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Protein

Connector enhancer of kinase suppressor of ras 2

Gene

Cnksr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as an adapter protein or regulator of Ras signaling pathways, in synaptic junctions.

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

  • postsynapse organization Source: SynGO
  • regulation of signal transduction Source: InterPro

Enzyme and pathway databases

ReactomeiR-RNO-5674135 MAP2K and MAPK activation

Names & Taxonomyi

Protein namesi
Recommended name:
Connector enhancer of kinase suppressor of ras 2
Short name:
Connector enhancer of KSR 2
Alternative name(s):
CNK homolog protein 2
Short name:
CNK2
Membrane-associated guanylate kinase-interacting protein
Short name:
Maguin
Gene namesi
Name:Cnksr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi708454 Cnksr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899721 – 1032Connector enhancer of kinase suppressor of ras 2Add BLAST1032

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Modified residuei338PhosphoserineBy similarity1
Modified residuei390PhosphoserineCombined sources1
Modified residuei683PhosphotyrosineBy similarity1
Modified residuei685PhosphoserineCombined sources1
Modified residuei687PhosphoserineCombined sources1
Modified residuei756PhosphoserineCombined sources1
Modified residuei767PhosphoserineCombined sources1
Modified residuei906PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z1T4
PRIDEiQ9Z1T4

PTM databases

iPTMnetiQ9Z1T4
PhosphoSitePlusiQ9Z1T4

Expressioni

Tissue specificityi

Expressed in neurons and localized in the cell body and neurites.1 Publication

Gene expression databases

BgeeiENSRNOG00000007014 Expressed in 8 organ(s), highest expression level in brain
GenevisibleiQ9Z1T4 RN

Interactioni

Subunit structurei

Interacts with RAF1, RAB2L and RAL GTPase proteins (By similarity). Interacts with DLG4 and AIP1.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248765, 1 interactor
IntActiQ9Z1T4, 3 interactors
MINTiQ9Z1T4
STRINGi10116.ENSRNOP00000009802

Structurei

3D structure databases

ProteinModelPortaliQ9Z1T4
SMRiQ9Z1T4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 76SAMPROSITE-ProRule annotationAdd BLAST66
Domaini84 – 178CRICPROSITE-ProRule annotationAdd BLAST95
Domaini215 – 297PDZPROSITE-ProRule annotationAdd BLAST83
Domaini332 – 515DUF1170Add BLAST184
Domaini570 – 669PHPROSITE-ProRule annotationAdd BLAST100

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili874 – 917Sequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi354 – 357Poly-Pro4
Compositional biasi703 – 706Poly-Pro4
Compositional biasi875 – 886Poly-GluAdd BLAST12

Sequence similaritiesi

Belongs to the CNKSR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1738 Eukaryota
ENOG4110T89 LUCA
GeneTreeiENSGT00390000017199
HOGENOMiHOG000231501
HOVERGENiHBG051040
InParanoidiQ9Z1T4
KOiK17536
OMAiTSLYWYI
OrthoDBiEOG091G037J
PhylomeDBiQ9Z1T4
TreeFamiTF326495

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR010599 CNKSR2
IPR017874 CRIC_domain
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF10534 CRIC_ras_sig, 1 hit
PF06663 DUF1170, 1 hit
PF00595 PDZ, 1 hit
PF00169 PH, 1 hit
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51290 CRIC, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Z1T4-1) [UniParc]FASTAAdd to basket
Also known as: Maguin-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALIMEPVSK WSPSQVVDWM KGLDDCLQQY IKNFEREKIS GDQLLRITHQ
60 70 80 90 100
ELEDLGVSRI GHQELILEAV DLLCALNYGL ETENLKTLSH KLNASAKNLQ
110 120 130 140 150
NFITGRRRSG HYDGRTSRKL PNDFLTSVVD LIGAAKSLLA WLDRSPFAAV
160 170 180 190 200
TDYSVTRNNV IQLCLELTTI VQQDCTVYET ENKILHVCKT LSGVCDHIIS
210 220 230 240 250
LSSDPLVSQS AHLEVIQLAN IKPSEGLGMY IKSTYDGLHV ITGTTENSPA
260 270 280 290 300
DRCKKIHAGD EVIQVNHQTV VGWQLKNLVN ALREDPSGVI LTLKKRPQSM
310 320 330 340 350
LTSAPALLKN MRWKPLALQP LIPRSPTSSV ATPSSTISTP TKRDSSALQD
360 370 380 390 400
LYIPPPPAEP YIPRDEKGNL PCEDLRGHMV GKPVHKGSES PNSFLDQEYR
410 420 430 440 450
KRFNIVEEDT VLYCYEYEKG RSSSQGRRES TPTYGKLRPI SMPVEYNWVG
460 470 480 490 500
DYEDPNKMKR DSRRENSLLR YMSNEKIAQE EYMFQRNSKK DTGKKSKKKG
510 520 530 540 550
DKSTSPTHYS LLPSLQMDAL RQDIMGTPVP ETTLYHTFQQ SSLQHKSKKK
560 570 580 590 600
NKGAIAGKSK RRISCKDLGR GDCEGWLWKK KDAKSYFSQK WKKYWFVLKD
610 620 630 640 650
ASLYWYINEE DEKAEGFISL PEFKIDRASE CRKKYAFKAC HPKIKSFYFA
660 670 680 690 700
AEHLDDMNRW LNRINMLTAG YAERERIKQE QDYWSESDKE EADTPSTPKQ
710 720 730 740 750
DSPPPPYDTY PRPPSMSCAS PYVEAKHSRL SSTETSQSQS SHEEFRQEVT
760 770 780 790 800
GSSAVSPIRK TASQRRSWQD LIETPLTSSG LHYLQTLPLE DSVFSDSAAI
810 820 830 840 850
SPEHRRQSTL PTQKCHLQDH YGPYPLAESE RMQVLNGNGG KPRSFTLPRD
860 870 880 890 900
SGFNHCCLNA PVSACDPQDD IQPPEVEEEE EEEEEEAAGE NIGEKNENRE
910 920 930 940 950
EKLGDSLQDL YRALEEASLS PLGEHRISTK IEYKLSFIKR CNDPVMNEKL
960 970 980 990 1000
HRLRILKSTL KAREGEVAII DKVLDNPDLT SKEFQQWKQM YLDLFLDICQ
1010 1020 1030
NTTSNDPLSI SSEVDVITSS LTHTHSYIET HV
Length:1,032
Mass (Da):117,390
Last modified:May 1, 1999 - v1
Checksum:i02BD762461F8D7EC
GO
Isoform 2 (identifier: Q9Z1T4-2) [UniParc]FASTAAdd to basket
Also known as: Maguin-2

