Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

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  + ATP

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  = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)

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  + ADP

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  + H⁺

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  EC:2.7.1.153
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  Source: Rhea

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  . Show »« Hide
  a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  zoom

  +

  ATP

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  • See the description of this molecule in ChEBI.

  

  =

  a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  zoom

  +

  ADP

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  • See the description of this molecule in ChEBI.

  

  +

  H⁺

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  • See the description of this molecule in ChEBI.

  

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• 1-phosphatidylinositol-3-kinase activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Hepatocyte growth factor activates phosphoinositide 3-kinase C2 beta in renal brush-border plasma membranes."
    Crljen V., Volinia S., Banfic H.
    Biochem. J. 365:791-799(2002) [PubMed] [Europe PMC] [Abstract]
  • "Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor."
    Kaplan-Albuquerque N., Garat C., Desseva C., Jones P.L., Nemenoff R.A.
    J. Biol. Chem. 278:39830-39838(2003) [PubMed] [Europe PMC] [Abstract]
• 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• ATP binding Source: UniProtKB-KW
• insulin receptor substrate binding Source: RGDInferred from sequence orthologyⁱ
  • "Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation."
    Foukas L.C., Claret M., Pearce W., Okkenhaug K., Meek S., Peskett E., Sancho S., Smith A.J.H., Withers D.J., Vanhaesebroeck B.
    Nature 441:366-370(2006) [PubMed] [Europe PMC] [Abstract]
• kinase activity Source: RGDInferred from sequence orthologyⁱ
  • "Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo."
    Dowdle W.E., Nyfeler B., Nagel J., Elling R.A., Liu S., Triantafellow E., Menon S., Wang Z., Honda A., Pardee G., Cantwell J., Luu C., Cornella-Taracido I., Harrington E., Fekkes P., Lei H., Fang Q., Digan M.E.

    , Burdick D., Powers A.F., Helliwell S.B., D'Aquin S., Bastien J., Wang H., Wiederschain D., Kuerth J., Bergman P., Schwalb D., Thomas J., Ugwonali S., Harbinski F., Tallarico J., Wilson C.J., Myer V.E., Porter J.A., Bussiere D.E., Finan P.M., Labow M.A., Mao X., Hamann L.G., Manning B.D., Valdez R.A., Nicholson T., Schirle M., Knapp M.S., Keaney E.P., Murphy L.O.
    Nat. Cell Biol. 16:1069-1079(2014) [PubMed] [Europe PMC] [Abstract]
• phosphatidylinositol-3,4-bisphosphate 5-kinase activity Source: UniProtKB-EC
• phosphatidylinositol 3-kinase activity Source: RGD <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival."
    Coutant A., Rescan C., Gilot D., Loyer P., Guguen-Guillouzo C., Baffet G.
    Hepatology 36:1079-1088(2002) [PubMed] [Europe PMC] [Abstract]
• phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: UniProtKB-EC
• phosphatidylinositol kinase activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• angiogenesis involved in wound healing Source: RGDInferred from sequence orthologyⁱ
  • "Phosphoinositide 3-kinase beta mediates microvascular endothelial repair of thrombotic microangiopathy."
    Haddad G., Zhabyeyev P., Farhan M., Zhu L.F., Kassiri Z., Rayner D.C., Vanhaesebroeck B., Oudit G.Y., Murray A.G.
    Blood 124:2142-2149(2014) [PubMed] [Europe PMC] [Abstract]
• autophagy Source: UniProtKB-KW
• cell migration Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular calcium ion homeostasis Source: RGDInferred from sequence orthologyⁱ
  • "PI 3-kinase p110beta: a new target for antithrombotic therapy."
    Jackson S.P., Schoenwaelder S.M., Goncalves I., Nesbitt W.S., Yap C.L., Wright C.E., Kenche V., Anderson K.E., Dopheide S.M., Yuan Y., Sturgeon S.A., Prabaharan H., Thompson P.E., Smith G.D., Shepherd P.R., Daniele N., Kulkarni S., Abbott B.

    , Saylik D., Jones C., Lu L., Giuliano S., Hughan S.C., Angus J.A., Robertson A.D., Salem H.H.
    Nat. Med. 11:507-514(2005) [PubMed] [Europe PMC] [Abstract]
• embryonic cleavage Source: RGDInferred from sequence orthologyⁱ
  • "Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase."
    Bi L., Okabe I., Bernard D.J., Nussbaum R.L.
    Mamm. Genome 13:169-172(2002) [PubMed] [Europe PMC] [Abstract]
• endocytosis Source: UniProtKB-KW
• endothelial cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "Phosphoinositide 3-kinase beta mediates microvascular endothelial repair of thrombotic microangiopathy."
    Haddad G., Zhabyeyev P., Farhan M., Zhu L.F., Kassiri Z., Rayner D.C., Vanhaesebroeck B., Oudit G.Y., Murray A.G.
    Blood 124:2142-2149(2014) [PubMed] [Europe PMC] [Abstract]
• homophilic cell adhesion via plasma membrane adhesion molecules Source: RGDInferred from sequence orthologyⁱ
  • "PI 3-kinase p110beta: a new target for antithrombotic therapy."
    Jackson S.P., Schoenwaelder S.M., Goncalves I., Nesbitt W.S., Yap C.L., Wright C.E., Kenche V., Anderson K.E., Dopheide S.M., Yuan Y., Sturgeon S.A., Prabaharan H., Thompson P.E., Smith G.D., Shepherd P.R., Daniele N., Kulkarni S., Abbott B.

