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Entry version 128 (07 Oct 2020)
Sequence version 1 (01 May 1999)
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Protein

Adenomatous polyposis coli protein 2

Gene

Apc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenomatous polyposis coli protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Apc2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1346052, Apc2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice display abnormal head shape with shortened skull length and no change in the skull height. Brain ventricles of these mice are significantly larger and the thickness of the corpus callosum is significantly reduced. They show increased exploratory activity and have impaired learning memory function.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003136871 – 2274Adenomatous polyposis coli protein 2Add BLAST2274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1563PhosphoserineCombined sources1
Modified residuei1565PhosphoserineCombined sources1
Modified residuei1861PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Z1K7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Z1K7

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z1K7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Z1K7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Z1K7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain and other neural tissues.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Strongly expressed in fetal brain but expression decreases from P12 onward. Expressed in postmitotic neurons.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with APC, CTNNB1, TP53BP2 and possibly with AXIN2 (By similarity).

Interacts with MAPRE3, PSRC1 and probably MAPRE1.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-448, Beta-catenin destruction core complex, variant 2
CPX-452, Beta-catenin destruction core complex, variant 4
CPX-456, Beta-catenin destruction core complex, variant 6
CPX-458, Beta-catenin destruction core complex, variant 8

Protein interaction database and analysis system

More...
IntActi
Q9Z1K7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000100996

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Z1K7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Z1K7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati301 – 341ARM 1Add BLAST41
Repeati472 – 511ARM 2Add BLAST40
Repeati515 – 555ARM 3Add BLAST41
Repeati557 – 602ARM 4Add BLAST46
Repeati608 – 647ARM 5Add BLAST40
Repeati650 – 689ARM 6Add BLAST40
Repeati1049 – 10681Add BLAST20
Repeati1140 – 11592Add BLAST20
Repeati1250 – 12693Add BLAST20
Repeati1375 – 13944Add BLAST20
Repeati1546 – 15655Add BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1049 – 15655 X 20 AA approximate repeat of F-X-V-E-X-T-P-X-C-F-S-R-X-S-S-L-S-S-L-SAdd BLAST517
Regioni1049 – 1565Interaction with CTNNB1By similarityAdd BLAST517
Regioni1792 – 1871Required for localization to microtubules and function in microtubule stabilizationBy similarityAdd BLAST80
Regioni2037 – 2114Interaction with MAPRE1 and MAPRE3By similarityAdd BLAST78

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili5 – 59Sequence analysisAdd BLAST55
Coiled coili832 – 856Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1057 – 1186Ser-richAdd BLAST130
Compositional biasi1829 – 1922Pro-richAdd BLAST94

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2122, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Z1K7

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Z1K7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026837, APC2
IPR009234, APC_basic_dom
IPR026831, APC_dom
IPR026818, Apc_fam
IPR032038, APC_N
IPR036149, APC_N_sf
IPR041257, APC_rep
IPR009223, APC_rpt
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR009224, SAMP

