UniProtKB - Q9Z1Q9 (SYVC_MOUSE)
Protein
Valine--tRNA ligase
Gene
Vars
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- EC:6.1.1.9
Activity regulationi
Can be regulated by protein kinase C-dependent phosphorylation.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 864 | ATPBy similarity | 1 |
GO - Molecular functioni
- aminoacyl-tRNA editing activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- valine-tRNA ligase activity Source: MGI
GO - Biological processi
- valyl-tRNA aminoacylation Source: GO_Central
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Valine--tRNA ligase (EC:6.1.1.9)Alternative name(s): Protein G7a Valyl-tRNA synthetase Short name: ValRS |
Gene namesi | Name:Vars Synonyms:Bat6, G7a, Vars2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:90675 Vars |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Mitochondrion
- mitochondrion Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000106254 | 2 – 1263 | Valine--tRNA ligaseAdd BLAST | 1262 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 436 | PhosphoserineBy similarity | 1 | |
Modified residuei | 526 | PhosphoserineBy similarity | 1 | |
Modified residuei | 644 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9Z1Q9 |
jPOSTi | Q9Z1Q9 |
MaxQBi | Q9Z1Q9 |
PaxDbi | Q9Z1Q9 |
PRIDEi | Q9Z1Q9 |
PTM databases
iPTMneti | Q9Z1Q9 |
PhosphoSitePlusi | Q9Z1Q9 |
SwissPalmi | Q9Z1Q9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000007029 Expressed in 227 organ(s), highest expression level in testis |
ExpressionAtlasi | Q9Z1Q9 baseline and differential |
Genevisiblei | Q9Z1Q9 MM |
Interactioni
Subunit structurei
Forms high-molecular-mass aggregates with elongation factor 1.
By similarityProtein-protein interaction databases
BioGridi | 204498, 2 interactors |
IntActi | Q9Z1Q9, 5 interactors |
MINTi | Q9Z1Q9 |
STRINGi | 10090.ENSMUSP00000084572 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 89 – 219 | GST C-terminalAdd BLAST | 131 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 343 – 353 | 'HIGH' regionAdd BLAST | 11 | |
Motifi | 861 – 865 | 'KMSKS' region | 5 |
Sequence similaritiesi
Belongs to the class-I aminoacyl-tRNA synthetase family.Curated
Phylogenomic databases
eggNOGi | KOG0432 Eukaryota KOG0867 Eukaryota COG0525 LUCA |
GeneTreei | ENSGT00940000157775 |
HOGENOMi | HOG000020094 |
InParanoidi | Q9Z1Q9 |
KOi | K01873 |
OMAi | FATKLWN |
OrthoDBi | 229591at2759 |
PhylomeDBi | Q9Z1Q9 |
TreeFami | TF300648 |
Family and domain databases
CDDi | cd07962 Anticodon_Ia_Val, 1 hit |
Gene3Di | 1.10.287.380, 1 hit 3.40.50.620, 1 hit 3.90.740.10, 1 hit |
HAMAPi | MF_02004 Val_tRNA_synth_type1, 1 hit |
InterProi | View protein in InterPro IPR001412 aa-tRNA-synth_I_CS IPR002300 aa-tRNA-synth_Ia IPR033705 Anticodon_Ia_Val IPR010987 Glutathione-S-Trfase_C-like IPR036282 Glutathione-S-Trfase_C_sf IPR004046 GST_C IPR013155 M/V/L/I-tRNA-synth_anticd-bd IPR014729 Rossmann-like_a/b/a_fold IPR009080 tRNAsynth_Ia_anticodon-bd IPR037118 Val-tRNA_synth_C_sf IPR009008 Val/Leu/Ile-tRNA-synth_edit IPR002303 Valyl-tRNA_ligase |
