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Protein

Stress-associated endoplasmic reticulum protein 1

Gene

Serp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-381038 XBP1(S) activates chaperone genes

Names & Taxonomyi

Protein namesi
Recommended name:
Stress-associated endoplasmic reticulum protein 1
Alternative name(s):
Ribosome-attached membrane protein 4
Gene namesi
Name:Serp1
Synonyms:D3Ucla1, Ramp4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:92638 Serp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
Transmembranei39 – 59Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini60 – 66ExtracellularSequence analysis7

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002747951 – 66Stress-associated endoplasmic reticulum protein 1Add BLAST66

Proteomic databases

MaxQBiQ9Z1W5
PaxDbiQ9Z1W5
PRIDEiQ9Z1W5

PTM databases

PhosphoSitePlusiQ9Z1W5

Expressioni

Gene expression databases

BgeeiENSMUSG00000027808 Expressed in 293 organ(s), highest expression level in saliva-secreting gland
GenevisibleiQ9Z1W5 MM

Interactioni

Subunit structurei

Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029385

Structurei

3D structure databases

ProteinModelPortaliQ9Z1W5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3491 Eukaryota
ENOG411221U LUCA
GeneTreeiENSGT00390000012245
HOVERGENiHBG058555
InParanoidiQ9Z1W5
OMAiTSQWLIG
OrthoDBiEOG091G17CZ
PhylomeDBiQ9Z1W5
TreeFamiTF313229

Family and domain databases

InterProiView protein in InterPro
IPR010580 ER_stress-assoc
PANTHERiPTHR15601 PTHR15601, 1 hit
PfamiView protein in Pfam
PF06624 RAMP4, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z1W5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAKQRIRMA NEKHSKNITQ RGNVAKTSRN APEEKASVGP WLLALFIFVV
60
CGSAIFQIIQ SIRMGM
Length:66
Mass (Da):7,374
Last modified:May 1, 1999 - v1
Checksum:iDC15C0143AAE0D91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002653 mRNA Translation: BAB22260.1
AB041655 mRNA Translation: BAB93547.1
AK032680 mRNA Translation: BAC27985.1
AK050508 mRNA Translation: BAC34297.1
AK075776 mRNA Translation: BAC35950.1
AK144732 mRNA Translation: BAE26037.1
AK148485 mRNA Translation: BAE28580.1
AK149786 mRNA Translation: BAE29083.1
AK150005 mRNA Translation: BAE29232.1
AK150025 mRNA Translation: BAE29250.1
AK150368 mRNA Translation: BAE29501.1
AK150428 mRNA Translation: BAE29551.1
AK150659 mRNA Translation: BAE29745.1
AK150714 mRNA Translation: BAE29792.1
AK150770 mRNA Translation: BAE29836.1
AK150809 mRNA Translation: BAE29872.1
AK151323 mRNA Translation: BAE30304.1
AK151384 mRNA Translation: BAE30356.1
AK151456 mRNA Translation: BAE30415.1
AK151669 mRNA Translation: BAE30595.1
AK152373 mRNA Translation: BAE31163.1
AK152383 mRNA Translation: BAE31171.1
AK152583 mRNA Translation: BAE31333.1
AK152636 mRNA Translation: BAE31378.1
AK152806 mRNA Translation: BAE31511.1
AK152882 mRNA Translation: BAE31567.1
AK152996 mRNA Translation: BAE31639.1
AK153056 mRNA Translation: BAE31682.1
AK153118 mRNA Translation: BAE31733.1
AK153138 mRNA Translation: BAE31750.1
AK153286 mRNA Translation: BAE31869.1
AK153415 mRNA Translation: BAE31975.1
AK159271 mRNA Translation: BAE34950.1
AK161595 mRNA Translation: BAE36482.1
AK166004 mRNA Translation: BAE38513.1 Different termination.
AK166052 mRNA Translation: BAE38545.1
AK167482 mRNA Translation: BAE39563.1
AK167952 mRNA Translation: BAE39953.1
AK168046 mRNA Translation: BAE40028.1
AK168569 mRNA Translation: BAE40439.1
AK168734 mRNA Translation: BAE40575.1
AK168754 mRNA Translation: BAE40592.1
AK168947 mRNA Translation: BAE40753.1
AK169049 mRNA Translation: BAE40837.1
AK169175 mRNA Translation: BAE40954.1
AK170734 mRNA Translation: BAE41989.1
BC002114 mRNA Translation: AAH02114.1
CCDSiCCDS38436.1
RefSeqiNP_109610.1, NM_030685.3
UniGeneiMm.29702

