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Protein

Voltage-dependent calcium channel subunit alpha-2/delta-3

Gene

Cacna2d3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G).2 Publications

Miscellaneous

In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi262Divalent metal cationBy similarity1
Metal bindingi264Divalent metal cationBy similarity1
Metal bindingi266Divalent metal cationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel subunit alpha-2/delta-3
Alternative name(s):
Voltage-gated calcium channel subunit alpha-2/delta-3
Cleaved into the following 2 chains:
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1338890 Cacna2d3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 1068ExtracellularSequence analysisAdd BLAST1035
Transmembranei1069 – 1089HelicalSequence analysisAdd BLAST21
Topological domaini1090 – 1091CytoplasmicSequence analysis2

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000304651? – 1091Voltage-dependent calcium channel subunit delta-3Sequence analysis
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000030464934 – 1091Voltage-dependent calcium channel subunit alpha-2/delta-3Add BLAST1058
ChainiPRO_000030465034 – ?Voltage-dependent calcium channel subunit alpha-2-3Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi412 ↔ 1055Interchain (between alpha-2-3 and delta-3 chains)By similarity
Glycosylationi553N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi632N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei924PhosphotyrosineBy similarity1

Post-translational modificationi

N-glycosylated.1 Publication
May be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9Z1L5
PaxDbiQ9Z1L5
PeptideAtlasiQ9Z1L5
PRIDEiQ9Z1L5

PTM databases

PhosphoSitePlusiQ9Z1L5

Expressioni

Tissue specificityi

Brain-specific. Predominantly expressed in the caudate putamen, entorhinal complex, hippocampus and cortex.2 Publications

Gene expression databases

BgeeiENSMUSG00000021991 Expressed in 157 organ(s), highest expression level in caudate-putamen
ExpressionAtlasiQ9Z1L5 baseline and differential
GenevisibleiQ9Z1L5 MM

Interactioni

Subunit structurei

Dimer formed of alpha-2-2 and delta-2 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9Z1L5, 1 interactor
STRINGi10090.ENSMUSP00000022567

Structurei

3D structure databases

ProteinModelPortaliQ9Z1L5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini256 – 438VWFAPROSITE-ProRule annotationAdd BLAST183
Domaini452 – 549CacheAdd BLAST98

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi262 – 266MIDAS-like motif5

Domaini

The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2353 Eukaryota
ENOG410XPDX LUCA
GeneTreeiENSGT00530000062904
HOGENOMiHOG000010247
HOVERGENiHBG107124
InParanoidiQ9Z1L5
KOiK04860
OMAiGIESFKP
OrthoDBiEOG091G00UY
PhylomeDBiQ9Z1L5
TreeFamiTF315824

