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Entry version 87 (17 Jun 2020)
Sequence version 1 (01 May 1999)
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Protein

Golgi apparatus protein 1

Gene

GLG1

Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).By similarity

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandSialic acid

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgi apparatus protein 1
Alternative name(s):
E-selectin ligand 1
Short name:
ESL-1
Golgi sialoglycoprotein MG-160
Latent TGF-beta complexed protein 1
Short name:
LTCP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GLG1
Synonyms:ESL1, MG160
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10029 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeCricetulus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 1126ExtracellularSequence analysisAdd BLAST1108
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1127 – 1147HelicalSequence analysisAdd BLAST21
Topological domaini1148 – 1160CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001111919 – 1160Golgi apparatus protein 1Add BLAST1142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi562N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi658N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi767N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei942PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Fucosylation is essential for binding to E-selectin.By similarity
N-glycosylated. Contains sialic acid residues.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z1E9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10029.NP_001231202.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Z1E9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati97 – 130Cys-rich GLG1 1Add BLAST34
Repeati131 – 193Cys-rich GLG1 2Add BLAST63
Repeati196 – 259Cys-rich GLG1 3Add BLAST64
Repeati267 – 327Cys-rich GLG1 4Add BLAST61
Repeati328 – 394Cys-rich GLG1 5Add BLAST67
Repeati395 – 454Cys-rich GLG1 6Add BLAST60
Repeati456 – 518Cys-rich GLG1 7Add BLAST63
Repeati519 – 585Cys-rich GLG1 8Add BLAST67
Repeati590 – 649Cys-rich GLG1 9Add BLAST60
Repeati651 – 709Cys-rich GLG1 10Add BLAST59
Repeati710 – 769Cys-rich GLG1 11Add BLAST60
Repeati777 – 837Cys-rich GLG1 12Add BLAST61
Repeati839 – 892Cys-rich GLG1 13Add BLAST54
Repeati893 – 960Cys-rich GLG1 14Add BLAST68
Repeati961 – 1016Cys-rich GLG1 15Add BLAST56
Repeati1022 – 1082Cys-rich GLG1 16Add BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi61 – 67Poly-Gln7

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K06816

Database of Orthologous Groups

More...
OrthoDBi
189325at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001893 Cys-rich_GLG1_repeat
IPR017873 Cys-rich_GLG1_repeat_euk
IPR039728 GLG1

The PANTHER Classification System

More...
PANTHERi
PTHR11884 PTHR11884, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00839 Cys_rich_FGFR, 15 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51289 GLG1_C_RICH, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z1E9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRLSAALQL LLLAATGAQN NHGQVQVPGA NIGPLLGQAE GGSPAGQQLL
60 70 80 90 100
QLSQQQKQPP QQQQQQQPAF PAGGPPARRG GAGPGGTGGG WKLAEEESCR
110 120 130 140 150
EDVTRVCPKH TWSNNLAVLE CLQDVREPEN EISSDCNHLL WNYKLNLTTD
160 170 180 190 200
PKFESVAREV CKSTISEIKE CAEEPVGKGY MVSCLVDHRG NITEYQCHQY
210 220 230 240 250
ITKMTAIIFS DYRLICGFMD DCKNDINLLK CGSIRLGEKD AHSQGEVVSC
260 270 280 290 300
LEKGLVKEAE EKEPKIQVSE LCKKAILRVA ELSSDDFHLD RHLYFACRDD
310 320 330 340 350
RERFCENTQA GEGRVYKCLF NHKFEESMSE KCREALTTRQ KLIAQDYKVS
360 370 380 390 400
YSLAKSCKSD LKKYRCNVEN LPRSREARLS YLLMCLESAV HRGRQVSSEC
410 420 430 440 450
QGEMLDYRRM LMEDFSLSPE IILSCRGEIE HHCSGLHRKG RTLHCLMKVI
460 470 480 490 500
RGEKGNLGMN CQQALQTLIQ ETDPGADYRI DRALNEACES VIQTACKHIR
510 520 530 540 550
SGDPMILSCL MEHLYTEKMV EDCEHRLLEL QYFISRDWKL DPVLYRKCQG
560 570 580 590 600
DASRLCHTHG WNETSELMPP GAVFSCLYRH AYRTEEQGRR LSRECRAEVQ
610 620 630 640 650
RILHQRAMDV KLDPALQDKC LIDLGKWCSE KTETGQELEC LQDHLDDLAV
660 670 680 690 700
ECRDIVGNLT ELESEDIQIE ALLMRACEPI IQNFCHDVAD NQIDSGDLME
710 720 730 740 750
CLIQNKHQKD MNEKCAIGVT HFQLVQMKDF RFSYKFKMAC KEDVLKLCPN
760 770 780 790 800
IKKKVDVVIC LSTTVRNDTL QEAKEHRVSL KCRKQLRVEE LEMTEDIRLE
810 820 830 840 850
PDLYEACKSD IRGYCSTVQY GNAQIIECLK ENKKQLSTRC HQKVFKLQET
860 870 880 890 900
EMMDPELDYT LMRVCKQMIK RFCPEADSKT MLQCLKQNKN SELMDPKCKQ
910 920 930 940 950
MITKRQITQN TDYRLNPVLR KACKADIPKF CHGILTKAKD DSELEGQVIS
960 970 980 990 1000
CLKLRYADQR LSSDCEDQIR IIIQESALDY RLDPQLQLHC SDEIANLCAE
1010 1020 1030 1040 1050
EAAAQEQTGQ VEECLKVNLL KIRTELCKKE VLNMLKESKA DIFVDPVLHT
1060 1070 1080 1090 1100
ACALDIKHHC AAITPGRGRQ MSCLMEALED KRVRLQPECK KRLNDRIEMW
1110 1120 1130 1140 1150
SYAAKVAPAD GFSDLAMQVM TSPSKNYILS VISGSICILF LIGLMCGRIT
1160
KRVTRELKDR
Length:1,160
Mass (Da):132,326
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D30E2D1DAAC03CB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U51162 mRNA Translation: AAD00079.1

NCBI Reference Sequences

More...
RefSeqi
NP_001231202.1, NM_001244273.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100689240

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cge:100689240

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51162 mRNA Translation: AAD00079.1
RefSeqiNP_001231202.1, NM_001244273.1

3D structure databases

SMRiQ9Z1E9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10029.NP_001231202.1

Proteomic databases

PRIDEiQ9Z1E9

Genome annotation databases

GeneIDi100689240
KEGGicge:100689240

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2734

Phylogenomic databases

KOiK06816
OrthoDBi189325at2759

Family and domain databases

InterProiView protein in InterPro
IPR001893 Cys-rich_GLG1_repeat
IPR017873 Cys-rich_GLG1_repeat_euk
IPR039728 GLG1
PANTHERiPTHR11884 PTHR11884, 1 hit
PfamiView protein in Pfam
PF00839 Cys_rich_FGFR, 15 hits
PROSITEiView protein in PROSITE
PS51289 GLG1_C_RICH, 16 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGSLG1_CRIGR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z1E9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1999
Last modified: June 17, 2020
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
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