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Protein

Leukocyte cell-derived chemotaxin 1

Gene

Cnmd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development (By similarity). Inhibits in vitro tube formation and mobilization of endothelial cells (By similarity). Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.By similarity1 Publication

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processChondrogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte cell-derived chemotaxin 1Curated
Alternative name(s):
ChondromodulinImported
Cleaved into the following 2 chains:
Chondrosurfactant protein
Short name:
CH-SP
Alternative name(s):
Chondromodulin-I
Short name:
ChM-I
Gene namesi
Name:CnmdImported
Synonyms:ChmiImported, Lect1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1341171 Cnmd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Extracellular matrix, Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Aged mice show enhanced VEGFA expression, angiogenesis, inflammatory cell infiltration, aortic stenosis, lipid deposition and calcification in the cardiac valves.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000053491 – 210Chondrosurfactant proteinBy similarityAdd BLAST210
PropeptideiPRO_0000005350211 – 214By similarity4
ChainiPRO_0000005351215 – 334Chondromodulin-1By similarityAdd BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi132 ↔ 193By similarity
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi282 ↔ 286By similarity
Disulfide bondi283 ↔ 323By similarity
Disulfide bondi293 ↔ 317By similarity
Disulfide bondi297 ↔ 313By similarity

Post-translational modificationi

After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z1F6
PRIDEiQ9Z1F6

PTM databases

PhosphoSitePlusiQ9Z1F6

Expressioni

Tissue specificityi

Detected in the four cardiac valves, valvular interstitial cells and extracellular matrix (at protein level).1 Publication

Developmental stagei

Detected from E9.5 in the cardiac valve precursor cells from the atrioventricular cushions and outflow. At E10 expressed in the cardiac jelly covering the trabeculating cardiomyocytes of the left ventricle, the outer curvature of the right ventricle and the outflow tract. Expression in the ventricles decreased gradually as development progressed, and disappeared by mid-embryogenesis (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000022025 Expressed in 142 organ(s), highest expression level in humerus cartilage element
CleanExiMM_LECT1
ExpressionAtlasiQ9Z1F6 baseline and differential
GenevisibleiQ9Z1F6 MM

Structurei

3D structure databases

ProteinModelPortaliQ9Z1F6
SMRiQ9Z1F6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 201BRICHOSPROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Belongs to the chondromodulin-1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFAS Eukaryota
ENOG410YVHU LUCA
GeneTreeiENSGT00480000042679
HOGENOMiHOG000234812
HOVERGENiHBG004387
InParanoidiQ9Z1F6
OMAiIMPVKYE
TreeFamiTF329712

Family and domain databases

InterProiView protein in InterPro
IPR007084 BRICHOS_dom
PfamiView protein in Pfam
PF04089 BRICHOS, 1 hit
SMARTiView protein in SMART
SM01039 BRICHOS, 1 hit
PROSITEiView protein in PROSITE
PS50869 BRICHOS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Z1F6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTENSDKVPI TMVGPEDVEF CSPPAYTTVT VKPSGSPTRL LKVGAVVLIS
60 70 80 90 100
GAVLLLFGAI GAFYFWKGND NHIYNVHYSM SINGKLQDGS MEIDAVNNLE
110 120 130 140 150
TFKMGSGAEE AIEVNDFKNG ITGIRFAGGE KCYIKAQVKA RIPEVGTVTK
160 170 180 190 200
QSISELEGKI MPANYEENSL IWVAVDQPVK DSSFLSSKIL ELCGDLPIFW
210 220 230 240 250
LKPMYPKEIQ RERREVVRNS APSTTRRPHS EPRGNAGPGR LSNGTRPNVQ
260 270 280 290 300
DDAEPFNPDN PYHQQEGESM TFDPRLDHEG ICCIECRRSY THCQKICEPL
310 320 330
GGYYPWPYNY QGCRSACRVV MPCSWWVARI LGMV
Length:334
Mass (Da):37,225
Last modified:July 27, 2011 - v2
Checksum:iBFAAA0B224DC9944
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E8Z6G5E8Z6_MOUSE
Leukocyte cell derived chemotaxin 1...
Cnmd Chmd, Lect1, mCG_19384
338Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108A → R in BAB29095 (PubMed:16141072).Curated1
Sequence conflicti109E → K in AAD00027 (Ref. 1) Curated1
Sequence conflicti163A → V in AAD00027 (Ref. 1) Curated1
Sequence conflicti207K → KANFA in BAB29095 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43509 mRNA Translation: AAD00027.1
AK013975 mRNA Translation: BAB29095.1
CH466535 Genomic DNA Translation: EDL35758.1
BC045152 mRNA Translation: AAH45152.1
CCDSiCCDS27302.1
RefSeqiNP_001297584.1, NM_001310655.1
NP_034831.2, NM_010701.3
UniGeneiMm.46561

Genome annotation databases

EnsembliENSMUST00000022603; ENSMUSP00000022603; ENSMUSG00000022025
GeneIDi16840
KEGGimmu:16840
UCSCiuc007utg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43509 mRNA Translation: AAD00027.1
AK013975 mRNA Translation: BAB29095.1
CH466535 Genomic DNA Translation: EDL35758.1
BC045152 mRNA Translation: AAH45152.1
CCDSiCCDS27302.1
RefSeqiNP_001297584.1, NM_001310655.1
NP_034831.2, NM_010701.3
UniGeneiMm.46561

3D structure databases

ProteinModelPortaliQ9Z1F6
SMRiQ9Z1F6
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiQ9Z1F6

Proteomic databases

PaxDbiQ9Z1F6
PRIDEiQ9Z1F6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022603; ENSMUSP00000022603; ENSMUSG00000022025
GeneIDi16840
KEGGimmu:16840
UCSCiuc007utg.2 mouse

Organism-specific databases

CTDi11061
MGIiMGI:1341171 Cnmd

Phylogenomic databases

eggNOGiENOG410IFAS Eukaryota
ENOG410YVHU LUCA
GeneTreeiENSGT00480000042679
HOGENOMiHOG000234812
HOVERGENiHBG004387
InParanoidiQ9Z1F6
OMAiIMPVKYE
TreeFamiTF329712

Miscellaneous databases

PROiPR:Q9Z1F6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022025 Expressed in 142 organ(s), highest expression level in humerus cartilage element
CleanExiMM_LECT1
ExpressionAtlasiQ9Z1F6 baseline and differential
GenevisibleiQ9Z1F6 MM

Family and domain databases

InterProiView protein in InterPro
IPR007084 BRICHOS_dom
PfamiView protein in Pfam
PF04089 BRICHOS, 1 hit
SMARTiView protein in SMART
SM01039 BRICHOS, 1 hit
PROSITEiView protein in PROSITE
PS50869 BRICHOS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCNMD_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1F6
Secondary accession number(s): Q80UX1, Q9CXU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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