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Protein

Protein-arginine deiminase type-1

Gene

Padi1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the deimination of arginine residues of proteins.By similarity

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.By similarity

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi153Calcium 1By similarity1
Metal bindingi155Calcium 1By similarity1
Metal bindingi155Calcium 2By similarity1
Metal bindingi157Calcium 1By similarity1
Metal bindingi157Calcium 2By similarity1
Metal bindingi164Calcium 1By similarity1
Metal bindingi175Calcium 1By similarity1
Metal bindingi178Calcium 1By similarity1
Metal bindingi178Calcium 2By similarity1
Metal bindingi350Calcium 4By similarity1
Metal bindingi352Calcium 3By similarity1
Metal bindingi363Calcium 2By similarity1
Metal bindingi370Calcium 3By similarity1
Metal bindingi371Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi374Calcium 3By similarity1
Metal bindingi408Calcium 4; via carbonyl oxygenBy similarity1
Metal bindingi411Calcium 4; via carbonyl oxygenBy similarity1
Active sitei644NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

  • histone citrullination Source: GO_Central
  • protein citrullination Source: UniProtKB

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-3247509 Chromatin modifying enzymes

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-1 (EC:3.5.3.15By similarity)
Alternative name(s):
Peptidylarginine deiminase I
Protein-arginine deiminase type I
Gene namesi
Name:Padi1
Synonyms:Pad1, Pdi1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1338893 Padi1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002200241 – 662Protein-arginine deiminase type-1Add BLAST662

Proteomic databases

MaxQBiQ9Z185
PaxDbiQ9Z185
PRIDEiQ9Z185

PTM databases

PhosphoSitePlusiQ9Z185

Expressioni

Tissue specificityi

Expressed only in the epidermis and uterus.1 Publication

Developmental stagei

Expressed during the estrus cycle. Expression is maximum at proestrus and moderate at estrus. Not expressed in diestrus and metaestrus phases.

Inductioni

By estrogen.

Gene expression databases

BgeeiENSMUSG00000025329 Expressed in 47 organ(s), highest expression level in uterine cervix
CleanExiMM_PADI1
ExpressionAtlasiQ9Z185 baseline and differential
GenevisibleiQ9Z185 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026378

Structurei

3D structure databases

ProteinModelPortaliQ9Z185
SMRiQ9Z185
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

eggNOGiENOG410IF3F Eukaryota
ENOG410ZKF3 LUCA
GeneTreeiENSGT00390000008680
HOGENOMiHOG000220908
HOVERGENiHBG053016
InParanoidiQ9Z185
KOiK01481
OMAiGRRMAKV
OrthoDBiEOG091G02QG
PhylomeDBiQ9Z185
TreeFamiTF331952

