Bub1b

Functionⁱ

Essential component of the mitotic checkpoint. Required for normal mitosis progression and tumor suppression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. Essential for tumor suppression. May play a role in regulating aging and fertility (By similarity).By similarity2 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Activity regulationⁱ

Kinase activity stimulated by CENPE.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	784	ATPPROSITE-ProRule annotation		1
Active siteⁱ	871	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	762 – 770	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein serine/threonine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
cell division Source: UniProtKB-KW
meiotic sister chromatid cohesion, centromeric
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metaphase/anaphase transition of mitotic cell cycle
Source: MGI
Inferred from genetic interactionⁱ
- 15767571
mitotic spindle assembly checkpoint
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein localization to chromosome, centromeric region
Source: MGI
Inferred from mutant phenotypeⁱ
- 19283064
protein localization to kinetochore Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Apoptosis, Cell cycle, Cell division, Mitosis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.11.1 3474
Reactomeⁱ	R-MMU-141430 Inactivation of APC/C via direct inhibition of the APC/C complex R-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-MMU-176409 APC/C:Cdc20 mediated degradation of mitotic proteins R-MMU-179409 APC-Cdc20 mediated degradation of Nek2A R-MMU-2467813 Separation of Sister Chromatids R-MMU-2500257 Resolution of Sister Chromatid Cohesion R-MMU-5663220 RHO GTPases Activate Formins R-MMU-68877 Mitotic Prometaphase

BRENDAⁱ

2.7.11.1 3474

Reactomeⁱ

R-MMU-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-MMU-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-MMU-179409 APC-Cdc20 mediated degradation of Nek2A
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC:2.7.11.1) Alternative name(s): MAD3/BUB1-related protein kinase Short name: BubR1 Mitotic checkpoint kinase MAD3L
Gene namesⁱ	Name:Bub1b Synonyms:Mad3l
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:1333889 Bub1b

Keywords - Cellular componentⁱ

Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Defects in Bub1b are involved in the development of lung and intestinal adenocarcinomas after exposure to a carcinogen.

Disruption phenotypeⁱ

Mice die in utero.1 Publication

Keywords - Diseaseⁱ

Tumor suppressor

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000085674	1 – 1052	Mitotic checkpoint serine/threonine-protein kinase BUB1 betaAdd BLAST		1052

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	243	N6-acetyllysine; by PCAFBy similarity	1
Modified residueⁱ	360	PhosphoserineBy similarity	1
Modified residueⁱ	428	PhosphoserineBy similarity	1
Modified residueⁱ	535	PhosphoserineBy similarity	1
Modified residueⁱ	659	PhosphoserineBy similarity	1
Modified residueⁱ	665	Phosphoserine; by PLK1By similarity	1
Modified residueⁱ	686	PhosphoserineBy similarity	1
Modified residueⁱ	781	Phosphothreonine; by PLK1By similarity	1
Modified residueⁱ	998	Phosphothreonine; by PLK1By similarity	1
Modified residueⁱ	1033	PhosphoserineBy similarity	1
Modified residueⁱ	1050	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Proteolytically cleaved by caspase-3 in a cell cycle specific manner. The cleavage might be involved in the durability of the cell cycle delay.By similarity

Acetylation at Lys-243 regulates its degradation and timing in anaphase entry.By similarity

Ubiquitinated. Degraded by the proteasome (By similarity).By similarity

Sumoylated with SUMO2 and SUMO3. The sumoylation mediates the association with CENPE at the kinetochore (By similarity).By similarity

Autophosphorylated in vitro. Intramolecular autophosphorylation stimulated by CENPE. Phosphorylated during mitosis and hyperphosphorylated in mitotically arrested cells. Phosphorylation at Ser-659 and Ser-1033 occurs at kinetochores upon mitotic entry with dephosphorylation at the onset of anaphase.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	572 – 573	Cleavage; by caspase-3By similarity		2
Siteⁱ	603 – 604	Cleavage; by caspase-3By similarity		2

Keywords - PTMⁱ

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9Z1S0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9Z1S0
PaxDbⁱ	Q9Z1S0
PeptideAtlas More...PeptideAtlasⁱ	Q9Z1S0
PRIDEⁱ	Q9Z1S0

PTM databases

iPTMnetⁱ	Q9Z1S0
PhosphoSitePlusⁱ	Q9Z1S0

Expressionⁱ

Tissue specificityⁱ

Highly expressed in thymus followed by spleen.

