Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 173 (02 Jun 2021)
Sequence version 3 (27 Jul 2011)
Previous versions | rss
Add a publicationFeedback
Protein

V-type proton ATPase 116 kDa subunit a1

Gene

Atp6v0a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1222556, ROS and RNS production in phagocytes
R-MMU-6798695, Neutrophil degranulation
R-MMU-77387, Insulin receptor recycling
R-MMU-917977, Transferrin endocytosis and recycling
R-MMU-983712, Ion channel transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.2.2.6, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
V-type proton ATPase 116 kDa subunit a1
Short name:
V-ATPase 116 kDa subunit a1
Alternative name(s):
Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit
Vacuolar adenosine triphosphatase subunit Ac116
Vacuolar proton pump subunit 1
Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Atp6v0a1
Synonyms:Atp6n1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:103286, Atp6v0a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 395CytoplasmicSequence analysisAdd BLAST395
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei396 – 414HelicalSequence analysisAdd BLAST19
Topological domaini415 – 416VacuolarSequence analysis2
Transmembranei417 – 433HelicalSequence analysisAdd BLAST17
Topological domaini434 – 448CytoplasmicSequence analysisAdd BLAST15
Transmembranei449 – 478HelicalSequence analysisAdd BLAST30
Topological domaini479 – 542VacuolarSequence analysisAdd BLAST64
Transmembranei543 – 562HelicalSequence analysisAdd BLAST20
Topological domaini563 – 580CytoplasmicSequence analysisAdd BLAST18
Transmembranei581 – 601HelicalSequence analysisAdd BLAST21
Topological domaini602 – 646VacuolarSequence analysisAdd BLAST45
Transmembranei647 – 666HelicalSequence analysisAdd BLAST20
Topological domaini667 – 726CytoplasmicSequence analysisAdd BLAST60
Transmembranei727 – 751HelicalSequence analysisAdd BLAST25
Topological domaini752 – 772VacuolarSequence analysisAdd BLAST21
Transmembranei773 – 811HelicalSequence analysisAdd BLAST39
Topological domaini812 – 839CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001192121 – 839V-type proton ATPase 116 kDa subunit a1Add BLAST839

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei257PhosphothreonineCombined sources1
Modified residuei367PhosphothreonineBy similarity1
Modified residuei371PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Z1G4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Z1G4

PeptideAtlas

More...
PeptideAtlasi
Q9Z1G4

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z1G4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
300178 [Q9Z1G4-1]
300179 [Q9Z1G4-2]
300180 [Q9Z1G4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Z1G4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Z1G4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9Z1G4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000019302, Expressed in Ammon's horn and 318 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Z1G4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Z1G4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The V-ATPase is a heteromultimeric enzyme composed of at least thirteen different subunits. It has a membrane peripheral V1 sector for ATP hydrolysis and an integral V0 for proton translocation. The V1 sector comprises subunits A-H, whereas V0 includes subunits a, d, c, c', and c''.

Interacts with SPAAR (PubMed:28024296).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
198267, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Z1G4, 6 interactors

Molecular INTeraction database

More...
MINTi
Q9Z1G4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000044838

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Z1G4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Z1G4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2189, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182881

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005230_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Z1G4

Identification of Orthologs from Complete Genome Data

More...
OMAi
LIYMFLQ

Database of Orthologous Groups

More...
OrthoDBi
181796at2759

TreeFam database of animal gene trees

More...
TreeFami
TF300346

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002490, V-ATPase_116kDa_su
IPR026028, V-type_ATPase_116kDa_su_euka