The PANTHER Classification System

More...
PANTHERi
PTHR12607, PTHR12607, 1 hit
PTHR12607:SF3, PTHR12607:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05956, APC_basic, 1 hit
PF16689, APC_N_CC, 1 hit
PF05923, APC_r, 3 hits
PF18797, APC_rep, 1 hit
PF00514, Arm, 1 hit
PF05924, SAMP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185, ARM, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF58050, SSF58050, 1 hit
SSF82931, SSF82931, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9Z1K7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSSMASYEQ LVRQVEALKA ENTHLRQELR DNSSHLSKLE TETSGMKEVL
60 70 80 90 100
KHLQGKLEQE ARVLVSSGQT EVLEQLKALQ TDISSLYNLK FHAPALGPEP
110 120 130 140 150
AARTPEGSPV HGSGPSKDSF GELSRATIRL LEELDQERCF LLSEIEKEEK
160 170 180 190 200
EKLWYYSQLQ GLSKRLDELP HVDTFSMQMD LIRQQLEFEA QHIRSLMEER
210 220 230 240 250
FGTSDEMVQR AQIRASRLEQ IDKELLEAQD RVQQTEPQAL LAVKPVAVEE
260 270 280 290 300
EQEAEVPTHP EDGTPQPGNS KVEVVFWLLS MLATRDQEDT ARTLLAMSSS
310 320 330 340 350
PESCVAMRRS GCLPLLLQIL HGTEAGSVGR AGIPGAPGAK DARMRANAAL
360 370 380 390 400
HNIVFSQPDQ GLARKEMRVL HVLEQIRAYC ETCWDWLQAR DSGTETPVPI
410 420 430 440 450
EPQICQATCA VMKLSFDEEY RRAMNELGGL QAVAELLQVD YEMHKMTRDP
460 470 480 490 500
LNLALRRYAG MTLTNLTFGD VANKATLCAR RGCMEAIVAQ LGSESEELHQ
510 520 530 540 550
VVSSILRNLS WRADINSKKV LREVGSMTAL MECVLRASKE STLKSVLSAL
560 570 580 590 600
WNLSAHSTEN KAAICQVDGA LGFLVSTLTY RCQGNSLAVI ESGGGILRNV
610 620 630 640 650
SSLIATREDY RQVLRDHNCL QTLLQHLTSH SLTIVSNACG TLWNLSARSP
660 670 680 690 700
RDQELLWDLG AVGMLRNLVH SKHKMIAMGS AAALRNLLAH RPAKYQAAAM
710 720 730 740 750
AVSPGTCVPS LYVRKQRALE AELDTRHLVH ALGHLEKQSL PEAETTSKKP
760 770 780 790 800
LPPLRHLDGL VQDYASDSGC FDDDDAPSLA AAATTAEPAS PAVMSMFLGG
810 820 830 840 850
PFLQGQALAR TPPARQGGLE AEKEAGGEAA VAAKAKAKLA LAVARIDRLV
860 870 880 890 900
EDISALHTSS DDSFSLSSGD PGQEAPREGR AQSCSPCRGT EGGRREAGSR
910 920 930 940 950
AHPLLRLKAA HTSLSNDSLN SGSTSDGYCT REHMTPCPLA ALAEHRDDPV
960 970 980 990 1000
RGQTRPRRLD LDLPSRAELP ARDTAATDAR VRTIKLSPTY QHVPLLDGAA
1010 1020 1030 1040 1050
GAGVRPLVGP GTSPGARKQA WIPADSLSKV PEKLVASPLP IASKVLQKLV
1060 1070 1080 1090 1100
AQDGPMSLSR CSSLSSLSST GHAVPSQAEN LDSDSSLEGL EEAGPGEAEL
1110 1120 1130 1140 1150
GRAWRASGST SLPVSIPAPQ RGRSRGLGVE DATPSSSSEN CVQETPLVLS
1160 1170 1180 1190 1200
RCSSVSSLGS FESRSIASSI PSDPCSGLGS GTVSPSELPD SPGQTMPPSR
1210 1220 1230 1240 1250
SKTPPAPPGQ PETSQFSLQW ESYVKRFLDI ADCRERCQPP SELDAGSVRF
1260 1270 1280 1290 1300
TVEKPDENFS CASSLSALAL HELYVQQDVE LRLRPPACPE RAVGGGGHRR
1310 1320 1330 1340 1350
RDEAASRLDG PAPAGSRARS ATDKELEALR ECLGAAMPAR LRKVASALVP
1360 1370 1380 1390 1400
GRRSLPVPVY MLVPAPARGD DSGTDSAEGT PVNFSSAASL SDETLQGPSR
1410 1420 1430 1440 1450
DKPAGPGDRQ KPTGRAAPAR QTRSHRPKAA GAGKSTEHTR GPCRNRAGLE
1460 1470 1480 1490 1500
LPLSRPQSAR SNRDSSCQTR TRGDGALQSL CLTTPTEEAV YCFYDSDEEP
1510 1520 1530 1540 1550
PATAPPPRRA SAIPRALKRE KPAGRKETPS RAAQPATLPV RAQPRLIVDE
1560 1570 1580 1590 1600
TPPCYSLTSS ASSLSEPEAP EQPANHARGP EQGSKQDSSP SPRAEEELLQ
1610 1620 1630 1640 1650
RCISLAMPRR RTQVPGSRRR KPRALRSDIR PTEITQKCQE EVAGSDPASD
1660 1670 1680 1690 1700
LDSVEWQAIQ EGANSIVTWL HQAAAKASLE ASSESDSLLS LVSGVSAGST
1710 1720 1730 1740 1750
LQPSKLRKGR KPAAEAGGAW RPEKRGTTST KINGSPRLPN GPEKAKGTQK
1760 1770 1780 1790 1800
MMAGESTMLR GRTVIYSAGP ASRTQSKGIS GPCTTPKKTG TSGTTQPETV
1810 1820 1830 1840 1850
TKAPSPEQQR SRSLHRPGKI SELAALRHPP RSATPPARLA KTPSSSSSQT
1860 1870 1880 1890 1900
SPASQPLPRR SPLATPTGGP LPGPGGSLVP KSPARALLAK QHKTQKSPVR
1910 1920 1930 1940 1950
IPFMQRPARR VPPPLARPSP EPGSRGRAGA EGTPGARGSR LGLVRMASAR
1960 1970 1980 1990 2000
SSGSESSDRS GFRRQLTFIK ESPGLLRRRR SELSSADSTA STSQAASPRR
2010 2020 2030 2040 2050
GRPALPAVFL CSSRCDELRV SPRQPLAAQR SPQAKPGLAP LAPRRTSSES
2060 2070 2080 2090 2100
PSRLPVRASP GRPETVKRYA SLPHISVSRR SDSAVSVPTT QANATRRGSD
2110 2120 2130 2140 2150
GEARPLPRVA PPGTTWRRIK DEDVPHILRS TLPATALPLR VSSPEDSPAG
2160 2170 2180 2190 2200
TPQRKTSDAV VQTEDVATSK TNSSTSPSLE SRDPPQAPAS GPVAPQGSDV
2210 2220 2230 2240 2250
DGPVLTKPPA SAPFPHEGLS AVIAGFPTSR HGSPSRAARV PPFNYVPSPM
2260 2270
AAATMASDSA VEKAPVSSPA SLLE
Length:2,274
Mass (Da):243,139
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75ABDA15D0F707F5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E832G5E832_MOUSE
Adenomatous polyposis coli protein ...
Apc2
2,274Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YTR0D3YTR0_MOUSE
Adenomatous polyposis coli protein ...
Apc2
2,303Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z344D3Z344_MOUSE
Adenomatous polyposis coli protein ...
Apc2
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YYQ9D3YYQ9_MOUSE
Adenomatous polyposis coli protein ...
Apc2
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z3K9D3Z3K9_MOUSE
Adenomatous polyposis coli protein ...
Apc2
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ130783 AJ130796 Genomic DNA Translation: CAA10207.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24016.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T30258