    , Saylik D., Jones C., Lu L., Giuliano S., Hughan S.C., Angus J.A., Robertson A.D., Salem H.H.
    Nat. Med. 11:507-514(2005) [PubMed] [Europe PMC] [Abstract]
• phosphatidylinositol 3-kinase signaling Source: RGDInferred from sequence orthologyⁱ
  • "Human IgA Fc receptor FcalphaRI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment."
    Wehrli M., Cortinas-Elizondo F., Hlushchuk R., Daudel F., Villiger P.M., Miescher S., Zuercher A.W., Djonov V., Simon H.U., von Gunten S.
    J. Immunol. 193:5649-5659(2014) [PubMed] [Europe PMC] [Abstract]
• phosphatidylinositol-3-phosphate biosynthetic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• phosphatidylinositol-mediated signaling Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• phosphatidylinositol phosphorylation Source: RGDInferred from direct assayⁱ
  • "Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor."
    Kaplan-Albuquerque N., Garat C., Desseva C., Jones P.L., Nemenoff R.A.
    J. Biol. Chem. 278:39830-39838(2003) [PubMed] [Europe PMC] [Abstract]
• phosphorylation Source: RGDInferred from sequence orthologyⁱ
  • "Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo."
    Dowdle W.E., Nyfeler B., Nagel J., Elling R.A., Liu S., Triantafellow E., Menon S., Wang Z., Honda A., Pardee G., Cantwell J., Luu C., Cornella-Taracido I., Harrington E., Fekkes P., Lei H., Fang Q., Digan M.E.

    , Burdick D., Powers A.F., Helliwell S.B., D'Aquin S., Bastien J., Wang H., Wiederschain D., Kuerth J., Bergman P., Schwalb D., Thomas J., Ugwonali S., Harbinski F., Tallarico J., Wilson C.J., Myer V.E., Porter J.A., Bussiere D.E., Finan P.M., Labow M.A., Mao X., Hamann L.G., Manning B.D., Valdez R.A., Nicholson T., Schirle M., Knapp M.S., Keaney E.P., Murphy L.O.
    Nat. Cell Biol. 16:1069-1079(2014) [PubMed] [Europe PMC] [Abstract]
• platelet activation Source: RGDInferred from sequence orthologyⁱ
  • "PI 3-kinase p110beta: a new target for antithrombotic therapy."
    Jackson S.P., Schoenwaelder S.M., Goncalves I., Nesbitt W.S., Yap C.L., Wright C.E., Kenche V., Anderson K.E., Dopheide S.M., Yuan Y., Sturgeon S.A., Prabaharan H., Thompson P.E., Smith G.D., Shepherd P.R., Daniele N., Kulkarni S., Abbott B.

    , Saylik D., Jones C., Lu L., Giuliano S., Hughan S.C., Angus J.A., Robertson A.D., Salem H.H.
    Nat. Med. 11:507-514(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "Phosphoinositide 3-kinase beta mediates microvascular endothelial repair of thrombotic microangiopathy."
    Haddad G., Zhabyeyev P., Farhan M., Zhu L.F., Kassiri Z., Rayner D.C., Vanhaesebroeck B., Oudit G.Y., Murray A.G.
    Blood 124:2142-2149(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neutrophil apoptotic process Source: RGDInferred from sequence orthologyⁱ
  • "Human IgA Fc receptor FcalphaRI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment."
    Wehrli M., Cortinas-Elizondo F., Hlushchuk R., Daudel F., Villiger P.M., Miescher S., Zuercher A.W., Djonov V., Simon H.U., von Gunten S.
    J. Immunol. 193:5649-5659(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of cell-matrix adhesion Source: RGDInferred from sequence orthologyⁱ
  • "PI 3-kinase p110beta: a new target for antithrombotic therapy."
    Jackson S.P., Schoenwaelder S.M., Goncalves I., Nesbitt W.S., Yap C.L., Wright C.E., Kenche V., Anderson K.E., Dopheide S.M., Yuan Y., Sturgeon S.A., Prabaharan H., Thompson P.E., Smith G.D., Shepherd P.R., Daniele N., Kulkarni S., Abbott B.