The PANTHER Classification System

More...
PANTHERi
PTHR11629, PTHR11629, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01496, V_ATPase_I, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001293, ATP6V0A1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform A1-II (identifier: Q9Z1G4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK
60 70 80 90 100
FVNEVRRCEE MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEAN
110 120 130 140 150
FEKIENELKE INTNQEALKR NFLELTELKF ILRKTQQFFD EAELHHQQMA
160 170 180 190 200
DPDLLEESSS LLEPNEMGRG APLRLGFVAG VINRERIPTF ERMLWRVCRG
210 220 230 240 250
NVFLRQAEIE NPLEDPVTGD YVHKSVFIIF FQGDQLKNRV KKICEGFRAS
260 270 280 290 300
LYPCPETPQE RKEMASGVNT RIDDLQMVLN QTEDHRQRVL QAAAKNIRVW
310 320 330 340 350
FIKVRKMKAI YHTLNLCNID VTQKCLIAEV WCPVTDLDSI QFALRRGTEH
360 370 380 390 400
SGSTVPSILN RMQTNQTPPT YNKTNKFTHG FQNIVDAYGI GTYREINPAP
410 420 430 440 450
YTVITFPFLF AVMFGDFGHG ILMTLFAVWM VLRESRILSQ KHENEMFSMV
460 470 480 490 500
FSGRYIILLM GLFSIYTGLI YNDCFSKSLN IFGSSWSVRP MFTQGNWTEE
510 520 530 540 550
TLLGSSVLQL NPAIPGVFGG PYPFGIDPIW NIATNKLTFL NSFKMKMSVI
560 570 580 590 600
LGIIHMLFGV SLSLFNHIYF KKPLNIYFGF IPEIIFMSSL FGYLVILIFY
610 620 630 640 650
KWTAYDAHSS RNAPSLLIHF INMFLFSYPE SGNAMLYSGQ KGIQCFLIVV
660 670 680 690 700
AMLCVPWMLL FKPLILRHQY LRKKHLGTLN FGGIRVGNGP TEEDAEIIQH
710 720 730 740 750
DQLSTHSEDA EEFDFGDTMV HQAIHTIEYC LGCISNTASY LRLWALSLAH
760 770 780 790 800
AQLSEVLWTM VIHIGLHVRS LAGGLGLFFI FAAFATLTVA ILLIMEGLSA
810 820 830
FLHALRLHWV EFQNKFYTGT GFKFLPFSFE HIREGKFDE
Length:839
Mass (Da):96,467
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE102667721450C06
GO
Isoform A1-I (identifier: Q9Z1G4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-148: Missing.
     712-712: E → EPTEDEV

Show »
Length:838
Mass (Da):96,294
Checksum:i1A96E0FA5D521FE0
GO
Isoform A1-III (identifier: Q9Z1G4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-148: Missing.

Show »
Length:832
Mass (Da):95,623
Checksum:i62BD9D631F7484AF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K3W4T3K3W4T3_MOUSE
V-type proton ATPase subunit a
Atp6v0a1
838Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A599A2A599_MOUSE
V-type proton ATPase subunit a
Atp6v0a1
79Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti36Q → N in AAC83083 (Ref. 1) Curated1
Sequence conflicti88 – 92VPFPR → APLPW in AAC83083 (Ref. 1) Curated5
Sequence conflicti112N → D in AAC83083 (Ref. 1) Curated1
Sequence conflicti190F → S in AAC83083 (Ref. 1) Curated1
Sequence conflicti262K → T in AAC83083 (Ref. 1) Curated1
Sequence conflicti337L → P in AAC83083 (Ref. 1) Curated1
Sequence conflicti357S → F in AAC83083 (Ref. 1) Curated1
Sequence conflicti415G → R in AAC83083 (Ref. 1) Curated1
Sequence conflicti518F → L in AAC83083 (Ref. 1) Curated1
Sequence conflicti683G → W in AAC83083 (Ref. 1) Curated1
Sequence conflicti803H → L in AAC83083 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti194L → F. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000342142 – 148Missing in isoform A1-I and isoform A1-III. 1 Publication7
Alternative sequenceiVSP_000343712E → EPTEDEV in isoform A1-I. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U13836 mRNA Translation: AAC83083.1
AF218249 mRNA Translation: AAF59918.1
AF218250 mRNA Translation: AAF59919.1
AF218251 mRNA Translation: AAF59920.1
AB022321 mRNA Translation: BAA93005.1
AL591425 Genomic DNA No translation available.
CH466677 Genomic DNA Translation: EDL03866.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25443.1 [Q9Z1G4-2]
CCDS56808.1 [Q9Z1G4-1]
CCDS56809.1 [Q9Z1G4-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001229979.1, NM_001243050.1 [Q9Z1G4-3]
NP_001229980.1, NM_001243051.1 [Q9Z1G4-1]
NP_058616.1, NM_016920.3 [Q9Z1G4-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000044721; ENSMUSP00000044838; ENSMUSG00000019302 [Q9Z1G4-2]
ENSMUST00000092663; ENSMUSP00000090333; ENSMUSG00000019302 [Q9Z1G4-3]
ENSMUST00000103110; ENSMUSP00000099399; ENSMUSG00000019302 [Q9Z1G4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11975