Pfami | View protein in Pfam PF08264 Anticodon_1, 1 hit PF00043 GST_C, 1 hit PF00133 tRNA-synt_1, 1 hit |
PRINTSi | PR00986 TRNASYNTHVAL |
SUPFAMi | SSF47323 SSF47323, 1 hit SSF47616 SSF47616, 1 hit SSF50677 SSF50677, 1 hit |
TIGRFAMsi | TIGR00422 valS, 1 hit |
PROSITEi | View protein in PROSITE PS00178 AA_TRNA_LIGASE_I, 1 hit PS50405 GST_CTER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q9Z1Q9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSILYVSPHP DAFPSLRALI AARYGEAGDG PGWGGPHPRI CLQPPPSSRT
60 70 80 90 100
PFPPPRLPAL EQGPGGLWVW GAPAVAQLLW PAGLGGPGGS RAAVLVQQWV
110 120 130 140 150
SYADTELIPA ACGATLPALG LRGPGQDPQA ALGALGKALN PLEDWLRLHT
160 170 180 190 200
YLAGDAPTLA DLAAVTALLL PFRYVLDPSA RRIWGNVTRW FNTCVRQPEF
210 220 230 240 250
RAVLGEVALY SGARSVTQQP GSEVIAPQKT PAQLKKEAKK REKLEKFQQK
260 270 280 290 300
QKTQQQPPHG EKKPKPEKKE KRDPGVITYD LPTPPGEKKD VSGAMPDSYS
310 320 330 340 350
PQYVEAAWYP WWERQGFFKP EYGRPSVSAP NPRGVFMMCI PPPNVTGSLH
360 370 380 390 400
LGHALTNAIQ DSLTRWHRMR GETTLWNPGC DHAGIATQVV VEKKLWKERG
410 420 430 440 450
LNRHQLGREA FLEEVWKWKA EKGDRIYHQL KKLGSSLDWD RACFTMDPKL
460 470 480 490 500
SATVTEAFVR LHEEGVIYRS TRLVNWSCTL NSAISDIEVD KKELTGRTLL
510 520 530 540 550
PVPGYKEKVE FGVLVSFAYK VQGSDSDEEV VVATTRIETM LGDVAVAVHP
560 570 580 590 600
KDPRYQHLKG KCVVHPFLSR SLPIVFDDFV DMEFGTGAVK ITPAHDQNDY
610 620 630 640 650
EVGQRHRLEA ISIMDSKGAL INVPPPFLGL PRFEARKAVL AALKERGLFR
660 670 680 690 700
GVKDNPMVVP LCNRSKDVVE PLLRPQWYVR CGEMAQAASA AVTRGDLRIL
710 720 730 740 750
PEAHQRTWHS WMDNIRDWCI SRQLWWGHRI PAYFITVHDP AVPPGEDPDG
760 770 780 790 800
RYWVSGRTEA EAREKAAREF GVSPDKISLQ QDEDVLDTWF SSGLFPFSIF
810 820 830 840 850
GWPNQSEDLS VFYPGTLLET GHDILFFWVA RMVMLGLKLT GKLPFREVYL
860 870 880 890 900
HAIVRDAHGR KMSKSLGNVI DPLDVIHGVS LQGLYDQLLN SNLDPSEVEK
910 920 930 940 950
AKEGQKADFP AGIPECGTDA LRFGLCAYTS QGRDINLDVN RILGYRHFCN
960 970 980 990 1000
KLWNATKFAL RGLGKGFVPS ATSKPEGHES LVDRWIRSRL TEAVRLSNEG
1010 1020 1030 1040 1050
FQAYDFPAIT TAQYSFWLYE LCDVYLECLK PVLNGVDQVA AECARQTLYT
1060 1070 1080 1090 1100
CLDVGLRLLS PFMPFVTEEL FQRLPRRTPK APASLCVTPY PEPSECSWKD
1110 1120 1130 1140 1150
PEAEAALELA LSITRAVRSL RADYNLTRTR PDCFLEVADE ATGALASAVS
1160 1170 1180 1190 1200
GYVQALASAG VVAVLALGAP APQGCAVAVA SDRCSIHLQL QGLVDPAREL
1210 1220 1230 1240 1250
GKLQAKRSEA QRQAQRLQER RAASSYSAKV PLEVQEADEA KLQQTEAELR
1260
KVDEAIALFQ KML
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3UY93 | G3UY93_MOUSE | Valine--tRNA ligase | Vars | 1,278 | Annotation score: | ||
G3UZX1 | G3UZX1_MOUSE | Valine--tRNA ligase | Vars | 130 | Annotation score: | ||
G3UYW2 | G3UYW2_MOUSE | Valine--tRNA ligase | Vars | 125 | Annotation score: | ||
G3UZ22 | G3UZ22_MOUSE | Valine--tRNA ligase | Vars | 230 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 959 | A → R in AAD26532 (PubMed:10199925).Curated | 1 | |
Sequence conflicti | 959 | A → R in AAD26531 (PubMed:10199925).Curated | 1 | |
Sequence conflicti | 1219 | E → K in AAD26532 (PubMed:10199925).Curated | 1 | |
Sequence conflicti | 1219 | E → K in AAD26531 (PubMed:10199925).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087680 mRNA Translation: AAD26532.1 AF087141 Genomic DNA Translation: AAD26531.1 AF109905 Genomic DNA Translation: AAC84151.1 AF109906 Genomic DNA Translation: AAC84172.1 |
