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Protein

Nestin

Gene

NES

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • intermediate filament binding Source: UniProtKB
  • structural molecule activity Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processNeurogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NestinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NESBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMesocricetus auratus (Golden hamster)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10036 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000189706 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000403464‹1 – 1818NestinAdd BLAST›1818

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei133PhosphoserineBy similarity1
Modified residuei137PhosphothreonineBy similarity1
Modified residuei160PhosphothreonineBy similarity1
Modified residuei180PhosphoserineBy similarity1
Modified residuei210PhosphothreonineBy similarity1
Modified residuei288PhosphoserineBy similarity1
Modified residuei390PhosphoserineBy similarity1
Modified residuei400PhosphoserineBy similarity1
Modified residuei448PhosphoserineBy similarity1
Modified residuei513PhosphoserineBy similarity1
Modified residuei591PhosphoserineBy similarity1
Modified residuei737PhosphoserineBy similarity1
Modified residuei803PhosphoserineBy similarity1
Modified residuei824PhosphoserineBy similarity1
Modified residuei915PhosphoserineBy similarity1
Modified residuei957PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1043Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki1043Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei1052PhosphoserineBy similarity1
Modified residuei1063PhosphoserineBy similarity1
Modified residuei1073PhosphoserineBy similarity1
Modified residuei1123PhosphoserineBy similarity1
Modified residuei1134PhosphoserineBy similarity1
Modified residuei1162PhosphoserineBy similarity1
Modified residuei1238PhosphoserineBy similarity1
Modified residuei1495PhosphoserineBy similarity1
Modified residuei1499PhosphoserineBy similarity1
Modified residuei1523PhosphoserineBy similarity1
Modified residuei1614PhosphoserineBy similarity1
Modified residuei1623PhosphoserineBy similarity1
Modified residuei1698PhosphoserineBy similarity1
Modified residuei1700PhosphoserineBy similarity1
Modified residuei1791PhosphoserineBy similarity1
Modified residuei1814PhosphoserineBy similarity1
Modified residuei1815PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z1Q1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FHOD3 (By similarity). Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%.By similarity1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Z1Q1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini‹1 – 135IF rodPROSITE-ProRule annotationAdd BLAST›135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni‹1 – ›14Coil 1BSequence analysisAdd BLAST›14
Regioni15 – 17Linker 2Sequence analysis3
Regioni18 – 135Coil 2BSequence analysisAdd BLAST118
Regioni136 – 1818TailSequence analysisAdd BLAST1683

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006463

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR031211 Nestin

The PANTHER Classification System

More...
PANTHERi
PTHR23239 PTHR23239, 2 hits
PTHR23239:SF131 PTHR23239:SF131, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragments.

Q9Z1Q1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
WREKLEAEVQ RQNLYQERVA HMESSLGQAR ERLGRAVRGA REGRLELQQL
60 70 80 90 100
QAERDGLQER REALEQRLEG RWQDRLQATE KFQLAVEALE QEKQGLQSQI
110 120 130 140 150
AQILEGGQQL AHLKMSLSLE VATYRTLLEA ENSRLQTPGR SSQASLGFQD
160 170 180 190 200
PKLKLRFLGT PENQHLGSVL PVLSPTPLPS PLPDTLETPV TAFLKTQEFL
210 220 230 240 250
QARIPTLAST PIPPMTEAPC LAKAEVRAQD APLSLLQTQG ERQQAPEPLW
260 270 280 290 300
AKATASVSTG VLTELEEAGG QQPGHFPEDA TASAPSLSPH HPVLEAKDGD
310 320 330 340 350
STESRGSSIF QEDEGQIWEL VEKEAAIELK VESSLAQETQ EDGLHTEEIQ
360 370 380 390 400
DSQGPLQKET LEALGEEPLM SLKIQNHETP GKENCNSLRS VDENQGTLKS
410 420 430 440 450
PEEEKQTLLK SLEEKDVEVE KTLEKGVPEL SKPLGKEDPR IEDQELMSPE
460 470 480 490 500
GTLETLSFIG KRNEEVVRSS EEENIESLAA FKKESQHPLG CPEEEIQRVE
510 520 530 540 550
RLIEKEGQES LSSPEEEDQE TDRPLEKENG EPLKPVEEED QLFETLIEKE
560 570 580 590 600
GQESLSSPEE EDQETDRPLE KEEDQLVERL VEKEGQESLS SPEEEDQETD
610 620 630 640 650
RPLEKENGEP LKPVEEEDQL FETLIEKEGQ ESLSSPEEED QETDRPLEKE
660 670 680 690 700
EDQLVERLVE KEGQESLSSP EEEDQETDRP LEKEEDQLVE TLIEKQGQEC
710 720 730 740 750
LSSPEEEDQE TDRPLEKEED QRVERLIEKE GQESLSSPEE EDQETYRLLE
760 770 780 790 800
KENGEPLKPV EEEDQRVERL IEKEDQESLS SLKEEDQRIV KTLERENWES
810 820 830 840 850
LRSLDENLDT VMPLESKNQK PLKSLEAEEE QRIVKPLEKV SQDSIGSLEK
860 870 880 890 900
ENVELLRSLE DDQITESLLK KGTQESLESH EDRNQETQDP QRFLEEEGQG
910 920 930 940 950
IVKQLEKENQ GFLGSLEEEK VVKRSLEREN HEPLSSVEKD WVTESLLERE
960 970 980 990 1000
SQDSGKSLEG QEAFRCLGKE DPESLQFPEV QDQEIQRSLQ QETQQTLGAL
1010 1020 1030 1040 1050
GDEQMASEPP EKVGPELLKF LGNGQEIVRS LEEQNQESLV SVKETSVETA
1060 1070 1080 1090 1100
KSSDMEDIEP LKSADEDLEI INSAGAQESL WSMEVTRETT RPLEKEVQES
1110 1120 1130 1140 1150
LGFVGGNQEI LRPLERGNEE LGSLGKWNLE AVDSPEAVEE GRQPLGEEAC
1160 1170 1180 1190 1200
LEMGEHQEPP RSLGEVEQGL PGSGNQQKWE DRAVENAAAD QGPTLGRTGI
1210 1220 1230 1240 1250
ESEDEAELPL SGQGEKEEDA EERELQLDAM GEAWSLASSE PQEPRVPSEG
1260 1270 1280 1290 1300
GSAGAPQGLE GQSEQVGVLG VPVGQGMPEV TEPLLQEDVA QAGKRDPIEL
1310 1320 1330 1340 1350
TLGSDAATRA GLGLEQEVAG SGGSRHLARE EAIHPSLGEE SVEAKIAHDL
1360 1370 1380 1390 1400
EGPGKEPKEA GALESEISEL PRTSSDVLES KGCKQSEPVL GWAVEEASVE
1410 1420 1430 1440 1450
ASDHEGSDAP EPRPSETEGD EGAQAALAPP GPKLMEPCSP TPILKDAYEW
1460 1470 1480 1490 1500
QPQAEGTRET GRQLEGGSAS LERVEDEQEF GLGGIPEGLQ DWEESREESE
1510 1520 1530 1540 1550
ADELGETLPD STPLGLYLRS PTSPKWDQAG EQRLSPQGEA RKEGWGPAVP
1560 1570 1580 1590 1600
AAQGLSNPPG EEERGHDSDL SSEEFEDLGT EASLLPGLPK EVADHLGQVP
1610 1620 1630 1640 1650
PGPEPECWDQ GGESDGFADE EESGEEGEEE EHEDGTESGA QWWGSGPSKV
1660 1670 1680 1690 1700
QHVTQRGDLQ EHESVGISGP WDDGWRGAAA GISVTGLETE SQDSAEPSGS
1710 1720 1730 1740 1750
EVSESVSSEG EDQAPDHLDT PQGVTNVVPG AGDTFGISGQ APNLESEHMN
1760 1770 1780 1790 1800
GRLENGLEQS EGQGVLDRHQ DQGHPSQQQE VGALKAPLLG SPVHRGPSQS
1810
LEFPLSGADR DSWSSGED
Length:1,818
Mass (Da):200,577
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i323AC1FF4B0AC4F0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
<p>This subsection of the ‘Sequence’ section is used to indicate that two residues in a sequence are not consecutive and that there is an undetermined number of unsequenced residues between them.<p><a href='/help/non_cons' target='_top'>More...</a></p>Non-adjacent residuesi14 – 151 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF110498 mRNA Translation: AAC98312.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T34518

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110498 mRNA Translation: AAC98312.1
PIRiT34518

3D structure databases

SMRiQ9Z1Q1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9Z1Q1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006463

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR031211 Nestin
PANTHERiPTHR23239 PTHR23239, 2 hits
PTHR23239:SF131 PTHR23239:SF131, 2 hits
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEST_MESAU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z1Q1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 11, 2011
Last modified: July 18, 2018
This is version 63 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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