancer-binding factor 3Add BLAST898

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei67PhosphothreonineCombined sources1
Modified residuei100N6-acetyllysineBy similarity1
Modified residuei188Phosphothreonine; by PKR1 Publication1
Modified residuei190PhosphoserineCombined sources1
Modified residuei315Phosphothreonine; by PKR1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki348Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei382PhosphoserineBy similarity1
Modified residuei384PhosphoserineBy similarity1
Cross-linki396Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei460N6-acetyllysineBy similarity1
Modified residuei476PhosphoserineBy similarity1
Modified residuei477PhosphoserineBy similarity1
Modified residuei482PhosphoserineCombined sources1
Modified residuei486PhosphoserineCombined sources1
Cross-linki489Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei592PhosphothreonineBy similarity1
Modified residuei794PhosphoserineBy similarity1
Modified residuei812PhosphoserineBy similarity1
Modified residuei814PhosphoserineBy similarity1
Modified residuei818PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Thr-188 and Thr-315 by PKR in response to RNA viruses. This phosphorylation results in the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can bind to viral RNAs and impede viral replication.1 Publication
Methylated by protein arginine N-methyltransferase 1.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Z1X4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Z1X4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Z1X4

PeptideAtlas

More...PeptideAtlasi		Q9Z1X4

PRoteomics IDEntifications database

More...PRIDEi		Q9Z1X4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Z1X4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Z1X4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expressed at high levels in the thymus, testis, ovary and at lower levelss in the spleen.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000032178, Expressed in undifferentiated genital tubercle and 355 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Z1X4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Z1X4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

Interacts with FUS and SMN.

Interacts (via C-terminus) with PRMT1.

Forms a complex with ILF2. Can also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of XRCC6/KU70 and XRCC5/KU80.

Forms a heteromeric complex with ZNF346 and ILF3.

Found in a nuclear export complex with XPO5, ILF3, Ran and double-stranded RNA or double-stranded minihelix VA1 RNA.

Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA.

Interacts with XPO5 and ZNF346.

Forms a complex with ILF2, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA.

Interacts with AGO1 and AGO2.

Interacts with DHX36; this interaction occurs in a RNA-dependent manner.

Interacts with ELAVL1; this interaction occurs in a RNA-dependent manner (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		200648, 59 interactors

Protein interaction database and analysis system

More...IntActi		Q9Z1X4, 4 interactors

Molecular INTeraction database

More...MINTi		Q9Z1X4

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000065770

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Z1X4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1898
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Z1X4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 378DZFPROSITE-ProRule annotationAdd BLAST374
Domaini398 – 467DRBM 1PROSITE-ProRule annotationAdd BLAST70
Domaini524 – 590DRBM 2PROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni609 – 898Interaction with PRMT1By similarityAdd BLAST290

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi371 – 389Bipartite nuclear localization signalSequence analysisAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi385 – 389Poly-Lys5
Compositional biasi634 – 637Poly-Pro4
Compositional biasi640 – 659Arg/Gly-richAdd BLAST20
Compositional biasi701 – 710Poly-Gly10
Compositional biasi796 – 800Poly-Gly5

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3792, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156719

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Z1X4

Identification of Orthologs from Complete Genome Data

More...OMAi		YSHGQGN

Database of Orthologous Groups

More...OrthoDBi		612611at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Z1X4

TreeFam database of animal gene trees

More...TreeFami		TF320194

Family and domain databases

Conserved Domains Database

More...CDDi		cd00048, DSRM, 2 hits

Database of protein disorder

More...DisProti		DP01562

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.460.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014720, dsRBD_dom
IPR006561, DZF_dom
IPR033099, ILF3/NF90
IPR043519, NT_sf

The PANTHER Classification System

More...PANTHERi		PTHR45762:SF4, PTHR45762:SF4, 3 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00035, dsrm, 2 hits
PF07528, DZF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00358, DSRM, 2 hits
SM00572, DZF, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50137, DS_RBD, 2 hits
PS51703, DZF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Z1X4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPMRIFVND DRHVMAKHSS VYPTQEELEA VQNMVSHTER ALKAVSDWID 
        60         70         80         90        100
EQEKGNSELS EAENMDTPPD DESKEGAGEQ KAEHMTRTLR GVMRVGLVAK 
       110        120        130        140        150
GLLLKGDLDL ELVLLCKEKP TTALLDKVAD NLAIQLTTVT EDKYEILQSV 
       160        170        180        190        200
DDAAIVIKNT KEPPLSLTIH LTSPVVREEM EKVLAGETLS VNDPPDVLDR 
       210        220        230        240        250
QKCLAALASL RHAKWFQARA NGLKSCVIVI RVLRDLCTRV PTWGPLRGWP 
       260        270        280        290        300
LELLCEKSIG TANRPMGAGE ALRRVLECLA SGIVMPDGSG IYDPCEKEAT 
       310        320        330        340        350
DAIGHLDRQQ REDITQSAQH ALRLAAFGQL HKVLGMDPLP SKMPKKPKNE 
       360        370        380        390        400
NPVDYTVQIP PSTTYAITPM KRPMEEDGEE KSPSKKKKKI QKKEEKADPP 
       410        420        430        440        450
QAMNALMRLN QLKPGLQYKL ISQTGPVHAP IFTMSVEVDG SNFEASGPSK 
       460        470        480        490        500
KTAKLHVAVK VLQDMGLPTG AEGRDSSKGE DSAEESDGKP AIVAPPPVVE 
       510        520        530        540        550
AVSNPSSVFP SDATTEQGPI LTKHGKNPVM ELNEKRRGLK YELISETGGS 
       560        570        580        590        600
HDKRFVMEVE VDGQKFQGAG SNKKVAKAYA ALAALEKLFP DTPLALEANK 
       610        620        630        640        650
KKRTPVPVRG GPKFAAKPHN PGFGMGGPMH NEVPPPPNIR GRGRGGNIRG 
       660        670        680        690        700
RGRGRGFGGA NHGGGYMNAG AGYGSYGYSS NSATAGYSQF YSNGGHSGNA 
       710        720        730        740        750
GGGGSGGGGG SSSYSSYYQG DSYNSPVPPK HAGKKPLHGG QQKASYSSGY 
       760        770        780        790        800
QSHQGQQQPY NQSQYSSYGT PQGKQKGYGH GQGSYSSYSN SYNSPGGGGG 
       810        820        830        840        850
SDYSYDSKFN YSGSGGRSGG NSYGSSGSSS YNTGSHGGYG TGSGGSSSYQ 
       860        870        880        890 
GKQGGYSSQS NYSSPGSSQS YSGPASSYQS SQGGYSRNTE HSMNYQYR
Length:898
Mass (Da):96,021
Last modified:April 12, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i171B31100D1181F7
GO
Isoform 2 (identifier: Q9Z1X4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MALYHHHFITRRRR
     689-703: QFYSNGGHSGNAGGG → DFFTDCYGYHDFGAS
     704-898: Missing.

Show »
Length:716
Mass (Da):78,093
Checksum:i31524B0E69250CCB
GO
Isoform 3 (identifier: Q9Z1X4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MALYHHHFITRRRR

Show »
Length:911
Mass (Da):97,766
Checksum:iD5D1428778212A8A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q45VK5Q45VK5_MOUSE
Interleukin enhancer-binding factor...
Ilf3
703Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1STE4A0A1L1STE4_MOUSE
Interleukin enhancer-binding factor...
Ilf3
908Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SSU8A0A1L1SSU8_MOUSE
Interleukin enhancer-binding factor...
Ilf3
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1ST48A0A1L1ST48_MOUSE
Interleukin enhancer-binding factor...
Ilf3
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SU19A0A1L1SU19_MOUSE
Interleukin enhancer-binding factor...
Ilf3
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SQR7A0A1L1SQR7_MOUSE
Interleukin enhancer-binding factor...
Ilf3
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SQ69A0A1L1SQ69_MOUSE
Interleukin enhancer-binding factor...
Ilf3
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SR62A0A1L1SR62_MOUSE
Interleukin enhancer-binding factor...
Ilf3
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC71052 differs from that shown. Reason: Frameshift.Curated
The sequence BAC36863 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti796G → C in AAC71052 (PubMed:10337617).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0134061M → MALYHHHFITRRRR in isoform 2 and isoform 3. 4 Publications1
Alternative sequenceiVSP_013407689 – 703QFYSN…NAGGG → DFFTDCYGYHDFGAS in isoform 2. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_013408704 – 898Missing in isoform 2. 2 PublicationsAdd BLAST195

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF506968 Genomic DNA Translation: AAM34210.1
AF098967 mRNA Translation: AAC71052.1 Frameshift.
AF497751 mRNA Translation: AAO23054.1
AF497752 mRNA Translation: AAO23055.1
AK048096 mRNA Translation: BAC33239.1
AK077560 mRNA Translation: BAC36863.1 Frameshift.
AK088604 mRNA Translation: BAC40448.1
BC047272 mRNA Translation: AAH47272.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS40552.1 [Q9Z1X4-1]
CCDS90512.1 [Q9Z1X4-2]
CCDS90514.1 [Q9Z1X4-3]

