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Protein

Neuronal-specific septin-3

Gene

Sept3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102GTPBy similarity1
Binding sitei265GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei280GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 75GTPBy similarity8
Nucleotide bindingi208 – 216GTPBy similarity9

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: MGI
  • identical protein binding Source: MGI
  • protein-containing complex scaffold activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal-specific septin-3
Gene namesi
Name:Sept3
Synonyms:Sep3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1345148 Sept3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735181 – 350Neuronal-specific septin-3Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z1S5
PeptideAtlasiQ9Z1S5
PRIDEiQ9Z1S5

2D gel databases

UCD-2DPAGEiQ9Z1S5

PTM databases

iPTMnetiQ9Z1S5
PhosphoSitePlusiQ9Z1S5

Expressioni

Gene expression databases

BgeeiENSMUSG00000022456 Expressed in 222 organ(s), highest expression level in cerebellum
CleanExiMM_SEPT3
GenevisibleiQ9Z1S5 MM

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204863, 5 interactors
IntActiQ9Z1S5, 6 interactors
MINTiQ9Z1S5
STRINGi10090.ENSMUSP00000023095

Structurei

3D structure databases

ProteinModelPortaliQ9Z1S5
SMRiQ9Z1S5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 331Septin-type GPROSITE-ProRule annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 75G1 motifPROSITE-ProRule annotation8
Regioni125 – 128G3 motifPROSITE-ProRule annotation4
Regioni207 – 210G4 motifPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1547 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144020
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiQ9Z1S5
KOiK16938
OMAiNRWGVVN
OrthoDBiEOG091G08V5
PhylomeDBiQ9Z1S5
TreeFamiTF101078

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
IPR008114 Septin3
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
PRINTSiPR01741 SEPTIN3
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Z1S5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKGLPEART DAAMSELVPE PRPKPAVPMK PVSINSNLLG YIGIDTIIEQ
60 70 80 90 100
MRKKTMKTGF DFNIMVVGQS GLGKSTLVNT LFKSQVSRKA SSWNREEKIP
110 120 130 140 150
KTVEIKAIGH VIEEGGVKMK LTVIDTPGFG DQINNENCWE PIEKYINEQY
160 170 180 190 200
EKFLKEEVNI ARKKRIPDTR VHCCLYFISP TGHSLRPLDL EFMKHLSKVV
210 220 230 240 250
NIIPVIAKAD TMTLEEKSEF KQRVRKELEV NGIEFYPQKE FDEDLEDKTE
260 270 280 290 300
NDKIRQESMP FAVVGSDKEY QVNGKRVLGR KTPWGIIEVE NLNHCEFALL
310 320 330 340 350
RDFVIRTHLQ DLKEVTHNIH YETYRAKRLN DNGGLPPVSV DTEESHDSNP
Length:350
Mass (Da):40,038
Last modified:May 15, 2007 - v2
Checksum:iAEF37C023AB21C0D
GO
Isoform 2 (identifier: Q9Z1S5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Show »
Length:337
Mass (Da):38,709
Checksum:iC090F23E9C97B919
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8W6V9A0A2R8W6V9_MOUSE
Neuronal-specific septin-3
Sept3 mCG_133080
341Annotation score:
A0A2R8VHR7A0A2R8VHR7_MOUSE
Neuronal-specific septin-3
Sept3
201Annotation score:
A0A2R8VHB2A0A2R8VHB2_MOUSE
Neuronal-specific septin-3
Sept3
75Annotation score:

Sequence cautioni

The sequence AAD02884 differs from that shown. Reason: Frameshift at position 344.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221 – 235KQRVR…NGIEF → LPSEGI in AAD02884 (PubMed:10446280).CuratedAdd BLAST15

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0254001 – 13Missing in isoform 2. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104411 mRNA Translation: AAD02884.1 Frameshift.
AK164861 mRNA Translation: BAE37945.1
AK169916 mRNA Translation: BAE41456.1
AK141915 mRNA Translation: BAE24884.1
BC055738 mRNA Translation: AAH55738.1
CCDSiCCDS37157.1 [Q9Z1S5-2]
RefSeqiNP_036019.2, NM_011889.2 [Q9Z1S5-2]
UniGeneiMm.309707

Genome annotation databases

EnsembliENSMUST00000023095; ENSMUSP00000023095; ENSMUSG00000022456 [Q9Z1S5-2]
ENSMUST00000116423; ENSMUSP00000112124; ENSMUSG00000022456 [Q9Z1S5-2]
GeneIDi24050
KEGGimmu:24050
UCSCiuc007wyq.1 mouse [Q9Z1S5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104411 mRNA Translation: AAD02884.1 Frameshift.
AK164861 mRNA Translation: BAE37945.1
AK169916 mRNA Translation: BAE41456.1
AK141915 mRNA Translation: BAE24884.1
BC055738 mRNA Translation: AAH55738.1
CCDSiCCDS37157.1 [Q9Z1S5-2]
RefSeqiNP_036019.2, NM_011889.2 [Q9Z1S5-2]
UniGeneiMm.309707

3D structure databases

ProteinModelPortaliQ9Z1S5
SMRiQ9Z1S5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204863, 5 interactors
IntActiQ9Z1S5, 6 interactors
MINTiQ9Z1S5
STRINGi10090.ENSMUSP00000023095

PTM databases

iPTMnetiQ9Z1S5
PhosphoSitePlusiQ9Z1S5

2D gel databases

UCD-2DPAGEiQ9Z1S5

Proteomic databases

PaxDbiQ9Z1S5
PeptideAtlasiQ9Z1S5
PRIDEiQ9Z1S5

Protocols and materials databases

DNASUi24050
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023095; ENSMUSP00000023095; ENSMUSG00000022456 [Q9Z1S5-2]
ENSMUST00000116423; ENSMUSP00000112124; ENSMUSG00000022456 [Q9Z1S5-2]
GeneIDi24050
KEGGimmu:24050
UCSCiuc007wyq.1 mouse [Q9Z1S5-1]

Organism-specific databases

CTDi55964
MGIiMGI:1345148 Sept3

Phylogenomic databases

eggNOGiKOG1547 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144020
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiQ9Z1S5
KOiK16938
OMAiNRWGVVN
OrthoDBiEOG091G08V5
PhylomeDBiQ9Z1S5
TreeFamiTF101078

Miscellaneous databases

PROiPR:Q9Z1S5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022456 Expressed in 222 organ(s), highest expression level in cerebellum
CleanExiMM_SEPT3
GenevisibleiQ9Z1S5 MM

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
IPR008114 Septin3
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
PRINTSiPR01741 SEPTIN3
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEPT3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1S5
Secondary accession number(s): Q3TNZ2, Q7TNT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 15, 2007
Last modified: November 7, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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