    , Saylik D., Jones C., Lu L., Giuliano S., Hughan S.C., Angus J.A., Robertson A.D., Salem H.H.
    Nat. Med. 11:507-514(2005) [PubMed] [Europe PMC] [Abstract]
  • "Phosphoinositide 3-kinase beta mediates microvascular endothelial repair of thrombotic microangiopathy."
    Haddad G., Zhabyeyev P., Farhan M., Zhu L.F., Kassiri Z., Rayner D.C., Vanhaesebroeck B., Oudit G.Y., Murray A.G.
    Blood 124:2142-2149(2014) [PubMed] [Europe PMC] [Abstract]
• response to wounding Source: RGDInferred from sequence orthologyⁱ
  • "Phosphoinositide 3-kinase beta mediates microvascular endothelial repair of thrombotic microangiopathy."
    Haddad G., Zhabyeyev P., Farhan M., Zhu L.F., Kassiri Z., Rayner D.C., Vanhaesebroeck B., Oudit G.Y., Murray A.G.
    Blood 124:2142-2149(2014) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• insulin receptor substrate binding Source: RGDInferred from sequence orthologyⁱ
  • "Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation."
    Foukas L.C., Claret M., Pearce W., Okkenhaug K., Meek S., Peskett E., Sancho S., Smith A.J.H., Withers D.J., Vanhaesebroeck B.
    Nature 441:366-370(2006) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MCFRSIMPPA MADTLDIWAV DSQIASDGSI SVDFLLPTGI YIQLEVPREA 
        60         70         80         90        100
TISYIKQMLW KQVHNYPMFN LLMDIDSYMF ACVNQTAVYE ELEDETRRLC 
       110        120        130        140        150
DVRPFLPVLK LVTRSCDPAE KLDSKIGVLI GKGLHEFDAL KDPEVNEFRR 
       160        170        180        190        200
KMRKFSEDKI QSLVGLSWID WLKHTYPPEH EPSVLENLED KLYGGKLVVA 
       210        220        230        240        250
VHFENSQDVF SFQVSPNLNP IKINELAIQK RLTIRGKEEE ASPCDYVLQV 
       260        270        280        290        300
SGRVEYVFGD HPLIQFQYIR NCVMNRTLPH FILVECCKIK KMYEQEMIAI 
       310        320        330        340        350
EAAINRNSSS LPLPLPPKKT RVISHVWGNN NPFQIVLVKG NKLNTEETVK 
       360        370        380        390        400
VHVRAGLFHG TELLCKTVVS SEISGKNDHI WNEQLEFDIN ICDLPRMARL 
       410        420        430        440        450
CFAVYAVLDK VKTKKSTKTI NPSKYQTIRK AGKVHYPVAW VNTMVFDFKG 
       460        470        480        490        500
QLRSGDVILH SWSSFPDELE EMLNPMGTVQ TNPYAENATA LHIKFPENKK 
       510        520        530        540        550
QPYYYPPFDK IIEKAAEIAS GDSANVSSRG GKKFLAVLKE ILDRDPLSQL 
       560        570        580        590        600
CENEMDLIWT LRQDCRENFP QSLPKLLLSI KWNKLEDVAQ LQALLQIWPK 
       610        620        630        640        650
LPPREALELL DFNYPDQYVR EYAVGCLRQM SDEELSQYLL QLVQVLKYEP 
       660        670        680        690        700
FLDCALSRFL LERALDNRRI GQFLFWHLRS EVHTPAVSIQ FGVILEAYCR 
       710        720        730        740        750
GSVGHMKVLS KQVEALNKLK TLNSLIKLNA MKLNRAKGKE AMHTCLKQSA 
       760        770        780        790        800
YREALSDLQS PLNPCVILSE LYVEKCRYMD SKMKPLWLVY SNRAFGEDAV 
       810        820        830        840        850
GVIFKNGDDL RQDMLTLQML RLMDLLWKEA GLDLRMLPYG CLATGDRSGL 
       860        870        880        890        900
IEVVSTSETI ADIQLNSSNV AATAAFNKDA LLNWLKEYNS GDDLDRAIEE 
       910        920        930        940        950
FTLSCAGYCV ASYVLGIGDR HSDNIMVKKT GQLFHIDFGH ILGNFKSKFG 
       960        970        980        990       1000
IKRERVPFIL TYDFIHVIQQ GKTGNTEKFG RFRQCCEDAY LILRRHGNLF 
      1010       1020       1030       1040       1050
ITLFALMLTA GLPELTSVKD IQYLKDSLAL GKSEEEALKQ FKQKFDEALR 
      1060       1070
ESWTTKVNWM AHTVRKDYRS                                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PATHWAY comments
   Index of metabolic and biosynthesis pathways
2. SIMILARITY comments
   Index of protein domains and families