NCBI Reference Sequences

More...RefSeqi		NP_001036172.1, NM_001042707.2 [Q9Z1X4-1]
NP_001036173.1, NM_001042708.2 [Q9Z1X4-2]
NP_001264250.1, NM_001277321.1
NP_001264251.1, NM_001277322.1 [Q9Z1X4-3]
NP_034691.2, NM_010561.3 [Q9Z1X4-3]
XP_006510094.1, XM_006510031.2 [Q9Z1X4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000067646; ENSMUSP00000065770; ENSMUSG00000032178 [Q9Z1X4-1]
ENSMUST00000213603; ENSMUSP00000149483; ENSMUSG00000032178 [Q9Z1X4-3]
ENSMUST00000214758; ENSMUSP00000151032; ENSMUSG00000032178 [Q9Z1X4-3]
ENSMUST00000216892; ENSMUSP00000149786; ENSMUSG00000032178 [Q9Z1X4-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		16201

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:16201

UCSC genome browser

More...UCSCi		uc009old.2, mouse [Q9Z1X4-3]
uc009ole.2, mouse [Q9Z1X4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506968 Genomic DNA Translation: AAM34210.1
AF098967 mRNA Translation: AAC71052.1 Frameshift.
AF497751 mRNA Translation: AAO23054.1
AF497752 mRNA Translation: AAO23055.1
AK048096 mRNA Translation: BAC33239.1
AK077560 mRNA Translation: BAC36863.1 Frameshift.
AK088604 mRNA Translation: BAC40448.1
BC047272 mRNA Translation: AAH47272.1
CCDSiCCDS40552.1 [Q9Z1X4-1]
CCDS90512.1 [Q9Z1X4-2]
CCDS90514.1 [Q9Z1X4-3]
RefSeqiNP_001036172.1, NM_001042707.2 [Q9Z1X4-1]
NP_001036173.1, NM_001042708.2 [Q9Z1X4-2]
NP_001264250.1, NM_001277321.1
NP_001264251.1, NM_001277322.1 [Q9Z1X4-3]
NP_034691.2, NM_010561.3 [Q9Z1X4-3]
XP_006510094.1, XM_006510031.2 [Q9Z1X4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AT7X-ray1.90B1-381[»]
4AT8X-ray2.69B/D1-381[»]
4AT9X-ray2.80B1-381[»]
4ATBX-ray3.10B/D1-381[»]
5DV7X-ray3.50C4-701[»]
SMRiQ9Z1X4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi200648, 59 interactors
IntActiQ9Z1X4, 4 interactors
MINTiQ9Z1X4
STRINGi10090.ENSMUSP00000065770

PTM databases

iPTMnetiQ9Z1X4
PhosphoSitePlusiQ9Z1X4

Proteomic databases

EPDiQ9Z1X4
jPOSTiQ9Z1X4
PaxDbiQ9Z1X4
PeptideAtlasiQ9Z1X4
PRIDEiQ9Z1X4

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1051, 330 antibodies

Genome annotation databases

EnsembliENSMUST00000067646; ENSMUSP00000065770; ENSMUSG00000032178 [Q9Z1X4-1]
ENSMUST00000213603; ENSMUSP00000149483; ENSMUSG00000032178 [Q9Z1X4-3]
ENSMUST00000214758; ENSMUSP00000151032; ENSMUSG00000032178 [Q9Z1X4-3]
ENSMUST00000216892; ENSMUSP00000149786; ENSMUSG00000032178 [Q9Z1X4-2]
GeneIDi16201
KEGGimmu:16201
UCSCiuc009old.2, mouse [Q9Z1X4-3]
uc009ole.2, mouse [Q9Z1X4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3609
MGIiMGI:1339973, Ilf3

Phylogenomic databases

eggNOGiKOG3792, Eukaryota
GeneTreeiENSGT00940000156719
InParanoidiQ9Z1X4
OMAiYSHGQGN
OrthoDBi612611at2759
PhylomeDBiQ9Z1X4
TreeFamiTF320194

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		16201, 6 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ilf3, mouse

Protein Ontology

More...PROi		PR:Q9Z1X4
RNActiQ9Z1X4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000032178, Expressed in undifferentiated genital tubercle and 355 other tissues
ExpressionAtlasiQ9Z1X4, baseline and differential
GenevisibleiQ9Z1X4, MM

Family and domain databases

CDDicd00048, DSRM, 2 hits
DisProtiDP01562
Gene3Di3.30.460.10, 1 hit
InterProiView protein in InterPro
IPR014720, dsRBD_dom
IPR006561, DZF_dom
IPR033099, ILF3/NF90
IPR043519, NT_sf
PANTHERiPTHR45762:SF4, PTHR45762:SF4, 3 hits
PfamiView protein in Pfam
PF00035, dsrm, 2 hits
PF07528, DZF, 1 hit
SMARTiView protein in SMART
SM00358, DSRM, 2 hits
SM00572, DZF, 1 hit
PROSITEiView protein in PROSITE
PS50137, DS_RBD, 2 hits
PS51703, DZF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiILF3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z1X4
Secondary accession number(s): Q80VD5
, Q812A1, Q8BP80, Q8C2H8, Q8K588
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: April 12, 2005
Last modified: February 10, 2021
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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