Family and domain databases

Gene3Di2.60.40.1700, 1 hit
2.60.40.1860, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR004303 PAD
IPR013530 PAD_C
IPR036556 PAD_central_sf
IPR013732 PAD_N
IPR038685 PAD_N_sf
IPR013733 Prot_Arg_deaminase_cen_dom
PANTHERiPTHR10837 PTHR10837, 1 hit
PfamiView protein in Pfam
PF03068 PAD, 1 hit
PF08527 PAD_M, 1 hit
PF08526 PAD_N, 1 hit
PIRSFiPIRSF001247 Protein-arginine_deiminase, 1 hit
SUPFAMiSSF110083 SSF110083, 1 hit
SSF49503 SSF49503, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z185-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPRAVQLS LRKPTHAVCV VGVETLVNVY SDVPKGAKTF GVSGSSEVKI
60 70 80 90 100
YMVYDPSRVA EPAGWAHWPL DANVDVVVVA DTVSKDLYDF KVKVSYFESQ
110 120 130 140 150
EAAALAHSVL YLTAVDVSLD VDTGRTGKVK KGSGDKKTWR WGPGGSGAIL
160 170 180 190 200
LVNCDRDIHG SREDLHANHL KSLEDLQDMS PMVLSCGGPD ELFESHKLVL
210 220 230 240 250
KASLSDSRRL KVFCARGGTS LSNYKQVLGP RHSSYEVERH SGERAIQFYV
260 270 280 290 300
EGLAFPDASF SGLLSLSVSL VDTRPLSEVS VFTDSVTFRV APWIMTPNTQ
310 320 330 340 350
PPLELYVCSV TDIHGRNDKF LEDMSHLATK ANCKLVVCPR AENRNDRWIQ
360 370 380 390 400
DELEFGYIDA PHKSFPVVFD SPRNRGLRDF ALKRILGPDF GYVTREIEFA
410 420 430 440 450
GASGLDSFGN LDVSPPVRVG NTDYPLGRIL IGGSFPKPSG RRMARVVRDF
460 470 480 490 500
LQAQQVQSPV ELYSDWLSVG HVDEFLSFVP TSDQKGFRLL LASPSACLQL
510 520 530 540 550
FQEKKEEGYG EAEQFDGLKH KAKRSINDIL ADKHLRRDSA HVQKCIDWNR
560 570 580 590 600
EVLKRELGLS ESDIVDIPQL FFLKGAYAEA FFPDMVNMVV LGKYLGIPKP
610 620 630 640 650
FGPLINGRCC LEEKVRSLLE PLGLRCVFID DFLFYHQLLG EIHCGTNVRR
660
KPFTFKWWNS VP
Length:662
Mass (Da):73,824
Last modified:May 1, 1999 - v1
Checksum:iF9A6C7DFF1031D8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013848 mRNA Translation: BAA34181.1
AB121692 Genomic DNA Translation: BAD16625.1
CCDSiCCDS18856.1
PIRiPH0203
RefSeqiNP_035189.1, NM_011059.2
UniGeneiMm.20854

Genome annotation databases

EnsembliENSMUST00000026378; ENSMUSP00000026378; ENSMUSG00000025329
GeneIDi18599
KEGGimmu:18599
UCSCiuc008vnh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013848 mRNA Translation: BAA34181.1
AB121692 Genomic DNA Translation: BAD16625.1
CCDSiCCDS18856.1
PIRiPH0203
RefSeqiNP_035189.1, NM_011059.2
UniGeneiMm.20854

3D structure databases

ProteinModelPortaliQ9Z185
SMRiQ9Z185
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026378

PTM databases

PhosphoSitePlusiQ9Z185

Proteomic databases

MaxQBiQ9Z185
PaxDbiQ9Z185
PRIDEiQ9Z185

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026378; ENSMUSP00000026378; ENSMUSG00000025329
GeneIDi18599
KEGGimmu:18599
UCSCiuc008vnh.1 mouse

Organism-specific databases

CTDi29943
MGIiMGI:1338893 Padi1

Phylogenomic databases

eggNOGiENOG410IF3F Eukaryota
ENOG410ZKF3 LUCA
GeneTreeiENSGT00390000008680
HOGENOMiHOG000220908
HOVERGENiHBG053016
InParanoidiQ9Z185
KOiK01481
OMAiGRRMAKV
OrthoDBiEOG091G02QG
PhylomeDBiQ9Z185
TreeFamiTF331952

Enzyme and pathway databases

ReactomeiR-MMU-3247509 Chromatin modifying enzymes

Miscellaneous databases

PROiPR:Q9Z185
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025329 Expressed in 47 organ(s), highest expression level in uterine cervix
CleanExiMM_PADI1
ExpressionAtlasiQ9Z185 baseline and differential
GenevisibleiQ9Z185 MM

Family and domain databases

Gene3Di2.60.40.1700, 1 hit
2.60.40.1860, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR004303 PAD
IPR013530 PAD_C
IPR036556 PAD_central_sf
IPR013732 PAD_N
IPR038685 PAD_N_sf
IPR013733 Prot_Arg_deaminase_cen_dom
PANTHERiPTHR10837 PTHR10837, 1 hit
PfamiView protein in Pfam
PF03068 PAD, 1 hit
PF08527 PAD_M, 1 hit
PF08526 PAD_N, 1 hit
PIRSFiPIRSF001247 Protein-arginine_deiminase, 1 hit
SUPFAMiSSF110083 SSF110083, 1 hit
SSF49503 SSF49503, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPADI1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z185
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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