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UniProtKB - Q9Z1L0 (PK3CB_RAT)

Entry version 155 (23 Feb 2022)
Sequence version 1 (01 May 1999)
Previous versions | rss
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Protein

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Gene

Pik3cb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phosphatidylinositol phosphate biosynthesis

This protein is involved in the pathway phosphatidylinositol phosphate biosynthesis, which is part of Phospholipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol phosphate biosynthesis and in Phospholipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processAutophagy, Cell adhesion, Endocytosis, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.1.153, 5301

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-109704, PI3K Cascade
R-RNO-112399, IRS-mediated signalling
R-RNO-114604, GPVI-mediated activation cascade
R-RNO-1257604, PIP3 activates AKT signaling
R-RNO-1660499, Synthesis of PIPs at the plasma membrane
R-RNO-186763, Downstream signal transduction
R-RNO-198203, PI3K/AKT activation
R-RNO-201556, Signaling by ALK
R-RNO-202424, Downstream TCR signaling
R-RNO-2029485, Role of phospholipids in phagocytosis
R-RNO-210993, Tie2 Signaling
R-RNO-2424491, DAP12 signaling
R-RNO-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-RNO-4420097, VEGFA-VEGFR2 Pathway
R-RNO-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling
R-RNO-5673001, RAF/MAP kinase cascade
R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-8853659, RET signaling
R-RNO-9027276, Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
R-RNO-912526, Interleukin receptor SHC signaling
R-RNO-912631, Regulation of signaling by CBL

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00220

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC:2.7.1.153By similarity)
Short name:
PI3-kinase subunit beta
Short name:
PI3K-beta
Short name:
PI3Kbeta
Short name:
PtdIns-3-kinase subunit beta
Alternative name(s):
Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta
Short name:
PtdIns-3-kinase subunit p110-beta
Short name:
p110beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pik3cb
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...RGDi		620917, Pik3cb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3608198

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000887891 – 1070Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformAdd BLAST1070

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei324PhosphoserineBy similarity1
Modified residuei1070PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Z1L0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Z1L0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Z1L0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a catalytic subunit PIK3CB and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interaction with PIK3R2 is required for nuclear localization and nuclear export (By similarity).

Part of a complex with PIK3R1 and PTEN (By similarity). Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions (By similarity).

Part of a complex involved in autophagosome formation composed of PIK3C3 and PIK3R4 (By similarity).

Interacts with BECN1, ATG14 and RAB5A (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9Z1L0, 9 interactors

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000022179

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9Z1L0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Z1L0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 115PI3K-ABDPROSITE-ProRule annotationAdd BLAST90
Domaini194 – 285PI3K-RBDPROSITE-ProRule annotationAdd BLAST92
Domaini327 – 496C2 PI3K-typePROSITE-ProRule annotationAdd BLAST170
Domaini524 – 701PIK helicalPROSITE-ProRule annotationAdd BLAST178
Domaini772 – 1053PI3K/PI4K catalyticPROSITE-ProRule annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni778 – 784G-loopPROSITE-ProRule annotation7
Regioni916 – 924Catalytic loopPROSITE-ProRule annotation9
Regioni935 – 961Activation loopPROSITE-ProRule annotationAdd BLAST27

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi410 – 418Nuclear localization signal (NLS)By similarity9

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1; the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1; and the PI3K/PI4K kinase domain with the cSH2 (C-terminal SH2) region of PIK3R1. The inhibitory interaction between the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1 is weak. The nuclear localization signal (NLS) is required for its function in cell survival (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0904, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Z1L0