Genome annotation databases

EnsembliENSMUST00000029385; ENSMUSP00000029385; ENSMUSG00000027808
GeneIDi28146
KEGGimmu:28146
UCSCiuc008phs.2 mouse

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002653 mRNA Translation: BAB22260.1
AB041655 mRNA Translation: BAB93547.1
AK032680 mRNA Translation: BAC27985.1
AK050508 mRNA Translation: BAC34297.1
AK075776 mRNA Translation: BAC35950.1
AK144732 mRNA Translation: BAE26037.1
AK148485 mRNA Translation: BAE28580.1
AK149786 mRNA Translation: BAE29083.1
AK150005 mRNA Translation: BAE29232.1
AK150025 mRNA Translation: BAE29250.1
AK150368 mRNA Translation: BAE29501.1
AK150428 mRNA Translation: BAE29551.1
AK150659 mRNA Translation: BAE29745.1
AK150714 mRNA Translation: BAE29792.1
AK150770 mRNA Translation: BAE29836.1
AK150809 mRNA Translation: BAE29872.1
AK151323 mRNA Translation: BAE30304.1
AK151384 mRNA Translation: BAE30356.1
AK151456 mRNA Translation: BAE30415.1
AK151669 mRNA Translation: BAE30595.1
AK152373 mRNA Translation: BAE31163.1
AK152383 mRNA Translation: BAE31171.1
AK152583 mRNA Translation: BAE31333.1
AK152636 mRNA Translation: BAE31378.1
AK152806 mRNA Translation: BAE31511.1
AK152882 mRNA Translation: BAE31567.1
AK152996 mRNA Translation: BAE31639.1
AK153056 mRNA Translation: BAE31682.1
AK153118 mRNA Translation: BAE31733.1
AK153138 mRNA Translation: BAE31750.1
AK153286 mRNA Translation: BAE31869.1
AK153415 mRNA Translation: BAE31975.1
AK159271 mRNA Translation: BAE34950.1
AK161595 mRNA Translation: BAE36482.1
AK166004 mRNA Translation: BAE38513.1 Different termination.
AK166052 mRNA Translation: BAE38545.1
AK167482 mRNA Translation: BAE39563.1
AK167952 mRNA Translation: BAE39953.1
AK168046 mRNA Translation: BAE40028.1
AK168569 mRNA Translation: BAE40439.1
AK168734 mRNA Translation: BAE40575.1
AK168754 mRNA Translation: BAE40592.1
AK168947 mRNA Translation: BAE40753.1
AK169049 mRNA Translation: BAE40837.1
AK169175 mRNA Translation: BAE40954.1
AK170734 mRNA Translation: BAE41989.1
BC002114 mRNA Translation: AAH02114.1
CCDSiCCDS38436.1
RefSeqiNP_109610.1, NM_030685.3
UniGeneiMm.29702

3D structure databases

ProteinModelPortaliQ9Z1W5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029385

PTM databases

PhosphoSitePlusiQ9Z1W5

Proteomic databases

MaxQBiQ9Z1W5
PaxDbiQ9Z1W5
PRIDEiQ9Z1W5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029385; ENSMUSP00000029385; ENSMUSG00000027808
GeneIDi28146
KEGGimmu:28146
UCSCiuc008phs.2 mouse

Organism-specific databases

CTDi27230
MGIiMGI:92638 Serp1

Phylogenomic databases

eggNOGiKOG3491 Eukaryota
ENOG411221U LUCA
GeneTreeiENSGT00390000012245
HOVERGENiHBG058555
InParanoidiQ9Z1W5
OMAiTSQWLIG
OrthoDBiEOG091G17CZ
PhylomeDBiQ9Z1W5
TreeFamiTF313229

Enzyme and pathway databases

ReactomeiR-MMU-381038 XBP1(S) activates chaperone genes

Miscellaneous databases

ChiTaRSiSerp1 mouse
PROiPR:Q9Z1W5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027808 Expressed in 293 organ(s), highest expression level in saliva-secreting gland
GenevisibleiQ9Z1W5 MM

Family and domain databases

InterProiView protein in InterPro
IPR010580 ER_stress-assoc
PANTHERiPTHR15601 PTHR15601, 1 hit
PfamiView protein in Pfam
PF06624 RAMP4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSERP1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1W5
Secondary accession number(s): Q3TMC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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