The sequence of this isoform differs from the canonical sequence as follows:
     896-896: N → S
     897-1032: Missing.

Show »
Length:896
Mass (Da):101,663
Checksum:iD8F73127405D1AA7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010891896N → S in isoform 2. 1 Publication1
Alternative sequenceiVSP_010892897 – 1032Missing in isoform 2. 1 PublicationAdd BLAST136

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102853 mRNA Translation: AAD04567.1
AF102854 mRNA Translation: AAD04568.1
PIRiT18293
RefSeqiNP_001106837.1, NM_001113366.1 [Q9Z1T4-1]
NP_067718.1, NM_021686.3 [Q9Z1T4-2]
UniGeneiRn.42893

Genome annotation databases

EnsembliENSRNOT00000009802; ENSRNOP00000009802; ENSRNOG00000007014 [Q9Z1T4-1]
ENSRNOT00000080512; ENSRNOP00000071915; ENSRNOG00000007014 [Q9Z1T4-2]
GeneIDi59322
KEGGirno:59322

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102853 mRNA Translation: AAD04567.1
AF102854 mRNA Translation: AAD04568.1
PIRiT18293
RefSeqiNP_001106837.1, NM_001113366.1 [Q9Z1T4-1]
NP_067718.1, NM_021686.3 [Q9Z1T4-2]
UniGeneiRn.42893

3D structure databases

ProteinModelPortaliQ9Z1T4
SMRiQ9Z1T4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248765, 1 interactor
IntActiQ9Z1T4, 3 interactors
MINTiQ9Z1T4
STRINGi10116.ENSRNOP00000009802

PTM databases

iPTMnetiQ9Z1T4
PhosphoSitePlusiQ9Z1T4

Proteomic databases

PaxDbiQ9Z1T4
PRIDEiQ9Z1T4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009802; ENSRNOP00000009802; ENSRNOG00000007014 [Q9Z1T4-1]
ENSRNOT00000080512; ENSRNOP00000071915; ENSRNOG00000007014 [Q9Z1T4-2]
GeneIDi59322
KEGGirno:59322

Organism-specific databases

CTDi22866
RGDi708454 Cnksr2

Phylogenomic databases

eggNOGiKOG1738 Eukaryota
ENOG4110T89 LUCA
GeneTreeiENSGT00390000017199
HOGENOMiHOG000231501
HOVERGENiHBG051040
InParanoidiQ9Z1T4
KOiK17536
OMAiTSLYWYI
OrthoDBiEOG091G037J
PhylomeDBiQ9Z1T4
TreeFamiTF326495

Enzyme and pathway databases

ReactomeiR-RNO-5674135 MAP2K and MAPK activation

Miscellaneous databases

PROiPR:Q9Z1T4

Gene expression databases

BgeeiENSRNOG00000007014 Expressed in 8 organ(s), highest expression level in brain
GenevisibleiQ9Z1T4 RN

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR010599 CNKSR2
IPR017874 CRIC_domain
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF10534 CRIC_ras_sig, 1 hit
PF06663 DUF1170, 1 hit
PF00595 PDZ, 1 hit
PF00169 PH, 1 hit
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51290 CRIC, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50105 SAM_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCNKR2_RAT
AccessioniPrimary (citable) accession number: Q9Z1T4
Secondary accession number(s): Q9R093
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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