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:11975

UCSC genome browser

More...
UCSCi
uc007lmt.2, mouse [Q9Z1G4-3]
uc007lmu.2, mouse [Q9Z1G4-2]
uc007lmx.2, mouse [Q9Z1G4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13836 mRNA Translation: AAC83083.1
AF218249 mRNA Translation: AAF59918.1
AF218250 mRNA Translation: AAF59919.1
AF218251 mRNA Translation: AAF59920.1
AB022321 mRNA Translation: BAA93005.1
AL591425 Genomic DNA No translation available.
CH466677 Genomic DNA Translation: EDL03866.1
CCDSiCCDS25443.1 [Q9Z1G4-2]
CCDS56808.1 [Q9Z1G4-1]
CCDS56809.1 [Q9Z1G4-3]
RefSeqiNP_001229979.1, NM_001243050.1 [Q9Z1G4-3]
NP_001229980.1, NM_001243051.1 [Q9Z1G4-1]
NP_058616.1, NM_016920.3 [Q9Z1G4-2]

3D structure databases

SMRiQ9Z1G4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi198267, 11 interactors
IntActiQ9Z1G4, 6 interactors
MINTiQ9Z1G4
STRINGi10090.ENSMUSP00000044838

Protein family/group databases

TCDBi3.A.2.2.6, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

PTM databases

iPTMnetiQ9Z1G4
PhosphoSitePlusiQ9Z1G4
SwissPalmiQ9Z1G4

Proteomic databases

jPOSTiQ9Z1G4
PaxDbiQ9Z1G4
PeptideAtlasiQ9Z1G4
PRIDEiQ9Z1G4
ProteomicsDBi300178 [Q9Z1G4-1]
300179 [Q9Z1G4-2]
300180 [Q9Z1G4-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
16938, 102 antibodies

The DNASU plasmid repository

More...
DNASUi
11975

Genome annotation databases

EnsembliENSMUST00000044721; ENSMUSP00000044838; ENSMUSG00000019302 [Q9Z1G4-2]
ENSMUST00000092663; ENSMUSP00000090333; ENSMUSG00000019302 [Q9Z1G4-3]
ENSMUST00000103110; ENSMUSP00000099399; ENSMUSG00000019302 [Q9Z1G4-1]
GeneIDi11975
KEGGimmu:11975
UCSCiuc007lmt.2, mouse [Q9Z1G4-3]
uc007lmu.2, mouse [Q9Z1G4-2]
uc007lmx.2, mouse [Q9Z1G4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
535
MGIiMGI:103286, Atp6v0a1

Phylogenomic databases

eggNOGiKOG2189, Eukaryota
GeneTreeiENSGT00950000182881
HOGENOMiCLU_005230_0_1_1
InParanoidiQ9Z1G4
OMAiLIYMFLQ
OrthoDBi181796at2759
TreeFamiTF300346

Enzyme and pathway databases

ReactomeiR-MMU-1222556, ROS and RNS production in phagocytes
R-MMU-6798695, Neutrophil degranulation
R-MMU-77387, Insulin receptor recycling
R-MMU-917977, Transferrin endocytosis and recycling
R-MMU-983712, Ion channel transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
11975, 6 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Atp6v0a1, mouse

Protein Ontology

More...
PROi
PR:Q9Z1G4
RNActiQ9Z1G4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000019302, Expressed in Ammon's horn and 318 other tissues
ExpressionAtlasiQ9Z1G4, baseline and differential
GenevisibleiQ9Z1G4, MM

Family and domain databases

InterProiView protein in InterPro
IPR002490, V-ATPase_116kDa_su
IPR026028, V-type_ATPase_116kDa_su_euka
PANTHERiPTHR11629, PTHR11629, 1 hit
PfamiView protein in Pfam
PF01496, V_ATPase_I, 1 hit
PIRSFiPIRSF001293, ATP6V0A1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVPP1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z1G4
Secondary accession number(s): A2A5A1
, Q9JHJ4, Q9JL13, Q9JL14
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: June 2, 2021
This is version 173 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again