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Protein

Apolipoprotein M

Gene

Apom

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138Fatty acidBy similarity1
Binding sitei145Fatty acidBy similarity1

GO - Molecular functioni

  • antioxidant activity Source: BHF-UCL
  • lipid transporter activity Source: MGI
  • phospholipid binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein M
Short name:
Apo-M
Short name:
ApoM
Gene namesi
Name:Apom
Synonyms:Ng20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1930124 Apom

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232791 – 190Apolipoprotein MAdd BLAST190
Signal peptidei1 – ?22Not cleavedSequence analysisAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 169By similarity
Disulfide bondi95 ↔ 1851 Publication
Disulfide bondi130 ↔ 1591 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9Z1R3
PaxDbiQ9Z1R3
PeptideAtlasiQ9Z1R3
PRIDEiQ9Z1R3

PTM databases

iPTMnetiQ9Z1R3
PhosphoSitePlusiQ9Z1R3

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Gene expression databases

BgeeiENSMUSG00000024391 Expressed in 135 organ(s), highest expression level in liver
CleanExiMM_APOM
GenevisibleiQ9Z1R3 MM

Interactioni

Subunit structurei

Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025249

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Z1R3
SMRiQ9Z1R3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Z1R3

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IG6S Eukaryota
ENOG4111Z0U LUCA
GeneTreeiENSGT00390000001026
HOGENOMiHOG000034009
HOVERGENiHBG018735
InParanoidiQ9Z1R3
OMAiWYFIAGA
OrthoDBiEOG091G0L0Y
PhylomeDBiQ9Z1R3
TreeFamiTF330771

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR022734 ApoM
IPR012674 Calycin
PANTHERiPTHR32028 PTHR32028, 1 hit
PfamiView protein in Pfam
PF11032 ApoM, 1 hit
SUPFAMiSSF50814 SSF50814, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z1R3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFHQVWAALL SLYGLLFNSM NQCPEHSQLT ALGMDDTETP EPHLGLWYFI
60 70 80 90 100
AGAASTTEEL ATFDPVDNIV FNMAAGSAPR QLQLRATIRT KSGVCVPRKW
110 120 130 140 150
TYRLTEGKGN MELRTEGRPD MKTDLFSSSC PGGIMLKETG QGYQRFLLYN
160 170 180 190
RSPHPPEKCV EEFQSLTSCL DFKAFLVTPR NQEACPLSSK
Length:190
Mass (Da):21,273
Last modified:May 1, 1999 - v1
Checksum:i3D5614DADF2B77C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207820 mRNA Translation: AAF23407.1
AF109719 Genomic DNA Translation: AAC82478.1
AK004530 mRNA Translation: BAB23349.1
CCDSiCCDS28687.1
RefSeqiNP_061286.1, NM_018816.1
UniGeneiMm.2161

Genome annotation databases

EnsembliENSMUST00000025249; ENSMUSP00000025249; ENSMUSG00000024391
GeneIDi55938
KEGGimmu:55938
UCSCiuc008cga.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAPOM_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1R3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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