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Entry version 132 (29 Sep 2021)
Sequence version 2 (01 Oct 2001)
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Protein

Protein LYRIC

Gene

Mtdh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein LYRIC
Alternative name(s):
Lysine-rich CEACAM1 co-isolated protein
Metadherin
Metastasis adhesion protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mtdh
Synonyms:Lyric
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Rat genome database

More...
RGDi
620992, Mtdh

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 49LumenalSequence analysisAdd BLAST49
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 581CytoplasmicSequence analysisAdd BLAST511

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus, Tight junction

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000845351 – 581Protein LYRICAdd BLAST581

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei142PhosphothreonineBy similarity1
Modified residuei179PhosphoserineBy similarity1
Modified residuei215PhosphoserineBy similarity1
Modified residuei250PhosphoserineBy similarity1
Modified residuei263N6-acetyllysineBy similarity1
Modified residuei297PhosphoserineCombined sources1
Modified residuei305PhosphoserineBy similarity1
Modified residuei310PhosphoserineBy similarity1
Modified residuei343PhosphoserineBy similarity1
Modified residuei368PhosphoserineBy similarity1
Modified residuei414PhosphoserineBy similarity1
Modified residuei425PhosphoserineCombined sources1
Modified residuei456PhosphoserineCombined sources1
Modified residuei477PhosphoserineBy similarity1
Modified residuei493PhosphoserineBy similarity1
Modified residuei495PhosphoserineBy similarity1
Modified residuei567PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Z1W6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Z1W6

PeptideAtlas

More...
PeptideAtlasi
Q9Z1W6

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z1W6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Z1W6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Z1W6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9Z1W6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels in liver, kidney, prostate and small intestine. Not detected in endothelial cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000006870, Expressed in quadriceps femoris and 21 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Z1W6, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BCCIP, CREBBP/CBP and RELA/p65.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9Z1W6, 5 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000009989

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Z1W6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 71Activation of NF-kappa-BBy similarityAdd BLAST71
Regioni72 – 168Interaction with BCCIPBy similarityAdd BLAST97
Regioni77 – 221DisorderedSequence analysisAdd BLAST145
Regioni100 – 204Interaction with RELABy similarityAdd BLAST105
Regioni280 – 581DisorderedSequence analysisAdd BLAST302
Regioni380 – 442Lung-homing for mammary tumorsBy similarityAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi105 – 143Basic and acidic residuesSequence analysisAdd BLAST39
Compositional biasi170 – 198Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi280 – 301Polar residuesSequence analysisAdd BLAST22
Compositional biasi311 – 336Polar residuesSequence analysisAdd BLAST26
Compositional biasi343 – 368Polar residuesSequence analysisAdd BLAST26
Compositional biasi419 – 439Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi451 – 478Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi487 – 501Polar residuesSequence analysisAdd BLAST15
Compositional biasi521 – 565Polar residuesSequence analysisAdd BLAST45

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QU7P, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154181

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_034908_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Z1W6

Identification of Orthologs from Complete Genome Data

More...
OMAi
KNRGSHE

Database of Orthologous Groups

More...
OrthoDBi
1432988at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Z1W6