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Z1L0

Family and domain databases

Conserved Domains Database

More...CDDi		cd05173, PI3Kc_IA_beta, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR035892, C2_domain_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR002420, PI3K-type_C2_dom
IPR003113, PI3K_ABD
IPR001263, PI3K_accessory_dom
IPR042236, PI3K_accessory_sf
IPR000341, PI3K_Ras-bd_dom
IPR037702, PI3Kbeta_dom
IPR015433, PI_Kinase
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...PANTHERi		PTHR10048, PTHR10048, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00454, PI3_PI4_kinase, 1 hit
PF00792, PI3K_C2, 1 hit
PF02192, PI3K_p85B, 1 hit
PF00794, PI3K_rbd, 1 hit
PF00613, PI3Ka, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00142, PI3K_C2, 1 hit
SM00143, PI3K_p85B, 1 hit
SM00144, PI3K_rbd, 1 hit
SM00145, PI3Ka, 1 hit
SM00146, PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit
SSF49562, SSF49562, 1 hit
SSF54236, SSF54236, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51547, C2_PI3K, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS51544, PI3K_ABD, 1 hit
PS51546, PI3K_RBD, 1 hit
PS51545, PIK_HELICAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Z1L0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCFRSIMPPA MADTLDIWAV DSQIASDGSI SVDFLLPTGI YIQLEVPREA 
        60         70         80         90        100
TISYIKQMLW KQVHNYPMFN LLMDIDSYMF ACVNQTAVYE ELEDETRRLC 
       110        120        130        140        150
DVRPFLPVLK LVTRSCDPAE KLDSKIGVLI GKGLHEFDAL KDPEVNEFRR 
       160        170        180        190        200
KMRKFSEDKI QSLVGLSWID WLKHTYPPEH EPSVLENLED KLYGGKLVVA 
       210        220        230        240        250
VHFENSQDVF SFQVSPNLNP IKINELAIQK RLTIRGKEEE ASPCDYVLQV 
       260        270        280        290        300
SGRVEYVFGD HPLIQFQYIR NCVMNRTLPH FILVECCKIK KMYEQEMIAI 
       310        320        330        340        350
EAAINRNSSS LPLPLPPKKT RVISHVWGNN NPFQIVLVKG NKLNTEETVK 
       360        370        380        390        400
VHVRAGLFHG TELLCKTVVS SEISGKNDHI WNEQLEFDIN ICDLPRMARL 
       410        420        430        440        450
CFAVYAVLDK VKTKKSTKTI NPSKYQTIRK AGKVHYPVAW VNTMVFDFKG 
       460        470        480        490        500
QLRSGDVILH SWSSFPDELE EMLNPMGTVQ TNPYAENATA LHIKFPENKK 
       510        520        530        540        550
QPYYYPPFDK IIEKAAEIAS GDSANVSSRG GKKFLAVLKE ILDRDPLSQL 
       560        570        580        590        600
CENEMDLIWT LRQDCRENFP QSLPKLLLSI KWNKLEDVAQ LQALLQIWPK 
       610        620        630        640        650
LPPREALELL DFNYPDQYVR EYAVGCLRQM SDEELSQYLL QLVQVLKYEP 
       660        670        680        690        700
FLDCALSRFL LERALDNRRI GQFLFWHLRS EVHTPAVSIQ FGVILEAYCR 
       710        720        730        740        750
GSVGHMKVLS KQVEALNKLK TLNSLIKLNA MKLNRAKGKE AMHTCLKQSA 
       760        770        780        790        800
YREALSDLQS PLNPCVILSE LYVEKCRYMD SKMKPLWLVY SNRAFGEDAV 
       810        820        830        840        850
GVIFKNGDDL RQDMLTLQML RLMDLLWKEA GLDLRMLPYG CLATGDRSGL 
       860        870        880        890        900
IEVVSTSETI ADIQLNSSNV AATAAFNKDA LLNWLKEYNS GDDLDRAIEE 
       910        920        930        940        950
FTLSCAGYCV ASYVLGIGDR HSDNIMVKKT GQLFHIDFGH ILGNFKSKFG 
       960        970        980        990       1000
IKRERVPFIL TYDFIHVIQQ GKTGNTEKFG RFRQCCEDAY LILRRHGNLF 
      1010       1020       1030       1040       1050
ITLFALMLTA GLPELTSVKD IQYLKDSLAL GKSEEEALKQ FKQKFDEALR 
      1060       1070
ESWTTKVNWM AHTVRKDYRS
Length:1,070
Mass (Da):122,608
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E8EB2333E96E4D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V839G3V839_RAT
Phosphatidylinositol-4,5-bisphospha...
Pik3cb rCG_25555
1,070Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ012482 mRNA Translation: CAA10046.1