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013680 VDCC_a2/dsu
IPR013608 VWA_N
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF08473 VGCC_alpha2, 1 hit
PF13768 VWA_3, 1 hit
PF08399 VWA_N, 1 hit
SMARTiView protein in SMART
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9Z1L5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGPGSLCCA SRGASALLAT ALLYAALGDV VRSEQQIPLS VVKLWASAFG
60 70 80 90 100
GEIKSIAAKY SGSQLLQKKY KEYEKDVAIE EIDGLQLVKK LAKIMEEMFH
110 120 130 140 150
KKSEAVRRLV EAAEEAHLKH EFDADLQYEY FNAVLINERD KDGNFLELGK
160 170 180 190 200
EFILAPNDHF NNLPVNISLS DVQVPTNMYN KDPAIVNGVY WSESLNKVFV
210 220 230 240 250
DNFDRDPSLI WQYFGSAKGF FRQYPGIKWE PDENGVIAFD CRNRKWYIQA
260 270 280 290 300
ATSPKDVVIL VDVSGSMKGL RLTIAKQTVS SILDTLGDDD FFNIITYNEE
310 320 330 340 350
LHYVEPCLNG TLVQADRTNK EHFREHLDKL FAKGIGMLDI ALNEAFNILS
360 370 380 390 400
DFNHTGQGSI CSQAIMLITD GAVDTYDTIF AKYNWPDRKV RIFTYLIGRE
410 420 430 440 450
AAFADNLKWM ACANKGFFTQ ISTLADVQEN VMEYLHVLSR PKVIDQEHDV
460 470 480 490 500
VWTEAYIDST LPQAQKLADD QGLVLMTTVA MPVFSKQNET RSKGILLGVV
510 520 530 540 550
GTDVPVKELL KTIPKYKLGI HGYAFAITNN GYILTHPELR PLYEEGKKRR
560 570 580 590 600
KPNYSSVDLS EVEWEDRDDV LRNAMVNRKT GKFSMEVKKT VDKGKRVLVM
610 620 630 640 650
TNDYYYTDIK GTPFSLGVAL SRGHGKYFFR GNVTIEEGLH DLEHPDVSLA
660 670 680 690 700
DEWSYCNTDL HPEHRHLSQL EAIKLYLKGK EPLLQCDKEL IQEVLFDAVV
710 720 730 740 750
SAPIEAYWTS LALNKSENSD KGVEVAFLGT RTGLSRINLF VGAEQLTNQD
760 770 780 790 800
FLKAGDKENI FNADHFPLWY RRAAEQIAGS FVYSIPFSTG TVNKSNVVTA
810 820 830 840 850
STSIQLLDER KSPVVAAVGI QMKLEFFQRK FWTASRQCAS LDGKCSISCD
860 870 880 890 900
DETVNCYLID NNGFILVSED YTQTGDFFGE VEGAVMNKLL TMGSFKRITL
910 920 930 940 950
YDYQAMCRAN KESSDSAHGL LDPYKAFLSA AKWIMTELVL FLVEFNLCSW
960 970 980 990 1000
WHSDMTAKAQ KLKQTLEPCD TEYPAFVSER TIKETTGNIA CEDCSKSFVI
1010 1020 1030 1040 1050
QQIPSSNLFM VVVDSSCLCE SVAPITMAPI EIRYNESLKC ERLKAQKIRR
1060 1070 1080 1090
RPESCHGFHP EENARECGGA SSLQAQAALL LLPLVSSLFS R
Length:1,091
Mass (Da):122,778
Last modified:May 1, 1999 - v1
Checksum:i7AEE2BDA10077A0A
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YCT5A0A286YCT5_MOUSE
Voltage-dependent calcium channel s...
Cacna2d3
359Annotation score:
A0A286YE06A0A286YE06_MOUSE
Voltage-dependent calcium channel s...
Cacna2d3
134Annotation score:
A0A286YCF6A0A286YCF6_MOUSE
Voltage-dependent calcium channel s...
Cacna2d3
264Annotation score:
A0A286YCK6A0A286YCK6_MOUSE
Voltage-dependent calcium channel s...
Cacna2d3
100Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010949 mRNA Translation: CAA09423.1
PIRiT30256
RefSeqiNP_033915.1, NM_009785.1
UniGeneiMm.386754

Genome annotation databases

EnsembliENSMUST00000022567; ENSMUSP00000022567; ENSMUSG00000021991
GeneIDi12294
KEGGimmu:12294
UCSCiuc007sui.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010949 mRNA Translation: CAA09423.1
PIRiT30256
RefSeqiNP_033915.1, NM_009785.1
UniGeneiMm.386754

3D structure databases

ProteinModelPortaliQ9Z1L5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z1L5, 1 interactor
STRINGi10090.ENSMUSP00000022567

PTM databases

PhosphoSitePlusiQ9Z1L5

Proteomic databases

MaxQBiQ9Z1L5
PaxDbiQ9Z1L5
PeptideAtlasiQ9Z1L5
PRIDEiQ9Z1L5

Protocols and materials databases

DNASUi12294
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022567; ENSMUSP00000022567; ENSMUSG00000021991
GeneIDi12294
KEGGimmu:12294
UCSCiuc007sui.1 mouse

Organism-specific databases

CTDi55799
MGIiMGI:1338890 Cacna2d3

Phylogenomic databases

eggNOGiKOG2353 Eukaryota
ENOG410XPDX LUCA
GeneTreeiENSGT00530000062904
HOGENOMiHOG000010247
HOVERGENiHBG107124
InParanoidiQ9Z1L5
KOiK04860
OMAiGIESFKP
OrthoDBiEOG091G00UY
PhylomeDBiQ9Z1L5
TreeFamiTF315824

Miscellaneous databases

ChiTaRSiCacna2d3 mouse
PROiPR:Q9Z1L5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021991 Expressed in 157 organ(s), highest expression level in caudate-putamen
ExpressionAtlasiQ9Z1L5 baseline and differential
GenevisibleiQ9Z1L5 MM

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013680 VDCC_a2/dsu
IPR013608 VWA_N
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF08473 VGCC_alpha2, 1 hit
PF13768 VWA_3, 1 hit
PF08399 VWA_N, 1 hit
SMARTiView protein in SMART
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCA2D3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1L5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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