TreeFam database of animal gene trees

More...
TreeFami
TF331350

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031402, LYRIC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15686, LYRIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Z1W6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAARSWQDEL AQQAEEGSAR LRELLSVGLG FLRTELGLDL GLEPKRYPSW
60 70 80 90 100
VILVGTGALG LLLLFLLGYG WAAACAGARK KRRSPPRKRE EVTPPTPAPE
110 120 130 140 150
DPAQLKNLRS EEQKKKNRKK LPEKPKPNGR TVEIPEDEVV RTPRSITAKQ
160 170 180 190 200
PPETDKKNEK SKKNKKKSKS DAKAVQNSSR HDGKEVDEGA WETKISHREK
210 220 230 240 250
RQQRKRDKVL TDSGSLDSTI PGIENTITVT TEQLTTASFP VGSKKNKGDS
260 270 280 290 300
HLNVQVSNFK SGKGDSTLQV SSGLNENITV NGGGWSEKSV KLSSQLSAGE
310 320 330 340 350
EKWNSVPPAS AGKRKTEQSA WTQDPGDTNA NGKDWGRNWS DRSIFSGIGS
360 370 380 390 400
TAEPVSQSTT SDYQWDGSRN QPHIDDEWSG LNGLSSADPS SDWNAPAEEW
410 420 430 440 450
GNWVDEDRAS LLKSQEPISN DQKDSDDDKE KGEGALPTGK SKKKKKKKKK
460 470 480 490 500
QGEDNSITQD TEDLEKDTRE ELPVNTSKAR PKQEKACSLK TMSTSDPVEV
510 520 530 540 550
LIKNSQPIKT LPPAISAEPS VTLSKGDSDK SSSQVPPMLQ DTDKPKSNAK
560 570 580
QNSVPPSQTK SETNWESPKQ IKKKKKARRE T
Length:581
Mass (Da):63,969
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F86534238C3513C
GO
Isoform 2 (identifier: Q9Z1W6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-269: Missing.

Show »
Length:559
Mass (Da):61,669
Checksum:i6A2D604D37556D39
GO
Isoform 3 (identifier: Q9Z1W6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     349-382: Missing.

Show »
Length:547
Mass (Da):60,221
Checksum:i85792C6633BBDB9D
GO
Isoform 4 (identifier: Q9Z1W6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-269: Missing.
     349-382: Missing.

Show »
Length:525
Mass (Da):57,921
Checksum:iF8CB16CB4878988C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012227248 – 269Missing in isoform 2 and isoform 4. CuratedAdd BLAST22
Alternative sequenceiVSP_012228349 – 382Missing in isoform 3 and isoform 4. CuratedAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF100421 mRNA Translation: AAC72405.2

NCBI Reference Sequences

More...
RefSeqi
NP_596889.1, NM_133398.1 [Q9Z1W6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000009989; ENSRNOP00000009989; ENSRNOG00000006870 [Q9Z1W6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
170910

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:170910

UCSC genome browser

More...
UCSCi
RGD:620992, rat [Q9Z1W6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100421 mRNA Translation: AAC72405.2
RefSeqiNP_596889.1, NM_133398.1 [Q9Z1W6-1]

3D structure databases

SMRiQ9Z1W6
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9Z1W6, 5 interactors
STRINGi10116.ENSRNOP00000009989

PTM databases

iPTMnetiQ9Z1W6
PhosphoSitePlusiQ9Z1W6
SwissPalmiQ9Z1W6

Proteomic databases

jPOSTiQ9Z1W6
PaxDbiQ9Z1W6
PeptideAtlasiQ9Z1W6
PRIDEiQ9Z1W6

Genome annotation databases

EnsembliENSRNOT00000009989; ENSRNOP00000009989; ENSRNOG00000006870 [Q9Z1W6-1]
GeneIDi170910
KEGGirno:170910
UCSCiRGD:620992, rat [Q9Z1W6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
92140
RGDi620992, Mtdh

Phylogenomic databases

eggNOGiENOG502QU7P, Eukaryota
GeneTreeiENSGT00940000154181
HOGENOMiCLU_034908_0_0_1
InParanoidiQ9Z1W6
OMAiKNRGSHE
OrthoDBi1432988at2759
PhylomeDBiQ9Z1W6
TreeFamiTF331350

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9Z1W6

Gene expression databases

BgeeiENSRNOG00000006870, Expressed in quadriceps femoris and 21 other tissues
GenevisibleiQ9Z1W6, RN

Family and domain databases

InterProiView protein in InterPro
IPR031402, LYRIC
PfamiView protein in Pfam
PF15686, LYRIC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLYRIC_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z1W6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: October 1, 2001
Last modified: September 29, 2021
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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