NCBI Reference Sequences

More...RefSeqi		NP_445933.1, NM_053481.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		85243

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:85243

UCSC genome browser

More...UCSCi		RGD:620917, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012482 mRNA Translation: CAA10046.1
RefSeqiNP_445933.1, NM_053481.2

3D structure databases

SMRiQ9Z1L0
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9Z1L0, 9 interactors
STRINGi10116.ENSRNOP00000022179

Chemistry databases

BindingDBiQ9Z1L0
ChEMBLiCHEMBL3608198

PTM databases

iPTMnetiQ9Z1L0
PhosphoSitePlusiQ9Z1L0

Proteomic databases

PaxDbiQ9Z1L0

Genome annotation databases

GeneIDi85243
KEGGirno:85243
UCSCiRGD:620917, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5291
RGDi620917, Pik3cb

Phylogenomic databases

eggNOGiKOG0904, Eukaryota
InParanoidiQ9Z1L0
PhylomeDBiQ9Z1L0

Enzyme and pathway databases

UniPathwayiUPA00220
BRENDAi2.7.1.153, 5301
ReactomeiR-RNO-109704, PI3K Cascade
R-RNO-112399, IRS-mediated signalling
R-RNO-114604, GPVI-mediated activation cascade
R-RNO-1257604, PIP3 activates AKT signaling
R-RNO-1660499, Synthesis of PIPs at the plasma membrane
R-RNO-186763, Downstream signal transduction
R-RNO-198203, PI3K/AKT activation
R-RNO-201556, Signaling by ALK
R-RNO-202424, Downstream TCR signaling
R-RNO-2029485, Role of phospholipids in phagocytosis
R-RNO-210993, Tie2 Signaling
R-RNO-2424491, DAP12 signaling
R-RNO-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-RNO-4420097, VEGFA-VEGFR2 Pathway
R-RNO-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling
R-RNO-5673001, RAF/MAP kinase cascade
R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-8853659, RET signaling
R-RNO-9027276, Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
R-RNO-912526, Interleukin receptor SHC signaling
R-RNO-912631, Regulation of signaling by CBL

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9Z1L0

Family and domain databases

CDDicd05173, PI3Kc_IA_beta, 1 hit
Gene3Di1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR035892, C2_domain_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR002420, PI3K-type_C2_dom
IPR003113, PI3K_ABD
IPR001263, PI3K_accessory_dom
IPR042236, PI3K_accessory_sf
IPR000341, PI3K_Ras-bd_dom
IPR037702, PI3Kbeta_dom
IPR015433, PI_Kinase
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR10048, PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454, PI3_PI4_kinase, 1 hit
PF00792, PI3K_C2, 1 hit
PF02192, PI3K_p85B, 1 hit
PF00794, PI3K_rbd, 1 hit
PF00613, PI3Ka, 1 hit
SMARTiView protein in SMART
SM00142, PI3K_C2, 1 hit
SM00143, PI3K_p85B, 1 hit
SM00144, PI3K_rbd, 1 hit
SM00145, PI3Ka, 1 hit
SM00146, PI3Kc, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF49562, SSF49562, 1 hit
SSF54236, SSF54236, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51547, C2_PI3K, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS51544, PI3K_ABD, 1 hit
PS51546, PI3K_RBD, 1 hit
PS51545, PIK_HELICAL, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPK3CB_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z1L0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: February 23, 2022
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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