Gene expression databases

Bgeeⁱ	ENSMUSG00000040084 Expressed in 231 organ(s), highest expression level in secondary oocyte
Genevisibleⁱ	Q9Z1S0 MM

Interactionⁱ

Subunit structureⁱ

Interacts with CENPE (PubMed:12925705). Interacts with CENPF, mitosin, PLK1 and BUB3. Part of a complex containing BUB3, CDC20 and BUB1B. Interacts with anaphase-promoting complex/cyclosome (APC/C). Interacts with KNL1. Interacts with RIPK3 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridⁱ	198405, 50 interactors
IntActⁱ	Q9Z1S0, 47 interactors
STRINGⁱ	10090.ENSMUSP00000037126

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Z1S0
SMRⁱ	Q9Z1S0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	56 – 219	BUB1 N-terminalPROSITE-ProRule annotationAdd BLAST		164
Domainⁱ	756 – 1040	Protein kinasePROSITE-ProRule annotationAdd BLAST		285

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	146 – 179	Necessary for interaction with KNL1By similarityAdd BLAST		34

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	105 – 112	Nuclear localization signalSequence analysis		8
Motifⁱ	217 – 225	D-box		9

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	205 – 208	Poly-Glu		4
Compositional biasⁱ	675 – 680	Poly-Ser		6

Domainⁱ

The D-box targets the protein for rapid degradation by ubiquitin-dependent proteolysis during the transition from mitosis to interphase.Curated

The BUB1 N-terminal domain directs kinetochore localization and binding to BUB3.

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG410IQA2 Eukaryota ENOG410XUW7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00520000055622
HOGENOMⁱ	HOG000231849
HOVERGENⁱ	HBG050748
InParanoidⁱ	Q9Z1S0
KEGG Orthology (KO) More...KOⁱ	K06637
OMAⁱ	DHLCSCY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01MC
TreeFamⁱ	TF105456

Family and domain databases

InterProⁱ	View protein in InterPro IPR015661 Bub1/Mad3 IPR011009 Kinase-like_dom_sf IPR013212 Mad3/Bub1_I IPR000719 Prot_kinase_dom
PANTHERⁱ	PTHR14030 PTHR14030, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08311 Mad3_BUB1_I, 1 hit
SMARTⁱ	View protein in SMART SM00777 Mad3_BUB1_I, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51489 BUB1_N, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9Z1S0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAEASEAMCL EGAEWELSKE NIQPLRHGRV MSTLQGALAK QESAGHTALQ 
        60         70         80         90        100
QQKRAFESEI RFYSGDDPLD VWDRYINWTE QNYPQGGKES NMSALVERAI 
       110        120        130        140        150
EALQGETRYY NDPRFLSLWI KLGHLCNEPL DMYSYLQSQG IGVSLAQFYI 
       160        170        180        190        200
SWAEEYEARE NFKKADIIFQ EGIERKAEPL DRLQSQHRQF QSRVSRQAFL 
       210        220        230        240        250
ALGNEEEEAL EPSEPQRSSL AELKSRGKKM ARAPISRVGG ALKAPGQSRG 
       260        270        280        290        300
FLNAVPQPVH GNRRITVFDE NADTASRTEL SKPVAQPWMA PPVPRAKENE 
       310        320        330        340        350
LQPGPWSTDR PAGRRPHDNP ASVTSIPSVL PSFTPYVEES AQQTVMTPCK 
       360        370        380        390        400
IEPSINHVLS TRKPGREEGD PLQRVQSHQQ GCEEKKEKMM YCKEKIYAGV 
       410        420        430        440        450
GEFSFEEIRA EVFRKKLKER REAELLTSAK KREEMQKQIE EMERRLKAMQ 
       460        470        480        490        500
AVQQEGAGGQ QEEKMPTEDP ARLQIASGPQ EMSGVPLSCS ICPLSSNPRE 
       510        520        530        540        550
ISPAENILQE QPDSKGSSMP FSIFDESLSD KKDKSPATGG PQVLNAQRRP 
       560        570        580        590        600
LSVLKTTEVG TTNEDVSPDI CDELTELEPL SEDAIITGFR NVTLCPNPED 
       610        620        630        640        650
TCDFARAARL ASTPFHEILS SKGIAADPEG LLQEEDLDGK AAEAHHTVHH 
       660        670        680        690        700
QALIIKKLSP IIEESREATH SSGFSRSSSS APSTSSIKGF QLLEKLELTN 
       710        720        730        740        750
DGAEDAIQSP WCSQYRLQLL KSLLELSAFA EFSVEDRPMP VLEIGKEIEL 
       760        770        780        790        800
GPEDYVIKQE HLTCDDYRLF WVAPRSSAEL TMIKASSQPI PWDFYINLKL 
       810        820        830        840        850
KERLNEDYDQ LCSCCQYQDG HVVWYQYINC STLQNLLQHS EFVTHEIIVL 
       860        870        880        890        900
IIYNLLTIVE KLHRAEIVHG DLSPRSLILR NRIHDPYDYV NKDDHAVRIM 
       910        920        930        940        950
DFSYSVDLRV QLDAFAYSGF RTAQILEGQK ILANCSSPYH VDLLGIADLA 
       960        970        980        990       1000
HLLLFKEHLH VFWDGLLWKL SQSTSELKDS ELWNKFFVRI LNASDKSTVS 
      1010       1020       1030       1040       1050
VLGELAAEMG GAFDATFHSH LNRALWKLGK TISPEALLTQ QDKQPGGSQS 

PA

Length:1,052

Mass (Da):118,392

Last modified:July 27, 2011 - v2

Checksum:ⁱ9EF1ECF3735DD1F4

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	275	A → T in AAD11940 (PubMed:9889005).Curated	1
Sequence conflictⁱ	278	T → P in AAD11940 (PubMed:9889005).Curated	1
Sequence conflictⁱ	664	E → D in AAD11940 (PubMed:9889005).Curated	1
Sequence conflictⁱ	705	D → N in AAD11940 (PubMed:9889005).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF107296 mRNA Translation: AAD11940.1 AL845470, AL929381 Genomic DNA Translation: CAM17418.1 AL929381, AL845470 Genomic DNA Translation: CAM19078.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16579.1
NCBI Reference Sequences More...RefSeqⁱ	NP_033903.2, NM_009773.3
UniGeneⁱ	Mm.29133

Genome annotation databases

Ensemblⁱ	ENSMUST00000038341; ENSMUSP00000037126; ENSMUSG00000040084
GeneIDⁱ	12236
KEGGⁱ	mmu:12236
UCSC genome browser More...UCSCⁱ	uc008lse.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Z1S0	Uncharacterized protein		MOUSE		1052	UniRef90_Q9Z1S0
UPI000A319D2F		MUSCR		1053
UPI000A313AAB		MUSPA		1049
Budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)		MOUSE		1052
UPI0003D77324		MOUSE		1053
+1

Protein	Similar proteins		Species	Score	Length	Source
Q9Z1S0	Isoform 3 of Mitotic checkpoint serine/threonine-protein kinase BUB1 beta		HUMAN		1064	UniRef50_O60566-3
Uncharacterized protein		RHIRO		1073
Uncharacterized protein		MACMU		1066
Uncharacterized protein		MACFA		1064
Uncharacterized protein		MACNE		1058
+182

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF107296 mRNA Translation: AAD11940.1 AL845470, AL929381 Genomic DNA Translation: CAM17418.1 AL929381, AL845470 Genomic DNA Translation: CAM19078.1
CCDSⁱ	CCDS16579.1
RefSeqⁱ	NP_033903.2, NM_009773.3
UniGeneⁱ	Mm.29133

3D structure databases

ProteinModelPortalⁱ	Q9Z1S0
SMRⁱ	Q9Z1S0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198405, 50 interactors
IntActⁱ	Q9Z1S0, 47 interactors
STRINGⁱ	10090.ENSMUSP00000037126

PTM databases

iPTMnetⁱ	Q9Z1S0
PhosphoSitePlusⁱ	Q9Z1S0

Proteomic databases

EPDⁱ	Q9Z1S0
MaxQBⁱ	Q9Z1S0
PaxDbⁱ	Q9Z1S0
PeptideAtlasⁱ	Q9Z1S0
PRIDEⁱ	Q9Z1S0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000038341; ENSMUSP00000037126; ENSMUSG00000040084
GeneIDⁱ	12236
KEGGⁱ	mmu:12236
UCSCⁱ	uc008lse.2 mouse

Organism-specific databases

CTDⁱ	701
MGIⁱ	MGI:1333889 Bub1b

Phylogenomic databases

eggNOGⁱ	ENOG410IQA2 Eukaryota ENOG410XUW7 LUCA
GeneTreeⁱ	ENSGT00520000055622
HOGENOMⁱ	HOG000231849
HOVERGENⁱ	HBG050748
InParanoidⁱ	Q9Z1S0
KOⁱ	K06637
OMAⁱ	DHLCSCY
OrthoDBⁱ	EOG091G01MC
TreeFamⁱ	TF105456

Enzyme and pathway databases

BRENDAⁱ	2.7.11.1 3474
Reactomeⁱ	R-MMU-141430 Inactivation of APC/C via direct inhibition of the APC/C complex R-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-MMU-176409 APC/C:Cdc20 mediated degradation of mitotic proteins R-MMU-179409 APC-Cdc20 mediated degradation of Nek2A R-MMU-2467813 Separation of Sister Chromatids R-MMU-2500257 Resolution of Sister Chromatid Cohesion R-MMU-5663220 RHO GTPases Activate Formins R-MMU-68877 Mitotic Prometaphase

BRENDAⁱ

2.7.11.1 3474

Reactomeⁱ

R-MMU-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-MMU-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-MMU-179409 APC-Cdc20 mediated degradation of Nek2A
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRSⁱ	Bub1b mouse
Protein Ontology More...PROⁱ	PR:Q9Z1S0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000040084 Expressed in 231 organ(s), highest expression level in secondary oocyte
Genevisibleⁱ	Q9Z1S0 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR015661 Bub1/Mad3 IPR011009 Kinase-like_dom_sf IPR013212 Mad3/Bub1_I IPR000719 Prot_kinase_dom
PANTHERⁱ	PTHR14030 PTHR14030, 1 hit
Pfamⁱ	View protein in Pfam PF08311 Mad3_BUB1_I, 1 hit
SMARTⁱ	View protein in SMART SM00777 Mad3_BUB1_I, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51489 BUB1_N, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BUB1B_MOUSE
Accessionⁱ	Q9Z1S0Primary (citable) accession number: Q9Z1S0 Secondary accession number(s): A2ARS1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

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Cytoskeleton

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

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Sequence databases

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Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