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ130783 AJ130796 Genomic DNA Translation: CAA10207.1
CCDSiCCDS24016.1
PIRiT30258

3D structure databases

SMRiQ9Z1K7
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-448, Beta-catenin destruction core complex, variant 2
CPX-452, Beta-catenin destruction core complex, variant 4
CPX-456, Beta-catenin destruction core complex, variant 6
CPX-458, Beta-catenin destruction core complex, variant 8
IntActiQ9Z1K7, 1 interactor
STRINGi10090.ENSMUSP00000100996

PTM databases

iPTMnetiQ9Z1K7
PhosphoSitePlusiQ9Z1K7

Proteomic databases

MaxQBiQ9Z1K7
PaxDbiQ9Z1K7
PRIDEiQ9Z1K7

Organism-specific databases

MGIiMGI:1346052, Apc2

Phylogenomic databases

eggNOGiKOG2122, Eukaryota
InParanoidiQ9Z1K7
PhylomeDBiQ9Z1K7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Apc2, mouse

Protein Ontology

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PROi
PR:Q9Z1K7
RNActiQ9Z1K7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR026837, APC2
IPR009234, APC_basic_dom
IPR026831, APC_dom
IPR026818, Apc_fam
IPR032038, APC_N
IPR036149, APC_N_sf
IPR041257, APC_rep
IPR009223, APC_rpt
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR009224, SAMP
PANTHERiPTHR12607, PTHR12607, 1 hit
PTHR12607:SF3, PTHR12607:SF3, 1 hit
PfamiView protein in Pfam
PF05956, APC_basic, 1 hit
PF16689, APC_N_CC, 1 hit
PF05923, APC_r, 3 hits
PF18797, APC_rep, 1 hit
PF00514, Arm, 1 hit
PF05924, SAMP, 1 hit
SMARTiView protein in SMART
SM00185, ARM, 7 hits
SUPFAMiSSF48371, SSF48371, 1 hit
SSF58050, SSF58050, 1 hit
SSF82931, SSF82931, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPCL_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z1K7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 1999
Last modified: October 7, 2020
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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