CCDSi | CCDS37593.1 |
RefSeqi | NP_035820.3, NM_011690.3 XP_017172884.1, XM_017317395.1 |
Genome annotation databases
Ensembli | ENSMUST00000087315; ENSMUSP00000084572; ENSMUSG00000007029 |
GeneIDi | 22321 |
KEGGi | mmu:22321 |
UCSCi | uc008cez.2 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087680 mRNA Translation: AAD26532.1 AF087141 Genomic DNA Translation: AAD26531.1 AF109905 Genomic DNA Translation: AAC84151.1 AF109906 Genomic DNA Translation: AAC84172.1 |
CCDSi | CCDS37593.1 |
RefSeqi | NP_035820.3, NM_011690.3 XP_017172884.1, XM_017317395.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 204498, 2 interactors |
IntActi | Q9Z1Q9, 5 interactors |
MINTi | Q9Z1Q9 |
STRINGi | 10090.ENSMUSP00000084572 |
PTM databases
iPTMneti | Q9Z1Q9 |
PhosphoSitePlusi | Q9Z1Q9 |
SwissPalmi | Q9Z1Q9 |
Proteomic databases
EPDi | Q9Z1Q9 |
jPOSTi | Q9Z1Q9 |
MaxQBi | Q9Z1Q9 |
PaxDbi | Q9Z1Q9 |
PRIDEi | Q9Z1Q9 |
Genome annotation databases
Ensembli | ENSMUST00000087315; ENSMUSP00000084572; ENSMUSG00000007029 |
GeneIDi | 22321 |
KEGGi | mmu:22321 |
UCSCi | uc008cez.2 mouse |
Organism-specific databases
CTDi | 7407 |
MGIi | MGI:90675 Vars |
Phylogenomic databases
eggNOGi | KOG0432 Eukaryota KOG0867 Eukaryota COG0525 LUCA |
GeneTreei | ENSGT00940000157775 |
HOGENOMi | HOG000020094 |
InParanoidi | Q9Z1Q9 |
KOi | K01873 |
OMAi | FATKLWN |
OrthoDBi | 229591at2759 |
PhylomeDBi | Q9Z1Q9 |
TreeFami | TF300648 |
Miscellaneous databases
ChiTaRSi | Vars mouse |
PROi | PR:Q9Z1Q9 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000007029 Expressed in 227 organ(s), highest expression level in testis |
ExpressionAtlasi | Q9Z1Q9 baseline and differential |
Genevisiblei | Q9Z1Q9 MM |
Family and domain databases
CDDi | cd07962 Anticodon_Ia_Val, 1 hit |
Gene3Di | 1.10.287.380, 1 hit 3.40.50.620, 1 hit 3.90.740.10, 1 hit |
HAMAPi | MF_02004 Val_tRNA_synth_type1, 1 hit |
InterProi | View protein in InterPro IPR001412 aa-tRNA-synth_I_CS IPR002300 aa-tRNA-synth_Ia IPR033705 Anticodon_Ia_Val IPR010987 Glutathione-S-Trfase_C-like IPR036282 Glutathione-S-Trfase_C_sf IPR004046 GST_C IPR013155 M/V/L/I-tRNA-synth_anticd-bd IPR014729 Rossmann-like_a/b/a_fold IPR009080 tRNAsynth_Ia_anticodon-bd IPR037118 Val-tRNA_synth_C_sf IPR009008 Val/Leu/Ile-tRNA-synth_edit IPR002303 Valyl-tRNA_ligase |
Pfami | View protein in Pfam PF08264 Anticodon_1, 1 hit PF00043 GST_C, 1 hit PF00133 tRNA-synt_1, 1 hit |
PRINTSi | PR00986 TRNASYNTHVAL |
SUPFAMi | SSF47323 SSF47323, 1 hit SSF47616 SSF47616, 1 hit SSF50677 SSF50677, 1 hit |
TIGRFAMsi | TIGR00422 valS, 1 hit |
PROSITEi | View protein in PROSITE PS00178 AA_TRNA_LIGASE_I, 1 hit PS50405 GST_CTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYVC_MOUSE | |
Accessioni | Q9Z1Q9Primary (citable) accession number: Q9Z1Q9 Secondary accession number(s): Q9QUN2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | October 16, 2019 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries - SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot