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Protein

Ribosomal protein S6 kinase beta-2

Gene

Rps6kb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphorylates specifically ribosomal protein S6.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99ATPPROSITE-ProRule annotation1
Active sitei194Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi73 – 81ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • positive regulation of translational initiation Source: MGI
  • protein kinase B signaling Source: MGI
  • protein phosphorylation Source: MGI

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 3474
ReactomeiR-MMU-198693 AKT phosphorylates targets in the nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S6 kinase beta-2 (EC:2.7.11.1)
Short name:
S6K-beta-2
Short name:
S6K2
Alternative name(s):
70 kDa ribosomal protein S6 kinase 2
p70 ribosomal S6 kinase beta
Short name:
p70 S6 kinase beta
Short name:
p70 S6K-beta
Short name:
p70 S6KB
Gene namesi
Name:Rps6kb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1927343 Rps6kb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000862151 – 485Ribosomal protein S6 kinase beta-2Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineBy similarity1
Modified residuei417PhosphoserineBy similarity1
Modified residuei420PhosphothreonineCombined sources1
Modified residuei423PhosphoserineCombined sources1
Modified residuei476Phosphoserine; by PKCBy similarity1

Post-translational modificationi

Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Z1M4
MaxQBiQ9Z1M4
PaxDbiQ9Z1M4
PRIDEiQ9Z1M4

PTM databases

iPTMnetiQ9Z1M4
PhosphoSitePlusiQ9Z1M4

Expressioni

Gene expression databases

BgeeiENSMUSG00000024830 Expressed in 252 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ9Z1M4 baseline and differential
GenevisibleiQ9Z1M4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025749

Structurei

3D structure databases

ProteinModelPortaliQ9Z1M4
SMRiQ9Z1M4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 328Protein kinasePROSITE-ProRule annotationAdd BLAST262
Domaini329 – 399AGC-kinase C-terminalAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi474 – 480Nuclear localization signalBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi411 – 485Pro-richAdd BLAST75

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0598 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00920000148962
HOGENOMiHOG000233033
HOVERGENiHBG108317
InParanoidiQ9Z1M4
KOiK04688
OMAiVQKHPFF
OrthoDBiEOG091G05Z7
PhylomeDBiQ9Z1M4
TreeFamiTF313438

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016238 Ribosomal_S6_kinase
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
PIRSFiPIRSF000605 Ribsml_S6_kin_1, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

Q9Z1M4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVFDLDLE TEEGSEGEGE PEFSPADVCP LGELRAAGLE TVGHYEEVEL
60 70 80 90 100
TESSVNLGPE RIGPHCFELL SVLGKGGYGK VFQVRKVQGT NLGKIYAMKV
110 120 130 140 150
LRKAKIVCSA KDTAHTRAER NILESVKHPF IVELAYAFQT GGKLYLILEC
160 170 180 190 200
LSGGELFTHL EREGIFLEDT ACFYLAEITL ALGHLHSHGI IYRDLKPENI
210 220 230 240 250
MLSSQGHIKL TDFGLCKESI HEGAITHTFC GTIEYMAPEI LVRTGHNRAV
260 270 280 290 300
DWWSLGALMY DMLTGSPPFT AENRKKTMDK IIKGKLVLPP YLTPDARDLA
310 320 330 340 350
KKFLKRNPTQ RIGGGLGDAA DVQRHPFFRH INWDDLLARR VDPPFRPSLQ
360 370 380 390 400
SEEDVSQFDA RFTRQTPVDS PDDTALSESA NQAFLGFTYV APSVLDSIKE
410 420 430 440 450
GFSFQPKLRS PRRLNSSPRT PISPLKFSPF EGFRPSPGPP EPMEPSLPPL
460 470 480
LPSPPSPPPT STAPLPIRPP SGTKKSKKGR GRSGR
Length:485
Mass (Da):53,538
Last modified:May 1, 1999 - v1
Checksum:i396929ADAB0F6CB6
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YWB8D3YWB8_MOUSE
Non-specific serine/threonine prote...
Rps6kb2
392Annotation score:
D6RH86D6RH86_MOUSE
Ribosomal protein S6 kinase beta-2
Rps6kb2
285Annotation score:
E9PUN3E9PUN3_MOUSE
Ribosomal protein S6 kinase beta-2
Rps6kb2
312Annotation score:
Q80X26Q80X26_MOUSE
Ribosomal protein S6 kinase beta-2
Rps6kb2
153Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007938 mRNA Translation: CAA07774.1
AK014412 mRNA Translation: BAB29335.1
CCDSiCCDS29419.1
RefSeqiNP_067460.1, NM_021485.2
UniGeneiMm.271937

Genome annotation databases

EnsembliENSMUST00000025749; ENSMUSP00000025749; ENSMUSG00000024830
ENSMUST00000181245; ENSMUSP00000137802; ENSMUSG00000097721
GeneIDi58988
KEGGimmu:58988
UCSCiuc008fzb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007938 mRNA Translation: CAA07774.1
AK014412 mRNA Translation: BAB29335.1
CCDSiCCDS29419.1
RefSeqiNP_067460.1, NM_021485.2
UniGeneiMm.271937

3D structure databases

ProteinModelPortaliQ9Z1M4
SMRiQ9Z1M4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025749

PTM databases

iPTMnetiQ9Z1M4
PhosphoSitePlusiQ9Z1M4

Proteomic databases

EPDiQ9Z1M4
MaxQBiQ9Z1M4
PaxDbiQ9Z1M4
PRIDEiQ9Z1M4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025749; ENSMUSP00000025749; ENSMUSG00000024830
ENSMUST00000181245; ENSMUSP00000137802; ENSMUSG00000097721
GeneIDi58988
KEGGimmu:58988
UCSCiuc008fzb.1 mouse

Organism-specific databases

CTDi6199
MGIiMGI:1927343 Rps6kb2

Phylogenomic databases

eggNOGiKOG0598 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00920000148962
HOGENOMiHOG000233033
HOVERGENiHBG108317
InParanoidiQ9Z1M4
KOiK04688
OMAiVQKHPFF
OrthoDBiEOG091G05Z7
PhylomeDBiQ9Z1M4
TreeFamiTF313438

Enzyme and pathway databases

BRENDAi2.7.11.1 3474
ReactomeiR-MMU-198693 AKT phosphorylates targets in the nucleus

Miscellaneous databases

PROiPR:Q9Z1M4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024830 Expressed in 252 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ9Z1M4 baseline and differential
GenevisibleiQ9Z1M4 MM

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016238 Ribosomal_S6_kinase
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
PIRSFiPIRSF000605 Ribsml_S6_kin_1, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKS6B2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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