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Protein

V-type proton ATPase subunit C 1

Gene

Atp6v1c1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Protein family/group databases

TCDBi3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit C 1
Short name:
V-ATPase subunit C 1
Alternative name(s):
Vacuolar proton pump subunit C 1
Gene namesi
Name:Atp6v1c1
Synonyms:Atp6c, Atp6c1, Vatc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1913585 Atp6v1c1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002093492 – 382V-type proton ATPase subunit C 1Add BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Z1G3
MaxQBiQ9Z1G3
PaxDbiQ9Z1G3
PeptideAtlasiQ9Z1G3
PRIDEiQ9Z1G3

PTM databases

iPTMnetiQ9Z1G3
PhosphoSitePlusiQ9Z1G3
SwissPalmiQ9Z1G3

Expressioni

Tissue specificityi

Ubiquitous. Abundant in brain, liver, kidney and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000022295 Expressed in 305 organ(s), highest expression level in prefrontal cortex
CleanExiMM_ATP6V1C1
GenevisibleiQ9Z1G3 MM

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Protein-protein interaction databases

BioGridi211393, 1 interactor
IntActiQ9Z1G3, 5 interactors
STRINGi10090.ENSMUSP00000022904

Structurei

3D structure databases

ProteinModelPortaliQ9Z1G3
SMRiQ9Z1G3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase C subunit family.Curated

Phylogenomic databases

eggNOGiKOG2909 Eukaryota
COG5127 LUCA
GeneTreeiENSGT00390000004263
HOGENOMiHOG000207528
HOVERGENiHBG002470
InParanoidiQ9Z1G3
KOiK02148
OMAiCRENKFI
OrthoDBiEOG091G03CP
PhylomeDBiQ9Z1G3
TreeFamiTF314912

Family and domain databases

CDDicd14785 V-ATPase_C, 1 hit
InterProiView protein in InterPro
IPR004907 ATPase_V1-cplx_csu
IPR036132 Vac_ATP_synth_c_sf
PANTHERiPTHR10137 PTHR10137, 1 hit
PfamiView protein in Pfam
PF03223 V-ATPase_C, 1 hit
SUPFAMiSSF118203 SSF118203, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9Z1G3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEFWLISAP GEKTCQQTWE KLHAATTKNN NLAVSSKFNI PDLKVGTLDV
60 70 80 90 100
LVGLSDELAK LDAFVEGVVK KVAQYMADVL EDSKDKVQEN LLASGVDLVT
110 120 130 140 150
YITRFQWDMA KYPIKQSLKN ISEIIAKGVT QIDNDLKSRA SAYNNLKGNL
160 170 180 190 200
QNLERKNAGS LLTRSLAEIV KKDDFVLDSE YLVTLLVVVP KLNHNDWIKQ
210 220 230 240 250
YETLAEMVVP RSSNVLSEDQ DSYLCNVTLF RKAVDDFRHK ARENKFIVRD
260 270 280 290 300
FQYNEEEMKA DKEEMTRLST DKKKQFGPLV RWLKVNFSEA FIAWIHIKAL
310 320 330 340 350
RVFVESVLRY GLPVNFQAML LQPNKKSVKK LREVLHELYK HLDSSAAAII
360 370 380
DAPMDIPGLN LSQQEYYPYV YYKIDCNLLE FK
Length:382
Mass (Da):43,888
Last modified:May 1, 2007 - v4
Checksum:i6D1851D8C81DF98F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BPD0A0A2I3BPD0_MOUSE
V-type proton ATPase subunit C
Atp6v1c1
101Annotation score:
A0A2I3BQD9A0A2I3BQD9_MOUSE
V-type proton ATPase subunit C
Atp6v1c1
31Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti267R → E in AAC83084 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB088407 mRNA Translation: BAC57953.1
U13839 mRNA Translation: AAC83084.1
AK075779 mRNA Translation: BAC35953.1
AK151237 mRNA Translation: BAE30229.1
BC010217 mRNA Translation: AAH10217.1
CCDSiCCDS27439.1
RefSeqiNP_079770.2, NM_025494.3
UniGeneiMm.276618

Genome annotation databases

EnsembliENSMUST00000022904; ENSMUSP00000022904; ENSMUSG00000022295
ENSMUST00000229037; ENSMUSP00000155467; ENSMUSG00000116394
GeneIDi66335
KEGGimmu:66335
UCSCiuc007vnv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB088407 mRNA Translation: BAC57953.1
U13839 mRNA Translation: AAC83084.1
AK075779 mRNA Translation: BAC35953.1
AK151237 mRNA Translation: BAE30229.1
BC010217 mRNA Translation: AAH10217.1
CCDSiCCDS27439.1
RefSeqiNP_079770.2, NM_025494.3
UniGeneiMm.276618

3D structure databases

ProteinModelPortaliQ9Z1G3
SMRiQ9Z1G3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211393, 1 interactor
IntActiQ9Z1G3, 5 interactors
STRINGi10090.ENSMUSP00000022904

Protein family/group databases

TCDBi3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

PTM databases

iPTMnetiQ9Z1G3
PhosphoSitePlusiQ9Z1G3
SwissPalmiQ9Z1G3

Proteomic databases

EPDiQ9Z1G3
MaxQBiQ9Z1G3
PaxDbiQ9Z1G3
PeptideAtlasiQ9Z1G3
PRIDEiQ9Z1G3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022904; ENSMUSP00000022904; ENSMUSG00000022295
ENSMUST00000229037; ENSMUSP00000155467; ENSMUSG00000116394
GeneIDi66335
KEGGimmu:66335
UCSCiuc007vnv.2 mouse

Organism-specific databases

CTDi528
MGIiMGI:1913585 Atp6v1c1

Phylogenomic databases

eggNOGiKOG2909 Eukaryota
COG5127 LUCA
GeneTreeiENSGT00390000004263
HOGENOMiHOG000207528
HOVERGENiHBG002470
InParanoidiQ9Z1G3
KOiK02148
OMAiCRENKFI
OrthoDBiEOG091G03CP
PhylomeDBiQ9Z1G3
TreeFamiTF314912

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Miscellaneous databases

ChiTaRSiAtp6v1c1 mouse
PROiPR:Q9Z1G3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022295 Expressed in 305 organ(s), highest expression level in prefrontal cortex
CleanExiMM_ATP6V1C1
GenevisibleiQ9Z1G3 MM

Family and domain databases

CDDicd14785 V-ATPase_C, 1 hit
InterProiView protein in InterPro
IPR004907 ATPase_V1-cplx_csu
IPR036132 Vac_ATP_synth_c_sf
PANTHERiPTHR10137 PTHR10137, 1 hit
PfamiView protein in Pfam
PF03223 V-ATPase_C, 1 hit
SUPFAMiSSF118203 SSF118203, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVATC1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1G3
Secondary accession number(s): Q91Z42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2007
Last modified: September 12, 2018
This is version 146 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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