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Protein

Zinc finger protein with KRAB and SCAN domains 5

Gene

Zkscan5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri341 – 363C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri708 – 730C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri764 – 786C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri792 – 814C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 5
Alternative name(s):
Zinc finger protein 95
Short name:
Zfp-95
Gene namesi
Name:Zkscan5
Synonyms:Zfp95
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107533 Zkscan5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473161 – 819Zinc finger protein with KRAB and SCAN domains 5Add BLAST819

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki214Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki246Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki302Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki700Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki776Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9Z1D8
PaxDbiQ9Z1D8
PRIDEiQ9Z1D8

PTM databases

iPTMnetiQ9Z1D8
PhosphoSitePlusiQ9Z1D8

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSMUSG00000055991 Expressed in 250 organ(s), highest expression level in secondary oocyte
CleanExiMM_ZKSCAN5
ExpressionAtlasiQ9Z1D8 baseline and differential
GenevisibleiQ9Z1D8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082814

Structurei

3D structure databases

ProteinModelPortaliQ9Z1D8
SMRiQ9Z1D8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 132SCAN boxPROSITE-ProRule annotationAdd BLAST82
Domaini216 – 287KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri341 – 363C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri708 – 730C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri764 – 786C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri792 – 814C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOVERGENiHBG018163
InParanoidiQ9Z1D8
KOiK09229
OrthoDBiEOG091G02KC
TreeFamiTF338146

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9Z1D8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIMTESRAVI HLEPPAETSQ EQADLLIVKV EEEDCSWMQG YNRPVLETFY
60 70 80 90 100
QRFKHFQYHE AAGPRDALSQ LRVLCCEWLR PELHTKEQIL ELLVLEQFLT
110 120 130 140 150
ILPEEFQAWV REHHPESGEE AVAVIESIQR ELEERRQQIA TSPEVLPQKM
160 170 180 190 200
VPPGATQESF SHQCLPVEAQ PERESQNLLE ENALPVLQVS SVPLKDSQEL
210 220 230 240 250
TDSLLSDGPQ KLVKTEDVAD VAVSFILEEW AHLDQSQKSL GRDSRKEDCE
260 270 280 290 300
STTPVDYEPK EGNLEFTVQQ VSDAADPHWV AAERTEKNGV QRPESGEVSD
310 320 330 340 350
LKDMVPRWQV NPTSGNPRQK RPLRSGPDVN RKQKSNGERG HRCGDCGKFF
360 370 380 390 400
LQASNFIQHR RIHTGEKPFK CGECGKSYNQ RVHLTQHQRV HTGEKPYKCQ
410 420 430 440 450
VCGKAFRVSS HLVQHHSVHS GERPYGCNEC GKSFGRHSHL IEHLKRHFRE
460 470 480 490 500
KSQRCSDRRS KNTKLNIKQI PGLSEADLEL SGEVQRNACQ AEGHSEGCEH
510 520 530 540 550
QDGQQGVVMK ETLGQSSSKR TDCNEFSYVH KKSSPGERPH QCNECGKSFI
560 570 580 590 600
QSAHLIQHRR IHTGEKPFRC EECGKSYNQR VHLTQHHRVH TGEKPYACHL
610 620 630 640 650
CGKAFRVRSH LVQHQSVHSR ERPFKCNECG KGFGRRSHLA GHLRLHSRDK
660 670 680 690 700
SHQCHECGEI FFQYVSLLEH QVLHVGQKSE KNGICEEAYS WNLTVIKDKK
710 720 730 740 750
LELQEQPYQC DSCGKAFSYS SDLIQHYRTH SAEKPQKCDA CRDSTCQCPH
760 770 780 790 800
IKQQQKSCPS GKSHQCNECG RGFSLKSHLS QHQRIHTGEK PLQCKECGMS
810
FSWSCSLFKH LRSHERTDP
Length:819
Mass (Da):93,788
Last modified:July 27, 2011 - v2
Checksum:i51F5C332FBFCCB5A
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6PAK4Q6PAK4_MOUSE
Zinc finger protein with KRAB and S...
Zkscan5 Zfp95
746Annotation score:
F6SSC9F6SSC9_MOUSE
Zinc finger protein with KRAB and S...
Zkscan5
148Annotation score:
E0CX87E0CX87_MOUSE
Zinc finger protein with KRAB and S...
Zkscan5
219Annotation score:
F6TRS7F6TRS7_MOUSE
Zinc finger protein with KRAB and S...
Zkscan5
52Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186V → A in AAD00103 (PubMed:12860387).Curated1
Sequence conflicti584T → I in AAD00103 (PubMed:12860387).Curated1
Sequence conflicti742R → T in AAD00103 (PubMed:12860387).Curated1
Sequence conflicti792L → F in AAD00103 (PubMed:12860387).Curated1
Sequence conflicti807L → F in AAD00103 (PubMed:12860387).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62907 mRNA Translation: AAD00103.1
AC127411 Genomic DNA No translation available.
CCDSiCCDS39386.1
RefSeqiNP_057892.2, NM_016683.2
UniGeneiMm.332842

Genome annotation databases

EnsembliENSMUST00000085671; ENSMUSP00000082814; ENSMUSG00000055991
GeneIDi22757
KEGGimmu:22757
UCSCiuc009amn.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62907 mRNA Translation: AAD00103.1
AC127411 Genomic DNA No translation available.
CCDSiCCDS39386.1
RefSeqiNP_057892.2, NM_016683.2
UniGeneiMm.332842

3D structure databases

ProteinModelPortaliQ9Z1D8
SMRiQ9Z1D8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082814

PTM databases

iPTMnetiQ9Z1D8
PhosphoSitePlusiQ9Z1D8

Proteomic databases

MaxQBiQ9Z1D8
PaxDbiQ9Z1D8
PRIDEiQ9Z1D8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085671; ENSMUSP00000082814; ENSMUSG00000055991
GeneIDi22757
KEGGimmu:22757
UCSCiuc009amn.2 mouse

Organism-specific databases

CTDi23660
MGIiMGI:107533 Zkscan5

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOVERGENiHBG018163
InParanoidiQ9Z1D8
KOiK09229
OrthoDBiEOG091G02KC
TreeFamiTF338146

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

PROiPR:Q9Z1D8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055991 Expressed in 250 organ(s), highest expression level in secondary oocyte
CleanExiMM_ZKSCAN5
ExpressionAtlasiQ9Z1D8 baseline and differential
GenevisibleiQ9Z1D8 MM

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZKSC5_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1D8
Secondary accession number(s): E9QLY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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